• Biomolecules & Therapeutics
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• v.10 no.1
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• pp.19-24
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• 2002

The effects of a newly synthesized $H^+/K^+$ ATPase inhibitor,1-(2-methyl-4-methoxypheny)-4-[(3-hy-droxypropyl)amino] -6-methyl-2,3-dihydropyrrolo (3,2-c) quinoline (DBM-819) , on the central nervous system, isolated smooth muscle, cardiovascular and digestive systems and renal function were investigated in various experimental animals. Oral administration of DBM-819 had no effect on the central nervous system except body temperature of mice slightly decreased at doses of 15 and 50 mg／kg. DBM-819 produced a moderate analgesic effect in acetic acid-induced writhing test in mice at 50 mg／kg (p.o.). In conscious rats, DBM-819 (15 and 50 mg／kg, p.o.) showed a slight increase in blood pressure and a small decrease in heart rate. DBM-819 had an significant effect on agonist-induced contraction of guinea pig ileum at $1.5{\times}10^{-5}g/ml.$ No significant effect of DBM-819 (5 and 15 mg／kg, i.p) on urinary volume or urinary excretion of $Na^+,\;K^+$ and Cl- was observed in rats. DBM-819 had no significant effect on intestinal transport of a semisolid meal in mice at 15 and 50 mg／kg (p.o.). These findings suggest that DBM-819 exerts no significant pharmacological effects on the central nervous system and renal function at 15 mg／kg (p.o.), but produces some effects on the smooth muscle and circulatory system.

• Biomolecules & Therapeutics
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• v.27 no.3
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• pp.265-275
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• 2019

Technological advances of mankind, through the development of electrical and communication technologies, have resulted in the exposure to artificial electromagnetic fields (EMF). Technological growth is expected to continue; as such, the amount of EMF exposure will continue to increase steadily. In particular, the use-time of smart phones, that have become a necessity for modern people, is steadily increasing. Social concerns and interest in the impact on the cranial nervous system are increased when considering the area where the mobile phone is used. However, before discussing possible effects of radiofrequency-electromagnetic field (RF-EMF) on the human body, several factors must be investigated about the influence of EMFs at the level of research using in vitro or animal models. Scientific studies on the mechanism of biological effects are also required. It has been found that RF-EMF can induce changes in central nervous system nerve cells, including neuronal cell apoptosis, changes in the function of the nerve myelin and ion channels; furthermore, RF-EMF act as a stress source in living creatures. The possible biological effects of RF-EMF exposure have not yet been proven, and there are insufficient data on biological hazards to provide a clear answer to possible health risks. Therefore, it is necessary to study the biological response to RF-EMF in consideration of the comprehensive exposure with regard to the use of various devices by individuals. In this review, we summarize the possible biological effects of RF-EMF exposure.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2003.05a
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• pp.78-83
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• 2003

We investigated the physiological patterns of cybersickness in a Virtual Reality(VR). Subject were exposed to the VR for 9.5 min, and required to detect specific virtual objects. Sixteen electrophysiological signals were recorded before, during, and after the virtual navigation. five questionnaires on the VR experience were acquired form 61 healthy subjects. During the virtual navigation, subjects with the high cybersickness susceptibility showed significant physiological changes, which included increased gastric tachyarrhythmia, eyeblink frequency, and EEG delta wave and decreased EEG beta wave. These results suggest that cybersickness may induce or accompany the changes in central nervous system and autonomic nervous system. Also, these results suggest that there may be increased sympathetic activation in autonomic drive for cybersickness.

• Physical Therapy Korea
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• v.5 no.1
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• pp.79-90
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• 1998

Neurodevelopmental treatment(NDT) is a widely used technique by physical and occupational therapists in the treatment of neuromuscular disorders. Childeren with cerebral palsy are frequently referred for physical and occupational therapy, yet the effectiveness of treatment has not been well-documented. More than 40 years ago, the Bobath introduced a treatment concept for individuals with central nervous system impairment. A theoretical framework for the approach was based on the common belief in the 1940s that the nervous system functions in a hierarchy. Clinical aspects of the NDT approach have grown and changed during the past 40 years. This article details the original NDT concepts and looks at the concept with regard to newer theoretical frameworks of nervous system.

• Proceedings of the Zoological Society Korea Conference
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• 1999.04a
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• pp.65.2-65
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• 1999

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 1996.10a
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• pp.139.1-139
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• 1996

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 1997.04a
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• pp.75.2-75
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• 1997

No Abstract, See Full Text

• Proceedings of the Korean Society of Applied Entomolohy Conference
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• 2002.11a
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• pp.105-105
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• 2002

• Proceedings of the Zoological Society Korea Conference
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• 2003.08a
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• pp.158.3-158
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• 2003

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 2001.04a
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• pp.73.1-73
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• 2001

No Abstract, See Full Text