• Title/Summary/Keyword: Central Europe

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Quantitative Analysis and Enantiomeric Separation of Ephedra Alkaloids in Ma Huang Related Products by HPLC-DAD and UPLC-MS/MS

  • Kyoung-Moon Han;Jinwoo Hwang;Sun Hee Lee;Boreum Park;Hyungil Kim;Sun Young Baek
    • Natural Product Sciences
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    • v.28 no.4
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    • pp.168-180
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    • 2022
  • Ephedra is a genus of the Ephedraceae family and is found in temperate regions, such as Central Asia and Europe. Among the various ephedra species, Ma Huang (Ephedra herb) is derived from the aerial parts of Ephedra sinica S tapf, Ephedra equisetina Bunge, and Ephedra intermedia Schrenk & C.A. Mey. Ma Huang contains various ephedra alkaloids, including (-)-ephedrine, (+)-pseudoephedrine, (-)-norephedrine, (+)-norpseudoephedrine, (-)-methylephedrine, and (+)-methylpseudoephedrine, which are found naturally as single enantiomers, although they can be prepared as racemates. Although the use of Ma Huang in foods is prohibited in Korea, products containing Ma Huang can be imported, and so it is necessary to develop a suitable analytical technique for the detection of Ma Huang in foods. Herein, we report the development of analytical methods for the detection of ephedra alkaloids in products containing Ma Huang. Following sample purification by solid phase extraction, quantitative analysis was performed using ultra-performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-MS/MS). Additionally, the enantiomers were successfully separated using HPLC-DAD. We successfully analyzed various food samples, where the ephedra alkaloids were qualitatively and quantitatively determined, and the enantiomers were separated. It is expected that these methods may contribute toward preventing the distribution of illegal products containing Ma Huang.

Regional Innovation Clusters Policy in Germany: Focusing on the State Baden-Württemberg (독일의 지역 혁신클러스터 정책: 바덴-뷔르템베르크주를 중심으로)

  • Young-Jin Ahn;Ji-Yeung Gu
    • Journal of the Economic Geographical Society of Korea
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    • v.26 no.4
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    • pp.391-407
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    • 2023
  • The state of Baden-Württemberg has one of the strongest regional economies in Germany and is known as one of the most innovative regions in both Germany and Europe. Clusters have played a central role in innovation strategies. The article analyzes the current cluster policy in Baden-Württemberg. The Baden-Württemberg cluster policy has systematically supported the development of clusters, cluster initiatives, and state-wide networks. It has also provided increasing support to regions in developing and implementing innovation and networking activities. The cluster policy has specifically focused on promoting collaborations across different industries and technologies, as well as implementing measures for internationalization. The goal of the Baden-Württemberg state cluster policy was to professionalize cluster management and improve its quality. The cluster policy in Baden-Württemberg has adopted a bottom-up approach and utilized various measures and instruments to promote dialogue. The cluster policy in Baden-Württemberg has established a dedicated cluster agency responsible for developing strategies and implementing individual measures.

International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy

  • Seung Joo Kang;Chung Hyun Tae;Chang Seok Bang;Cheol Min Shin;Young-Hoon Jeong;Miyoung Choi;Joo Ha Hwang;Yutaka Saito;Philip Wai Yan Chiu;Rungsun Rerknimitr;Christopher Khor;Vu Van Khien;Kee Don Choi;Ki-Nam Shim;Geun Am Song;Oh Young Lee
    • Clinical Endoscopy
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    • v.57 no.2
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    • pp.141-157
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    • 2024
  • Antithrombotic agents, including antiplatelet agents and anticoagulants, are widely used in Korea because of the increasing incidence of cardiocerebrovascular disease and the aging population. The management of patients using antithrombotic agents during endoscopic procedures is an important clinical challenge. The clinical practice guidelines for this issue, developed by the Korean Society of Gastrointestinal Endoscopy, were published in 2020. However, new evidence on the use of dual antiplatelet therapy and direct anticoagulant management has emerged, and revised guidelines have been issued in the United States and Europe. Accordingly, the previous guidelines were revised. Cardiologists were part of the group that developed the guideline, and the recommendations went through a consensus-reaching process among international experts. This guideline presents 14 recommendations made based on the Grading of Recommendations, Assessment, Development, and Evaluation methodology and was reviewed by multidisciplinary experts. These guidelines provide useful information that can assist endoscopists in the management of patients receiving antithrombotic agents who require diagnostic and elective therapeutic endoscopy. It will be revised as necessary to cover changes in technology, evidence, or other aspects of clinical practice.

Investigation of Forest Maschines and Tools in Central Europe (1) - On the Ax - (유럽 중부지방(中部地方)의 산림작업용(山林作業用) 기기(機器)의 조사검토(調査検討) (1) - 도끼편 -)

  • Ma, Sang Kyu
    • Journal of Korean Society of Forest Science
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    • v.53 no.1
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    • pp.62-74
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    • 1981
  • The developed record of forest maschines and tools in West Germany, Austria and Swiss, their technical characteristics and the working methods with them have been tried to investigate through the study of literature and observation. The aim of this investigation is to find out and introduce the technical information for training our forest men with them and for improving or developing our forest maschines and tools. Although ax chosen as first report for this aim is the oldest tool in the mankind history, still this is widely using in the forest work. And this has some special working filed that any other maschines could not overcome and sometimes should be recommended in the agronomical sideview. Through this investigation several points could be proposed as the technical informations when we will try to improve our ax 1. Radius of as-face curvature is proposed to be 150 mm and it's central point to be passed at one third point near to ax-eye. 2. Cutting angle is proposed to be $30^{\circ}$, ax-thick at 12 mm distance from ax-face to be 4 mm, thick at 30 mm distance from face to be 5 to 6 mm and ax-face width to be $125{\pm}5mm$. 3. Neck size is proposed to be $3.5{\pm}0.5{\times}5.5{\pm}0.5cm$ with a little curvature and neck thick from ax-house to be more than 1.5 cm. 4. Ax weight is proposed to be 1,000 gr with the stupid back and the sharp front. 5. The handle length of ax will be followed to the arm length of our forest workers.

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THE BUDDHIST HERITAGE ON THE SILK ROAD: FROM GANDHARA TO KOREA

  • KHAN, M. ASHRAF
    • Acta Via Serica
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    • v.1 no.1
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    • pp.95-104
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    • 2016
  • The Silk Route in ancient times served as a link between the World's greatest civilizations and as a source of knowledge, art, religion and philosophy. This network of ancient caravan paths formed the first bridge between East and West, where two different civilizations came in contact with their respective cultural traditions and religious beliefs, as well as their scientific and technological achievements. One of the main routes of the Great Silk Route passed through the Karakoram, linking Kashgar with Kashmir and the Gandhara regions. The Karakoram Highway connects the Chinese province with Pakistan and follows the ancient Silk Route, which connected the Heartlands of Asia with the Western fringes and further beyond the entire continent of Europe. Evidences of the history of humankind, ranging from Pre-historic times to the spread of Buddhism from South Asia to China and the Far East, is depicted in the rocky cliffs on the waysides and on rough boulders scattered in the upper valley of the Indus River and its tributaries. The ancient trade routes also carried scholars, teachers, missionaries and monks of different beliefs and practices, who met and exchanged ideas. The Buddhists as well as Zoroastrians and other missionaries all followed the Silk Route, leaving permanent footprints of their passage. The ancient greater Gandhara is situated in the North-West of the Indian Sub-continent, with the steep mountain ranges of the Karakoram, the Pamir and the Hindu-Kush bordering it and the dry areas of Central Asia to its rear. A number of races from Central Asia migrated to Gandhara because of its mild climate and plentiful farm products and fruits. This area was an entry point of Western Culture into India and at the same times the exit point of Indian Culture, including Buddhism, to the West. In Gandhara, the diffusion of different cultures developed an art form, during the 1-7th centuries CE commonly known after its geographic name as "Gandhara Art". The Buddhism's route of introduction into China originated in Gandhara, then reached in Korea and Japan and other countries. The fame of Gandhara however, rested on its capital, "Taxila" which was a great centre of learning. From the time of the Achaemenians, down through Muslim period, Gandhara continued to establish and maintain a link between East & West, as shown by material evidences recovered from Taxila and other Buddhist centres of Gandhara during the course of archaeological excavations.

A Study of the Synoptic Climatology on the January's Cold and Warm Winter Especially in 600hPa Circulation : Case Study 1992 and 1984 in January (500hPa면 순환특성을 중심으로 한 동계 이상 한.난월의 종관기후학적 연구 -1992년과 1984년의 1월의 경우-)

  • Lee, Byung-Gon;Min, Woo-Ki
    • Journal of the Korean association of regional geographers
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    • v.2 no.2
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    • pp.103-111
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    • 1996
  • I followed the results of Lee and Min(1996) for classification of the months of cold and warm winter. The winter of 1992 and 1984 recorded extraordinary cold and warm. Study of the Synoptic Climatology on the January's cold and warm winter is below: (1) Climatology's characteristic. Temperature of extremely high temperature month is higher compared with extremely low temperature month. Also precipitation is more than over low temperature month compared with extremely high temperature month. (2) In circulation of 500hPa surface. (1) Extremely high temperature month At 500hPa, negative geopotential height anomalies in high latitude, three trough developed over eastern Canada. In midlatitude, a deep trough persisted in the central North Pacific and conspicuous positive height anomalies showed over northwestern Europe, Where a blocking anticyclone developed. It had been warmer than normal since last year in Korea due mainly to positive height anomalies stretched from central Siberia (2) Extremely low temperature month Appeared the strong meridional circulation and negative height anomalies showed from Far East to the Mid-Pacific and appeared ridge in the west of the North America and Atlantic. Alutien Low shows negative deviation during 1984. In northern hemisphere shows negative deviation. Therefore, we can show that the surface pressure distribution and height distribution of 500hPa level are closely connected with each other as parts of general circulation. (3) The characteristics of the general circulation pattern of the 500hPa (1) Extremely high temperature month is high than extremely low temperature month1984 in Zonal index (2) The majority type is S type in 500hPa level circulation of extremely high temperature month but extremely high temperature month is M type (3) The wave number in 500hPa all shows 3 wave. So can not distinguished by only predominant wave number pattern.

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Implications of China's Maritime Power and BRI : Future China- ROK Strategic Cooperative Partnership Relations (중국의 해양강국 및 일대일로 구상과 미래 한·중 협력 전망)

  • Yoon, Sukjoon
    • Strategy21
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    • s.37
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    • pp.104-143
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    • 2015
  • China's new grand strategy, the "One Belt, One Road Initiative" (also Belt Road Initiative, or BRI) has two primary components: Chinese President Xi Jinping announced the "Silk Road Economic Belt" in September 2013 during a visit to Kazakhstan, and the "21st Century Maritime Silk Route Economic Belt" in a speech to the Indonesian parliament the following month. The BRI is intended to supply China with energy and new markets, and also to integrate the countries of Central Asia, the Association of Southeast Asia Nations (ASEAN), and the Indian Ocean Region - though not Northeast Asia - into the "Chinese Dream". The project will be supported by the Asian Infrastructure Investment Bank (AIIB), due to open in 2016 with 57 founding members from all around the world, and China has already promised US$ 50 billion in seed funding. China's vision includes networks of energy pipelines, railways, sea port facilities and logistics hubs; these will have obvious commercial benefits, but also huge geopolitical significance. China seems to have two distinct aims: externally, to restore its historical sphere of influence; and internally, to cope with income inequalities by creating middle-class jobs through enhanced trade and the broader development of its economy. In South Korea, opinion on the BRI is sharply polarized. Economic and industrial interests, including Korea Railroad Corporation (KORAIL), support South Korean involvement in the BRI and closer economic interactions with China. They see how the BRI fits nicely with President Park Geun-hye's Eurasia Initiative, and anticipate significant commercial benefits for South Korea from better connections to energy-rich Russia and the consumer markets of Europe and Central Asia. They welcome the prospect of reduced trade barriers between China and South Korea, and of improved transport infrastructure, and perceive the political risks as manageable. But some ardently pro-US pundits worry that the political risks of the BRI are too high. They cast doubt on the feasibility of implementing the BRI, and warn that although it has been portrayed primarily in economic terms, it actually reveals a crucial Chinese geopolitical strategy. They are fearful of China's growing regional dominance, and worried that the BRI is ultimately a means to supplant the prevailing US-led regional security structure and restore the Middle Kingdom order, with China as the only power that matters in the region. According to this view, once China has complete control of the regional logistics hubs and sea ports, this will severely limit the autonomy of China's neighbors, including South Korea, who will have to toe the Chinese line, both economically and politically, or risk their own peace and prosperity.

A Study on the Structural Changes in Global Container Ports' Throughput(2003~'19) based on Top 100 Container Ports in the World (글로벌 컨테이너 항만 물동량의 구조적 변화에 관한 연구(2003~'19) - 세계 100대 컨테이너 항만을 대상으로)

  • Lee, Choong-bae;Lee, Young Shin;Liu, Yanfeng
    • Journal of Korea Port Economic Association
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    • v.37 no.3
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    • pp.55-74
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    • 2021
  • The role of container ports contributes greatly to international trade and national or regional economic development by supporting maritime transportation and occupies a central position in the supply chain connecting sea and land. The performance(traffic volume) of a port generally depends on geographic, economic, and operational factors etc. For the past several decades, container port volumes have grown with fluctuation. This study amis to analyze how global ports have undergone changes in terms of cargo volume by region, size and period. For the analysis, only the volumes of global top 100 ports were used. Shift-share analysis and BCG matrix analysis were employed as methodologies. According to the result of the analysis, the relative volatility of port traffic over the past 16 years as a whole was found to be limited. On the other hand, ports in China and Southeast and Southwest Asia, which are economically growing for the last decades, showed growing trends, while ports in Northeast Asia and Europe appeared to be in a stagnant or declining phase. It also shows that most of the global ports maintain limited changes in cargo volume because they are already positioned as central ports in the region. In addition, it can be seen that the global port volume has a close relationship with the change in the economic capability of the relevant region or country.

A Study on the Characteristics of Commemoration in the World War II Cemeteries - Focus on the Military Cemeteries of United States, the Commonwealth, and Germany in Western Europe - (제2차 세계대전 전쟁 묘지에 나타난 기념성 - 서유럽에 있는 미국군, 영연방군, 독일군 묘지를 대상으로 -)

  • Lee, Sang-Seok
    • Journal of the Korean Institute of Landscape Architecture
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    • v.49 no.5
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    • pp.97-111
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    • 2021
  • The purpose of this study was to analyze commemoration characteristics of the United States of America, the Commonwealth, and Germany through representative 14 military cemeteries of World war II in Western Europe. Based on the commemoration characteristics such as spacial characteristic, commemorative elements, and graves and headstone, the commemoration culture among U.S., the Commonwealth. and Germany were studied comparatively. The results are as follows. First, taking geometrical form with mainly square type, rarely circle and spiral patterned, most cemeteries were structured spatial central axis with symmetry, those cemeteries were styled neoclassical, but some of the U.S. cemeteries were modernistic, connecting spaces organically with curved line layout. Second, chapel, the wall of missing, the wall of battle map, and sculpture in the U.S military cemeteries, and 'the cross of sacrifice' and 'the stone of remembrance' as classical monument in the Commonwealth war cemeteries were commonly applied standardized commemorative elements, but commemorative monuments in German military cemeteries were restricted except monumental cross. Third, the symbolic cross of christianism was used all cemeteries to console and cherish the soul of soldiers, specially the Latin crosses in the U.S military cemeteries delivered political message as the american martyr for Western Europe and also the power of the U.S., but the cross in German and the Commonwealth war cemeteries were basically cherish and comfort individual spirit. Fourth, showing the power of victory with national patriotism, the U.S. strongly represented christianism and liberal democracy against communism, the Commonwealth showed imperialistic style, and German military cemeteries were quietly appeared as traditional style forwarding reconciliation and peace. This study suggest the war cemeteries have national identity with typical form and symbolic aesthetics. Further study will be required to materialize sublime commemoration in national cemeteries and to form advanced commemorative culture in Korea.

원격탐사 자료 공공 활용을 위한 한-유럽 국제협력

  • Kim, Yun-Su;Lee, Gwang-Jae;Triebnig, Gerhard;Hoersch, Bianca
    • Aerospace Engineering and Technology
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    • v.4 no.2
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    • pp.220-229
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    • 2005
  • The Earth observation imagery from satellite provide valuable informations for the central government, local governments and diverse public organizations. The analysis of applications and data, which are sold by commercial distributors of Earth observation satellite data, shows this phenomenon clearly. The Government of Republic of Korea established and carried out a national space development plan to meet the national needs for remotely sensed imagery. After this national space development plan and on behalf of Korean government KARI has developed and launched successfully the KOMPSAT-1 and operates it up to now. KARI is now to launch by the end of year 2005 another optical remote sensing satellite with very high resolution and named as KOMPSAT-2. For the application of such very high resolution remotely sensed data the product validation should be done carefully and this product validation require lots of ancillary data such as in-situ measurements. For the purpose of diverse ancillary data acquisition joint work with other nations, related institutes and international bodies is essential. In this paper the status of Korean European Cooperations will be introduced, which are derived by KARI, ARCS and ESA for the wide use of KOMPSAT data in Europe.

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