• Title/Summary/Keyword: Cell size model

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Traffic Characteristics and Adaptive model analysis in ATM Network (ATM망의 트래픽 특성과 적응모델 분석)

  • 김영진;김동일
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.2 no.4
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    • pp.583-592
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    • 1998
  • In this paper, the cell loss rate is analyzed in terms of the input traffic stream of different speed in ATM network. The cell loss rate is calculated by birth-death process of Leaky-Bucket mechanism as the representative algorithm of usage parameter control. The cell loss rate assumed 2-state MMPP input process to be birth-death process by considering the character of token pool about finite capacity queue. The results from numerical analysis show that the cell loss rate decreases abruptly according to the buffer size increase. The computer simulation by SIMSCRIPT II.5 has been done and compared with on/off input source case to verify the analysis results.

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Emerging role of Hippo pathway in the regulation of hematopoiesis

  • Inyoung Kim;Taeho Park;Ji-Yoon Noh;Wantae Kim
    • BMB Reports
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    • v.56 no.8
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    • pp.417-425
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    • 2023
  • In various organisms, the Hippo signaling pathway has been identified as a master regulator of organ size determination and tissue homeostasis. The Hippo signaling coordinates embryonic development, tissue regeneration and differentiation, through regulating cell proliferation and survival. The YAP and TAZ (YAP/TAZ) act as core transducers of the Hippo pathway, and they are tightly and exquisitely regulated in response to various intrinsic and extrinsic stimuli. Abnormal regulation or genetic variation of the Hippo pathway causes a wide range of human diseases, including cancer. Recent studies have revealed that Hippo signaling plays a pivotal role in the immune system and cancer immunity. Due to pathophysiological importance, the emerging role of Hippo signaling in blood cell differentiation, known as hematopoiesis, is receiving much attention. A number of elegant studies using a genetically engineered mouse (GEM) model have shed light on the mechanistic and physiological insights into the Hippo pathway in the regulation of hematopoiesis. Here, we briefly review the function of Hippo signaling in the regulation of hematopoiesis and immune cell differentiation.

Analysis of the soft handoff rate in DS-CDMA cellular systems (DS-CDMA 셀룰라 시스쳄에서의 소프트 핸드오프율에 대한 분석)

  • 조무호;김광식;조경록
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.22 no.8
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    • pp.1659-1667
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    • 1997
  • In DS-CDMA cellular systems, using the same frequency channel at the adjacent cells simultaneously makes soft handoff possible. In soft handoff, mobiles use multiple radio resources for the space diversity of signal in the overlapped region. The previous traffic models of hard handoff are not applicable to the system with soft handoff due to switching radio channels in that region. The handoff rate can be calculated by the mobility of mobiles, which is a function of the size and shape of a cell, and the speed and density of the mobiles. In this paper, we propose an analytical traffic model to study the soft handoff rate. We assume that the system uses a two-way handoff scheme for practical purposes, which connects only two cells to a mobile during soft handoff. We performed a computer simulation to confirm the accuracy of the proposed soft handoff model. The simulation results show good agreement with the analytical model.

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ELECTRO-MICROSCOPE BASED 3D PLANT CELL IMAGE PROCESSING METHOD

  • Lee, Choong-Ho;Umeda Mikio;Takesi Sugimoto
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 2000.11b
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    • pp.227-235
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    • 2000
  • Agricultural products are easily deformable its shape because of some external forces. However, these force behavior is difficult to measure quantitatively. Until now, many researches on the mechanical property was performed with various methods such as material testing, chemical analysis and non-destructive methods. In order to investigate force behavior on the cellular unit of agricultural products, electro-microscope based 3D image processing method will contribute to analysis of plant cells behavior. Before image measurement of plant cells, plant sample was cut off cross-sectioned area in a size of almost 300-400 ${\mu}$ m units using the micron thickness device, and some of preprocessing procedure was performed with fixing and dyeing. However, the wall structure of plant cell is closely neighbor each other, it is necessary to separate its boundary pixel. Therefore, image merging and shrinking algorithm was adopted to avoid disconnection. After then, boundary pixel was traced through thinning algorithm. Each image from the electro-microscope has a information of x,y position and its height along the z axis cross sectioned image plane. 3D image was constructed using the continuous image combination. Major feature was acquired from a fault image and measured area, thickness of cell wall, shape and unit cell volume. The shape of plant cell was consist of multiple facet shape. Through this measured information, it is possible to construct for structure shape of unit plant cell. This micro unit image processing techniques will contribute to the filed of agricultural mechanical property and will use to construct unit cell model of each agricultural products and information of boundary will use for finite element analysis on unit cell image.

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Potentiating Dietary Green Tea Extracts Anti-Tumor Activity of Cisplatin in BALB/c Mice Bearing CT26 Colon Carcinoma (대장암(CT 26) 생쥐에서 녹차추출물 음용에 의한 시스플라틴 항암작용 증강효과)

  • Lee, Byoung-Rai;Park, Pyoung-Sim
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.41 no.8
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    • pp.1100-1105
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    • 2012
  • Green tea intake is known to have preventive effects against cancer. In this study, we evaluated the tumor suppressive effects of dietary green tea extracts (GTE) as a modulator on cisplatin in an established colon cancer mouse model. The cisplatin-induced cytotoxicity was determined with cell viability of the mouse colon cancer cell line (CT26) in vitro. The influence of GTE on the anti-tumor activity of cisplatin was evaluated by measuring tumor size with digital calipers in mice bearing CT26 colon carcinomas. The CT26 cell viability decreased to 93% at a $20{\mu}g/mL$ concentration of cisplatin. However, cell viability decreased to 15% with a combination of $20{\mu}g/mL$ cisplatin and GTE ($75{\mu}g/mL$). There were no apparent changes in cisplatin-induced cytotoxicity with GTE and epigallocathechin gallate (EGCG) treatments. Tumor size decreased in dietary GTE combining intra-peritoneal cisplatin-injected tumors bearing mice compared with cisplatin or GTE alone administered to tumor-bearing mice. These experiments showed that dietary GTE has a potentiating effect on the cisplatin anti-tumor activity of an established mice colon cancer model. Therefore, the GTE may be a candidate for modulators in anticancer treatments with cisplatin.

Estimation of Genetic Parameters for Somatic Cell Scores of Holsteins Using Multi-trait Lactation Models in Korea

  • Alam, M.;Cho, C.I.;Choi, T.J.;Park, B.;Choi, J.G.;Choy, Y.H.;Lee, S.S.;Cho, K.H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.3
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    • pp.303-310
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    • 2015
  • The study was conducted to analyze the genetic parameters of somatic cell score (SCS) of Holstein cows, which is an important indicator to udder health. Test-day records of somatic cell counts (SCC) of 305-day lactation design from first to fifth lactations were collected on Holsteins in Korea during 2000 to 2012. Records of animals within 18 to 42 months, 30 to 54 months, 42 to 66 months, 54 to 78 months, and 66 to 90 months of age at the first, second, third, fourth and fifth parities were analyzed, respectively. Somatic cell scores were calculated, and adjusted for lactation production stages by Wilmink's function. Lactation averages of SCS ($LSCS_1$ through $LSCS_5$) were derived by further adjustments of each test-day SCS for five age groups in particular lactations. Two datasets were prepared through restrictions on number of sires/herd and dams/herd, progenies/sire, and number of parities/cow to reduce data size and attain better relationships among animals. All LSCS traits were treated as individual trait and, analyzed through multiple-trait sire models and single trait animal models via VCE 6.0 software package. Herd-year was fitted as a random effect. Age at calving was regressed as a fixed covariate. The mean LSCS of five lactations were between 3.507 and 4.322 that corresponded to a SCC range between 71,000 and 125,000 cells/mL; with coefficient of variation from 28.2% to 29.9%. Heritability estimates from sire models were within the range of 0.10 to 0.16 for all LSCS. Heritability was the highest at lactation 2 from both datasets (0.14/0.16) and lowest at lactation 5 (0.11/0.10) using sire model. Heritabilities from single trait animal model analyses were slightly higher than sire models. Genetic correlations between LSCS traits were strong (0.62 to 0.99). Very strong associations (0.96 to 0.99) were present between successive records of later lactations. Phenotypic correlations were relatively weaker (<0.55). All correlations became weaker at distant lactations. The estimated breeding values (EBVs) of LSCS traits were somewhat similar over the years for a particular lactation, but increased with lactation number increment. The lowest EBV in first lactation indicated that selection for SCS (mastitis resistance) might be better with later lactation records. It is expected that results obtained from these multi-trait lactation model analyses, being the first large scale SCS data analysis in Korea, would create a good starting step for application of advanced statistical tools for future genomic studies focusing on selection for mastitis resistance in Holsteins of Korea.

A predicting model for thermal conductivity of high permeability-high strength concrete materials

  • Tan, Yi-Zhong;Liu, Yuan-Xue;Wang, Pei-Yong;Zhang, Yu
    • Geomechanics and Engineering
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    • v.10 no.1
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    • pp.49-57
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    • 2016
  • The high permeability-high strength concrete belongs to the typical of porous materials. It is mainly used in underground engineering for cold area, it can act the role of heat preservation, also to be the bailing and buffer layer. In order to establish a suitable model to predict the thermal conductivity and directly applied for engineering, according to the structure characteristics, the thermal conductivity predicting model was built by resistance network model of parallel three-phase medium. For the selected geometric and physical cell model, the thermal conductivity forecast model can be set up with aggregate particle size and mixture ratio directly. Comparing with the experimental data and classic model, the prediction model could reflect the mixture ratio intuitively. When the experimental and calculating data are contrasted, the value of experiment is slightly higher than predicting, and the average relative error is about 6.6%. If the material can be used in underground engineering instead by the commonly insulation material, it can achieve the basic requirements to be the heat insulation material as well.

An Efficient Delay Calculation Tool for Timing Analysis (타이밍 분석을 위한 효율적인 시간 지연 계산 도구)

  • Kim, Joon-Hee;Kim, Boo-Sung;Kal, Won-Koang;Maeng, Tae-Ho;Baek, Jong-Humn;Kim, Seok-Yoon
    • Proceedings of the KIEE Conference
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    • 1998.11b
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    • pp.612-614
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    • 1998
  • As chip feature size decrease, interconnect delay gains more importance. A accurate timing analysis required to estimate interconnect delay as well as cell delay. In this paper, we present a timing-level delay calculation tool of which the accuracy is bounded within 10% of SPICE results. This delay calculation tool generates delay values in SDF(Standard Delay Format) for parasitic data extracted in SPEF(Standard Parasitic Exchange Format). The efficiency of the tool is easily seen because it uses AWE(Asymptotic Waveform Evaluation) algorithm for interconnect delay calculation, and precharacterized library and effective capacitance model for cell delay calculation.

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Mechanical Properties Prediction by Manufacturing Parameters for Braided Composites

  • Kim, Myungjun
    • Journal of Aerospace System Engineering
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    • v.14 no.4
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    • pp.25-31
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    • 2020
  • The development of manufacturing technology for braided composites has led to farther extension of the applications in aerospace structures. Since the mechanical characteristics of braided composites are affected by various materials and manufacturing parameters, it is important to determine the parameters required to appropriately design the braided composite structures. In this study, we proposed a geometric model of RUC (repeating unit cell) for 2D braided composites, and predicted the mechanical properties according to the change of fiber volume fraction, fiber filament size, braiding angle, and gap between adjacent yarns by the yarn slicing technique and stress averaging method. Finally, we analyze the characteristics of mechanical properties according to each manufacturing parameter of the braided composite material.

A dynamic connection admission control algorithm using variable-sized moving window in ATM networks (가변 크기 Moving Window를 적용한 ATM 망에서의 동적 호 접속 제어 연구)

  • 이수경;송주석
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.22 no.3
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    • pp.593-603
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    • 1997
  • Connection admission decision in ATM networks requires decision made in real time using fast algorithm. It is difficult to construct a model of the multiplexed traffic and thus, approximation of the traffic load is necessary. In this paper, we propose a measurement-based dynamic CAC(Connection admission Control) in ATM(Asynchronous Transfer Mode) networks, which observes current traffic by the moving window and set the window size to the value which is computed from the measured cell loss amount. It is based on the measurements of the traffic load over an admission period that is load enough to reflect the current traffic behavior instead of analytic modeling. And, the dynamic reallocation of bandwidth for each class leads to effective bandwidth utilization. The performance of proposed method is analyzed through computer simulation. The performance of proposed method is analyzed by using SIMAN simulation package and FORTRAN language. As can be seen in the simulation result, cell loss performance and bandwidth utilization have been increased.

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