• BMB Reports
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• 제33권5호
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• pp.359-365
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• 2000

Ribozymes are catalytic RNAs that can cleave RNAs at specific sites, thus they have been employed to degrade a target mRNA in vivo. Development of allosterically controllable ribozymes is of great current interest, but it remained difficult to furnish such functions to ribozymes in cultured cells or in animals. Recently, we designed allosterically controllable ribozymes termed maxizymes, which have sensor arms that recognize target mRNA sequences and, in the presence of such target sequences only, they form a cavity that can capture catalytically indispensable $Mg^{2+}$ ions, cleaving the target. The maxizyme was applied to therapy for chronic myelogenous leukemia (CML). It cleaved specifically the chimeric BCR-ABL mRNA, which caused CML, without damaging the normal ABL or BCR mRNA in mammalian cells and also in mice, providing the first successful example for allosteric control of the activity of artificial ribozymes in vivo.

• 대한후두음성언어의학회지
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• 제10권1호
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• pp.50-57
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• 1999

A study to get the data of normal stop consonants production as preliminary study for cleft palate patients was performed. Normal Korean native 21 speakers were pronounced $VCV(V=/a/,C=/P/,/{P^1}/,/P^h/,/t/,/{t^1}/,/{t^h}/,/k/,/{k^1}/,/{k^h}/)$ syllables with natural speech rate and intensity. With intrapharyngeal pressure waveforms by pressure sensor in oropharyngeal cavity, amplitude and time duration of intrapharyngeal pressure were analyzed, and with acoustic waveforms and spectrograms, closure duration and VOT were analyzed. As results, the highest amplitude of intrapharyngeal pressure showed in alveolars and heavily aspirated consonants. Velars and unaspirated consonants were higher than bilabials and slightly aspirated ones each, in intrapharyngeal pressure. Bilabilas, alveolars and velars showed similar rise time of intrapharyngeal pressure build-up, but in decay time and total duration time, bilabials were slightly shorter than alveolars and velars, with no statistic significance. In the aspects of tensity, unaspirated consonants showed the longest rise time, heavily aspirated, the second, and slightly aspirated consonants, the shortest, which were also seen in decay time and total duration time. In closure duration, slightly aspirated consonants had the shortest closure duration, and the heavily aspirated ones, the second, and unaspirated consonants showed the longest. In VOT, heavily aspirated consonants showed the longest, slightly aspirated ones, the second and unaspirated ones showed the shortest.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1488-1490
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• 2008

The gyroscope is the sensor for detecting the rotation in inertial reference frame and constitute the navigation system together an accelerometer. As the inertial reference equipment for attitude determination and control in the satellite, the mechanical gyroscope has been used but it bring the disturbance for mass unbalance so the disturbance give a bad influence to the observation satellite mission because the mechanical gyroscope has the rotation parts. During the launch, The mechanical gyroscope is weak in vibration, shock and has the defect of narrow operating temperature range so it need the special design in integration. Recently the low orbit observation satellite for seeking the high pointing accuracy of image camera payload accept the FOG(Fiber Optic Gyro) or RLG(Ring Laser Gyro) for the attitude determination and control. The Ring Laser Gyro makes use of the Sanac effect within a resonant ring cavity of a He-Ne laser and has more accuracy than the other gyros. It need the 1000V DC to create the He-Ne plasma in discharge tube. In this paper, the design process of the High Voltage Power Supply for RLG(Ring Laser Gyroscope) is described. The specification for High Voltage Power Supply(HVPS) is proposed. Also, The analysis of flyback converter topology is explained. The Design for the HVPS is composed of the inverter circuit, feedback control circuit, high frequency switching transformer design and voltage doubler circuit.

• 한국CDE학회논문집
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• 제17권3호
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• pp.156-163
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• 2012

Real-time three-dimensional shape measurement is becoming increasingly important in various fields, including medical sciences, high-technology industry, and microscale measurements. However, there are not so many 3D profile tools specially designed for specifically narrow space, for example, to scan the tooth shape of a human jaw. In this paper, a real-time 3D intraoral scanner is proposed for the measurement of tooth profile in the mouth cavity. The proposed system comprises a laser diode beam, a micro charge-coupled device, a graticule, a piezoelectric transducer, a set of optical lenses, and a polhemus device sensor. The phase-shifting technique is used along with an accurate calibration method for the measurement of the tooth profile. Experimental and theoretical inspection of the phase-to-coordinate relation is presented. In addition, a nonlinear system model is developed for collimating illumination that gives the more accurate mathematical representation of the system, thus improves the shape measurement accuracy. Experiment results are presented to verify the feasibility and performance of the developed system. The experimental results indicate that overall measurement error accuracy can be controlled within 0.4 mm with a variability of ${\pm}0.01$.

• 전기학회논문지
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• 제59권2호
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• pp.390-396
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• 2010

An 80MHz surface acoustic wave (SAW)-based gyroscope utilizing a progressive wave was developed on a piezoelectric substrate. The developed sensor consists of two SAW oscillators in which one is used for sensing element and has metallic dots in the cavity between input and output IDTs. The other is used for a reference element. Coupling of mode (COM) modeling was conducted to determine the optimal device parameters prior to fabrication. According to the simulation results, the device was fabricated and then measured on a rate table. When the device was subjected to an angular rotation, oscillation frequency differences between the two oscillators were observed because of the Coriolis force acting on the metallic dots. Depending on the angular rate, the difference of the oscillation frequency was modulated. The obtained sensitivity was approximately 52.35 Hz/deg.s within the angular rate range of 0~1000 deg/s. The performances of devices with three IDT structures for two kinds of piezoelectric substrates were characterized. Good thermal stability was also observed during the evaluation process.

• 한국추진공학회지
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• 제24권6호
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• pp.108-119
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• 2020

액체로켓엔진 연소기와 가스터빈에 사용되는 동압센서는 고온의 환경에서 작동되어야 하므로 보통 리세스 마운트로 체결된다. 리세스 마운트 방식은 고온의 연소가스로부터 센서를 보호할 수 있으나 튜브-캐비티 시스템에서 튜브 공진이 발생한다. 본 연구에서는 이를 줄이기 위해 ITP를 도입하였다. 과거 문헌에서 제안한 ITP 모델을 실험 결과와 검증하고 응답특성을 분석하였다. 이 모델을 이용하여 기하학적 형상과 물리량을 변화시켜 주파수 응답 분포를 변화시킴으로써 ITP를 설계하기 위한 가이드라인을 제안하였다.

• 전기전자학회논문지
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• 제22권4호
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• pp.1214-1217
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• 2018

본 논문에서는 소형 $360^{\circ}$ 구강 스캐너 임베디드 보드의 개발을 제안한다. 제안하는 소형 $360^{\circ}$ 구강 스캐너 임베디드 보드은 이미지 레벨 및 전송방식 변경 부, FPGA 부, 메모리 부, FIFO to USB 전송부 등으로 구성된다. 이미지 레벨 및 전송방식 변경 부는 소형 $360^{\circ}$ 전방위 구강 렌즈와 이미지 센서를 통해 들어온 MIPI 형식의 구강 영상을 Low Power Signal Mode와 High Speed Signal Mode로 나누어 포트에 분산 입력하고 레벨 시프트를 하여 FPGA 부에 전송한다. FPGA 부에서는 $360^{\circ}$ 영상 왜곡 보정, 영상 보정, 영상 처리, 영상 압축 등의 기능 등을 수행한다. FIFO to USB 전송부에서는 FPGA 내부의 FIFO를 통해 전달되어진 RAW 데이터를 트랜시버 칩을 사용하여 USB 3.0, USB 3.1 등의 통신 규격으로 PC에 전송한다. 제안된 소형 $360^{\circ}$ 구강 스캐너 임베디드 보드의 효율을 판단하기 위하여 공인시험기관에서 실험한 결과, 보정 영상 후 초당 프레임은 60fps 이상, 데이터 전송률은 4.99Gb/s로서 높은 수준의 결과가 산출되어 그 효용성이 입증되었다.

• 센서학회지
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• 제27권5호
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• pp.317-327
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• 2018

THz 시간 영역 분광학(TDS)은 이제 성숙한 분야가 되었고, 그 기술은 전 세계적으로 수백 개의 연구실에서 사용되고 있지만, THz 시스템의 개선에 대한 여지는 아직 많이 남아있다. 도전과제의 핵심은 모드-잠김 에지 방사(edge emitting) 반도체방출 반도체 레이저와 광전도 반도체 양자 구조의 개선이다. 또한 대량 생산을 위한 기술과 3D 프리팅과 같은 혁신적인 제조 기술도 매우 효과적이다. 최근에 상용제품으로 출시된 OSCAT 시스템과 ASOPS 시스템을 이용하여 분광/영상기법을 반도체 패키지 칩에 적용하기도 하였다. 한편, THz 분광법이 정적(static)이거나 또한 시간-분해적이든 간에 모두 반도체 소재 및 반도체 나노 구조의 특성을 평가하는 데 있어서 선도적인 기법이 될 것이다. 향후에는 점점 더 좁은 영역을 탐구하는 방법이나 THz 응용 시스템을 평형상태에서 벗어나게 하는 툴(tool)로써 사용될 가능성도 높다. 또한 메타(meta) 물질을 이용하여 THz 시스템에 적용할 경우, 가변 필터와 같은 순시적인 광학 부품이 가능하므로 광여기(photoexcited) 반도체 소자(신호원)으로 이용하는 구상/디자인도 할 수 있다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2013년도 추계학술대회 논문집
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• pp.763-764
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• 2013

A three-dimensional image capturing device and its signal processing algorithm and apparatus are presented. Three dimensional information is one of emerging differentiators that provides consumers with more realistic and immersive experiences in user interface, game, 3D-virtual reality, and 3D display. It has the depth information of a scene together with conventional color image so that full-information of real life that human eyes experience can be captured, recorded and reproduced. 20 Mega-Hertz-switching high speed image shutter device for 3D image capturing and its application to system prototype are presented[1,2]. For 3D image capturing, the system utilizes Time-of-Flight (TOF) principle by means of 20MHz high-speed micro-optical image modulator, so called 'optical resonator'. The high speed image modulation is obtained using the electro-optic operation of the multi-layer stacked structure having diffractive mirrors and optical resonance cavity which maximizes the magnitude of optical modulation[3,4]. The optical resonator is specially designed and fabricated realizing low resistance-capacitance cell structures having small RC-time constant. The optical shutter is positioned in front of a standard high resolution CMOS image sensor and modulates the IR image reflected from the object to capture a depth image (Figure 1). Suggested novel optical resonator enables capturing of a full HD depth image with depth accuracy of mm-scale, which is the largest depth image resolution among the-state-of-the-arts, which have been limited up to VGA. The 3D camera prototype realizes color/depth concurrent sensing optical architecture to capture 14Mp color and full HD depth images, simultaneously (Figure 2,3). The resulting high definition color/depth image and its capturing device have crucial impact on 3D business eco-system in IT industry especially as 3D image sensing means in the fields of 3D camera, gesture recognition, user interface, and 3D display. This paper presents MEMS-based optical resonator design, fabrication, 3D camera system prototype and signal processing algorithms.

• 한국전자통신학회논문지
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• 제18권6호
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• pp.1023-1030
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• 2023

본 논문은 눈, 비, 안개 등 열악한 운용환경에도 강건한 표적검출 특성을 가지는 FMCW LiDAR에 대해서 기술하고 있다. 특히 FMCW LiDAR의 거리 해상도, 가간섭거리 및 최대측정거리 성능에 직접적으로 영향을 미치는 주파수변조레이저의 성능개선에 대해 기술하고 있다. 불평형 Mach-Zehnder 레이저간섭계를 활용하여, 레이저의 발진주파수의 변화율을 실시간 측정하고, 주파수변조 오차를 보정하는 광학식 위상동기루프 기술을 이용한 주파수변조 방법에 대해 기술하였다. 가간섭거리가 긴 레이저 광원을 발진하기 위해 확장공진기형 레이저다이오드를 적용하였으며, 레이저에서 발진되는 주파수 측정을 위해 광집적회로 구조의 레이저간섭계를 적용하였다. 개발된 FMCW LiDAR의 대역폭과 거리해상도는 각각 10.045GHz와 0.84mm로 측정되었다.