• Title/Summary/Keyword: Cac1

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Prediction of Obstructive Coronary Artery Disease by Coronary Artery Calcification Finding on Low-dose CT Image for screening of lung diseases: Compared with Calcium Scoring CT (폐질환 선별검사를 위한 저선량 CT영상의 관상동맥 석회화 소견으로부터 폐쇄성 관상동맥질환 예측: 석회화수치 CT검사와 비교)

  • Lee, Won-Jeong
    • The Journal of the Korea Contents Association
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    • v.11 no.10
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    • pp.333-341
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    • 2011
  • To compare between calcium scoring CT (CSCT) and Low-dose CT (LDCT) image finding for coronary artery calcification (CAC) in screening of lung disease by MDCT. A total of 61 subjects who retired-workers exposed to inorganic dust were performed LDCT and CSCT by using a MDCT scanner on the same day, after be approved by the institutional review board, and obtaining the written informed consent from all subjects. LDCT images were read for detecting lung diseases as well as CAC by a experienced chest radiologist, then the subjects were divided either the positive group with CAC or the negative group without it. The CSCT was used to quantify and detect the presence of calcification in the coronary artery, and score of CAC calculated by using a Rapidia software (ver 2.8). In all coronary arteries, calcium score of positive group was higher better than that in negative group, especially in the total calcium (13.7 vs. 582.9, p=0.008) and the left anterior descending artery (3.2 vs. 249.0, p=0.006). CAC findings between CSCT and LDCT image were showed excellent agreement in cut-off point 100(K-value=0.80, 95% CI=0.69-0.91) from total calcium score. CAC findings on LDCT images showed the higher relation with CSCT. Therefore, the obstructive coronary artery disease could be predicted by CAC on LDCT images for screening of lung diseases.

Effect of Exogenous ATP and ionic Concentration on the Activity of Contractile Vacuoles in Amoeba proteus (배양액의 ATP첨가 및 이온 농도에 따른 Amoeba proteus 수축포의 배출작용)

  • 최범선;주윤수안태인
    • The Korean Journal of Zoology
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    • v.34 no.4
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    • pp.452-459
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    • 1991
  • 담수산 대형 아메바인 각moeba proteus의 위상차 현미경 관찰 및 사진 분석을 통하여 수축포의 배출활동을 조사하f:다. Chalkley's 무기 염류 배양액에 첨가한 0. 1 mM ATP(disodium salt)에 의해 수축포의 배출속도는 270%로 증가하f:으며, 이 ATP의 효과는 Na+ 이온농도가 0.46mM 이상일 때 유효하였다. 실험용액의 NaGl 농도를 10 mM까지 증가시켰을 때 배출작용은 230%에 이르기까지 완만한 직선적 증가를 보였으며, 0.1 mM ATP를 첨가했을 때는 소폭의 NaCl농도 증가(0.50 mM)에 대하여 급격한 상승을 보였다. 이 배출 촉진은 Na+이온에 대해서 선별적으로 이루어졌으며 K+이온으로는 대체될 수 없었다. 배출속도는 Cac12를 제외한 Chalkley's 액에 50 $\mu$ M EDTA(disodium)를 첨가하였을 때에는 2900ye로 증가하였으며 , Caclf 농도가 증가됨에 따라 현격한 감소를 보였다. Chalkley's용액의 Cac12, NaCl을 함께 제외한 경우 배출속도는 대조군 수준에 미달된 데 비하여 0.2 mM Cac12, 10 mM NaCl첨가시에는 대조군의 180%였다. 아메바 수축포의 배출작용이 Na+이온 배출기구로 보고(Pottier efaf., 1987) 이들 결과를 종합해 볼때 아메바의 세포막에는 Na+ 이온의 투과수단으로 칼슘제거에 의해서 촉진확산되는 것과 Na+이온 농도증가에 따른 단순확산이 있을 것으로 사료된다.

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Optimum Design of a Cooling Air Cooler Heat Exchanger by Using a Response Surface Method (반응표면법을 이용한 Cooling Air Cooler 열교환기의 최적 설계)

  • Kim, Seong-Soo;Jeong, Hyo-Min;Chung, Han-Shik
    • Journal of Power System Engineering
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    • v.21 no.3
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    • pp.85-92
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    • 2017
  • Global air traffic is forecast to grow at an average annual rate of around 5% in the next 20 years. The continuous growth of air traffic and raised environmental awareness put increasing pressure on aero engine manufacturers to reduce fuel burn and emissions. NEWAC are a new integrated program of the European Union with focus on innovative core engine concepts to achieve this problem. In this paper, Within NEWAC, active core engine configurations will be investigated. the investigation is focused on the optimal design of the CAC heat exchanger for active core. For optimal design of he CAC heat exchanger, the HTFS of basic design of heat exchanger are analyzed so as to proceed an optimization routines based on Response Surface Method(RSM) and Design of Experiment(DOE). As a result, CAC heat exchanger optimized by 1.0314 lb/s mass flow rate and 3.9058 mm TP of tube layout and 206.8181 mm height of heat exchanger and 918 tube number for heat transfer and pressure drop. We confirm the design optimization using RSM and DOE is useful on complex structure of heat exchanger.

Performance Analysis of S-SFR-based OFDMA Cellular Systems

  • Kim, Yi-Kang;Cho, Choong-Ho;Yoon, Seok-Ho;Kim, Seung-Yeon
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.13 no.1
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    • pp.186-205
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    • 2019
  • Intercell interference coordination (ICIC) is considered as a promising technique to increase the spectral efficiency of OFDMA cellular systems. The soft frequency reuse (SFR) and fractional frequency reuse (FFR) are representative and efficient management techniques for ICIC. Herein, to enhance the performance of the SFR scheme, we propose a call admission (CAC) scheme. In this CAC scheme, called Spectrum handoff-SFR(S-SFR), the spectrum handoff technique is applied to the user equipment (UE) located near the cell center. We derive the traffic analysis model to describe the S-SFR. In addition, a two-dimensional (2-D) Markov chain and an outage analysis are used in our analytical model. From the traffic analysis, the significant performance measures are the outage probability, call blocking probability, system throughput and resource utilization. Based on those, the outage probability and system throughput are obtained using resource utilization as an interference pattern. The analytical results are verified with computer simulation results. Finally, we compare our proposed scheme with other ICI schemes.

Active Vibration Control of a Composite Beam Using Piezoelectric Films (압전필름을 이용한 복합재료 외팔보의 능동진동제어)

  • Kim, S.H.;Choi, S.B.;Cheong, C.C.
    • Journal of the Korean Society for Precision Engineering
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    • v.11 no.1
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    • pp.54-62
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    • 1994
  • This paper presents active control methodologies to suppress structural deflections of a composite beam using a distributed piezoelectric-film actuator and sensor. Three types of different controllers are employed to achieve vibration suppression. The controllers are established depending upon the information on the velocity components of the structrue and on the deflection magnitudes as well. They are constant-amplitude controller(CAC), constant-gain mcontroller(CGC), and constant-amplitude-gain controller(CAGC). For the minimization of the residual vibration (chattering in a settled phase), which is the practical shortcoming of the conventional CAC dur to time delay phenomenon of the hardware system, a new control algoritym CAGCis designed by selecting switching constants in an optimal manner with respect to the initial tip deflection and the applied voltage. The experimental investigations of the transient and forced vibration control for the first vibrational mode are undertaken in order to compare the suppression efficiency of each control algorithm. Moreover, simultaneous controllability of various vibrational modes through the proposed scheme is also experimentally verified by pressenting both the transfer function and the phase.

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Effects of Advanced Modeled Iterative Reconstruction on Coronary Artery Calcium (CAC) Scores (ADMIRE가 관상동맥 칼슘(CAC) 점수에 미치는 영향)

  • Lee, Sang-Heon;Lee, Hyo-Young
    • Journal of the Korean Society of Radiology
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    • v.15 no.5
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    • pp.603-612
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    • 2021
  • The effect of Advanced Modeled Iterative Reconstruction (ADMIRE) on the coronary artery calcium (CAC) score of computed tomography was evaluated. Coronary artery calcium images (348 calcium, 6 groups, total of 2088 calcium) were acquired by 128-slice dual-source CT of 89 patients.Volume score and Agatston score were measured from images reconstructed with filtered back projection (FBP) and ADMIRE (1-5). The difference between FBP and ADMIRE Strength (1-5) was confirmed through the Kruskal-Wallis test, and the post-hoc analysis was performed using the Mann-Whitney U test based on FBP. Both volume score and Agatston score showed statistically significant differences between FBP and ADMIRE (1-5) (P=0.015, P=0.0.38). As a result of post hoc analysis, the volume score decreased to 9.5% in ADMIRE 4 (Z=-2.359, P=0.018) and 13.2% in ADMIRE 5 (Z=-3.113, P=0.002) based on FBP. Agatston score decreased to 10.4% in ADMIRE 4 (Z=-2.051, P=0.040) and 14.0% in ADMIRE 5 (Z=-2.718, P=0.007) based on FBP. High ADMIRE strength affected the volume score and Agatston score due to the decrease in calcium area. In addition, the change in the Density factor due to the decrease in Maximum HU may affect the calculation of the Agatston score.

Physicochemical properties of a calcium aluminate cement containing nanoparticles of zinc oxide

  • Amanda Freitas da Rosa;Thuany Schmitz Amaral;Maria Eduarda Paz Dotto;Taynara Santos Goulart;Hebert Luis Rossetto;Eduardo Antunes Bortoluzzi;Cleonice da Silveira Teixeira;Lucas da Fonseca Roberti Garcia
    • Restorative Dentistry and Endodontics
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    • v.48 no.1
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    • pp.3.1-3.14
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    • 2023
  • Objectives: This study evaluated the effect of different nanoparticulated zinc oxide (nano-ZnO) and conventional-ZnO ratios on the physicochemical properties of calcium aluminate cement (CAC). Materials and Methods: The conventional-ZnO and nano-ZnO were added to the cement powder in the following proportions: G1 (20% conventional-ZnO), G2 (15% conventional-ZnO + 5% nano-ZnO), G3 (12% conventional-ZnO + 3% nano-ZnO) and G4 (10% conventional-ZnO + 5% nano-ZnO). The radiopacity (Rad), setting time (Set), dimensional change (Dc), solubility (Sol), compressive strength (Cst), and pH were evaluated. The nano-ZnO and CAC containing conventional-ZnO were also assessed using scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray spectroscopy. Radiopacity data were analyzed by the 1-way analysis of variance (ANOVA) and Bonferroni tests (p < 0.05). The data of the other properties were analyzed by the ANOVA, Tukey, and Fisher tests (p < 0.05). Results: The nano-ZnO and CAC containing conventional-ZnO powders presented particles with few impurities and nanometric and micrometric sizes, respectively. G1 had the highest Rad mean value (p < 0.05). When compared to G1, groups containing nano-ZnO had a significant reduction in the Set (p < 0.05) and lower values of Dc at 24 hours (p < 0.05). The Cst was higher for G4, with a significant difference for the other groups (p < 0.05). The Sol did not present significant differences among groups (p > 0.05). Conclusions: The addition of nano-ZnO to CAC improved its dimensional change, setting time, and compressive strength, which may be promising for the clinical performance of this cement.

Functional Characterization of cAMP-Regulated Gene, CAR1, in Cryptococcus neoformans

  • Jung, Kwang-Woo;Maeng, Shin-Ae;Bahn, Yong-Sun
    • Mycobiology
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    • v.38 no.1
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    • pp.26-32
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    • 2010
  • The cyclic AMP (cAMP) pathway plays a major role in growth, sexual differentiation, and virulence factor synthesis of pathogenic fungi. In Cryptococcus neoformans, perturbation of the cAMP pathway, such as a deletion in the gene encoding adenylyl cyclase (CAC1), causes defects in the production of virulence factors, including capsule and melanin production, as well as mating. Previously, we performed a comparative transcriptome analysis of the Ras- and cAMP- pathway mutants, which revealed 163 potential cAMP-regulated genes (38 genes at a 2-fold cutoff). The present study characterized the role of one of the cAMP pathway-dependent genes (serotype A identification number CNAG_ 06576.2). The expression patterns were confirmed by Northern blot analysis and the gene was designated cAMP-regulated gene 1 (CAR1). Interestingly, deletion of CAR1 did not affect biosynthesis of any virulence factors and the mating process, unlike the cAMP-signaling deficient cac1$\Delta$ mutant. Furthermore, the car1$\Delta$ mutant exhibited wild-type levels of the stress-response phenotype against diverse environmental cues, indicating that Car1, albeit regulated by the cAMP-pathway, is not essential to confer a cAMP-dependent phenotype in C. neoformans.

Development and Validation of Analytical Method for Nitroxoline in Chicken Using HPLC-PDA (HPLC-PDA를 이용한 닭고기 중 Nitroxoline 분석법 개발)

  • Cho, Yoon-Jae;Chae, Young-Sik;Kim, Jae-Eun;Kim, Jae-Young;Kang, Ilhyun;Lee, Sang-Mok;Do, Jung-Ah;Oh, Jae-Ho;Chang, Moon-Ik;Hong, Jin-Hwan
    • Korean Journal of Environmental Agriculture
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    • v.32 no.1
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    • pp.70-77
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    • 2013
  • BACKGROUND: Nitroxoline is an antibiotic agent. It is used for the treatment of the second bacterial infection by the colibacillosis, salmonellosis and viral disease of the poultry. When the nitroxoline is indiscreetly used, the problem about the abuse of the antibiotics can occur. Therefore, this study presented the residue analytical method of nitroxoline in food for the safety management of animal farming products. METHODS AND RESULTS: A simple, sensitive and specific method for nitroxoline in chicken muscle by high performance liquid chromatograph with PDA was developed. Sample extraction with acetonitrile, purification with SPE cartridge (MCX) were applied, then quantitation by HPLC with C18 column under the gradient condition with 0.1 % tetrabutylammonium hydroxide-phosphoric acid and methanol was performed. Standard calibration curve presented linearity with the correlation coefficient ($r^2$) > 0.999, analysed from 0.02 to 0.5 mg/L concentration. Limit of quantitation in chicken muscle showed 0.02 mg/kg, and average recoveries ranged from 72.9 to 88.1 % in chicken muscle. The repeatability of measurements expressed as coefficient of variation (CV %) was less than 12 % in 0.02 and 0.04 mg/kg. CONCLUSION(S): Newly developed method for nitroxoline in chicken muscle was applicable to food inspection with the acceptable level of sensitivity, repeatability and reproducibility.