• BMB Reports
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• v.49 no.10
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• pp.527-528
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• 2016

In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell cycle progression. Here, we describe that the regulation of Oct4 by Aurora kinase b (Aurkb)/protein phosphatase 1 (PP1) axis during the cell cycle is important for resetting Oct4 to pluripotency and cell cycle related target genes in determining the identity of ESCs. Aurkb starts to phosphorylate Oct4(S229) at the onset of G2/M phase, inducing the dissociation of Oct4 from chromatin, whereas PP1 binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle. Furthermore, Aurkb phosphormimetic and PP1 binding-deficient mutations in Oct4 disrupt the pluripotent cell cycle, lead to the loss of pluripotency in ESCs, and decrease the efficiency of somatic cell reprogramming. Based on our findings, we suggest that the cell cycle is directly linked to pluripotency programs in ESCs.

• Journal of the Korean Society of Clothing and Textiles
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• v.41 no.4
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• pp.673-686
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• 2017

This study is to understand the problems of cycle wear. Interviews and surveys were done to target male and female cyclists in order to understand the wearing conditions and satisfaction of cycle wearers. A total of 443 surveys were used to analyze demographic information, inconvenience and design preference. The average age of male respondents was 34.45 and females was 33.39. The majority were in their 20s and 30s. As for the bicycle riding time, 41.9% of females cycled in the morning and 39.5% cycled in the evening. For men, 44.7% of males cycled in the evening and 33.3% cycled in the morning. The number of cycle wear owned by female respondents were higher than men. Quick water-absorbent and drying properties were considered as important functionality in cycle wear for 87.8% of males and females. When wearing cycle wear, it was found that females felt more discomfort than males in terms of jersey top length. The study results indicated that cycle wear wearing conditions were different according to gender.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.55 no.10
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• pp.399-409
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• 2006

This paper presents a novel method for satisfying the thermal comfort of indoor environment and reducing the summer peak demand power by minimizing the power consumption for an Air-conditioner within a space. Korea Electric Power Corporation (KEPCO) use the fixed duty cycle control method regardless of the indoor thermal environment. However, this method has disadvantages that energy saving depends on the set-point value of the Air-Conditioner and direct load control (DLC) has no net effects on Air-conditioners if the appliance has a lower operating cycle than the fixed duty cycle. In this paper, the variable duty cycle control method is proposed in order to compensate the weakness of conventional fixed duty cycle control method and improve the satisfaction of residents and the reduction of peak demand. The proposed method estimates the predict mean vote (PMV) at the next step with predicted temperature and humidity using the back propagation neural network model. It is possible to reduce the energy consumption by maintaining the Air-conditioner's OFF state when the PMV lies in the thermal comfort range. To verify the effectiveness of the proposed variable duty cycle control method, the case study is performed using the historical data on Sep. 7th, 2001 acquired at a classroom in Seoul and the obtained results are compared with the fixed duty cycle control method.

• The KSFM Journal of Fluid Machinery
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• v.12 no.4
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• pp.30-36
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• 2009

Recently, there has been growing interest in the oxyfuel combustion cycle since it enables high-purity $CO_2 capture with high$ efficiency. However, the oxyfuel combustion cycle has some important issues regarding to its performance such as the requirement of water recirculation to decrease a turbine inlet temperature and proper combustion to enhance cycle efficiency. Also, Some of water vapour remain not condensed at condenser outlet because cycle working fluid contains non-condensable gas, i.e., $CO_2$. The purpose of the present study is to analyze performance characteristics of the oxyfuel combustion cycle with different turbine inlet temperatures, combustion pressures and condenser pressure. It is expected that increasing the turbine inlet temperature improves cycle efficiency, on the other hand, the combustion pressure has specific value to display highest cycle efficiency. And increasing condensing pressure improves water vapour condensing rate.

• Korean Medical Education Review
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• v.10 no.2
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• pp.19-24
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• 2008

Purpose: The 'learning cycle' proposed by Guilbert in 1981 has been accredited as an effective and useful model for curriculum design. Three components of learning cycle, learning objective, instructional method, and assessment are connected organically and form basic structure of curriculum. In this study, we intend to analyze how the learning cycle and its three components are applied to present medical curriculum and examine the points at issue of the learning cycle in medical education. Also, we try to identify the educational significance of the leaning cycle in medical education. Results: First, concerning the learning objective, it was identified that impractical and abstract expressions are major controversial points. Also, there is a need to make learning objectives covering entire medical curriculum. Second, because of various structural problems, it is hard to practice new and various instructional methods. Third, even though there is a growing need for medical curriculum to develop and utilize more various and detailed assessment and evaluation, it was revealed that only are standardized and traditional assessments mainly used. Conclusion: Synthetically, we have some suggestions as follows. First, it is necessary to specify and actualize the learning objectives. Also, instructional methods and assessments should be diversified. And finally, there is a need to build organic and delicate medical curriculum by applying the learning cycle to medical education more actively.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.20 no.12
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• pp.775-780
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• 2008

A dynamic model to simulate LNG reliquefaction process has been developed. The model was applied to two candidate cycles for LNG reliquefaction process, which are Reverse Brayton and Claude cycles. The simulation was intended to simulate the pilot plant under construction for operation of the two cycles and evaluate their feasibility. According to the simulation results, both satisfy control requirements for safe operation of brazed aluminum plate-fin type heat exchangers. In view of energy consumption, the Reverse Brayton cycle is more efficient than the Claude cycle. The latter has an expansion valve in addition to the common facilities sharing with the Reverse Brayton cycle. The expansion valve is a main cause to the efficiency loss. It generates a significant amount of entropy associated with its throttling and increases circulation flow rates of the refrigerant and power consumption caused by its leaking resulting in lowered pressure ratio. It is concluded that the Reverse Brayton cycle is more efficient and simpler in control and construction than the Claude cycle.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.6
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• pp.550-560
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• 2000

In order to minimize compression power and analyze the cause of exergy loss for a dry ice production cycle with 3-stage compression, the variation of compression power was investigated and the exergy analysis was peformed for the cycle. In this cycle, $CO_2$, is used both as a refrigerant and as a raw material for dry ice. The behavior of compression power and irreversibility in the cycle were examined as a function of intermediate pressure. From this result, the conditions for the minimum compression power were obtained in terms of the first stage or the third stage pressure. In addition, the irreversibilities for the cycle were investigated with respect to the efficiency of compressor. Result shows that the optimum pressure is not consistent with the conventional pressure obtained from the equal-pressure-ratio assumption. This is mainly due to the change in mass flow rate of the intermediate stage compressor by the flash gas evaporation from the flash drums. Most important is that the present exergy analysis enabled us to find bad performance components for the cycle and informed us of methods to improve the cycle performance.

• Journal of the Korean Society of Systems Engineering
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• v.4 no.1
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• pp.11-18
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• 2008

As a government agency or the Government-donated Research Institute or industrial research institute is intended to develop a product or to construct a system such as a railway safety systems by research and development process, a life cycle model leading a product development or a research and development is essential to them to systematically and effectively progress it. In this paper, the refined life cycle model to effectively conduct the national railway safety project consists of the life cycle phases and their detail descriptions with reference to other life cycle model in the international standard and the other national guidance and other industrial domain such as ship-building, weapon system, and aerospace areas, the proposed life cycle model in the paper considerably reflects the characteristics of the traditional research and development project in railway safety domain. A guidance of a life cycle model which based on lots of the life cycle model in other domains proposes additionally.

• International Journal of Air-Conditioning and Refrigeration
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• v.17 no.4
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• pp.135-140
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• 2009

A dynamic model to simulate LNG reliquefaction process has been developed. The model was applied to two candidate cycles for LNG reliquefaction process, which are Reverse Brayton and Claude cycles. The simulation was intended to simulate the pilot plant under construction for operation of the two cycles and evaluate their feasibility. According to the simulation results, both satisfy control requirements for safe operation of brazed aluminum plate-fin type heat exchangers. In view of energy consumption, the Reverse Brayton cycle is more efficient than the Claude cycle. The latter has an expansion valve in addition to the common facilities sharing with the Reverse Brayton cycle. The expansion valve is a main cause to the efficiency loss. It generates a significant amount of entropy associated with its throttling and increases circulation flow rates of the refrigerant and power consumption caused by its leaking resulting in lowered pressure ratio. It is concluded that the Reverse Brayton cycle is more efficient and simpler in control and construction than the Claude cycle.

• Advances in materials Research
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• v.7 no.3
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• pp.195-201
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• 2018

High Strength low alloy steels containing various levels of C, Nb and Mn were used and for each of which, a simulated double thermal cycle was applied with the same first peak temperature and different second peak temperatures to produce HAZ microstructure corresponding to multi-pass weld. Effect of double cycle second temperature on the microstructure was observed and compared with single cycle results obtained from previous works, it was found that the percentage of martensite austenite constituent (MA) increases by Nb addition for all steels with the same Mn content and the increase in Mn content at the same Nb content shows an increase in MA area fraction as well. MA area fraction obtained for the double cycle is larger than that obtained for the single cycle for all steels used which imply that MA will have great role in the brittle fracture initiation for double cycle and the inter-pass temperature should be controlled for medium and high-carbon Mn steel to avoid large area fraction of MA. The beneficial effects of Niobium obtained in single pass weld were not observed for the double cycle or multi pass welds.