• Title/Summary/Keyword: Center move

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Precision evaluation of the treatment that used coordinates confirmation of couch in case of two forgets adjoined. (Couch의 좌표 확인을 이용한 치료 위치 이동의 정확성 평가)

  • Seo Jeong-min;Jeong Cheon-young;Park Young-hwan;Song Ki-won
    • The Journal of Korean Society for Radiation Therapy
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    • v.15 no.1
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    • pp.35-40
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    • 2003
  • I. Purpose Confirming an error to be able to break out in a method to move couch manually while operator sees the skin marks on patient in case of curing head who got 2 targets adjoined, so we analyze coordinates price of couch, evaluate reproducibility and precision of change movements between targets. II. Materials and Methods In radiotherapy, for confirming errors in manual movements by operators by exchanging between two targets to treat patient head, we read coordinates price(vertical, longitudinal, lateral three directions of couch) shown on a monitor of LINAC( CL 2100, Varian, USA) in order to evaluate accuracy about the length that moved in time for moving couch manually. After reading movement length of coordinates recorded in three directions of all treatment, we compared distance between targets recorded in RTP(Pinnacle, ADAC, USA) with reading coordinates price of couch, setting actually done the same patient for ten times, coordinates were recorded, treated for evaluating averages and degrees of errors and standard deviations. III. Results In method to confirm skin marks of patient by operators' view and to move couch manually, average standard deviations of movements between two targets are vertical 1.4mm, longitudinal 0.9mm, lateral 2.2mm in each direction. As for the error in straight dimension, it is about 3.6mm averages and 5.1mm maximum. The average of errors in each directions was vertical 1mm, longitudinal 0.7mm, lateral 2.7mm. The greatest error broke out in lateral direction with $25\%$ of all cases ; to exceed an error average. IV. Conclusions If operators moved manually couch for changing target points, errors about 3.6mm average degrees occur. It is important that operators confirm the errors prices of actual couch coordinates for asking a correct movement between the targets adjoined each other ; in case of treatment demanding high precision like 3D conformal therapy or IMRT. Therefore, if we apply couch coordinates confirmation to reproducibility and to precision evaluation of treatment, it's expected that we can execute high-quality radiotherapy.

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The dose distribution and DVH change analysis wing to effect of the patient setup error (환자 SET-UP ERROR에 따른 선량분포와 DVH 변화 분석)

  • Kim KyoungTae;Ju SangGyu;Ahn JaeHong;Park YoungHwan
    • The Journal of Korean Society for Radiation Therapy
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    • v.16 no.2
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    • pp.81-89
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    • 2004
  • Introduction : The setup error due to the patient and the staff from radiation treatment as the reason which is important the treatment record could be decided is a possibility of effect. The SET-UP ERROR of the patient analyzes the effect of dose distribution and DVH from radiation treatment of the patient. Material & Methode : This test uses human phantom and when C-T scan doing, It rotated the Left direction of the human phantom and it made SET-UP ERROR , Standard plan and 3mm, 5mm, 7mm, 10mm, 15mm, 20mm with to distinguish, it made the C-T scan error. With the result, The SET-UP ERROR got each C-T image Using RTP equipment It used the plan which is used generally from clinical - Box plan, 3Dimension plan( identical angle 5beam plan) Also, ( CTV+1cm margin, CTV+0.5cm margin, CTV+0.3,cm margin = PTV) it distinguished the standard plan and each set-up error plan and The plan used a dose distribution and the DVH and it analyzed Result : The Box4 the plan and 3Dimension plan which it bites it got similar an dose distribution and DVH in 3mm, 5mm From rotation error and Rectilinear movement( $0\%{\sim}2\%$ ). Rotation error and rectilinear error 7mm, 10mm, 15mm, 20mm appeared effect it will go mad to a enough change in treatment ( $2\%{\sim}^11\%$ ) Conclusion : The diminishes the effect of the SET-UP ERROR must reduce move with tension of the patient Also, we are important accessory development and the supply that it reducing of reproducibility and the move

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Light and Electron Microscopy of Rainbow Trout Gonadotropes and Spermatogenic Cells (무지개송어 뇌하수체의 성선자극호르몬 분비세포와 정자형성세포의 광학 및 전자현미경적 미세구조)

  • Yoon, Jong-Man;Park, Hong-Yang
    • Development and Reproduction
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    • v.2 no.1
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    • pp.89-99
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    • 1998
  • This study was carried out to investigate the morphological changes of gonadotropes in pituitary gland and spermatogenic cells in testis, obtained from 150 of 3-year-old immature and mature male rainbow trout (Oncorhynchus mykiss) during the reproductive cycles from March to February in the following year. In the maturation cycle of the pituitary gonadotropes of cultured rainbow trout, three periods can be distinguished i.e. a period of resting(March-August), a period of full spermatogenesis (September-November), and a period of breeding (December-February). The ultrastructures of the gonadotropes largely parallel the cyclical changes in the tests. The seminiferous tubules contain all spermatogenetic stages and sperm cells in a period of early maturation. At first, the size of the nucleus and cytoplasm decrease gradually at every stages from spermatogonia to spermatids. In the secondary spermatocytes, the small mitochondria are located over the outer cytoplam. In spermatids, the cytoplasmic masses move toward the posterior part of the nucleus. In spermatids, the two large mitochondria are located over the cytoplasm. In spermatids, the cytoplasmic masses move towark the posterior part of the nucleus. In spermatids, the two large mitochondria are located over the cytoplasm and begin to elongate. In spermatozoa, the surface of the nucleus devreases in volume. Examination by TEM shows that the nuclear envelope and plasma membrane are slightlywrinkled and closely adhered to the nucleus of spermatozoa. Two oval mitochondria are quite separated and the flagellum is inserted into the base of the spermatozoa head.The axoneme in this fish has the typical pattern such as nine peripheral doublets and a central doublet(9+2). there are remarkable individual differences in the size and morphology of spermatozoa head as observed by transmission and scanning electron microscopy.

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On the Seasonal Migration of Arzentine Hake, Merluccius hubbsi Marini (알젠틴 대구의 계절적 회유에 관하여)

  • CHUNG Sang-Chul;TANAKA Syoiti
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.18 no.6
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    • pp.571-580
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    • 1985
  • Based on the data collected by R/V "Shinkai Maru" of the Japan Marine Fishery Resources Research Center during the period from April 1978 to April 1979, seasonal migration of Merluccius hubbsi was studied using the catch per fishing effort (tons/30 min. haul) and gonad maturity index (gonad weight /body weight X $10^3$). Merlurccius hubbsi are found in the area between $36^{\circ}S\;and\;54^{\circ}S$ along the coast of Arzentine and are abundant especially above the 100 fathoms in northern offshore of $48^{\circ}S$. It was observed that critical maturity body lengths (spawning minimum body length) in terms of gonad maturity index are 40 cm and 30cm in female and male respectively, while spawning seasons are from December to January and from November to December for female and male respectively. It was assumed that while the group which distrbutes in the north ($36^{\circ}S{\sim}39^{\circ}S$) in spring moves down south to $42^{\circ}{\sim}46^{\circ}S$ for spawning in summer (from December to January), the group which does not move or a part of this group which comes back to the north spawn in the area north of $42^{\circ}S$ throughout the long period except winter time (from July to August). Southern group as well might move north and spawn after mixing together with northern group at $42^{\circ}{\sim}46^{\circ}S$ area around the period of December to January,

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Study on the Shapes of Jung-kwa, Gi-kwa, Sin-kwa, Hyul-kwa (정기신혈과(精氣神血科)의 형상(形象)에 대한 연구)

  • Choi Byung-Tae;Choi Yung-Hyun;Baek Geun-Gi;Lee Yong-Tae
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.5
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    • pp.1181-1190
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    • 2005
  • After study about the shapes of Jung, Gi, Sin, Hyul-kwa advocated by Master Jisan, the conclusions are drawn as follows. It pursues the rules of universe being changed from formless to concrete objects that the Body Essence, Vital energy, Mentality, and Blood are materialized to Jung, GE, Sin, Hyul-kwa. It can be drawn an inference from the next three theories that Jisan considered Jung, Gi, Sin, Hyul-kwa as round, square, reverse triangle, and triangle or oval shape. First, it was taken to following the shapes of viscera. Namely Jung-kwa was taken as Kidney, Gi-kwa as Lung, Sin-kwa as Heart, Hyul-kwa as Liver. Second, it was adopted from five kinds of constitutions according to the five elements in [Yeongchu Yin and Yang twenty five shapes] that is Jung-kwa is purchased with Water-earth phases, Gi-kwa with metal phase Sin-kwa with fire phase, Hyul-kwa with Wood phase, Third, it is taken in order to eliminate contradictions. Hyul-kwa disliking to move is assumed to round shape to easily move. Gi-kwa tending to disperse is chosen to square in order to be unmoved. Sin-kwa declining to stagnate of seven emotions is pursued to reverse triangle to compose oneself. Hyul-kwa inclining to gather is preferred to acreage phase to harmonize ascending tendency. Among shapes which Jisan was divided Hado, Nakseo, Bokhee pal kwoe, Moonwang pal kwoe, Jung-kwa as round is Hado, Gi-kwa as square is Nakseo, Sin-kwa as reverse triangle is Bokhee pal kwoe order shape, Hyul-kwa as acreage phase or oval shape is accord with Moonwang pal kwoe order shape. The reason being classified into Jung, GE, Sin, Hyul-kwa from the shapes of the face is that the face is the place to reflect the whole conditions of the body connected with all of the viscera and meridian system such as semen of plants. Above contents are drawn an inference from the transcription of Jisan's lectures and his writings. And it is considered that insufficient parts of the Jisan's theory must be demonstrated continuously.

A Study on the general language use of ROOJIN : in Headline Database of Newspaper Articles and Balanced Corpus of Contemporary Written Japanese by KOKKEN (현대일본문장어의 「노인(老人)」사용실태 - 国硏「ことばに関する新聞記事見出しデ?タベ?ス」 「現代日本語書き言葉均衡コ?パス」를 분석대상으로)

  • Oh, Mi sun
    • Cross-Cultural Studies
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    • v.25
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    • pp.627-648
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    • 2011
  • The study analyzed a diachronic distribution, social meanings and social evaluations of ROOJIN. 'Headline Database of Newspaper Articles' and 'Balanced Corpus of Contemporary Written Japanese' by KOKKEN were used as research data. There were 305 newspaper articles (About 0.2%) which contained the word ROOJIN at 'Headline Database of Newspaper Articles'. The number of newspaper articles related to ROOJIN started to increase in a rapid rate in 1972 and 1973. They were also increased in 1976, from 1981 to 1987, 1992 and 1993. The reasons of increasing of newspaper articles related to ROOJIN on those 4 periods of time could be summarized as follows. Firstly, there was a increasement of ROOJIN who are lonely, are not able to move about freely or live alone. Secondly, the understanding of a symptom of aging called BOKE was necessary. Thirdly, there were negative evaluations in a society towards ROOJIN. There were 453 cases which contained the word ROOJIN at 'Balanced Corpus of Contemporary Written Japanese' on the data since 2000. The most frequently used words were ones that are related to senior care facilities. There were 109 cases (24%) which contain those words. '~SISETSU', '~SENTA-', '~HO-MU' were presented as words related to senior care facilities. Among them, 78 cases contained the word '~HO-MU' which was similar to a home with family members. The second most frequently used words were ones that are related to 'welfare for the aged' and they are led by 'medical care for the aged'. They occupied about 8%. Institutionalization of medical care for the aged, medical expenses, nursing were presented as words related to 'medical care for the aged'. Words that were related to 'welfare for the aged' led by 'senior care facilities' and 'medical care for the aged' occupied about 32% of research data. As mentioned above, problems of the aged in Modern Japan such as negative evaluations in a society towards ROOJIN, ROOJIN who are lonely, are not able to move about freely or live alone, BOKE could be identified by analyzing the data. Also, The frequent usage of words such as 'Home for the aged', 'medical care for the aged' and 'nursing' could be identified. The outcome of analysis suggested that a family traditionally had a function of solving problems of the aged but that function was reduced in modern Japan. It also suggested that there was a tendency to outsource problems of the aged as much as possible.

A Study on the Usability Test of People with Disabilities According to the Development of Powered Wheelchair of Standing Support Type (기립보조형 전동휠체어 개발에 따른 장애인 사용성 평가 연구)

  • Rhee, Kun-Min;Kim, Dong-Ok;Hwangbo, Chi-Wook
    • 재활복지
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    • v.20 no.1
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    • pp.211-233
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    • 2016
  • The purpose of this study is to figure out problems and to suggest improvement scheme by examining 31 of the disabled who used power wheelchair developed for safe moving and standing support. The results are as follows. First, standing power wheelchair that enables the disabled to sit and stand up was developed. It can also be used as means of transportation for moving in narrow space and in a short distance. In the usability test of this prototype, two groups were respectively examined in 60 evaluation items. One group consisted of 16 people with disabilities using manual wheelchairs. And the other one consisted of 15 people with disabilities using automatic wheelchairs. The entire average figure of two groups was shown to be 2.72 and standard deviation was 0.820. Specifically, the average figure of the group in manual wheelchair was 2.85 and the one of the other group in automatic wheelchair was 2.57. And both group replied that the move to stand up and sit on both types of wheelchair was the most inconvenient thing. It shows why ergonomic design for persons with under extremity disabilities to stand up and sit is needed. Second, with further study based on the results of usability test of the disabled, it will make contribution to increase the quality of people with disabilities by helping them move and do daily lives on their own.

Position Control of Micro Particles in a Fluid Flow Using Ultrasonic Standing Wave (정재초음파를 이용한 유동중 미세 입자 위치 제어)

  • Cho, Seung-Hyun;Seo, Dae-Cheol;Ahn, Bong-Young;Kim, Ki-Bok;Kim, Yong-Il
    • Journal of the Korean Society for Nondestructive Testing
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    • v.28 no.2
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    • pp.131-136
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    • 2008
  • Using ultrasonic standing waves, micro particles submerged or flowing in fluid can be manipulated. Due to acoustic radiation force of ultrasound, particles are forced to move to pressure nodal or antinodal lines. In this work, we propose a method to control the position of micro particle in a flow by adjusting the frequency of the standing wave. To this end, standing wave field generation system including a few millimeter thick micro channel was established using an immersible ultrasonic transducer. The present generation system works valid in a frequency range between 2.0 MHz and 2.5 MHz. We observed the SiC particles in water moved to pressure nodal lines by the standing wave. The effect of the channel thickness and operating frequency was also investigated. Interestingly, it was shown that the operating frequency have a close relation with the location of the pressure nodal line. Consequently, it fan be said that the position of particle movement rail be controlled by adjusting the ultrasound frequency. The maximum range of the controllable position was about 261 micrometers under the given condition. The resulted observations reveal the possibility of various applications of the ultrasonic standing wave to the manipulation of particles submerged in a fluid.

Plantar Pressure in Skilled and Unskilled Players during Baseball Batting (야구 타격시 숙련자와 미숙련자의 족저압력 분석)

  • Moon, Won-Ho;Lee, Joong-Sook;Kim, Chang-Hyun;Jang, Young-Min;Jeong, Jin-Woo
    • Korean Journal of Applied Biomechanics
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    • v.23 no.1
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    • pp.25-35
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    • 2013
  • This study examined 24 right-handed amateur baseball players. Twelve who had played baseball for more than 6 years were grouped as skilled players, while 12 who had played for 1-3 years were the unskilled player group. The swing motion was divided into four event phases: stance, backswing, impact, and follow-through. The mean and maximum plantar pressure, center of pressure, and ground reaction force were measured during each event phase. The mean and standard deviations for each variables were calculated and differences were validated with the independent sample t-test. A p-value <0.05 was considered statistically significant. The results were as follows. 1)The ideal stance is a stable, balanced position with more than 65% of weight on the right foot. There was significant difference in mean left plantar pressure, while the maximal plantar pressure and mean right plantar pressure did not differ significant. 2)The effective backswing of a skilled player is comprised a rightward shift in weight to build maximum energy. More than 90% of the weight was on the right foot. There was a significant difference in the mean left plantar pressure, while the maximal plantar pressure and mean right plantar pressure did not differ significantly. 3) For an effective impact, a rapid shift in weight to the left foot is essential, so that a power hit is obtained. Significant difference in the mean and maximum plantar pressures of both feet were observed. 4)Follow-through requires wight balance, more on the right than the left, without leaning leftward. There was no significant difference in the mean or maximum plantar pressure. 5)The center of plantar pressure should move from the center of the foot to the toe. 6)The analyses of the ground reaction force suggest that a good swing involves a gradual shift in weight to the right side and a rapid leftward shift at impact. Good balance, with the center of gravity on the right side at follow-through, is also required.

Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes

  • Yawut, Natpaphan;Kaowinn, Sirichat;Cho, Il-Rae;Budluang, Phatcharaporn;Kim, Seonghye;Kim, Suhkmann;Youn, So Eun;Koh, Sang Seok;Chung, Young-Hwa
    • BMB Reports
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    • v.55 no.2
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    • pp.98-103
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    • 2022
  • Increased mRNA levels of cancer upregulated gene (CUG)2 have been detected in many different tumor tissues using Affymetrix microarray. Oncogenic capability of the CUG2 gene has been further reported. However, the mechanism by which CUG2 overexpression promotes cancer stem cell (CSC)-like phenotypes remains unknown. With recent studies showing that pyruvate kinase muscle 2 (PKM2) is overexpressed in clinical tissues from gastric, lung, and cervical cancer patients, we hypothesized that PKM2 might play an important role in CSC-like phenotypes caused by CUG2 overexpression. The present study revealed that PKM2 protein levels and translocation of PKM2 into the nucleus were enhanced in CUG2-overexpressing lung carcinoma A549 and immortalized bronchial BEAS-2B cells than in control cells. Expression levels of c-Myc, CyclinD1, and PKM2 were increased in CUG2-overexpressing cells than in control cells. Furthermore, EGFR and ERK inhibitors as well as suppression of Yap1 and NEK2 expression reduced PKM2 protein levels. Interestingly, knockdown of β-catenin expression failed to reduce PKM2 protein levels. Furthermore, reduction of PKM2 expression with its siRNA hindered CSC-like phenotypes such as faster wound healing, aggressive transwell migration, and increased size/number of sphere formation. The introduction of mutant S37A PKM2-green fluorescence protein (GFP) into cells without ability to move to the nucleus did not confer CSC-like phenotypes, whereas forced expression of wild-type PKM2 promoted such phenotypes. Overall, CUG2-induced increase in the expression of nuclear PKM2 contributes to CSC-like phenotypes by upregulating c-Myc and CyclinD1 as a co-activator.