• 제목/요약/키워드: Carcinogenicity.

검색결과 202건 처리시간 0.035초

Carcinogenicity : a Case Study of DA-8159

  • Ahn, Byoung-Ok
    • 한국환경성돌연변이발암원학회:학술대회논문집
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    • 한국환경성돌연변이발암원학회 2004년도 KSOT/KEMS Fall Annual Meeting
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    • pp.90-95
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    • 2004
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흡입노출에 의한 만성·발암성시험 대상물질 및 우선순위 선정 연구 (Selection of Candidate Materials and their Prioritization for Chronic Inhalation and Carcinogenicity Test)

  • 임경택;임철홍;안병준
    • 한국산업보건학회지
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    • 제24권4호
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    • pp.587-612
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    • 2014
  • Objectives: There is requirement to select candidate materials for chronic inhalation/carcinogenicity testing, so we would like to set the priority of candidate materials. Methods and Results: We recommend the priorities for candidate materials based on the chemicals stipulated in the Occupational Safety and Health Act(OSHAct) and the Toxic Chemicals Control Act(TCCA) in Korea. Conclusions: We presented candidate chemicals consisting of solids(powders), gases and liquids(Such as organic solvents) with priorities.

이온화방사선 피폭에 의한 골수세포의 Ornithine Decarboxylase 활성도의 변화에 대한 전계장의 영향에 관한 실험적 연구 (An Experimental Study on the Effect of Electric Field the Ornithine Decarboxylase Activity Change of Myeloid Cells According to Ionizing Radiation Exposure)

  • 정문호
    • 한국환경보건학회지
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    • 제21권1호
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    • pp.78-85
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    • 1995
  • Ornithine decarboxylase(ODC) is an indicate enzyme in carcinogenesis. We divided Sprague Dawley rats into six groups: control, electric field exposure, X-ray only irradiation, X-ray irradiation with electric field exposure group, Sr-90 injected group and Sr-90 and electric field complex exposure group. The ODC activity was measured in rat's bone marrow cell every week. The results were summarized as follows: The ODC activitied was increased in X-ray irradiated, Sr-90 injected and Sr-90 and electric field complex exposed group as compared with that of control(p<0.05). The ODC activity was increased comparing that of control neither in X-ray and electric field complex exposed group nor electric field only exposed group. This result suggests that the electric field doesn't have myeloid carcinogenicity and myeloid cancer incidence caused by ionized radiation is suppressed by electric field exposure.

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중기발암성시험기법을 이용한 Carbendazim의 간발암성 검색 (Hepatocarcinogenic Screening of Carbendazim Using Medium-term Carcinogenicity Bioassay)

  • 성하정;이제봉;정미혜;이해근
    • Environmental Analysis Health and Toxicology
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    • 제13권3_4호
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    • pp.71-75
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    • 1998
  • Carbendazim, which is widely used fungicide, was investigated for rat hepatocarcinogenesis using a medium-term carcinogenicity bioassay. All rats were initially given a single dose (200mg/kg) of diethylnitrosamine (DEN) i.p. and then, starting 2 weeks later, carbendazim treatment group and positive control group received carbendazim (7 mg/kg/ day) and 2-acetylaminofluorene (2-AAF, 1%), respectively, in the diet for 6 weeks. All rats were subjected to two-thirds partial hepatectomy (PH) at week 3 and sacrificed at week 8. Carcinogenic potential was scored by comparing the number and area per cm$^2$ of induced glutathione-S-transferase placental form (GST-P) positive foci in the liver. Carbendazim had no effect in the increase of body weight, hematological and biochemical values, and the number and area of GST-P positive loci. These results suggest that this bioassay using DEN-PH method can be useful for detection of hepatocarcinogenic potentials of pesticide.

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