• Title/Summary/Keyword: Castleman's disease

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Cases report of unicentric Castleman's disease: revisit of radiotherapy role

  • Noh, O Kyu;Lee, Sang-Wook;Lee, Jae Whan;Kim, Sang Yoon;Kim, Chung Soo;Choi, Eun Kyung;Kim, Jong Hoon;Ahn, Seung Do
    • Radiation Oncology Journal
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    • v.31 no.1
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    • pp.48-54
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    • 2013
  • Castleman's disease or angiofollicular lymph node hyperplasia is a rare lymphoproliferative disorder. Complete surgical resection was recommended in unicentric Castleman's disease. Radiotherapy was considered alternative therapeutic option. However, there have been consistent favorable responses to radiotherapy. We also experienced two cases of uncentric Castleman's disease salvaged successfully with radiotherapy. This paper described these cases and reviewed the literature about Castleman's disease treated with radiotherapy. Reviewed cases showed that radiotherapy is a successful treatment option in unicentric Castleman's disease. Furthermore, our report confirms the radiotherapy role in uncentric Castleman's disease.

Two Cases of Castlema's Disease in Childern (소아에 발생한 Castleman's Disease 2례)

  • Kim, Eun Ah;Lee, Chong Guk;Kim, Han Sung
    • Clinical and Experimental Pediatrics
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    • v.46 no.2
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    • pp.203-206
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    • 2003
  • Castleman's disease is an atypical lymphoproliferative disorder of unknown origin. It has three histologic variants(hyaline vascular, plasma-cell, and mixed) and two clinical types(localized and multicentric). Some sufferers have constitutional symptoms and laboratory abnormalities such as anemia, hypoalbuminemia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate. The localized form is cured by complete surgical excision whereas the multicentric form is managed by prednisone and other immunosuppressor drugs. The prognosis of the multicentric form is worse than the localized form since malignancies and severe infections may lead to a rapidly fatal outcome. Castleman's disease has been rarely reported at pediatric age in Korea. We experienced two cases of Castleman's disease detected at 3 and 5 years of age. They were presented with painless enlargement of submandibulars and axillary lymph nodes but had no associated symptoms. The lesions were excised and diagnosed as Castleman's disease, and no recurrence was noted during follow-up periods.

Castleman's Disease with Myasthenia Gravis

  • Lee, Sang-Kwon;Kim, Do-Hyung;Son, Bong-Soo
    • Journal of Chest Surgery
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    • v.45 no.3
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    • pp.199-201
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    • 2012
  • Castleman's disease is a rare disorder characterized by benign tumors that may develop in the lymph node tissue throughout the body. Castleman's disease associated with myasthenia gravis is an especially rare disease. Only less than 10 cases have been reported in the world literature. The cause of Castleman's disease is associated with immune mediated reaction, and myasthenia gravis also develops due to an antibody-mediated process. The cause of myasthenia gravis is the immune activity of Castleman's disease, which may be the promoter of the antibody-mediated process. We report here a case of Castleman's disease, which was incidentally found in a patient diagnosed with myasthenia gravis.

A Case Report of the Castleman`s Disease in Mediastinum (종격동에 발생한 Castleman`s Disease 1례 보고)

  • Im, Chang-Yeong;Kim, Gwang-Taek;Kim, Hyeong-Muk
    • Journal of Chest Surgery
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    • v.21 no.3
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    • pp.531-534
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    • 1988
  • Castleman`s disease is a rare disease entity of unknown etiology, with the characteristics of large, well marginated benign lymph node hyperplastic mass. This disease occurs predominantly in the mediastinum but also occurred in other areas of the body usually where lymph nodes are normally found. They have been divided into two histologic types: the hyaline vascular lesion which comprises over 90% of the cases; the plasma cell lesions, which was characterized by large follicle with plasma cell and systemic manifestation, such as fever, anemia elevated ESR, hypergammaglobulinemia, hypoalbuminemia. This disease have behaved in a benign fashion and complete surgical excision is the choice of treatment. We experienced a case of Castleman`s disease which was treated by surgical resection through the thoracotomy, and has good postoperative and follow up result. We report a case of the Castleman`s disease with its review.

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Castleman's Disease of the Neck (경부 Castleman씨 병(거대 림프절 증식증) 1예)

  • Yang Yoon-Soo;Lee Sang-Heon;Hong Ki-Hwan
    • Korean Journal of Head & Neck Oncology
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    • v.20 no.2
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    • pp.194-197
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    • 2004
  • Castleman's disease was first described from Benjamin Castleman in 1956. The disease today is enumerated among lymphoproliferative disorders and has unknown etiology. Although the mediastinum is a their most common location, they also occurs in other areas of the body, usually where lymph nodes are normally found. Castleman's disease of the neck is very rare. We describe a case of Castleman's disease of the neck in a middle aged man, and discuss the clinical presentation, radiological findings, and pathological features.

Incidentally found unicentric plasma cell variant Castleman's disease in mesentery: focus on ultrasonography and CT findings (우연히 발견된 장간막의 단중심성 형질세포형 Castleman병 1예: 초음파와 CT 소견 중심으로)

  • Kim, Hyun Min;Kim, Bong Soo;Jung, In Ho;Hyun, Chang Lim;Jung, Seung Wook;Jo, Jae Min
    • Journal of Medicine and Life Science
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    • v.15 no.1
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    • pp.19-22
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    • 2018
  • Castleman's disease is a benign lympho-proliferative disorder that commonly occurs in mediastinum. It is known that the disease rarely occurs in mesentery. Most localized abdominal Castleman's diseases are histologically hyaline vascular type. The contrast-enhanced CT in patient with hyaline vascular type Castleman's disease shows a well-defined mass with homogenously intense enhancement. On the other hand, the patient with plasma cell variant has systemic symptoms, but not specific imaging features. We report a unicentric plasma cell variant Castleman's disease in mesentery nearby superior mesenteric artery as presenting a single mass, not accompanied by systemic symptoms with similar characteristics to hyaline vascular type.

Giant Lymph Node Hyperplasia of Castleman - Report of 2 cases - (Castleman 거대림프절 증식증 2례 보)

  • 김응수
    • Journal of Chest Surgery
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    • v.20 no.3
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    • pp.582-587
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    • 1987
  • Castleman`s disease, giant lymph node hyperplasia, is a rare benign disease. The lesion usually consists of a single node, unassociated with any abnormality of the adjacent lymph nodes or other organs. In the first accounts of giant lymph node hyperplasia of Castleman, the lesion was described as solitary and localized to the mediastinum, which is still the most frequent site of involvement. The disease occurs in all age groups and there is no particular sex preference. It is symptomless and is usually detected on chest films as an incidental finding. On a single involvement, it does not recur after excision, whether total or partial, and the main indication of operation is to rule out more serious tumors. Recently multicentric form appears to be a variant of classic giant lymph node hyperplasia and is associated with significant morbidity and mortality. Histologically, two distinct types have been reported; hyaline-vascular and plasma cell. The hyaline-vascular type of lesion is much more common than the plasma cell type. We report two cases of the hyaline-vascular type of Castleman`s disease.

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Giant Lymph Node Hyperplasia (Castleman's Disease) as a Rare Cause of Back Pain

  • Kim, Kyoung-Han;Kim, Sang-Dae;Kim, Se-Hoon;Park, Jung-Yul
    • Journal of Korean Neurosurgical Society
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    • v.43 no.3
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    • pp.169-171
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    • 2008
  • Giant lymph node hyperplasia (Castleman's disease) is a nonneoplastic lymphoproliferative disorder of unknown etiology that usually occurs in the chest. Its morphological recognition is based on a composition of various histological features. The mass is often asymptomatic, but it can cause nonspecific thoracic symptoms, such as regional pain. This disease can be found wherever lymph nodes are present, but two-thirds of these tumors are found in the chest, along the tracheobronchial tree in the mediastinum or lung hilus. However, we experienced an unusual case of Castleman's disease as a cause of back pain that was localized in the posterior mediastinum bordering the chest wall.

A Case Report of Castleman's Disease of the Neck (경부에 발생한 Castleman씨 질환 2례)

  • 김광문;김명상;박국진;전희선
    • Korean Journal of Bronchoesophagology
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    • v.4 no.1
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    • pp.112-116
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    • 1998
  • Castleman's disease was originally described as a localized mediastinal lymph node enlargement characterized by angiofollicular hyperplasia and intrafollicular capillary proliferation, with surgical removal of mass the only treatment required. It has been divided into two distict histologic types. The hyaline-vascular type is more common and characterized by small hyaline-vascular follicles and interfollicular proliferation. The plasma-cell type is occurred less frequent and more likely to present with constituitional symptoms. It commonly involves the mediastinal and pulmonary lymph nodes, with neck involvement in only 15% to 20% of cases. We report two cases of hyaline-vascular type of Castleman's disease located in the neck area with references to recent literature.

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