• Title/Summary/Keyword: Cellular Metal

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Cadmium Altered Gene Expression Related to Zinc Homeostasis in the Mouse Brain (카드뮴이 마우스 뇌에서 아연의 항상성에 관여하는 유전자발현에 미치는 영향)

  • Park Jong-An;Yoe Eun-Young;Nam Sang-Hun;Jang Bong-Ki;Lee Jong-Wha;Kim Wan-Jong
    • Environmental Analysis Health and Toxicology
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    • v.19 no.4
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    • pp.389-399
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    • 2004
  • Metallothionein (MT), a small protein molecule which can bind or release metal ions, is involved in the regulation of cellular metal homeostasis. This study was investigated the accumulation of cadmium in blood, tissue (liver, kidney and brain), and the effect of cadmium on several key genes (MT-I, MT-II, ZnT-1) in zinc metabolism in the mouse. Mouses weighing 20∼25 g were randomly assigned to control and cadmium treated group (Cd group). Cd group was intraperitoneally injected with cadmium 2, 4, 8 mg/kg and control group was administerd with saline. Mouses of each group were sacrificed by decapitation 4 hours after the administration of cadmium. Cadmium contents in blood, liver, kidney and brain were increased by a dose-dependent manner. Accumulation of cadmium was mainly occurred in liver and kidney. Induction of MT-I and MT-II protein was increased, but ZnT-1 expression was decreased in a dose-dependent manner by the treatment of 2∼8 mg/kg cadmium. These results suggested that cadmium can be transported to brain and alter the expression of several key genes in zinc homeostasis.

A NOR-type High-Speed Dual-Modulus Prescaler (NOR 형태의 고속 dual-modulus 프리스케일러)

  • Seong, Gi-Hyeok;Kim, Lee-Seop
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.37 no.2
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    • pp.69-76
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    • 2000
  • A dual-modulus prescaler divides the input signal by one of the moduli according to the control signal. In this paper, a new fast dual-modulus prescaler is proposed. The proposed prescaler has a ratioed-NOR structure different from a conventional ratioed-NAND structure. The proposed one can operate at a higher speed by using parallely connected NMOSs instead of using series-connected ones. HSPICE simulation results using HYUNDAI 0.65(m 2-poly 2-metal CMOS process parameters show that the maximum operating frequency of the proposed dual-modulus prescaler is 2.8㎓ with power consumption of 40.7㎽ at 5V supply voltage at $25^{\circ}C$. The proposed dual-modulus prescaler can be utilized for the frequency-synthesis in cellular radio front-ends.

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Failure Maps and Derivation of Optimal Design Parameters for a Quasi-Kagome Truss Sandwich Panel Subjected to Bending Load (굽힘하중을 받는 준 카고메 트러스 샌드위치 판재의 파손선도와 최적설계변수의 도출)

  • Lim, Chai-Hong;Jeon, In-Su;Kang, Ki-Ju
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.31 no.9
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    • pp.943-950
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    • 2007
  • A new metallic sandwich panel with a quasi-Kagome truss core subjected to bending load has been analyzed. First, equations of the failure loads corresponding to the eight failure modes are presented. Then, non-dimensional forms of the equations are derived as functions of three geometric variables, one material parameter (yield strain), one load index and one weight index. Failure maps are presented for a given weight index. By using the dimensionless forms of equations as the design constraints, two kinds of optimization are performed. One is based on the weight, that is, the objective function, namely, the dimensionless load is to be maximized for a given weight. Another is based on the load, that is, the dimensionless weight is to be minimized for a given load. The results of the two optimization processes are found to agree each other. The optimized geometric variables are derived as a function of given weights or failure loads. The performance of the quasi-Kagome truss as the core of a sandwich panel is evaluated by comparison with those of honeycomb cored and octet truss cored panels.

Ballistic impact analyses of triangular corrugated plates filled with foam core

  • Panigrahi, S.K.;Das, Kallola
    • Advances in Computational Design
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    • v.1 no.2
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    • pp.139-154
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    • 2016
  • The usage of sandwich structure is extensively increasing in lightweight protective structures due to its low density and other useful properties. Sandwich panels made of metal sheets with unfilled cellular cores are found to exhibit lower deflections by comparing to an equivalent monolithic plate of same metal and similar mass per unit density. However, the process of localized impact on solid structures involving plastic deformation, high strain rates, temperature effect, material erosion, etc. does not hold effectively as that of monolithic plate. In present work, the applications of the sandwich plate with corrugated core have been extended to develop optimized lightweight armour using foam as medium of its core by explicit finite element analysis (FEA). The mechanisms of hardened steel projectile penetration of aluminum corrugated sandwich panels filled with foams have been numerically investigated by finite element analysis (FEA). A comparative study is done for the triangular corrugated sandwich plate filled with polymeric foam and metallic foam with different densities in order to achieve the optimum penetration resistance to ballistic impact. Corrugated sandwich plates filled with metallic foams are found to be superior when compared to the polymeric one. The optimized results are then compared with that of equivalent solid and unfilled cores structure to observe the effectiveness of foam-filled corrugated sandwich plate which provides an effective resistance to ballistic response. The novel structure can be the alternative to solid aluminum plate in the applications of light weight protection system.

Electroactive Polymer Actuator for Lens-Drive Unit in Auto-Focus Compact Camera Module

  • Lee, Hyung-Kun;Choi, Nak-Jin;Jung, Sun-Kyung;Park, Kang-Ho;Jung, He-Won;Shim, Jae-Kyu;Ryu, Jae-Wook;Kim, Jong-Dae
    • ETRI Journal
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    • v.31 no.6
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    • pp.695-702
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    • 2009
  • We propose a lens-drive unit composed of an ionic polymer-metal composite (IPMC) for an auto-focus compact camera module in cellular phones to solve the power consumption problem of voice coil motors which are widely used in commercial products. In this research, an IPMC incorporated into a lens-drive unit is designed to implement a large displacement in low-power consumption by using an anisotropic plasma treatment. Experimental results show that a camera module containing IPMCs can control and maintain the position of the lens by using proportional integral derivative control with a photo-reflective position sensor despite the non-linear actuation behavior of IPMCs. We demonstrate that the fabrication and commercialization of a lens actuator that has a large displacement and low power consumption using IPMCs is possible in the near future.

PFM-Mode Boost DC-DC Convertor for Mobile Multimedia Application (휴대용 멀티기기를 위한 PFM방식의 승압형 DC-DC 변환기)

  • Kim, Ji-Man;Park, Yong-Su;Song, Han-Jung
    • 전자공학회논문지 IE
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    • v.47 no.3
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    • pp.14-18
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    • 2010
  • In this paper, we describe a CMOS DC-DC converter with a variable output voltage(5-7V @100mA) for a portable battery-operated system applications. The proposed DC-DC converter is used along with a Pulse-Frequency Modulation (PFM) method and consists of reference circuit, a feedback resistor, a controller, and an internal oscillator. The integrated DC-DC converter with two external passive components(L,C) has been designed and fabricated on a 0.5um 2-poly 3-metal CMOS process and could be applied to the Personal Digital Assistants(PDA), cellular Phone, Laptop Computer, etc.

Implementation of a 32-Bit RISC Core for Portable Terminals (휴대 단말기용 32 비트 RISC 코어 구현)

  • Jung, Gab-Cheon;Park, Seong-Mo
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.38 no.6
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    • pp.82-92
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    • 2001
  • This paper describes implementation of an embedded 32-Bit RISC core for portable communication/information equipment, such as cellular phones, PDA(Personal Digital Assistants), notebook, etc. The RISC core implements the ARM$\circled$V 4 instruction set, operates with typical 5-stage pipeline. It supports Thumb code to improve the code density, and uses the dynamic power management method of pipeline registers. It was modeled and simulated in RTL level using VHDL, and verified with ARMulator of ADS (Arm Developer Suite) and had average CPI of 1.44. The core is synthesized automatically using the cell library based on $0.6{\mu}m$ CMOS 1-poly 3-metal CMOS technology. It consists of about 41,000 gates and the clock frequency is expected to be above 45 MHz.

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Proteome analysis of sorghum leaf and root in response to heavy metal stress

  • Roy, Swapan Kumar;Cho, Seong-Woo;Kwon, Soo Jeong;Kamal, Abu Hena Mostafa;Lee, Dong-Gi;Sarker, Kabita;Lee, Moon-Soon;Xin, Zhanguo;Woo, Sun-Hee
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2017.06a
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    • pp.24-24
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    • 2017
  • Heavy metals at toxic levels have the capability to interact with several vital cellular biomolecules such as nuclear proteins and DNA, leading to oxidative stress in plants. The present study was performed to explore the metal tolerance mechanism in Sorghum seedling. Morpho-physiological and metal ions uptake changes were observed prominently in the seedlings when the plants were subjected to different concentrations of $CuSO_4$ and $CdCl_2$. The observed morphological changes revealed that the plants treated with Cu and Cd displayed dramatically altered shoot lengths, fresh weights, and relative water content. In addition, the concentration of Cu and Cd was markedly increased by treatment with Cu and Cd, and the amount of interacting ions taken up by the shoots and roots was significantly and directly correlated with the applied level of Cu and Cd. Using the 2-DE method, a total of 24 and 21 differentially expressed protein spots from sorghum leaves and roots respectively, 33 protein spots from sorghum leaves under Cd stress were analyzed using MALDI-TOF/TOF MS. However, the over-expression of GAPDH plays a significant role in assisting Sorghum bicolor to attenuate the adverse effects of oxidative stress caused by Cu, and the proteins involved in resistance to stress helped the sorghum plants to tolerate high levels of Cu. Significant changes were absorbed in the levels of proteins known to be involved in carbohydrate metabolism, transcriptional regulation, translation and stress responses. In addition, the up-regulation of glutathione S-transferase and cytochrome P450 may play a significant role in Cd-related toxicity and stress responses. The results obtained from the present study may provide insights into the tolerance mechanism of seedling leaves and roots in Sorghum under heavy metal stress.

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The Effect of Fe and Fe2O3 Powder Mixing Ratios on the Pore Properties of Fe Foam Fabricated by a Slurry Coating Process (슬러리 코팅 공정으로 제조된 Fe 폼의 기공 특성에 미치는 Fe 및 Fe2O3 분말의 혼합 비율의 영향)

  • Choi, Jin Ho;Jeong, Eun-Mi;Park, Dahee;Yang, Sangsun;Hahn, Yoo-Dong;Yun, Jung-Yeul
    • Journal of Powder Materials
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    • v.21 no.4
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    • pp.266-270
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    • 2014
  • Metal foams have a cellular structure consisting of a solid metal containing a large volume fraction of pores. In particular, open, penetrating pores are necessary for industrial applications such as in high temperature filters and as a support for catalysts. In this study, Fe foam with above 90% porosity and 2 millimeter pore size was successfully fabricated by a slurry coating process and the pore properties were characterized. The Fe and $Fe_2O_3$ powder mixing ratios were controlled to produce Fe foams with different pore size and porosity. First, the slurry was prepared by uniform mixing with powders, distilled water and polyvinyl alcohol(PVA). After slurry coating on the polyurethane(PU) foam, the sample was dried at $80^{\circ}C$. The PVA and PU foams were then removed by heating at $700^{\circ}C$ for 3 hours. The debinded samples were subsequently sintered at $1250^{\circ}C$ with a holding time of 3 hours under hydrogen atmosphere. The three dimensional geometries of the obtained Fe foams with an open cell structure were investigated using X-ray micro CT(computed tomography) as well as the pore morphology, size and phase. The coated amount of slurry on the PU foam were increased with $Fe_2O_3$ mixing powder ratio but the shrinkage and porosity of Fe foams were decreased with $Fe_2O_3$ mixing powder ratio.

Design and Construction of a Loom for Obtaining Ultra-Light Metal Structure (초경량 금속 구조재 직조장치의 설계 및 제작)

  • Kim, Pan-Su;Kang, Ki-Ju
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.34 no.9
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    • pp.1235-1240
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    • 2010
  • Wire-woven Bulk Kagome (WBK) is fabricated by assembling helically formed wires in six directions. To date, WBK samples have been assembled manually. For industrial application, the assembly process must be automated. Furthermore, if WBK is to be fabricated using flexible wires that cannot maintain their helical shape during fabrication, a specialized automatic machine, i.e., a loom needs to be developed. In this work, we designed and constructed a loom for fabricating WBKs using flexible wires. This loom is operated by one rotation of the upper plate, two translations of the insertion device, and insertion of wires. So-called "comb devices" are placed between multiple layers of Kagome nets to prevent the wires that are already in place from getting entangled with those that are being inserted. This loom can be also used to fabricate semi-WBKs composed of helically formed wires and rigid straight wires.