• 동의신경정신과학회지
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• 제20권1호
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• pp.235-247
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• 2009

Objectives : Ginseng Radix Rubra water extract(RGE) has been used in vivo test for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with APP-related dementias and Alzheimer's disease (AD). APP derived from proteolytic processing of the ${\beta}$-amyloid precursor protein (APP), including the amyloid-${\beta}$ peptide (A${\beta}$), plays a critical role in the pathogenesis of Alzheimer's dementia. Methods : We determined that RGE inhibits formation of APP, which are the behavior, and possibly causative, feature of AD. Results and Conclusions : In the cells, RGE significantly activated antiapoptosis and decreased the activity of APP-grim, a key enzyme in the apoptosis cell-signaling cascade. These results suggest that neuronal damage in AD might be due to two factors: a direct APP toxicity and multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of APP, underlie the neuroprotective effects of RGE.

• 전력전자학회논문지
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• 제17권2호
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• pp.158-165
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• 2012

In this paper, the test bed using three-phase PWM converter connected with single phase inverter in series is set up to configure an active AC electric load. Since the two topologies, three-phase PWM converter and single-phase inverter, can be operated bidirectionally, the system not only re-generates surplus power to grid but also prevents power dissipation. However, the construction of system has a drawback. That is, ripple components two times of inverter operation frequency occur at DC-Link due to cascade connection, it can be cause of three phase unbalance Since the operational characteristic of the active AC electric load, the power frequency entered into the electric load can be varied, and the ripple of DC-Link is changed as well. In this paper, the three-phase PWM converter using a variable notch filter is proposed, and the reduction of three-phase current unbalance is presented. the validity of the proposed PWM converter using a variable notch filter is verified by the simulation and experimental results.

• Journal of international Conference on Electrical Machines and Systems
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• 제3권1호
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• pp.78-82
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• 2014

Power Transformers with more than one secondary winding are not uncommon in industrial applications. But new classes of applications where very large number of independent secondaries are used are becoming popular in controlled converters for medium and high voltage applications. Cascade H-bridge medium voltage drives and Pulse Step Modulation (PSM) based high voltage power supplies are such applications. Regulated high voltage power supplies (Fig. 1) with 35-100 kV, 5-10 MW output range with very fast dynamics (${\mu}S$ order) uses such transformers. Such power supplies are widely used in fusion research. Here series connection of isolated voltage sources with conventional switching semiconductor devices is achieved by large number of separate transformers or by single unit of multi-secondary transformer. Naturally, a transformer having numbers of secondary windings (~40) on single core is the preferred solution due to space and cost considerations. For design and simulation analysis of such a power supply, the model of a multi-secondary transformer poses special problem to any circuit analysis software as many simulation softwares provide transformer models with limited number (3-6) of secondary windings. Multi-Secondary transformer models with 3 different schemes are available. A comparison of test results from a practical Multi-secondary transformer with a simulation model using magnetic component is found to describe the behavior closer to observed test results. Earlier models assumed magnetising inductance in a linear loss less core model although in actual it is saturable core made-up of CRGO steel laminations. This article discusses a more detailed representation of flux coupled magnetic model with saturable core properties to simulate actual transformers very close to its observed parameters in test and actual usage.

• IMMUNE NETWORK
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• 제14권3호
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• pp.138-148
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• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.

• 대한한방내과학회지
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• 제27권3호
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• pp.603-616
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• 2006

The water extract of Gamiyaengshinhwan (GYH), has been used in vitro tests for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with CT105-related dementias and Alzheimer's disease(AD). CT105 derived from proteolytic processing of the $\beta$-amyloid precursor protein (APP), including the amyloid-$\beta$ peptide ($A{\beta}$), plays a critical role in the pathogenesis of Alzheimer's dementia. We determined that transfected overexpressing APP695 and $A{\beta}$ CT105 have a profound attenuation in the Increase in CT105 expressing neuro2A cells from GYH. Experimental evidence indicates that GYH protects against neuronal damage from cells, but its cellular and molecular mechanisms remain unknown. Using a neuroblastoma cell line stably expressing CT105-associated neuronal degeneration, we demonstrated that GYH inhibits formation of amyloid-$\beta$ fragment ($A{\beta}$ CT105). which are the characteristic, and possibly causative, features of AD. The decreased CT105 $A{\beta}$ in the presence of GYH was observed in the conditioned medium of this CT105-secreting cell line under in vitro. In the cells, GYH significantly attenuated mitochondrion-initiated apoptosis and decreased the activity of Bax, a key enzyme in the apoptosis cell-signaling cascade. These results suggest that neuronal damage in AD might be due to two factors: a direct CT05 toxicity and the apoptosis initiated by the mitochondria. Multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of CT105 aggregation, underlie the neuroprotective effects of GYH.

• 한국전자파학회논문지
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• 제25권3호
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• pp.269-281
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• 2014

본 논문에서는 루프 군지연을 이용하여 저위상 잡음을 갖는 5 GHz 전압제어 유전체 공진기 발진기(VTDRO: Voltage Tuned Dielectric Resonator Oscillator)의 체계적인 설계를 제안하였다. 설계된 발진기는 폐루프 구조로 공진부, 위상천이부, 증폭부로 구성된다. 먼저 기준 전압제어 유전체 공진기 발진기를 제작하고, 루프 군지연을 측정 후, 전기적 주파수 조정 범위 및 위상 잡음을 측정하였다. 기준 전압제어 유전체 공진기 발진기의 측정 결과로부터, 루프 군지연만 조정될 경우 새로운 전압제어 유전체 공진기 발진기의 전기적 주파수 조정 범위 및 위상 잡음을 수식적으로 예측할 수 있다. 루프군지연이 높을수록 위상 잡음은 개선되고, 전기적 주파수 조정 범위는 좁아지게 된다. 이러한 루프 군지연은 주로 공진부에 의해 결정된다. 따라서 높은 군지연 특성을 갖는 공진부 설계방법의 체계적인 절차를 제안하였다. 측정 결과, 루프군 지연은 약 700 nsec를 보였다. 또한, 5 GHz의 발진 주파수에서 위상 잡음은 수식으로부터 도출한 값과 근사한 100 kHz offset 주파수에서 -154.5 dBc/Hz를 얻었다. 전기적 주파수 조정 범위는 0~10 V의 조정 전압에서 448 kHz를 보였으며, 출력 전력은 약 4.39 dBm을 보였다.