• International Journal of Oral Biology
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• 제40권4호
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• pp.217-221
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• 2015

Cariogenic Streptococcus mutans encounters a variety of host defense factors produced in oral cavity. Nitric oxide (NO) and NO-mediated reactive nitrogen species are potential antimicrobials of innate immunity that can threaten the fitness of S. mutans in their ecological niches. Streptococcal strategies to detoxify cytotoxic NO, which allow S. mutans to persist in caries or other environments of the oral cavity, remain unknown. In this study, we directly measured NO consumption rates of S. mutans isolated in Korea. Surprisingly, all S. mutans strains were unable to consume exogenous NO efficiently, while an intracellular parasite Salmonella enterica serovar Typhimurium expressing the NO-metabolizing enzyme flavohemoglobin consumed most of the NO. This result suggested that S. mutans has alternative detoxification systems for tolerating NO-induced nitrosative stresses.

• 생약학회지
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• 제28권3호
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• pp.99-103
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• 1997

To develop anticariogenic agents, Scutellariae Radix was tested for its antibacterial activity against Streptococcus mutans OMZ176 which is known as a strong cariogenic bacterium. The antibacterial activity was evaluated with disk plate method and minimal inhibitory concentration (MIC). The ethyl acetate fraction showed significant activity. By means of activity-guided fractionation, baicalein and ganhuangenin were isolated as the active principles. The MICs of these compounds were $100{\mu}g/ml$ and $200{\mu}g/ml$, respectively.

• 동의생리병리학회지
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• 제25권4호
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• pp.635-640
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• 2011

Betulae Cortex of Betula platyphylla Suk. var. japonica Hara (Betulaceae) has long been used for treatment of various inflammation, fever and cough in Eastern Asia. In order to investigate antibacterial activity of the Betulae Cortex against Streptococcus mutans or Porphyromonas gingivalis, MIC (minimal inhibitory concentration) and pH were checked, and for anti-inflammation activity, the experiments about trypsin-induced paw edema, vascular permeability and myeloperoxidase activity in rat's hind-paw tissue, were carried out with various extracts of Betulae Cortex (BCXs) respectively. The BCXs showed significant antibacterial activity, and at the dose of over 50 mg/kg, BCX showed significant inhibition on the paw edema, vascular permeability and myeloperoxidase activity. These results indicate that BCXs have antibacterial activity against oral cariogenic bacteria and anti-inflammatory effect.

• Journal of the Korean Wood Science and Technology
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• 제33권2호통권130호
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• pp.72-77
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• 2005

Streptococcus mutans is known as a strong cariogenic bacterium and produces dental caries. This study was carried out to develop anticariogenic agents from Callistemon citrinus. Crude extracts and thier various solvent fractions of the plant extracts were tested for the antibacterial activity against S. mutans. The anticariogenic activity was evaluated with by paper disc diffusion method and minimal inhibition concentration (MIC). The extract from the fruit and its hexane fraction showed a strong inhibitory effect on the growth of S. mutans and the MICs were 31.2 and $3.9{\mu}g/m{\ell}$, respectively.

• 한국컴퓨터정보학회논문지
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• 제22권1호
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• pp.57-62
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• 2017

Children need oral care according to their developmental stage and accordingly, the appropriate dental treatment is different, which requires parents to have an active attitude and the applicable oral knowledge. As there is so much unreliable oral care information and PR, it is hard to find accurate information and parents are in need of a preventative oral healthcare mobile application for healthy oral care. Also, pediatric adolescent care should be focused on prevention rather than treatment and children should be instructed and educated to eat cariogenic foods as little as possible as well as told to brush before going to bed. This study designed a smart application for oral health care education to provide information and knowledge regarding oral health care for infants, oral health education, and oral health care prevention for parents of young children.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2011년도 추계학술대회
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• pp.934-937
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• 2011

약용식물로부터 충치예방물질을 개발하기 위하여 우리나라에서 전통적으로 널리 사용되어 왔던 10종류의 약용식물로부터 에탄올 추출물을 분리하였다. 이를 대상으로 충치 원인균인 Streptococcus sobrinus에 대한 항균활성을 나타내는 약용식물을 조사하였다. 관중의 에탄올 추출물이 S. sobrinus에 대해 항균활성을 나타냈다. 이 결과를 근거로 하여 관중의 추출물은 S. sobrinus에 대한 충치 예방물질로서 가능성이 있음을 나타낸다.

• 미생물학회지
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• 제18권4호
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• pp.180-187
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• 1980

Streptococcus mutans에 의한 sucrose로 부터 축적된 polysaccharide를 조사한 결과 1 균주이 따라 36시간 후 4.41mg/ml로 부터 1.86mg/ml사이의 polysaccharide가 축적되고 2 효소에 의해서도 10시간 후 2.36mg/ml에서 1.4mg/ml의 polysaccharide가 생성되고 3 생성된 polysaccharide는 통일형의 polysaccharide였다.

• 동의생리병리학회지
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• 제20권6호
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• pp.1625-1628
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• 2006

The (-)-pimara-9 (11), 15-dien-19-oic acid, acanthoic acid was extracted from the roots of Acanthopanax koreanum using bioassay-guided isolation of a MeOH extract. Acanthoic acid was assayed against Streptococcus mutans and Staphylococcus epidermidis causing dental caries and opportunistic pathogen. The minimum inhibitory concentration (MIC) of acanthoic acid against Streptococcus mutans and Staphylococcus epidermidis was 2 and 4 ${\mu}g/mL$, respectively, which was much lower than those of other natural antimicrobial agents such as 8 ${\mu}g/mL$ of tanshinone IIA. Acanthoic acid also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Streptococcus grodenii in the MIC range of 4${\sim}$32 ${\mu}g/mL$. Our findings suggest that acanthoic acid could be employed as a potential antibacterial agent for preventing dental caries and skin infections.

• 한국자원식물학회지
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• 제21권6호
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• pp.431-434
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• 2008

Dental caries is the destruction of the enamel of teeth by Streptoccus mutans. S. mutans has been isolated from human dental plaque and is associated with the initial development of enamel lesions. We have studied the antibacterial action of the fruit of Callistemon citrin us against a cariogenic bacterium, S. mutans. From the fruit of C. citrinus, piceatannol (3,3',4',5-tetrahydroxystilbene) was isolated by repeated column chromatography with $SiO_2$ and Sephadex LH-20. Its structure was elucidated by instrumental analysis using 1D-NMR, 2D-NMR and EI-MS. This compound was isolated from the fruit of C. citrin us for the first time. The anticarcinogenic activity of this compound was determined by using agar well-diffusion method and minimal inhibition concentration (MIC).

• 대한치과기공학회지
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• 제10권1호
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• pp.151-157
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• 1988

저자는 대구시내에 거주하는 국민학교 6학년생 64명과 농촌지역에 거주하는 국민학교 6학년생 58명 총 122명을 대상으로 Snyder 검사, 타액완충능 검사 및 타액분비량을 측정하여 이들과 DMFT 및 DMFS index와의 상호관계를 분석해 보았던 바 다음과 같은 결론을 얻었다. 1. Snyder 검사에 양성인자는 78.7%이었고, 양성인자중 현자한 자는 29.5%, 중등도인자는 30.3%, 경도인자는 18.7%이었고, 음성인자는 21.3%이었다. 2. Snyder 검사에 음성반응을 나타낸 군이 양성반응을 나타낸 군에 비해 DMFT 및 DMFS index가 현저히 낮았다(P<0.01). 3. 도시와 농촌지역 아동으로 나눈 Snyder 검사 결과 음성반응은 도시지역 아동이 73.45%, 농촌지역 아동이 84.48%이었다. 4. 자극성 타액의 분비량은 남자가 6.97$\pm$2.57, 여자가 6.34$\pm$2.45로 남자가 조금 높게 나타났으나 유의성은 없었다(P>0.05). 5. 자극성 타액분비량이 평균치 이하인 군이 평균치 이상인 군보다 월등히 높은 DMFT 및 DMFS index를 나타내었다(P<0.01). 6. 도시와 농촌지역 아동으로 구분한 타액분비량 측정결과 도시지역 아동이 약간 높았으나 유의성은 없었다(P>0.05). 7. 타액완충능은 남자가 7.65$\pm$2.19, 여자가 6.80$\pm$1.67로 남자가 유의성 있게 높게 나타났다(P<0.05). 8. 타액완충능이 평균치 이하인군이 평균치 이상인 군보다 월등히 높은 DMFT 및 DMFS index를 나타내었다(P<0.01). 9. 도시와 농촌지역 아동으로 나눈 타액 완충능 검사결과 도시지역 아동이 유의성 있게 높이 나타났다. 10. 자극성 타액분비량과 타액의 완충능이 높을 경우 영구치 우식발생에 억제적인 효과가 있음을 확인하였다.