• Nutrition Research and Practice
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• v.11 no.5
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• pp.419-429
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• 2017

BACKGROUND/OBJECTIVES: The relationship between folate and colorectal neoplasia remains controversial. We examined the association between serum folate concentrations and colorectal adenomas in a case-control study of Korean adults and conducted a meta-analysis. SUBJECTS/METHODS: Our case-control study included 113 pairs of case and control who underwent colonoscopy and provided blood samples. We used multivariable conditional logistic regression models to obtain the odds ratios and 95% confidence interval (CIs). For meta-analysis, we identified the relevant studies by searching the PubMed database up to February 2017, included our case-control study and combined the study-specific relative risks (RRs) using a random-effects model. RESULTS: In this case-control study, we included 58 men and 55 women with colorectal adenomas and sex and fasting status matched the controls. We did not find any significant association between the serum folate levels and colorectal adenomas in either men or women. For meta-analysis, a total of eleven studies were included in our analysis and classified into two groups; polyp clearance group (PC) for the studies that included participants who underwent endoscopies and had their polyps removed at baseline; and no polyp clearance group (NPC) for the studies that included participants whose histories of endoscopies were unknown or who underwent their first endoscopies. Four PC (1,311 cases and 1,672 non-cases) and eight NPC studies (3,501 cases and 11,347 non-cases) were included. The combined RRs (95% CIs) comparing the bottom with the top categories of circulating folate levels were 1.07 (0.97-1.18) for the NPC group but 1.45 (1.16-1.74) for the PC group. CONCLUSIONS: Low circulating folate levels were associated with new adenoma formation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.5
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• pp.1861-1885
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• 2020

Test Case Prioritization (TCP) involves the rearrangement of test cases on a prioritized basis for various services. This research work focuses on TCP in web services, as it has been a growing challenge for researchers. Web services continuously evolve and hence require reforming and re-execution of test cases to ensure the accurate working of web services. This study aims to investigate gaps, issues, and existing solutions related to test case prioritization. This study examines research publications within popular selected databases. We perform a meticulous screening of research publications and selected 65 papers through which to answer the proposed research questions. The results show that criteria-based test case prioritization techniques are reported mainly in 41 primary studies. Test case prioritization models, frameworks, and related algorithms are also reported in primary studies. In addition, there are eight issues related to TCP techniques. Among these eight issues, optimization and high effectiveness are most discussed within primary studies. This systematic review has identified that a significant proportion of primary studies are not involved in the use of statistical methods in measuring or comparing the effectiveness of TCP techniques. However, a large number of primary studies use 'Average Percentage of Faults Detected' (APFD) or extended APFD metrics to compute the performance of techniques for web services.

• The Journal of Information Systems
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• v.32 no.3
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• pp.205-224
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• 2023

Purpose This study investigates the impact of organizational characteristics on organizational performance through case studies of smart factory implementation in the context of Korean small and medium Enterprises (SMEs). To achieve this goal, this study adopts the smart factory index of KOSMO (Korea Smart Manufacturing Office) established by Korean Ministry of SMEs and Startups. We visited 3 firms implemented smart factory projects. This study presents the results of field study in detail with evaluation criteria on how organizational competences like AI technology adoption and facility automation can be exploited to positively influence organizational performance through smart factory implementation. Design/methodology/approach There are not so many results of empirical studies related to smart factories in Korea. This is because organizational support and user involvement are required for facility AI platform service beyond factory automation after the start of the 4th Industrial Revolution. Korean government's KOSMO (Korean Smart Manufacturing Office) has developed and proposed a level measurement index for smart factory implementation. This study conducts case studies based on the level measurement method proposed by KOSMO in the process of conducting case studies of three companies belonging to the root and mechanic industries in Korea. Findings The findings indicate that organizational competences, such as facility AI platform adoption and user involvement, are antecedents to influence smart factory implementation, while smart factory implementation has significant relationship with organizational performance. This study provides a better understanding of the connection between organizational competences and organizational performance through smart factory case studies. This study suggests that SMEs should focus on enhancing their organizational competences for improving organizational performance through implementing smart factory projects.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.1412-1417
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• 2009

BIM(Building Information Modeling) is considered a new paradigm and a powerful method in building design, construction and maintenance. However, it is still hard to implement environmental performance analysis using BIM in design stages. This study aims to reveal practical problems and evaluate interoperability between building design information and performance analysis with case studies. Three case studies are performed using two environmental analysis programs (IES/VE, EnergyPlus) and BIM-based architectural design programs (Revit, GoogleSketchUp) in this paper.

• Journal of Applied Reliability
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• v.6 no.3
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• pp.239-254
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• 2006

In this research, first, the effect of Six Sigma activities and business performance will be checked based on case studies involving companies adopting Six Sigma and, secondly, the Six Sigma training effectiveness, Customer Satisfaction and Financial Performance, etc, will be evaluated to find out how related to Six Sigma Implementation. Finally, Six Sigma's Implementation Categories will be analyzed. The method used in this research was to select the research model and research hypothesis based on theoretical studies and the interesting aspects of the recent Six Sigma, along with case studies and research based on actual proof. Case studies and research based on actual proof showed that among 11 companies analyzed, a total of 11 companies obtained good results, and KIs were found to be factors of their success.

• 대한예방의학회:학술대회논문집
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• 1994.02b
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• pp.188-195
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• 1994

To an increasing extent, case-control studies are being undertaken to determine if use of early detection procedures is associated with reduced mortality from cancer. The authors recommend that in such studies the analysis focus on screening activity in cases that occurs during an interval prior to diagnosis in which the cancer is believed to be detectable and still curable and to a corresponding time period in controls. This approach places a heavy burden on the investigator to estimate accurately the period during which the tumor ought to be detectable using the test in question and to sort out reliably tests done in response to signs or symptoms of the cancer from screening tests per se. Nonetheless, the authors feel that it offers the greatest ability to discern a true benefit of screening, while minimizing the numerous potential biases that can be present in this type of study.

• Communications for Statistical Applications and Methods
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• v.26 no.2
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• pp.103-129
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• 2019

The main goal of a case-control study is to learn the association between various risk factors and a primary outcome (e.g., disease status). Particularly recently, it is also quite common to perform secondary analyses of the case-control data in order to understand certain associations between the risk factors of the primary outcome. It has been repeatedly documented with case-control data, association studies of the risk factors that ignore the case-control sampling scheme can produce highly biased estimates of the population effects. In this article, we review the issues of the naive secondary analyses that do not account for the biased sampling scheme, and also the various methods that have been proposed to account for the case-control ascertainment. We additionally compare the results of many of the discussed methods in an example examining the association of a particular genetic variant with smoking behavior, where the data were obtained from a lung cancer case-control study.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.4
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• pp.70-87
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• 2023

Objectives : The purpose of this research is to review the efficacy and safety of taping therapy for facial palsy. Methods : Two foreign databases(Pubmed, CNKI) and one domestic database(OASIS) were used to search, and papers retrieved from the starting point of literature provision in each database until June 19, 2023 were included in the study. All studies in which other treatments were performed as a treatment intervention along with taping therapy were included, but cases where taping therapy was a comparative intervention were excluded. Results : 18 studies were selected. 14 studies were two-arm randomized controlled trials(RCT), and 4 studies were case reports. There was improvement in facial palsy in all 4 case reports, and in all 14 RCTs, the treatment effect in the observation group was significantly higher than in the control group. Conclusions : Taping therapy can be an effective and safe treatment method for facial palsy. However, the risk of bias in the selected studies was high, and there were many cases in which multiple interventions other than taping therapy were applied simultaneously. Therefore, well-designed studies with high quality are needed in the future.

• The Journal of Internal Korean Medicine
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• v.44 no.6
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• pp.1256-1270
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• 2023

Objectives: This study analyzes domestic research trends on herbal medicine treatments for ulcerative colitis (UC) by examining 28 selected domestic papers using the Oriental Medicine Advanced Searching System (OASIS) as the main search source. Methods: A total of 28 domestic papers were selected on the OASIS platform as the main search source using the keywords "(궤양성 대장염) or (궤양성 대장병)" and "(한약) or (한의학)". Results: There were 11 case report studies and 17 case-control studies published from 2002 to 2022. All the case-control studies only dealt with mice and did not include human subjects. The most common pathologies were damp heat and Changpung. Hwangryunhaedok-tang was the most frequently prescribed herbal formula, and Coptidis Rhizoma was the most commonly used herb across all studies. The results showed that many studies demonstrated the significant effects of herbal treatment. Conclusion: Herbal medicine may exhibit therapeutic effects on various aspects of UC. However, evidence-based studies, such as clinical trials involving human subjects, are needed.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7665-7671
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• 2014

Objectives: The association between body mass index (BMI) and ovarian cancer risk is unclear and requires further investigation. The present meta-analysis was conducted to assess the effect of overweight and obesity on ovarian cancer risk in the premenopausal and postmenopausal periods. Data sources: Major electronic databases were searched until February 2014 including Medline and Scopus. Reference lists and relevant conference databases were searched and the authors were contacted for additional unpublished references. Review Methods: All cohort and case-control studies addressing the effect of BMI on ovarian cancer were included, irrespective of publication date and language. The effect measure of choice was risk ratio (RR) for cohort studies and odds ratio (OR) for case-control studies. The results were reported using a random effects model with 95% confidence intervals (CIs). Results: Of 3,776 retrieved studies, 19 were ultimately analyzed including 10 cohort studies involving 29,237,219 person-years and 9 case-control studies involving 96,965 people. The results of both cohort and case-control studies showed being overweight and obesity increased the risk of ovarian cancer compared to women with normal weight during both premenopausal and postmenopausal periods: RR=1.08 (95%CI: 0.97, 1.19) and OR=1.26 (95%CI: 0.97, 1.63) for overweight and RR=1.27 (95%CI: 1.16, 1.38) and OR=1.26 (95%CI: 1.06, 1.50) for obesity. Conclusions: There is sufficient evidence that an increase in BMI can increase the risk of ovarian cancer regardless of the menopausal status, mimicking a dose-response relationship although the association is not very strong.