• 제목/요약/키워드: Cervix cancer

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A Single Measure of Cancer Burden Combining Incidence with Mortality Rates for Worldwide Application

  • Kim, Jeong Lim;Cho, Kyoung-Hee;Park, Eun-Cheol;Cho, Woo Hyun
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권1호
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    • pp.433-439
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    • 2014
  • We attempted to develop an indicator combining incidence with mortality rates (single measure of cancer burden, SMCB) and to compare the magnitudes of cancer burden by world region. The SMCB was used to measure the size of cancer burden summarizing the incidence and mortality. The incidence and mortality were divided in equivalent forms and were split. The criteria dividing the size of cancer burden were used as the maximum incidence and mortality by men and women according to the world database, and the value corresponding to 10% of each maximum was set as the cut-off value. In SMCB, the size of cancer burden was highest for men with lung cancer (SMCB=18) and for women with breast cancer (SMCB=14) in MDR (more developed regions) compared to the size of burden in LDR (lower developed regions) (lung, SMCB=11, breast, SMCB=8). For men, the size of cancer burden by region was highest in EURO (SMCB=18, lung), followed by WPRO (SMCB=16, lung), PAHO (SMCB=14, prostate), AFRO (SMCB=8, prostate) and SEARO (SMCB=7, lung). Moreover, for women, the size of cancer burden was greatest in EURO (SMCB=14, breast), followed by PAHO (SMCB=13, breast), AFRO (SMCB=11, cervix uteri), EMRO (SMCB=9, breast) or SEARO (SMCB=8, cervix uteri) and WPRO (SMCB=7, lung). The summary indicator will help to provide a priority setting for reducing cancer burden in health policy.

Follow-Up Consultations for Cervical Cancer Patients in a Mexican Cancer Center. Comparison with NCCN Guidelines

  • Serrano-Olvera, Alberto;Cetina, Lucely;Coronel, Jaime;Duenas-Gonzalez, Alfonso
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권20호
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    • pp.8749-8752
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    • 2014
  • Purpose: This study aimed to determine the patterns of follow-up visits for cervix cancer in a national cancer center in Mexico. Materials and Methods: The National Cancer Institute of Mexico is cancer center with 119 beds that mostly cares for an underserved and socially disadvantaged population. The medical records of cases of cervical cancer that had at least one year of clinical follow-up after being in complete response at the end of primary treatment were analyzed. We recorded the numbers of total and yearly follow-up visits and these were compared with the number of follow-up visits recommended by the National Comprehensive Cancer Network 2013, version 2 for cervical cancer. Results: Between March and June 2007, the medical records of 96 consecutive patients were reviewed. Twenty (21%) of these met inclusion criteria and were selected. In the first year the median number of visits was 11 (4-20). In the ensuing years, $2^{nd}$, $3^{rd}$, $4^{th}$ and $5^{th}$, the number of analyzed patients remaining in follow-up decreased to 17, 14, 13 and 9 respectively. There were 462 follow-up visits to primary treating services (Gynecology Oncology, Radiation Oncology and Medical Oncology) as compared to 220 suggested by the NCCN guidelines ($X^2$ test p<0.0001). There were 150 additional visits to other services. Conclusions: Our results suggest that in our institution there is an overuse of oncological services by cervical cancer patients once treatment is completed.

Distribution of Human Papilloma Virus Infections of Uterine Cervix among Women of Reproductive Age - a Cross Sectional Hospital-Based Study from North East India

  • Sarma, Usha;Mahanta, Jagadish;Borkakoty, Biswajyoti;Sarmah, Bidula
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권4호
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    • pp.1519-1523
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    • 2015
  • Infection of the uterine cervix by human papilloma viruses (HPV) may be associated with cervical pre-cancer and invasive cervical carcinoma if left untreated. With advance in molecular techniques, it has become easier to detect the resence of HPV DNA long before the appearance of any lesion. This study concerned cervical scrape samples of 310 married non-pregnant women attending a gynecology outpatient department for both Pap and PCR testing to detect HPV DNA. Nested PCR using primers for L1 consensus gene with My9/My11 and GP6+/GP5+followed by multiplex PCR were carried out to detect HPV 16 and HPV18. Result: HPV prevalence was 11.9% out of which 3.67% cases of negative for intra-epithelial lesion or malignancy (NILM) and in 71.1% (27/38) of atypical cervical smears were HPV positive. There was increasing trend of high-risk-HPV positivity (HR HPV 16 and 18), from 20% in benign cytology (NILM) to 42.9 % in LSIL, 71.41% in HSIL and 100% in SCC. There was highly significant association of HPV infection with cervical lesion ($x^2=144.0$, p<0.01) and also with type specific HPV prevalence ($x^2=7.761^*$, p<0.05).

임신중 자궁 경부암 (Cevix Cancer Associated with Pregnancy - A Case Report and Review of the Literature-)

  • 이태준;권형철
    • Radiation Oncology Journal
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    • 제7권1호
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    • pp.77-80
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    • 1989
  • 임신중의 침윤성 자궁경부암은 비교적 드물다. 임신중 자궁경부암 치료는 암의 제거뿐 아니라 태아의 생명도 고려해야 한다. 임신초기 및 중기에 진단을 받았을 시에는 치료는 즉시 시작되어야 하고 임신후기에는 태아의 생명력이 있을 때까지 치료는 연기되어야 한다.

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An Audit of 204 Histopathology Reports Over Three Years of Carcinoma of Cervix: Experience from a Tertiary Referral Centre

  • Pradhan, Anuja Prakash;Menon, Santosh;Rekhi, Bharat;Deodhar, Kedar
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권14호
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    • pp.5643-5645
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    • 2015
  • Background: The aim was to see compliance to minimum data set information in carcinoma cervix histopathology reports from a team of 13 pathologists; and also to analyse the distribution of parameters like tumor size, grade, depth of cervical stromal invasion, lymph node yield and pTNM stage. Materials and Methods: All pathology reports of radical hysterectomy for carcinoma cervix operated in house within a three year duration (2010-2012), (n=204) were retrieved from medical records and analyzed for the above parameters. Results: In 2010- 59 cases, in 2011- 67 cases and in 2012- 78 cases of carcinoma cervix underwent operations in our hospital. The median age was 50.5 years and the maximum T diameter was 2.8 cms in the reports of three years. Squamous carcinoma was the commonest subtype amongst all the tumors. It was noted that 60.8% of cases had cervical stromal involvement more than half the thickness of the cervical stroma. Parametrial involvement was seen in 4.82% of cases. pTNM Staging was not mentioned in 65.06% of the cases. The mean bilateral pelvic lymph node yield count in our study was 16.6 inclusive of all the three years. Conclusions: Compliance with provision of a minimum dataset in our team of 13 pathologists was generally good. Lymph node yield in our hands is reasonable, but constant striving for greater numbers should be made. pTNM staging should be more meticulously documented. Use of proformas /checklists is recommended.

한국에서 자궁경부알 방사선치료의 Patterns of Care Study 진행을 위한 문헌 비교 연구 (Literature Analysis of Radiotherapy in Uterine Cervix Cancer for the Processing of the Patterns of Care Study in Korea)

  • 최두호;김은석;김용호;김진희;양대식;강승희;우홍균;김일한
    • Radiation Oncology Journal
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    • 제23권2호
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    • pp.61-70
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    • 2005
  • 목적: 한국인의 여성암 중에서 호발하는 암 중의 하나인 자궁경부암의 검사 및 치료 형태와 치료 결과가 발표된 연구 논문을 통해 분석하고 미국과 일본 자궁경부암의 Patterns of Care Study (PCS)와 비교하여 한국 실정에 맞는 PCS 문항 개발의 진행을 위한 기본 자료를 제시하기 위해 문헌 비교 연구를 시행하였다. 대상 및 방법: 외국의 PCS 관련 자료는 PCS 홈페이지에 소개된 212편의 논문 및 초록 중에서 자궁경부암 및 PCS 구조부분의 논문(42편)과 최근에 발표된 논문을 대상으로 하였으며 한국에서 연구된 것은 Korean Pub Med에서 자궁경부암과 방사선치료에 관한 자료를 구하고(99편) 외국 잡지에 발표된 것을 포함하여 PCS의 비교 대상을 선정하여 PCS의 구조(Structure), 진행(Process), 결과(Outcome) 의 순서에 따라 비교 분석하였으며 시대에 따른 PCS의 패턴을 분석하기 위해 1980년대 이전과 1990년대 이후의 연구 결과로 나누어서 분석 하였다. 결과: 미국과 일본에서 자궁경부암의 PCS에 관한 논문이 각각 28편과 10편이 분석 가능하였고 한국은 73편이 PCS에서 다루는 항목을 포함하여 분석 가능하였다. 미국과 일본의 PCS는 공통적으로 치료기관의 규모, 의사 및 환자 수, 그리고 치료기관의 성격에 따라 계층화된 3~4개의 구조로 나누고 연구 대상 환자를 엄격하게 제한하였다. 그리고 연구의 진행을 위해 치료 전 병기 결정과정의 요소들을 나누고 시대에 따른 병기결정의 요소들을 분석하였으며 치료와 관련된 여러 가지 인자들을 다루고 FIGO 병기 이외의 예후인자들도 자세히 분석하며 기계에 대한 비교분석이 잘 되어 있다. 그러나 미국과 일본의 PCS도 그 나라의 특성상 미국은 인종간의 특성, 사회경제적 계층에 대한 분류를 시도하고 있으며, FIGO 병기에서 다루지 않은 종양의 크기(6편), 자궁방 또는 골반벽 침범이 한쪽 또는 양쪽으로 진행된 것에 따른 치료 결과의 분석이 활발하였고(5편), 일본은 종양표지자에 대한 연구가 포함되어 있다. 그리고 병기 결정 과정에서 공통적인 시대적 변화는 초창기의 림프과조영술, 바륨 관장술이 점차 사라지고 나중에 CT, MRI의 비중이 높아졌다. 한국 자료는 주로 단일 기관에서 한 연구로 구조(Structure)에 대한 언급이 없으며 기계적 특성에 따른 차이도 거의 분석하지 않았다. 그러나 최근의 연구 주제는 미국, 일본의 PCS에서 잘 다루지 않던 항암제의 병용 요법(9편), 치료기간(4편) 종양표지자(8편), 비전형적 분획 등을 다루고 있다. 결론: 여러 나라의 문헌을 비교 분석하여 한국에서 필요한 자궁경부암의 PCS를 이용한 문항개발이 이루어졌다. 그리고 후속적인 연구로 진행될 근접치료기 사용 및 치료의 결과, 부작용 등의 비교 분석을 포함하여 한국형 자궁경부암 PCS에서 필요한 항목을 합의 도출하여 완성하였으며 이 내용을 토대로 향후 표준화된 치료 모델 개발을 위한 PCS가 진행될 수 있으며 환자의 치료에 있어서 부족했던 분야에 대해 교정할 수 있는 교육적인 목적도 제시할 수 있을 것이다.

Opportunistic Screening for Cervical Cancer in a Tertiary Hospital in Karnataka, India

  • Kulkarni, Padmaja Ramesh;Rani, Hephzibah;Vimalambike, Manjunath Gubbanna;Ravishankar, Sunila
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권9호
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    • pp.5101-5105
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    • 2013
  • The incidence and mortality of cervical cancer remains high in India even after sixty years of introduction of the Pap smear (cervical cytology) which is an effective means of identifying preinvasive lesions of carcinoma cervix. The morbidity and mortality due to cervical cancer has come down drastically in countries with well established screening programmes at national level. This study aims at screening women for cervical cancer opportunistically during their visit to hospital and to study various types of neoplastic and non-neoplastic lesions of the cervix by cervical smear study (Pap smear study). In the present study, a total of 350 cervical smears were studied. The age of patients ranged from 19 years to 80 years with mean age being 37.5 years. Out of 350 cases, the diagnosis of neoplasia was given in 43 cases and 258 cases were diagnosed as inflammatory smears. Forty-cases were normal and 9 cases were inadequate to evaluate. Forty-three patients who were found to have neoplastic lesions on cytology were referred for further investigations like colposcopy and biopsy to confirm the diagnosis and avail proper treatment. Limitation of the present study was small sample size as all female patients aged between 20 and 60 years visiting hospital were not included in the screening, other screening tests like VIA (visual inspection with acetic acid test) and HPV DNA (human papilloma virus) tests were not done. Until the time centrally organised screening programmes for cervical cancer are established in India, arrangements should be made for hospital based opportunistic screening for all women attending hospital. The cost effectiveness of different screening tests for cervical cancer should be evaluated.

암 생존율에 대한 한국 대중의 인식과 역학적 사실 사이에서 발생하는 불일치 : 온라인 설문을 중심으로 (Discrepancies Between Public Perceptions and Epidemiological Facts Regarding Cancer Survival Rate in Korea : An Online Survey)

  • 김재우;강정규;김성호
    • 한국콘텐츠학회논문지
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    • 제17권1호
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    • pp.113-119
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    • 2017
  • 본 연구의 목적은 5대 암(위암, 대장암, 간암, 유방암, 자궁경부암)을 중심으로 5대 암에 대한 대중의 5년 생존율 인식을 조사하여 그 결과를 역학적 사실과 비교하고 암 생존율 인식에 미치는 요인을 규명하는 것이다. 자료는 2016년 4월 19일부터 24일까지 단면 인터넷 설문 조사를 수행하여 총 354명의 설문 응답을 수집하였다. 연구대상자의 특성을 파악하기 위한 빈도분석, 연구대상자의 5년 생존율 인식과 역학적 사실과의 비교를 위한 히스토그램 제시, 연구대상자의 5년 생존율에 미치는 요인을 검증하기 위한 다중회귀분석을 실시하였다. 분석결과, 위암, 대장암, 유방암, 자궁경부암의 생존율에 대한 대중의 인식은 역학적 사실보다 낮게, 간암의 생존율에 대한 대중의 인식은 역학적 사실보다 높게 인식하였다. 마지막으로 암 진단유무, 연령, 규칙적인 운동유무가 5년 생존율 인식에 유의한 영향을 주는 요인으로 나타났다.