• Journal of Korea Water Resources Association
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• v.57 no.3
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• pp.165-179
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• 2024

It is crucial to have a comprehensive understanding of inundation and water cycle in urban areas for mitigating flood risks and sustainable water resources management. In this study, we developed a Cellular Automata-based integrated Water cycle model (CAW). A comparative analysis with physics-based and conventional cellular automata-based models was performed in an urban watershed in Portland, USA, to evaluate the adequacy of spatiotemporal inundation simulation in the context of a high-resolution setup. A high similarity was found in the maximum inundation maps by CAW and Weighted Cellular Automata 2 Dimension (WCA2D) model presumably due to the same diffuse wave assumption, showing an average Root-Mean-Square-Error (RMSE) value of 1.3 cm and high scores of binary pattern indices (HR 0.91, FAR 0.02, CSI 0.90). Furthermore, through multiple simulation experiments estimating the effects of land cover and soil conditions on inundation and infiltration, as the impermeability rate increased by 41%, the infiltration decreased by 54% (4.16 mm/m²) while the maximum inundation depth increased by 10% (2.19 mm/m²). It was expected that high-resolution integrated inundation and water cycle analysis considering various land cover and soil conditions in urban areas would be feasible using CAW.

• The Korea Journal of Herbology
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• v.27 no.6
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• pp.7-13
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• 2012

Objectives : Reactive oxygen species (ROS) have been associated with pathogenic processes including carcinogenesis through direct effect on DNA directly and by acting as a tumor promoter. Therefore, it has been regarded that ROS may be a major target for cancer prevention. The root of Paeonia lactiflora pall (PL), a traditional Chinese herb, has been a component of effective prescriptions for treatment of liver disease. Also, there are some reports about the antioxidant activities of the extracts from PL. However, little has been known about the effects of PL against oxidative damage. This work aimed to elucidate the anti-oxidant effects of Paeonia lactiflora pall (PL) in the non-cellular system and cellular system. Methods : Antioxidant activities of PL were evaluated by hydroxyl radical scavenging assay and $Fe^{2+}$ chelating assay. Anti-oxidative effect of PL was evaluated by ${\varphi}X$-174 RF I plasmid DNA cleavage assay in non-cellular system. In addition, DNA migration assay, expression level of phospho-H2AX, MTT assay and lipid peroxidation assay were performed for evaluate the anti-oxidative effect of PL in cellular system. Results : PL had a dose-dependent hydroxyl radical scavenging and $Fe^{2+}$ chelating capacity. In addition, PL inhibited oxidative DNA and cell damage induced by hydroxyl radical in non-cellular system and cellular system. Conclusion : Taken together, P. lactiflora pall may be possible for the application to a potential drug for treating the oxidative diseases such as cancer.

• Proceedings of the Korean Association for Survey Research Conference
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• 2005.12a
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• pp.143-157
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• 2005

• The Journal of the Korean dental association
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• v.19 no.11 s.150
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• pp.957-963
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• 1981

• YAKHAK HOEJI
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• v.44 no.4
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• pp.340-346
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• 2000

Cervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year. A strong association between certain human papilloma viruses (HPV types 16 and 18) and cervical cancer has been well known. An extract of natural products, named as Somatid, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16. This Somatid inhibited the proliferation of human cervical cancer cell lines (C-33A, SiHa, CaSki) and HaCaT keratinocytes in a dose response manner, In vitro binding assay and ELISA showed that Somatid inhibited the in vitro biding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, Somatid inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of mRNA for E6 and E7 were also decreased by Somatid. Our data suggested that Somatid inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus can be used as a putative anti-HPV agent for the treatment of cervical carcinomas caused by HPV.

• IMMUNE NETWORK
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• v.13 no.2
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• pp.43-54
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• 2013

Over the past 40 years, flow cytometry has emerged as a leading, application-rich technology that supports high-resolution characterization of individual cells which function in complex cellular networks such as the immune system. This brief overview highlights advances in multiparameter flow cytometric technologies and reagent applications for characterization and functional analysis of cells modulating the immune network. These advances significantly support highthroughput and high-content analyses and enable an integrated understanding of the cellular and molecular interactions that underlie complex biological systems.

• CELLMED
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• v.13 no.3
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• pp.9.1-9.4
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• 2023

Objective: A case report on improvements in complex diseases (recurrent cystitis, etc.) through the use of nutritional therapy Methods: A 56-year-old Korean female. The patient has various diseases and her quality of life has been reduced due to health problems. Results: Complex diseases were improved after undergoing nutritional therapy. Conclusion: Nutritional therapy can assist in treating complex diseases.

• CELLMED
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• v.12 no.4
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• pp.18.1-18.2
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• 2022

In Korea, liver cancer is the sixth most prevalent malignancy and the second leading cause of cancer-related mortality. The peak incidence of liver cancer deaths occurs between the ages of 40 and 59. (e.g. Yoon et al. 2021) The patient is a 69-year-old female with bronchiectasis as an underlying condition. She underwent left lower lobe resection for the disease, and in 2009 she was diagnosed with liver cancer and experienced a recurrence after a full recovery. In the case of such patients, the most effective OCNT prescription is recommended.

• CELLMED
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• v.12 no.5
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• pp.3.1-3.3
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• 2022

Objective: A Case Report on Reduction of Inflammation Using Nutritional Therapy Methods: The patient is a Korean male aged 62 years. The wound has developed inflammation and is not healing while the patient complains of pain. Results: After nutritional therapy, inflammation diminished. Conclusion: Nutritional therapy can be beneficial for inflammation, for which even skin transplantation was advised.

• CELLMED
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• v.12 no.5
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• pp.1.1-1.3
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• 2022

Objective: A case report on the reduction of tinnitus and improvement in feeling of residual urine as a result of nutritional therapy Methods: A 46-year-old Korean man presented with tinnitus lasting for 10 days, and complained of discomfort with a feeling of residual urine for several years. Results: Tinnitus disappeared after one week of nutritional therapy, and the feeling of residual urine improved after 40 days. Conclusion: Nutritional therapy can be beneficial in the treatment of diseases for which a definitive diagnosis and treatment are lacking, such as tinnitus.