• Structural Engineering and Mechanics
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• v.84 no.3
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• pp.423-435
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• 2022

In this article, we present torsion-bending analysis of a composite FGM beam with an open section, according to the advanced and refined theory of 1D / 3D beams based on the 3D Saint-Venant's solution and taking into account the edge effects. The (initially one-dimensional) model contains a set of three-dimensional (3D) displacement modes of the cross section, reflecting its 3D mechanical behaviour. The modes are taken into account depending on the mechanical characteristics and the geometrical form of the cross-section of the composite FGM beam. The model considered is implemented on the CSB (Cross-Section and Beam Analysis) software package. It is based on the RBT/SV theory (Refined Beam Theory on Saint-Venant principle) of FGM beams. The mechanical and physical characteristics of the FGM beam continuously vary, depending on a power-law distribution, across the thickness of the beam. We compare the numerical results obtained by the three-beam theories, namely: The Classical Beam Theory of Saint-Venant (Classical Beam Theory CBT), the theory of refined beams (Refined Beam Theory RBT), and the theory of refined beams, using the higher (high) modes of distortion of the cross-section (Refined Beam Theory using distorted modes RBTd). The results obtained confirm a clear difference between those obtained by the three models at the level of the supports. Further from the support, the results of RBT and RBTd are of the same order, whereas those of CBT remains far from those of higher-order theories. The 3D stresses, strains and displacements, obtained by the present study, reflect the 3D behaviour of FGM beams well, despite the initially 1D nature of the problem. A validation example also shows a very good agreement of the proposed models with other models (classical or higher-order beam theory) and Carrera Unified Formulation 1D-beam model with Lagrange Expansion functions (CUF-LE).

• Genomics & Informatics
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• v.21 no.1
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• pp.4.1-4.18
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• 2023

Coronavirus disease 2019 (COVID-19) is an inflammatory and infectious disease caused by severe acute respiratory syndrome coronavirus 2 virus with a complex pathophysiology. While COVID-19 vaccines and boosters are available, treatment of the disease is primarily supportive and symptomatic. Several research have suggested the potential of herbal medicines as an adjunctive treatment for the disease. A popular herbal medicine approved in the Philippines for the treatment of acute respiratory disease is Vitex negundo L. In fact, the Department of Science and Technology of the Philippines has funded a clinical trial to establish its potential as an adjunctive treatment for COVID-19. Here, we utilized network pharmacology and molecular docking in determining pivotal targets of Vitex negundo compounds against COVID-19. The results showed that significant targets of Vitex negundo compounds in COVID-19 are CSB, SERPINE1, and PLG which code for cathepsin B, plasminogen activator inhibitor-1, and plasminogen, respectively. Molecular docking revealed that α-terpinyl acetate and geranyl acetate have good binding affinity in cathepsin B; 6,7,4-trimethoxyflavanone, 5,6,7,8,3',4',5'-heptamethoxyflavone, artemetin, demethylnobiletin, gardenin A, geranyl acetate in plasminogen; and 7,8,4-trimethoxyflavanone in plasminogen activator inhibitor-1. While the results are promising, these are bound to the limitations of computational methods and further experimentation are needed to completely establish the molecular mechanisms of Vitex negundo against COVID-19.

• Investigative Magnetic Resonance Imaging
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• v.11 no.1
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• pp.39-48
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• 2007

Purpose : To determine the diagnostic accuracy of four different sequences : moderately T2 weighted, two heavily T2-weighted single shot turbo spin-echo sequence and breath-hold axial-2D balanced turbo field-echo sequence(bFFE) for characterization of focal lesions. Materials and Methods : During the 3-month period between June and August 2005, seventy-six patients were proved to have ninety-three focal hepatic lesions on MR imaging. The patients consisted of 49 men and 27 women (age range, 15-75 years; mean age, 56.23 years). All MR images were acquired on a 1.5-T MR using the following sequences: 1. A breath-hold axial T2-weighted single shot turbo spin-echo sequence, 2. a breath-hold axial-2D balanced turbo field-echo sequence. Two radiologists performed quantitative analysis. Another radiologist measured the lesion-to-liver contrast-to-noise ratio at the region-of-interest in the four sequences. Results : There was no significant difference in inter-observer variability between the four sequences. The accuracy for both cyst and malignancy of moderate T2 weighted MRI (echo time: 80 msec) was also highest. There was significant difference for lesion characterization between moderate T2 weighted MRI and balanced steady state procession (p-value: 0.004) in the second reader. For longer echo time, the CNR of cystic lesions were markedly increased in comparison to lesions of other component. Conclusion : The accuracy and inter-observer variability of single shot turbo spin echo T2 weighted sequence was higher than bFFE. Although there was no statically significant difference, moderate T2 weighted MRI (echo time: 80 msec) was more accurate than heavily T2 weighted sequence (echo time: 300 msec). If the results for lesion characterization is equivocal in TE 80, the addition of heavily T2 weighted MRI (echo time: 180 msec) can be helpful.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.8B
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• pp.691-700
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• 2006

Based on the destination IP address of incoming packets, the Internet routers determine next hops and forward packets toward final destinations through If address lookup. The bandwidth of communication links increases exponentially fast as well as the routing table size grows significant as the number of single host networks attached to the Internet increases. Since packets should be processed at wire-speed, the increased link speed reduces the processing time of a packet in routers, and hence more efficient and fast IP address lookup algorithms and architectures are required in the next generation routers. Most of the previous IP lookup schemes compare routing prefixes of shorter length first with a given input IP address. Since IP address lookup needs to find the most specific route of the given input, search continues until the longest matched prefix is found while it keeps remembering the current test matching prefix. In this paper, based on binary search on prefix length, we proposed a new IP address lookup algorithm which compares longer prefixes first. The proposed scheme is consisted of multiple tries with prefixes on leaves only. The trie composed of the longest prefixes is primarily searched whether there is a match with the given input. This processing is repeated for the trio of the next longer prefixes until there finds a match. Hence the proposed algorithm provides the fast search speed. The proposed algorithm also provides the incremental update of prefixes while the previous binary search on length scheme does not provide the incremental update because of pre-processing requirement. In this paper, we performed extensive simulations and showed the performance comparisons with related works.

• Information and Communications Magazine
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• v.30 no.4
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• pp.23-28
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• 2013

개념적으로 존재하던 클라우드 컴퓨팅의 사용이 본격적으로 심화되면서 기업들의 클라우드 컴퓨팅에 대한 개념과 생각에도 많은 변화가 생기게 되었다. 클라우드 컴퓨팅 구축이 더욱 가속화되는 가운데, 그로 인한 비용절감이나 투자수익 창출 효과에 대한 검증이 활발해질 것으로 예측됐다. 시대를 뒤바꾸는 혁신적인 기술도 잇달아 등장할 것이란 기대도 높다. 2013년은 클라우드 컴퓨팅의 발전에 또 한번의 변곡점이 될 것으로 전망된다. 본 고에서는 2013년 클라우드 컴퓨팅에 관한 예측 몇 가지를 살펴보고자 한다. 첫째, 중소기업에서의 클라우드 컴퓨팅 사용 및 정착이 가속화될 것으로 보인다. 대기업의 경우에는 기존에 구축되어 있는 IT 시스템에 대한 거버넌스 체계를 완성해 나가고 있는 상황 속에서 중앙집중형과 사용자 편의성이 강화된 클라우드 컴퓨팅을 도입하기 위해서는 아직 추구 해야 할 과제가 많다. 하지만 중소기업은 예산을 문제로 대기업과 같은 수준의 IT 인프라를 갖추지 못하고 있기 때문에 클라우드 컴퓨팅 도입으로 비용대비 고효율의 IT 인프라를 갖출 수 있다. 둘째, CSP, CSB와 통합허브가 성장할 것이다. 플랫폼 전쟁이 시장 점유율 '횡령' 싸움임을 CSP들이 깨닫게 됨에 따라 이러한 가격 경쟁들은 더 잦아질 것으로 전망된다. 그리고 2013년 클라우드 벤더들은 클라우드 가격 책정이 비용-수익 관리(costyield management)의 연장선에 있음도 알게 될 것이다. 핵심은 효율적 설계와 저비용 운영, 그리고 무엇보다 높은 사용률에 있다. 또한 기업들이 점점 많은 애플리케이션을 소프트웨어 형태로 구매하고 있기 때문에 애플리케이션 자체를 통합하는 문제, 애플리케이션에 대한 보안과 감사 프로세스개발 등의 문제가 제기되고 있다. 시스템 통합 서비스와 통합 허브는 이런 문제를 해결하기 위해 노력하게 될 것이다 셋째, 2013년은 하이브리드 클라우드 컴퓨팅이 급부상할 것으로 전망된다. 앞으로는 클라우드 컴퓨팅 시장에서 공급업체끼리 경쟁하는 것은 의미가 없으며 기업들은 절대 한 가지 클라우드 기술이나 공급자에 안주하지 않을 것이다. 이것은 곧 2013년에는 하이브리드 및 이종 클라우드 컴퓨팅이 각광 받을 것을 의미한다. 이러한 하이브리드 클라우드 컴퓨팅을 도입하기 위해서는 클라우드 컴퓨팅의 단점과 문제 해결을 위해 하나의 목적을 가지고 다양한 산업체들이 모여 경쟁업체이면서도 협력관계를 이루는 것이 중요하다. 넷째, 멀티 디바이스를 이용한 클라우드 사용이 폭발적으로 증가될 것으로 보인다. 1인당 여러 대의 단말 보유, 이동성 향상 요구, 4G 확산 등 모바일 시장을 중심으로 한 환경 변화로 인해 이전보다 한층 진화된 클라우드 기반의 서비스가 다양하게 등장할 것으로 예상된다. 또한 4G 시대가 본격적으로 개막되면서 데이터 및 앱을 저장하는 것뿐만 아니라 앱을 실행하는 프로세싱까지도 모두 인터넷 상의 서버에서 이루어지는 방식인 클라우드 스트리밍(Cloud Streaming)이라는 신기술이 상용화될 것으로 기대된다. 다섯째, 2013년에는 'XaaS(Everything as a Service)' 개념이 보다 확장될 것이다. 클라우드 컴퓨팅의 사용이 확산됨에 따라 하드웨어의 도입, 소프트웨어 및 데이터베이스 개발과 구축, IT 서비스 등 IT 인프라 스트럭처의 토대에 많은 변화가 생겼다. 인프라스트럭처는 더 이상 고정불변의 자산으로서가 아니라 유연성과 확장성을 강조하는 서비스로서의 특징으로 점점 부각되고 있다. 따라서 모든 IT 인프라스트럭처가 Ondemand화 서비스로 제공되는 비즈니스 모델들이 부상하고 있으며 플랫폼, 하드웨어 데이터베이스 등 모든 IT 요소를 서비스 형태로 제공하는 XaaS가 2013년 새로운 개념으로 떠오를 것으로 기대된다. 여섯번째로 스토리지를 둘러싼 가격 경쟁이 더욱 심화될 것으로 보인다. 업체들의 가격 인하는 앞으로도 계속될 것이며 사용자들에게도 큰 혜택으로 돌아갈 것이지만 사람들은 가격만으로 서비스를 선택하지 않을 것이기 때문에 가격보다는 차별화된 기능 및 서비스 전략이 필요할 것이다.

• The KIPS Transactions:PartD
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• v.9D no.5
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• pp.801-812
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• 2002

On-line reorganization in a shared nothing database cluster is crucial to the performance of the database system in a dynamic environment like WWW where the number of users grows rapidly and changing access patterns may exhibit high skew. In the existing method of on-line reorganization have a drawback that needs excessive data migrations in case more than two nodes within a cluster have overload at the same time. In this paper, we propose an advanced B$^{+}$ tree based on-line reorganization method that solves data skew on multi-nodes. Our method facilitates fast and efficient data migration by including spare nodes that are added to cluster through on-line scaling. Also we apply CSB$^{+}$ tree (Cache Sensitive B$^{+}$ tree) to our method instead of B$^{+}$ tree for fast select and update queries. We conducted performance study and implemented the method on Ultra Fault-Tolerant Database Cluster developed for high scalability and availability. Empirical results demonstrate that our proposed method is indeed effective and fast than the existing method. method.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.6103-6108
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• 2013

Objective: Excision repair cross-complementing group 6 (ERCC6) is a major component of the nucleotide excision repair pathway that plays an important role in maintaining genomic stability and integrity. Several recent studies suggested a link of ERCC6 polymorphisms with susceptibility to various cancers. However, the relation of ERCC6 polymorphism with gastric cancer (GC) risk remains elusive. In this sex- and age-matched case-control study including 402 GC cases and 804 cancer-free controls, we aimed to investigate the association between a potentially functional polymorphism (rs1917799 T>G) in the ERCC6 regulatory region and GC risk. Methods: The genotypes of rs1917799 were determined by Sequenom MassARRAY platform and the status of Helicobacter pylori infection was detected by enzyme-linked immunosorbent assay. Odd ratios (ORs) and 95% confidential interval (CI) were calculated by logistic regression analysis. Results: Compared with the common TT genotype, the ERCC6 rs1917799 GG genotype was associated with increased GC risk (adjusted OR=1.46, 95%CI: 1.03-2.08, P=0.035). When compared with (GT+TT) genotypes, the GG genotype also demonstrated a statistical association with increased GC risk (adjusted OR=1.38, 95%CI: 1.01-1.89, P=0.044). This was also observed for the male subpopulation (GG vs. TT: adjusted OR=1.71, 95%CI: 1.12-2.62, P=0.013; G allele vs. T allele: adjusted OR=1.32, 95%CI: 1.07-1.62, P=0.009). Genetic effects on increased GC risk tended to be enhanced by H. pylori infection, smoking and drinking, but their interaction effects on GC risk did not reach statistical significance. Conclusions: ERCC6 rs1917799 GG genotype might be associated with increased GC risk in Chinese, especially in males.