• Title/Summary/Keyword: Ch/Ph molar ratio

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Studies on Anti-aging Action of Brown Algae (Undaria pinnatifida) -2. Dose Effect of Alginic Acid as Modulator of Anti-aging Action in Liver Membranes- (해조류 성분의 노화억제작용에 관한 연구 -2. 간장 세포막속의 노화억제작용의 조절성분으로서 알긴산의 투여효과-)

  • CHOI Jin-Ho;KIM Il-Sung;KIM Jae-Il;YOON Tae-Hyun
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.25 no.3
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    • pp.181-188
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    • 1992
  • To study the effect of alginic acid on modulation of the aging process, Sprague-Dawley(SD) male rats were fed the diets containing 0, 3, 6 and $9\%$ alginic acid isolated from brown algae(Undaria pinnatifida) for 16 weeks. The effects of alginic acid on body weight, malondialdehyde(MDA) content, peroxidizability index, cholesterol and phospholipid levels, cholesterol/phospholipid(Ch/Ph) molar ratio, and fatty acid compositions in liver membranes were investigated. Increasing alginic acid level in diets did not alter food intakes but effectively decreased body weights gain(p<0.01-0.005). Malondialdehyde(MDA) contents of diets containing 6 and $9\%$ alginic acid were effectively decreased in ranges of $54.1-43.0\%$ in mitochondria, and $65.5-87.7\%$ in microsome compared with $100\%$ of control group. Cholesterol levels of all diets containing alginic acid were significantly decreased in ranges of $87.0-72.3\%$ in mitochondria, and $87.4-68.1\%$ in microsome compared with $100\%$ of control group. Phopholipid levels in microsome were significantly decreased by diets containing 3 and $ 6\%$ alginic acid but Ch/Ph molar ratios in both membranes were decreased by diets containing 3 and $6\%$ alginic acid. Increasing alginic acid level in diets significantly decreased total fatty acid but effectively increased linoleic acid in microsome except for diet containing $9\%$ alginic acid. These data on liver membranes suggest that alginic acid added to diets can modulate the physiological changes if the aging process.

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