• Journal of Sensor Science and Technology
• /
• v.4 no.4
• /
• pp.81-87
• /
• 1995

A novel biomaterial capable of incorporating biotinylated biomolecule has been synthesized. Our strategy is to biotinylate one-dimensional electroactive polymers and use a bridging streptavidin protein on Langmuir-Blodgett (LB) organized films. These copolymers are derivatized with long alkyl chains and biotin moieties to bind, respectively, to the hydrophobic surface and the biotinylated species, through the biotin and streptavidin complexation. We utilize the polymer assembly approach to attach a signal transducing biomolecule biotinylated phycoerythrin (B-PE) into this novel biomaterial by binding the unoccupied biotin binding sites on the bound streptavidin (4 sites total). The pressure-area isotherm of the protein injected monolayer showed area expansion. A characteristic fluorescent emission peak at 576nm was detected from the monolayer transferred onto a solid substrate. These observations demonstrated the promise of the organized thin polymer assemblies for their application to the sensor system.

• The Journal of Information Systems
• /
• v.13 no.2
• /
• pp.49-64
• /
• 2004

Recently, SCM(Supply Chain Management) embraces the dynamic environmental changes of the participatory bodies in supply chain. Under this dynamic SCM environment, the selection of supplier and outsourcing company is very important. In their selection, the productivity and expertise of suppliers and outsourcing companies are, of course, to be considered as important factors, but whether or nottheycanmeettheduedateisacritical factor. In particular, this is true because an order-based manufacture ought to have CTP(Capable To Promise). For this purpose, by capitalizing onthevirtualmanufactureundertheSCM, this paper has tried to suggest a new agent system for the selection of supplier and outsourcing company. While performing virtual manufacture based on the integration scheduling, this system acquires the production environment and scheduling information of both suppliers and outsourcing companies on a real-timebasis,thusmakingintegrationschedulingpossible. Also, in order to provetheviabilityofthisstudy,thispaper has selected a specific domain and applied it.

• BMB Reports
• /
• v.57 no.1
• /
• pp.19-29
• /
• 2024

Mitochondrial DNA (mtDNA), a multicopy genome found in mitochondria, is crucial for oxidative phosphorylation. Mutations in mtDNA can lead to severe mitochondrial dysfunction in tissues and organs with high energy demand. MtDNA mutations are closely associated with mitochondrial and age-related disease. To better understand the functional role of mtDNA and work toward developing therapeutics, it is essential to advance technology that is capable of manipulating the mitochondrial genome. This review discusses ongoing efforts in mitochondrial genome editing with mtDNA nucleases and base editors, including the tools, delivery strategies, and applications. Future advances in mitochondrial genome editing to address challenges regarding their efficiency and specificity can achieve the promise of therapeutic genome editing.

• Proceedings of the Korea Society for Simulation Conference
• /
• 2000.04a
• /
• pp.73-77
• /
• 2000

최근 기업활동의 자재구매, 제조, 보관 및 운동, 유통/판매까지 포함한 공급체인 전체에 대한 통합관리(SCM: Supply Chain Management)가 중요한 과제로 부각되고 있다. 특히 기업의 글로벌화가 진행되고 고객요구가 다양화되면서, 고객 만족을 위한 제품의 Customization이 중요시되고 있다. 대부분의 다품종 주문생산형 장치산업에서는 다양한 제품을 제한된 라인에서 주어진 납기 내에 생산해야 한다. 대부분의 고객은 상당기간의 사용량을 한꺼번에 주문하고, 이를 필요시에 소량씩 출하하고, 주요 고객들은 생산일정 변경에 따른 긴급물량을 요구하며, 이에 따라 많은 고객에 대한 납기가 늦어지는 실정이다.본 연구에서는 고객과 납기를 협의하여 확정하고, 이 납기에 반드시 납품하는 납기확약(CTP: Capable to Promise) 기능을 도입하는 다품종 주문생산형 장치산업에서 적용 가능한 다양한 납기확약(CTP) 운영정책의 대안을 제시하고, 이들 성과를 컴퓨터 시뮬레이션으로 평가한다.

• International Journal of Automotive Technology
• /
• v.7 no.2
• /
• pp.145-154
• /
• 2006

In the companion paper, the composition and structure of the MATDYMO (Multi-Agent for Traffic Simulation with Vehicle Dynamic Model) were proposed. MATDYMO consists of the road management system, the vehicle motion control system, the driver management system, and the integration control system. Among these systems, the road management system and the integration control system were discussed In the companion paper. In this paper, the vehicle motion control system and the driver management system are discussed. The driver management system constructs the driver agent capable of having different driving styles ranging from slow and careful driving to fast and aggressive driving through the yielding index and passing index. According to these indices, the agents pass or yield their lane for other vehicles; the driver management system constructs the vehicle agents capable of representing the physical vehicle itself. A vehicle agent shows its behavior according to its dynamic characteristics. The vehicle agent contains the nonlinear subcomponents of engine, torque converter, automatic transmission, and wheels. The simulation is conducted for an interrupted flow model and its results are verified by comparison with the results from a commercial software, TRANSYT-7F. The interrupted flow model simulation is implemented for three cases. The first case analyzes the agents' behaviors in the interrupted flow model and it confirms that the agent's behavior could characterize the diversity of human behavior and vehicle well through every rule and communication frameworks. The second case analyzes the traffic signals changed at different intervals and as the acceleration rate changed. The third case analyzes the effects of the traffic signals and traffic volume. The results of these analyses showed that the change of the traffic state was closely related with the vehicle acceleration rate, traffic volume, and the traffic signal interval between intersections. These simulations confirmed that MATDYMO can represent the real traffic condition of the interrupted flow model. At the current stage of development, MATDYMO shows great promise and has significant implications on future traffic state forecasting research.

• Journal of the Korea Safety Management & Science
• /
• v.4 no.2
• /
• pp.71-81
• /
• 2002

Today's environment of enterprise is changing. They have to face customer' demands with the right product, the right service and supply them at the right time. And also cut down logistics and inventory cost and bring up the profit as much as they can. This means the change of putting enterprise first in importance to putting customer first importance. therefore to correspond to customer's demand, shorting lead time is becoming a essential condition. The answer to this changes of environment is supply chain management. In the Supply chain, The ATP function doesn't only give customers to conformation of delivery. It can be used by the core function with ATP rule that can reconcile supplies and demands on the supply chain. Therefore We can be acquire the conformation about on the due date of supplier by using the ATP function of management about real and concurrent access on the supply chain, also decide the affect about product availability due to forecasting or customer's orders through the ATP. In this paper, It consolidates the necessity on a CTP and analyzes data which is concerned of ATP. Under the these environments, defines the ATP rule that can improve the customer value and data flow related the LTV(Life Time Value) and builds on a algorithm.

• Proceedings of the KSRS Conference
• /
• 2003.11a
• /
• pp.100-102
• /
• 2003

This system is capable of obtaining quantitative information from images using natural features on the ortho-image maps that correspond with those from topographical maps. However, the qualitative information can also be obtained because because of the excellent visibility of ortho-image maps. There are plenty of promise for the use of ortho-image maps in the next generation topographic technology because of its wider applicability within the field. In keeping with the cutting edge, we produced ortho-image maps by scanning a specified area in narrow sections using the PKNU 2: a multispectral digital aerial photographing system made by ourselves. We evaluated the precision of the ortho-image maps, and performed an evaluation of the PKNU 2 system's capacity to improve the equipment of the PKNU 2. Ortho-image maps were made using Ground Control Points (GCPs) which were obtained from digital maps and aerial photographs of the PKNU 2. Thus, we demonstrated that it was possible to produce the ortho-image maps, which has a good constant level rate of less than 1m. The PKNU 2 system needs to be improving in the sensitivity of level maintenance equipment in the evaluation in terms of performance. It is thus required to survey the GCPs precisely for an accurate study.

• Physical Therapy Rehabilitation Science
• /
• v.13 no.1
• /
• pp.106-112
• /
• 2024

Objective: This study aimed to evaluate the validity of a depth camera-based system for monitoring physical function, assessing its feasibility for accurately monitoring activities of daily living. Design: A cross-sectional study. Methods: Twenty-three participants were enlisted to perform fifteen activities of daily living within a living laboratory designed to simulate a home environment. Activities were monitored using a depth camera system capable of classifying actions into standing, sitting, and lying down, with a conventional video camera employed for activity recording. The duration of each activity, as measured by the system, was compared to direct observations made by a physical therapist which were analyzed using a motion analysis software. The association between these two measurement approaches was assessed through correlation analysis, coefficient of determination, intraclass correlation coefficient (ICC), and Bland-Altman plots. Results: Our findings indicated that standing activities exhibited the highest correlation (r=0.847) between the system measurements and physical therapist observations, followed by sitting (r=0.817) and lying down (r=0.734), which demonstrated lower correlations. However, the ICC and Bland-Altman plots revealed notable variances between the two measurement methods, particularly for activities involving lying down. Conclusions: In this study, the depth camera-based physical monitoring system showed promise feasibility in distinguishing standing, sitting, and lying down activities at home environments. However, the current study also underlined some necessities of enhancements in capturing lying down activities.

• International Journal of Stem Cells
• /
• v.17 no.2
• /
• pp.120-129
• /
• 2024

Recent amendments to regulatory frameworks have placed a greater emphasis on the utilization of in vitro testing platforms for preclinical drug evaluations and toxicity assessments. This requires advanced tissue models capable of accurately replicating liver functions for drug efficacy and toxicity predictions. Liver organoids, derived from human cell sources, offer promise as a reliable platform for drug evaluation. However, there is a lack of standardized quality evaluation methods, which hinders their regulatory acceptance. This paper proposes comprehensive quality standards tailored for liver organoids, addressing cell source validation, organoid generation, and functional assessment. These guidelines aim to enhance reproducibility and accuracy in toxicity testing, thereby accelerating the adoption of organoids as a reliable alternative or complementary tool to animal testing in drug development. The quality standards include criteria for size, cellular composition, gene expression, and functional assays, thus ensuring a robust hepatotoxicity testing platform.

• Membrane and Water Treatment
• /
• v.9 no.6
• /
• pp.405-419
• /
• 2018

Persulfates (i.e., peroxymonosulfate and peroxydisulfate) are capable of oxidizing a wide range of organic compounds via direct reactions, as well as by indirect reactions by the radical intermediates. In aqueous solution, persulfates undergo self-decomposition, which is accelerated by thermal, photochemical and metal-catalyzed methods, which usually involve the generation of various radical species. The chemistry of persulfates has been studied since the early twentieth century. However, its environmental application has recently gained attention, as persulfates show promise in in situ chemical oxidation (ISCO) for soil and groundwater remediation. Persulfates are known to have both reactivity and persistence in the subsurface, which can provide advantages over other oxidants inclined toward either of the two properties. Besides the ISCO applications, recent studies have shown that the persulfate oxidation also has the potential for wastewater treatment and disinfection. This article reviews the chemistry regarding the hydrolysis, photolysis and catalysis of persulfates and the reactions of persulfates with organic compounds in aqueous solution. This article is intended to provide insight into interpreting the behaviors of the contaminant oxidation by persulfates, as well as developing new persulfate-based oxidation technologies.