• Title/Summary/Keyword: Carbontetrachloride

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Hepatoprotective Activities of Biologically Active Agents from Crude Drugs(I) -Hepatoprotective Activities of Traditional Korean Herbal Prescriptions- (식물성생리활성물질(植物性生理活性物質)의 간보호작용(肝保護作用)(I) -한약처방(韓藥處方)의 간보호작용(肝保護作用)-)

  • Kim, Chang-Johng;Cho, Seung-Kil;Choi, Chung-Sik;Choi, Yun-Suk
    • Korean Journal of Pharmacognosy
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    • v.21 no.3
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    • pp.223-234
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    • 1990
  • Hepatoprotective activities of 26 traditional Korean herbal prescriptions described in Donghibogam were evaluated in vivo and in vitro screening system. Twenty one prescriptions appeared to be active. Six prescriptions among them showed highly significant hepatoprotective activities; Shihogyegy-Tang(柴胡桂枝湯), Soshiho-Tang(小柴胡湯), Shiho plus Younggolmoryo-Tang(柴胡加龍骨牡蠣湯), Yinjinho-Tang(茵蔯蒿湯), Yinsam-Tang(人蔘湯) and Shashim-Tang(瀉心湯). Shihogyegy-Tang was most active. They reduced the release of transaminases from dissociated hepatocytes by thioacetamide, and serum transaminases and alkaline phosphatase activities of rat with carbontetrachloride-induced hepatitis. They inhibited significantly lipid peroxidation and cellular fatty change of liver by carbontetrachloride.

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Effects of Azalea(Rhododendron mucronulatum) Pollen on the Carbon Tetrachloride Induced Hepatotoxicity in Mice (사염화탄소로 인한 간 독성에 미치는 진달래(Rhododendron mucronulatum)화분의 영향)

  • Yoon, Soo-Hong;Kang, Jeong-Hae;Kwon, Chong-Suk
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.18 no.4
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    • pp.363-370
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    • 1989
  • Nutritional value of azalea pollen and its effect on the carbontetrachloride induced liver damage were investigated in this experiment. Azalea pollen was primary composed of 58.96% of carbohydrate, 21.86% crude protein, 2.26% fat, and 2.89% ash. 17 amino acids and 22 fatty acids were quantitatively analyzed, and the major component of them was lysine, and linolenic acid, respectively. After administration of pollen and carbontetrachloride concomitantly. serum ALT, AST, LDH activities and tissue lipid peroxidation decreased significantly, but serum total lipid and cholesterol levels did not changed.

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Hepatoprotective activity of Indigofera aspalathoides extract against CCl4-induced liver damage

  • Gupta, M.;Mazumder, U.K.;Haldar, P.K.;Manikandan, L.;Senthilkumar, G.P.;Kander, C.C.
    • Advances in Traditional Medicine
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    • v.4 no.2
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    • pp.100-103
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    • 2004
  • The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as serum glutamine oxaloacetate trasaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein (TP), thiobarbituric acid reactive substances (TBRS) and glutathione content of the liver were estimated to assess liver function and metabolism. Biochemical observations suggest that methanol extract of Indigofera aspalathoides (MEIA) significantly restored the liver function and metabolism towards normal condition in $CCl_{4}$-induced hepatic damage.

Hepatoprotective activity of Nyctanthes arbor-tristis (l.)

  • Wagh, A.E.;Yeotkar, U.S.;Nimbhorker, M.G.;Deshmukh, T.A.;Patil, V.R.
    • Advances in Traditional Medicine
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    • v.10 no.2
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    • pp.111-115
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    • 2010
  • The flowers of Nyctanthes arbor-tristis Linn. of Oleaceae widely used in Ayurvedic system of medicine for the treatment of diuresis, liver disorder, spleen enlargement sciatica, bitter, stomachic, carminative and tonic to hair. The aim of the present study was to evaluate the alcoholic and aqueous extracts of the flowers of Nyctanthes arbor-tristis for hepatoprotective effect against carbontetrachloride induced liver damage in rats. Administration of alcoholic and aqueous extracts of the leaves of Nyctanthes arbor-tristis protect the liver from toxic effects of carbontetrachloride by reducing the elevated levels of Serum glutamate pyruvate transaminase, Serum glutamate oxaloacetate transaminase, Alkaline phosphatase and serum bilirubin. Results revealed that both the alcoholic and aqueous extracts showed significant hepatoprotective activity by reducing the elevated levels of biochemical parameters at a dose of 200 mg/kg body weight. The results were supported by histopathological studies of liver samples which showed regeneration of hepatocytes by the extracts.

Anti-lipid Peroxidation Activity of Acanthopanax var, albeofructus (흰털오갈피나무 추출물의 지질과산화 억제작용)

  • 주시몽;양기숙
    • YAKHAK HOEJI
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    • v.48 no.1
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    • pp.99-103
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    • 2004
  • Acanthopanax species (Araliaceae) has been traditionally used as analgesics, stimulants of immune system, and replenishment of body functions. Acanthopanax divaricatus var. albeofructus is a indigenous plant in Korea. The anti-lipid peroxidation activities of the loaves and root bark extracts of A divaricatus var. albeofructus were determined. Activities of MeOH extracts were examined in vitro and in vivo with control group intoxicated by carbon tetrachloride. Both extracts showed significant inhibitory effects on the lipid peroxidation.

Effects of Bombyx mori Larvae Extracts on Carbon Tetrachloride-Induced Hepatotoxicity in Mice (사염화탄소에 의해 유발된 생쥐의 간독성에 미치는 누에 추출물의 영향)

  • 류강선;이희삼;김선여
    • Journal of Life Science
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    • v.9 no.4
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    • pp.375-381
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    • 1999
  • To evaluate the protective effects of extracts of silkworm on carbon tetrachloride-induced hepatotoxicity, serum glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and lactic dehydrogenase activities, malondialdehydes values and glutathione-S-transferase activity were measured in ICR mice. Extracts of silkworm was administered orally at 30min after the administration of CCl4 Mice were sacrificed at 24h after the administration of extracts of silkworm. The activities of serum aminotransferase and the hepatic content of lipid peroxide after carbon tetrachloride treatment were markedly increased than normal control but those levels were decreased by the treatment of butanol soluble fraction of silkworm methanol extract. Glutathione S-transferase activity was decreased by carbontetrachloride than control, but also inhibited by the treatment of butanol soluble fraction of silkworm methanol extract.

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Charge-Transfer Complex Formation of Amines with Organic Halides (II) Complex Forming Tendency by Various Electron Acceptors (아민과 有機할로겐 化合物間의 Charge Transfer Complex 形成에 關한 硏究 (II) Electron Acceptor 에 따른 Charge Transfer Complex 形成能에 關한 硏究)

  • Kim, Yoo-Sun;Oh, Jung-Hee
    • Journal of the Korean Chemical Society
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    • v.11 no.4
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    • pp.126-131
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    • 1967
  • Various amines (Triethylamine, Diethylamine, Dimethylaniline, Pyridine and Diphenylamine) and electron acceptors (Carbontetrachloride, iodine monochloride and iodine) were reacted in the hexane solvent system to form a charge transfer complex in each case. The tendency of forming a charge transfer complex by these electron acceptors was proportional to the basicity of amines and the different type of complex was formed as the polarity of electron donor had markedly changed, which were identified by ultraviolet spectrophotometry. A correlation between the formation of complex and the basicity of amine and the polarity of electron acceptor was discussed.

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