• Journal of the Korea Convergence Society
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• v.10 no.11
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• pp.233-239
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• 2019

The purpose of this study was to analyze factors affecting the health behaviors and Cardiovascular Disease and their effects on periodontitis by using data from the 6th KNHANES(2013~2015). The subjects were 19 years older who had Periodontitis and Cardiovascular Disease(hypertension, angina, myocardial infarction, stroke) The final 14,940 subjects were analyzed using SPSS (SPSS 23.0 Windows). Chi-quare test and complex sample logistic regression analysis were used to analyze the demographic characteristics, health behaviors, and Cardiovascular Disease and presence or absence of periodontitis. Results were related to hypertension, angina, myocardial infarction and stroke. The prevalence of periodontal disease was 0.684 times lower in the absence of hypertension. Men, age, education, pre-sleep brushing, floss and interdental toothbrushes were statistically significant. As a result, it is necessary to improve health behavior and systematic management of both diseases, and to help develop preventive education programs between diseases in the future.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.1
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• pp.15-24
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• 2022

The development of selective targeting of drug molecules towards the mitochondria is an important issue related to therapy efficacy. In this study, we report that gallic acid (GA)-mitochondria targeting sequence (MTS)-H₃R₉ exhibits a dual role as a mitochondria-targeting vehicle with antioxidant activity for disease therapy. In viability assays, GA-MTS-H₃R₉ showed a better rescue action compared to that of MTS-H₃R₉. GA-MTS-H₃R₉ dramatically exhibited cell penetration and intercellular uptake compared to MTS and fit escape from lysosome release to the cytosol. We demonstrated the useful targeting of GA-MTS-H₃R₉ towards mitochondria in AC16 cells. Also, we observed that the antioxidant properties of mitochondrial-accrued GA-MTS-H₃R₉ alleviated cell damage by reactive oxygen species production and disrupted mitochondrial membrane potential. GA-MTS-H₃R₉ showed a very increased cytoprotective effect against anticancer activity compared to that of MTS-H₃R₉. We showed that GA-MTS-H₃R₉ can act as a vehicle for mitochondria-targeting and as a reagent for therapeutic applications intended for cardiovascular disease treatment.

• Journal of Chest Surgery
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• v.56 no.4
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• pp.272-273
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• 2023

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.27 no.1
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• pp.111-134
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• 2016

The purpose of this study is to investigate and compare the intellectual structure of cardiovascular research area in Korea and the United States. For the purpose of this study, a data set was collected; one journal Korean Circulation Journal is in Korea and two journals Circulation, and Circulation Research are in the United States. Based on the frequency of citation counts, 45 authors and 53 authors were selected for author co-citation analysis. By multidimensional scaling, clustering, and factor analyses, the results demonstrate that researchers in both countries commonly tend to work on several, rather than focus on certain sub-areas. In both countries, the core areas are revealed as 'cardiovascular disease treatment', 'cardiovascular disease diagnose', 'cardiovascular disease fundamentals', and 'cardiovascular disease preventives'. One of distinctive differences between two is that research in Korea is likely to focus on clinical medicines while research in the United States tends to be on fundamental medicines. While the area of 'Disorders of Rhythm' is revealed in Korea, 'Pharmacology of the Cardiovascular System' area is found in the United States. In addition, the sub-areas of fundamental medicines such as 'Epidemiology of Cardiovascular Disease', 'Biology', 'Biochemistry', 'Physiology' are revealed distinctively in the United States.

• Proceedings of the Korean Society of Food Hygiene and Safety Conference
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• 1992.07a
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• pp.1-5
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• 1992

There is increasing awareness of the devastating socio-economic cost of cardiovascular disease. As a result there have been a lot of extensive researches both on basic mechanisms involved and on the areas of epidemiology and clinical trials. Now, it is being generally accepted that dietary n-3 fatty acids abundant in marine products, may reduce the incidence of cardiovascular disease. Fish oil, with its complement of n-3 fatty acids, has been shown to have diverse and sometimes potent actions on cells of the blood and vasculature, which may explain some of its positive effects on vascular disease. However, the appropriate intake of n-3 fatty acids has not been established. This may vary with desired effects, the duration of ingestion, the type of seafood or fish oil and amount of other fatty acids, especially nf fatty acid being consumed in the diet, Although the beneficial effects have been extensively studied, little is known about potential adverse effects with excessive intake of n-3 fatty acids. Thus, it is needed to study on the possible unfavorable effects including genetic effects.

• Journal of Nutrition and Health
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• v.26 no.9
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• pp.1071-1084
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• 1993

This study was performed to investigate the relationships between obese index and major risk factors of cardiovascular disease in CVD patients. Anthropometry, food intake patterns, blood pressure, serum lipids and hematological values were analyzed in 550 patients from June, 1991 to August, 1992. The results are as follows: Total food intakes, especially total vegetable food and alcohol intakes were significantly related with obese index, so that the heavier patients tended to consume more carbohydrate and less fat. The blood pressure were observed to have positive correlation with obese index in man but not in women. However, both in men and women, blood levels of TG, TC, and VLDL tended to be related to obese index positively, while HDL and HDL-C were shown to be oppositive. So, it seems that as the degree of obesity is higher the blood pressure and blood lipids patterns worse. Therefore, these results suggest that obesity is one of the major risk factors of CVD, and for prevention & treatment of the disease, controlling body weight by nutritionally adequate diet along with alcohol restriction is necessary.

• Journal of Chest Surgery
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• v.36 no.11
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• pp.862-865
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• 2003

Obstructive intracardiac lesions, like mitral stenosis or insufficiency (MR), by myxomas of the left atrium have been commonly reported, but the attenuation of MR by myxoma combined with coronary artery disease is very rare. We report a 70-year-old female patient whose left atrial myxoma had attenuated moderate MR to mild MR and required mitral valve surgery after removal of the myxoma. She also had coronary artery disease, severe pulmonary hypertension and moderate tricuspid regurgitation due to the mitral valve lesions obstructed by myxoma. The patient underwent removal of myxoma, mitral and tricuspid valve reconstructions, and coronary artery bypass grafting. She was discharged at the postoperative 14 day without any problems.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2006.10a
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• pp.62-62
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• 2006

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.05a
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• pp.69-70
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• 2002

• Korean Journal of Clinical Pharmacy
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• v.31 no.3
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• pp.198-204
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• 2021

Background: Cardiovascular (CV) disease is known as one of the major causes of death from disease worldwide. Statin therapy plays a pivotal role in atherosclerotic cardiovascular disease (ASCVD) lowering the LDL-cholesterol level effectively. The purpose of this study was to evaluate the association of the intensity of statin therapy in adult patients of Korea and the risk of ASCVD of the patient group. Methods: We used data from sample of patients from the Health Insurance Review and Assessment Service (HIRA-NPS-2018). We analyzed the patterns of prescribing statins including types of statin, statin intensity, and number of patients with ASCVD or risk of ASCVD. Results: 155,512 patients were included in the analysis, and 27,950 patients (18.0%) was over 75 years. High-intensity statin usage was increased in ASCVD patients compared with the low-intensity statin use. The OR (odds ratio) of high-intensity statin were increased in myocardial infarction patients compared with low-intensity statin use showing the highest OR; 12.40 (95% CI; 9.48-16.22). At patient groups of angina, ischemic heart disease and carotid disease, high-intensity statin prescription rate was increased compared with low-intensity statin. However, there was no statistical significance between both statin prescription rates in patients of peripheral arterial disease, abdominal aneurysm, diabetic mellitus and atherosclerosis. Conclusion: The statin prescription rate showed intensity increasing tendency according to the risk of ASCVD. More aggressive statin therapy might be beneficial for the ASCVD patients based on the recent guidelines of dyslipidemia.