• 한국융합학회논문지
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• 제10권11호
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• pp.233-239
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• 2019

본 연구는 국민건강영양조사 제6기(2013년~2015년) 자료를 토대로 건강행태 및 심혈관질환과 치주질환의 영향요인을 분석하고자 하였다. 연구대상은 심혈관질환(고혈압, 협심증, 심근경색증, 뇌졸중), 치주질환이 있는 만 19세 이상을 대상자로 선정하였고, SPSS(SPSS 23.0 for Windows)를 사용하여 14,940명을 분석하였다. 교차분석(chi-quare test) 및 복합표본 로지스틱 회귀분석을 사용하여 인구사회경제학적 특성, 건강행태 및 심혈관질환과 치주질환의 유무를 분석하였다. 결과로는 고혈압, 협심증, 심근경색증, 뇌졸중과 관련성이 있었다. 영향요인은 고혈압이 없을 경우 치주질환 유병률이 0.684배 낮았고, 남자, 연령, 학력, 교육수준, 흡연, 잠자기 전 칫솔질, 치실 치간칫솔 사용이 통계적으로 유의하였다. 결과로는 건강행태 개선과 두 질환의 체계적 관리가 요구되고, 향후 질환 간의 예방교육 프로그램 개발에 도움을 주고자 한다.

• The Korean Journal of Physiology and Pharmacology
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• 제26권1호
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• pp.15-24
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• 2022

The development of selective targeting of drug molecules towards the mitochondria is an important issue related to therapy efficacy. In this study, we report that gallic acid (GA)-mitochondria targeting sequence (MTS)-H₃R₉ exhibits a dual role as a mitochondria-targeting vehicle with antioxidant activity for disease therapy. In viability assays, GA-MTS-H₃R₉ showed a better rescue action compared to that of MTS-H₃R₉. GA-MTS-H₃R₉ dramatically exhibited cell penetration and intercellular uptake compared to MTS and fit escape from lysosome release to the cytosol. We demonstrated the useful targeting of GA-MTS-H₃R₉ towards mitochondria in AC16 cells. Also, we observed that the antioxidant properties of mitochondrial-accrued GA-MTS-H₃R₉ alleviated cell damage by reactive oxygen species production and disrupted mitochondrial membrane potential. GA-MTS-H₃R₉ showed a very increased cytoprotective effect against anticancer activity compared to that of MTS-H₃R₉. We showed that GA-MTS-H₃R₉ can act as a vehicle for mitochondria-targeting and as a reagent for therapeutic applications intended for cardiovascular disease treatment.

• Journal of Chest Surgery
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• 제56권4호
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• pp.272-273
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• 2023

• 한국비블리아학회지
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• 제27권1호
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• pp.111-134
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• 2016

본 연구는 저자동시인용분석 기법을 이용하여 국내와 미국의 심장혈관학(Cardiovascular Research) 분야의 지적구조 규명을 목적으로 하였다. 이를 위해서 2008년부터 2014년까지 국내의 "대한심장학회지"와 미국의 Circulation, Circulation Research를 선정하여 인용빈도 기준으로 각각 45명과 53명의 저자를 추출하였다. 저자동시인용 행렬을 기반으로 다차원척도분석, 군집분석, 요인분석을 실시하였다. 분석결과는 심장혈관학 분야에서 국내와 미국 연구자들은 공통적으로 여러 분야에 걸쳐 다양한 세부 분야에서 연구 활동을 하는 경향을 보였다. 국내와 미국의 심장혈관학 분야는 핵심연구 영역으로 '심혈관질환 치료', '심혈관질환 진단', '심혈관질환 기초과학', '심혈관질환 예방'으로 나타났다. 국내와 미국의 가장 큰 차이로 볼 수 있는 것은 국내 연구는 임상 중심이며, 미국 연구는 기초 의학 중심인 것으로 나타났다. 국내의 경우는 '리듬장애' 분야가 나타났으며, 이에 반해 미국은 '심혈관계 작용약물' 분야를 찾아볼 수 있다. 또한 미국의 분석결과에서는 기초의학 분야의 세부분야인 '역학', '생물학', '생화학', '생리학' 분야가 뚜렷하게 구분되어 나타났다.

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 1992년도 학술강연회
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• pp.1-5
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• 1992

There is increasing awareness of the devastating socio-economic cost of cardiovascular disease. As a result there have been a lot of extensive researches both on basic mechanisms involved and on the areas of epidemiology and clinical trials. Now, it is being generally accepted that dietary n-3 fatty acids abundant in marine products, may reduce the incidence of cardiovascular disease. Fish oil, with its complement of n-3 fatty acids, has been shown to have diverse and sometimes potent actions on cells of the blood and vasculature, which may explain some of its positive effects on vascular disease. However, the appropriate intake of n-3 fatty acids has not been established. This may vary with desired effects, the duration of ingestion, the type of seafood or fish oil and amount of other fatty acids, especially nf fatty acid being consumed in the diet, Although the beneficial effects have been extensively studied, little is known about potential adverse effects with excessive intake of n-3 fatty acids. Thus, it is needed to study on the possible unfavorable effects including genetic effects.

• Journal of Nutrition and Health
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• 제26권9호
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• pp.1071-1084
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• 1993

This study was performed to investigate the relationships between obese index and major risk factors of cardiovascular disease in CVD patients. Anthropometry, food intake patterns, blood pressure, serum lipids and hematological values were analyzed in 550 patients from June, 1991 to August, 1992. The results are as follows: Total food intakes, especially total vegetable food and alcohol intakes were significantly related with obese index, so that the heavier patients tended to consume more carbohydrate and less fat. The blood pressure were observed to have positive correlation with obese index in man but not in women. However, both in men and women, blood levels of TG, TC, and VLDL tended to be related to obese index positively, while HDL and HDL-C were shown to be oppositive. So, it seems that as the degree of obesity is higher the blood pressure and blood lipids patterns worse. Therefore, these results suggest that obesity is one of the major risk factors of CVD, and for prevention & treatment of the disease, controlling body weight by nutritionally adequate diet along with alcohol restriction is necessary.

• Journal of Chest Surgery
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• 제36권11호
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• pp.862-865
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• 2003

좌심방 점액종에 의한 승모판막 협착이나 폐쇄부전은 흔히 보고되지만 관상동맥질환을 동반하면서 승모판막폐쇄부전을 약화시킨 좌심방 점액종은 매우 드물다. 저자들은 좌심방 점액종에 의해 승모판막폐쇄부전이 경도로 약화되어 있었지만 종양 제거 후 중등도 이상으로 평가되어 승모판막성형술이 필요하였던 70세 여자 환자를 보고한다. 환자는 관상동맥 협착 및 승모판막의 우섬유각 및 후교련 부위의 심방중격에서 기시한 점액종에 의해 승모판막 개폐구의 폐쇄로 심한 폐고혈압과 중등도의 삼첨판막폐쇄부전이 동반되어 있었다. 좌심방 점액종 제거, 승모판막성형술, 관상동맥우회술 및 삼첨판륜성형술을 받은 후 14일째 환자는 특별한 합병증없이 퇴원하였다.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2006년도 The 6th Intermational Symposium on Developmental Biotechnology
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• pp.62-62
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• 2006

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2002년도 Current Trends in Toxicological Sciences
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• pp.69-70
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• 2002

• 한국임상약학회지
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• 제31권3호
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• pp.198-204
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• 2021

Background: Cardiovascular (CV) disease is known as one of the major causes of death from disease worldwide. Statin therapy plays a pivotal role in atherosclerotic cardiovascular disease (ASCVD) lowering the LDL-cholesterol level effectively. The purpose of this study was to evaluate the association of the intensity of statin therapy in adult patients of Korea and the risk of ASCVD of the patient group. Methods: We used data from sample of patients from the Health Insurance Review and Assessment Service (HIRA-NPS-2018). We analyzed the patterns of prescribing statins including types of statin, statin intensity, and number of patients with ASCVD or risk of ASCVD. Results: 155,512 patients were included in the analysis, and 27,950 patients (18.0%) was over 75 years. High-intensity statin usage was increased in ASCVD patients compared with the low-intensity statin use. The OR (odds ratio) of high-intensity statin were increased in myocardial infarction patients compared with low-intensity statin use showing the highest OR; 12.40 (95% CI; 9.48-16.22). At patient groups of angina, ischemic heart disease and carotid disease, high-intensity statin prescription rate was increased compared with low-intensity statin. However, there was no statistical significance between both statin prescription rates in patients of peripheral arterial disease, abdominal aneurysm, diabetic mellitus and atherosclerosis. Conclusion: The statin prescription rate showed intensity increasing tendency according to the risk of ASCVD. More aggressive statin therapy might be beneficial for the ASCVD patients based on the recent guidelines of dyslipidemia.