• Journal of Platform Technology
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• v.10 no.1
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• pp.20-28
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• 2022

Artificial intelligence-based health data verification has become an essential element not only to help clinical research, but also to develop new treatments. Since the US Food and Drug Administration (FDA) approved the marketing of medical devices that detect mild abnormal diabetic retinopathy in adult diabetic patients using artificial intelligence in the field of medical diagnosis, tests using artificial intelligence have been increasing. In this study, an artificial intelligence model based on image classification was created using a Teachable Machine supported by Google, and a predictive model was completed through learning. This not only facilitates the early detection of cataracts among eye diseases occurring among patients with chronic diseases, but also serves as basic research for developing a digital personal health healthcare app for eye disease prevention as a healthcare program for eye health.

• Physical Therapy Rehabilitation Science
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• v.11 no.3
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• pp.296-303
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• 2022

Objective: In general, macular degeneration, cataracts and glaucoma generally cause visual injury in clinical settings. This study aimed to examine the effects of low visual acuity simulations on hand manual dexterity function and brainwaves in healthy young adults. Design: Cross-sectional study design Methods: This study was an observational, cross-sectional study. Seventy healthy young adults participated in this study. To evaluate the effects of low visual acuity simulations on hand function and brain waves, this study involved four different visual conditions including (1) normal vision, (2) simulated cataracts, (3) simulated glaucoma, and (4) simulated macular degeneration. The hand function was measured to use the Minnesota manual dexterity test (MMDT), and the brainwaves was also measured to use the electroencephalography. Results: In hand function, placing and turning performance on the MMDT in the normal visual condition was significantly different than that in the cataract and macular degeneration conditions (p<0.05), and the placing performance was significantly differred in the normal condition than that in the simulated glaucoma. However, turning was not significantly different in the normal condition than that in the simulated glaucoma. The alpha, beta, and gamma waves did not significantly differ among the four visual conditions (p>0.05). Conclusions: The results suggest that limited visual information negatively affects the ability to perform tasks requiring arm-hand dexterity and eye-hand coordination. However, the effectiveness of low visual acuity on the brainwaves should be further studied for rehabilitative evidence of visual impairment.

• The Korean Journal of Vision Science
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• v.20 no.4
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• pp.497-504
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• 2018

Purpose : The purpose of this study was to investigate the temperature changes of the ocular surface before and after cataract surgery using thermography of a thermal imaging camera. Methods : The study included 75 patients (75 eyes) aged from 50 to 79 years who underwent cataract surgery. In the past, those who underwent corneal-related surgery, wearing contact lens, disorder of tear secretion and taking medication for systemic disease were excluded from this study. The temperature changes of the eyeball surface were measured using a thermal imager (Cox CX series, Answer, Korea) following Tear Break Up Time (TBUT) test, Mcmonnies questionnaire and Schirmer's Test in real time, Results : While the temperature of preoperative ocular surface was $35.20{\pm}0.54^{\circ}C$ and that of postoperative temperature was $35.30{\pm}0.53^{\circ}C$, the difference was not significant. The temperature changes in the ocular surface were statistically significant at $-0.12{\pm}0.08{\Delta}$ ($^{\circ}C/sec$) before the surgery and $-0.18{\pm}0.07{\Delta}$ ($^{\circ}C/sec$) after the surgery. In comparison of the age groups, it was shown that the changes in the surface temperature before the surgery were from $-0.19{\pm}0.05{\Delta}$ ($^{\circ}C/sec$) to $-0.14{\pm}0.09{\Delta}$ ($^{\circ}C/sec$) in the 50s group, and from $-0.12{\pm}0.08{\Delta}$ ($^{\circ}C/sec$) to $-0.15{\pm}0.07{\Delta}$ ($^{\circ}C/sec$) in 60s group, and $-0.18{\pm}0.07{\Delta}$ ($^{\circ}C$) to $-0.12{\pm}0.08{\Delta}/sec$) in the 70s group, showing significant changes in the ocular surface temperature at all ages. Conclusion : Following the cataract surgery, all the indicators of dry eye syndrome were decreased, and eye surface temperature changes were significant. The thermography technique of the ocular surface would be expected to be useful for the evaluation of various dry eye syndromes because it is easy to evaluate dry eye syndrome noninvasively and can be quantified.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.3
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• pp.355-362
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• 2015

Purpose: To investigate the effects of the transmittance of diffusive blurson visual acuity and contrast sensitivity. Methods: Visual acuity and contrast sensitivity were measured by using Optec$^{(R)}$ 6500 in Healthy 30 subjects aged $22.83{\pm}0.50$ (male 13, female 17) who were recruited from university students. Cataract simulator was used as a tool for diffusive blur. Visual acuity and contrast sensitivity were measured with varying the transmittance of diffusive blur in order to simulate progression of cataract and concentration in fog. Results: Visual acuity was reduced proportionally with decreasing the transmittance of the diffusive blur as follows: $VA(T)=1.84{\times}10^{-2}T-0.645$. Contrast sensitivity was decreased in all spatial frequencies. Contrast sensitivity in a high spatial frequency band was a greater effect and was off the normal range of contrast sensitivity. The peak of contrast sensitivity was moved in the direction to low frequency. From an intersection point of contrast sensitivity function, we could calculated the transmittance of the diffusive blur being off the normal range and the shift to peak spatial frequency. The peak of contrast sensitivity function was observed to move from 6 to 3 cpd at transmittance of about 78.70%, the contrast sensitivities for all frequencies at transmittance of about 69.71% were deviated from the normal range. Conclusions: The transmittance of diffusive blur causes a reduction in visual acuity and contrast sensitivity, a deviation of normal range of contrast sensitivity, and a shift of peak contrast sensitivity. Therefore the more attention is required when suffering from cataracts or driving in fog.

• Clinical and Experimental Pediatrics
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• v.57 no.3
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• pp.140-148
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• 2014

Purpose: Lowe syndrome is a rare, X-linked recessive disorder caused by mutations in the OCRL gene. It involves multiple anatomic systems, particularly the eyes, central nervous system, and kidneys, and leads to profound growth failure and global developmental delay. This study evaluated the clinical and genetic characteristics of Korean patients with Lowe syndrome. Methods: The clinical findings and results of genetic studies were reviewed for 12 male patients diagnosed with Lowe syndrome at a single medical institution. Results: The mean age of the patients at presentation was 2.2 months (range, 0-4 months), although the diagnosis was delayed by a mean of 2.8 years (range, 0-9.7 years). The mean follow-up period was 9.0 years (range, 0.6-16.7 years). Nine mutations in OCRL were identified in 11 patients (92%), with three novel mutations. The main presentation was congenital cataract in both eyes necessitating early cataract removal in the 11 patients with impaired visual acuity. Profound short stature and developmental delay were observed in all patients, and seizures occurred in 50% of the patients. All patients suffered from proximal renal tubular dysfunction, and one patient developed chronic renal failure. Other manifestations included pathologic fracture (50%), cutaneous cysts (42%), and cryptorchidism (42%). However, there was no bleeding tendency, and none of the patients died during the study period. Conclusion: This study describes the clinical and genetic characteristics of Korean patients with Lowe syndrome. The observations are helpful for understanding the natural courses of Lowe syndrome and for appropriate genetic counseling.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.3
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• pp.103-109
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• 2008

Purpose: This review illustrates an importance of oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation in association with eye disease, especially of cataract, and discusses an important role of lipid peroxide as a mediator of oxidative stress-related ocular dysfunction. Methods: Oxidative stress, resulted from the cellular production of ROS and RNS, is known to cause various forms of cellular damages such as protein oxidation, DNA breaks, apoptosis, and lipid peroxidation. These damages can be developed to human diseases. Accumulating evidence strongly suggests that continuous or constant exposure of eye tissues to oxidative stress is a main cause of cataractogenesis. Therefore, we investigated the action of oxidative stress in ocular dysfunction. Results: The ocular lens is continuously attacked by ROS inevitable generated from the process of cellular metabolism and the chronic exposure to ultraviolet. Excessive generation of ROS, resulting in degradation, oxidation, crosslinking and aggregation of lens proteins, is regarded as an important factor in development of cataract. Conclusions: These oxidative stress and oxidant/antioxidant imbalance produces the excess ROS which can lead to eye dysfunction. Even though known results, it should be noted that there is limited information on the molecular mechanism which can be better defined with the interrelation of oxidative stress and optic abnormalities.

• Journal of the Korean Society of Safety
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• v.9 no.1
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• pp.140-145
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• 1994

Contributions of global warming potentials on CFC(Chlorofluorocarbon) and Ozone were calculated by Stefan-Boltzmann's law and environmental effects of its were discussed. As the greenhouse effect on the unit volume of CFC is the most strong in the infrared gases and the destruction of Ozone in stratosphere is also depends on CFC, therefore release of CFC should be prohibited. But the effect of restriction on CFC will be appeared more than 10 years later. Eventhough the Ozone layer is related to global warming, It should be protected because of maitaining food chain mode of life, preventing human disease, for example, cataract, dermatics etc.

• Journal of Veterinary Clinics
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• v.19 no.4
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• pp.461-463
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• 2002

Pharmacological ablation of the ciliary body by intravitreal injection of a cytotoxic dose of gentamicin was utilized for the treatment of absolute glaucoma in 13 dogs. Complications of this procedure were hyphema(2), corneal opacity(2), iris bombe(1), cataract(1) and chronic inflammation(1). Injection time was one time in 10 dogs, two times in 2 dogs and 3 times in a dog. Intravitreal injection of gentamicin was thought as a economic salvage procedure and has resulted in successful lowering of intraocular pressure.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.235-237
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• 1997

Cataract and Retinal detachment eyes dogs were examined by ultrasonography. Ultrasonography of the immature and mature cataractous eyes showed echographic changes, and cataractous lens increased in thickness. The diagnosis of retinal detachment was made an echodense waving motion structure in the posterior segment was imaged. This investigation will provide basic information for the study of pathologic conditions affecting the eyes of dog using ultrasound unit commonly available to the veterinarian.

• 대한예방의학회:학술대회논문집
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• 2000.10a
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• pp.143-144
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• 2000