• BMB Reports
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• 제41권4호
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• pp.334-337
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• 2008

MCL1 expression has been found to be up-regulated during infection with virulent Mycobacterium tuberculosis. We investigated the genetic polymorphisms in MCL1 as potential candidate gene for a host genetic study of clinical TB infection. We have sequenced exons and their boundaries of MCL1, including the 1.5 kb promoter region, to identify polymorphisms, and eight polymorphisms were identified. The genetic associations of polymorphisms in MCL1 with clinical TB patients (n=486) and normal controls (n=370) were analyzed. Using statistical analyses, one common promoter polymorphism (MCL1-324C>A) which is absolutely linked with three other SNPs in the promoter and 3'UTR regions, were found to be significantly associated with increased risk of clinical TB disease. The frequency of the A-bearing genotype of -324C>A was higher in clinical TB patients than in normal controls (P=0.0008, OR=1.68). Our findings suggest that polymorphisms in MCL1 might be one of genetic factors for the risk of clinical tuberculosis development.

• Asian-Australasian Journal of Animal Sciences
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• 제21권3호
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• pp.309-313
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• 2008

The insulin-like growth factor binding protein 3 (IGFBP3) has been investigated as a candidate gene for growth promoting effects in beef cattle and a modulator of IGF bioactivity. Previously, we have reported twenty two sequence variants discovered in Korean native cattle (Hanwoo). In this study, we examined the association between gene-specific polymorphisms of IGFBP3 and cold carcass weight (CW) and marbling score (MS) among Korean native cattle. Among twenty two polymorphisms, four common polymorphic sites (-854G>C, -100G>A, +421G>T and +3863C>A) were genotyped in our beef cattle (n = 437). Statistical analysis revealed that one common polymorphism in the promoter region (-854G>C) showed putative associations with MS (p = 0.03). IGFBP3 variation/haplotype information analyzed in this study will provide valuable information into strategies for the production of a commercial line of beef cattle.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2003년도 Proceedings of the international symposium on the fusion technology
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• pp.684-689
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• 2003

One field identified by an inverse method is one of multiple candidate solutions those are independently obtained through a specific estimation technique. While averaging of optimized fields can provide a better description of the spatial feature of an unknown field, it deteriorates the flow and transport characteristics of the optimized fields. As a result, the averaged field is not suited for modeling aquifer performances. Based on genetic algorithm, an optimal field synthesis technique is developed, which combines diversely optimized fields into a refined group of fields. Each field in the population is paired, and a sub-region of each field is exchanged by crossover operation to create a group of synthesized fields of enhanced modeling capability. The population of the fields is evolved till the synthesized fields become sufficiently similar. Applications of the optimal field synthesis to synthetic cases indicate that the objective functions of the fields assessing the modeling capabilities are further reduced after the optimal field synthesis. The identified fields from various inverse techniques may yield a range of modeling results under varied flow situations. The uncertainty is narrowed down through the optimal field synthesis and the associated modeling results converge on that of the reference field. The developed inverse modeling facilitates the construction of a reliable simulation model and hence trustworthy predictions of the future performances.

• 한국광학회지
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• 제5권1호
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• pp.37-44
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• 1994

유도 브릴루앙 반사광을 고출력 레이저에 응용할 때 요구되는 반사광 특성이 실험적으로 조사되었다. 집속 렌즈의 초점거리에 따른 유도 브릴루앙 반사광의 peak power 반사율과 위상공액도가 측정되었다. 또한 반사광 가운데 펄스압축된 부분만의 위상공액도가 측정되었다. 초점거리가 긴 경우(f=100cm) 반사광의 peak power가 입사광의 약 2배에 이르렀다. 이때 반사광 중에서 압축된 선두펄스만의 위상공액도는 약 90%로 다른 시간의 펄스보다 위상공액도가 우수했다. 공간적으로는 유도 브릴루앙 이득이 가장 큰 광축부분의 바사관이 최대의 펄스압축, peak power 반사율, 위상공액도를 보여서 유도 브릴루앙 산란을 응용할 때 가장 유용한 부분으로 확인되었다.

• Industrial Engineering and Management Systems
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• 제12권3호
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• pp.190-197
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• 2013

People are living longer than ever before. As a result, life expectancy is going up and the demand of long-term care facilities is increasing in most countries. The facilities provide rehabilitative, restorative, and skilled nursing care to patients or residents in need of assistance with activities of daily living. This study deals with the capacitated location and allocation problem of long-term care facilities in a city that consists of a finite number of regions. Assuming that in each region candidate locations for three types of facilities are already given, two integer programming models are developed under the closest assignment rule reflecting the demand characteristics of the facilities. Both the location and type of the facilities to be built become decision variables. To show the validity of the models, numerical problems are solved with commercial software, CPLEX. Also, sensitivity studies were conducted to identify relationships between the system parameters.

• 한국콘텐츠학회논문지
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• 제7권12호
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• pp.311-321
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• 2007

본 논문은 영상에 포함된 얼굴을 보다 빠르고 강건하게 검출하기 위해서 이질적 템플릿 매칭의 결과들을 융합하여 얼굴을 검출하는 방법을 제안한다. 먼저 광범위한 조명 환경과 인종을 포괄하는 피부색 모델을 이용해 피부 영역을 검출한다. 그리고 영역 라벨링과 필터링으로 매칭에 필요한 검색 범위를 줄인 후, 피부색과 에지를 이용한 템플릿 매칭을 검출된 영역에 적용한다. 이들 매칭 결과가 융합되어 두 매칭 결과를 동시에 최적으로 만족하는 얼굴이 검출된다. 실험 결과는 제안된 방법이 단일 템플릿을 적용할 때보다 얼굴색과 유사한 배경에서 얼굴을 강건하게 검출하며, 얼굴 후보 영역으로 검색 범위를 줄여 검출 시간을 줄였음을 보여준다. 또한 전역 누산기를 사용하여 템플릿 매칭의 과도한 공간 요구의 문제점을 해결할 수 있었다.

• 대한의생명과학회지
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• 제11권2호
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• pp.227-235
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• 2005

It has been reported that endurance performance is influenced by various environmental and genetic factors. In view of an important role of human mitochondrial DNA (mtDNA) as a candidate for endurance performance, this study focused on the relationships between $VO_{2max}$ value as a measure of endurance performance or other associated phenotypes and four mtDNA restriction fragment length polymorphisms (RFLPs) (Bam HI, Hinc II1, Hinc II2 and Nci I) in the NADH dehydrogenase subunit 5 and one (Kpn I) in the D-loop region of mtDNA. MtDNA was purified from buffy coat in human peripheral blood, and PCR-RFLP analysis was performed to estimate the allele frequencies of each polymorphism in the mtDNA. There were no significant differences in allele distributions of all polymorphisms studied between male athletes and controls, respectively (P>0.05). However, the Kpn I polymorphism was significantly associated with diastolic blood pressure level in male athletes, respectively (P<0.05). Therefore, our results suggest that this polymorphism might be one of the factors modifying inter-individual difference in cardiovascular risk. Further studies using larger sample size will be required to generalize these results from the study described herein.

• 생물정신의학
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• 제8권2호
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• pp.246-250
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• 2001

The dopamine D4 receptor gene has a hypervariable segment in the coding region characterized by a varying number of 48bp repeats in exon III of the gene. Varying the numbers of repeated segments may change the length, structure, and function of the receptor, which makes this gene a possible candidate for variations in dopamine-related behaviors, such as alcoholism and drug abuse. We evaluated the dopamine D4 receptor genotype in male alcoholics and normal controls. All alcoholics and controls were unrelated and from the Korean population. Genotype and allele frequencies in 67 alcoholics were compared to 67 controls who were free of alcohol abuse, substance abuse, and major mental illness. No association was found between the dopamine D4 receptor allele and alcoholism. This result indicate that there is no association of the dopamine D4 receptor with alcoholism in Korean. Further systemized investigation to determine the role of dopamine D4 receptor gene in alcoholism with a larger sample size will be required.

• Biomolecules & Therapeutics
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• 제20권5호
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• pp.482-486
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• 2012

Cerebral monoamines play important roles as neurotransmitters that are associated with various stressful stimuli. Some components such as ginsenosides (triterpenoidal glycosides derived from the Ginseng Radix) may interact with monoamine systems. The aim of this study was to determine whether ginsenoside Rb1 can modulate levels of the monoamines such as dihydroxyphenylalanine (DOPA), dopamine (DA), norepinephrine (NE), epinephrine (EP), 3,4-dihydroxyphenylacetic acid (DOPAC), 5-hydorxytryptamine (5-HT), 5-hydroxindole-3-acetic acid (5-HIAA), and 5-hydroxytryptophan (5-HTP) in mice frontal cortex and cerebellum in response to immobilization stress. Mice were treated with ginsenoside Rb1 (10 mg/kg, oral) before a single 30 min immobilization stress. Acute immobilization stress resulted in elevation of monoamine levels in frontal cortex and cerebellum. Pretreatment with ginsenoside Rb1 attenuated the stress-induced changes in the levels of monoamines in each region. The present findings showed the anti-stress potential of ginsenoside Rb1 in relation to regulation effects on the cerebral monoaminergic systems. Therefore, the ginsenoside Rb1 may be a useful candidate for treating several brain symptoms related with stress.

• 한국축산식품학회지
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• 제32권6호
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• pp.776-782
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• 2012

Marbling (intramuscular fat) is the most economically important meat quality trait in Hanwoo (Korean cattle). The endothelial differentiation G-protein coupled receptor 1 (EDG1) gene, involved in blood vessel formation, is located within the genomic region of a quantitative trait locus (QTL) for marbling on bovine chromosome 3. Thus, the EDG1 gene can be considered as a positional and functional candidate gene for meat quality in beef cattle. This study aimed to identify single nucleotide polymorphisms (SNPs) in the EDG1 gene and to evaluate their associations with carcass traits in Hanwoo population. We have sequenced a fragment of 5'-UTR of the EDG1 gene and identified one SNP. Genotyping of the g.166A>G SNP marker was carried out using PCR-RFLP analysis in 309 Hanwoo steers in order to evaluate their association with carcass traits. The g.166A>G SNP marker showed a significant effect on the marbling score. Animals with the GG genotype had higher marbling score compared with AA and AG genotypes (p<0.05). This SNP marker also showed a significant additive effects for the marbling score (p<0.05). These results suggest that the EDG1 gene can be used as a molecular marker for DNA marker-assisted selection in order to increase the levels of the marbling score in Hanwoo.