• Steel and Composite Structures
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• 제22권4호
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• pp.777-796
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• 2016

In this paper, the behavior of woven E-glass fabric composite laminate was experimentally investigated under quasi-static indentation and high velocity impact by flat-ended, hemispherical, conical (cone angle of $37^{\circ}$ and $90^{\circ}$) and ogival (CRH of 1.5 and 2.5) cylindrical perforators. Moreover, the results are compared in order to explore the possibility of extending quasi-static indentation test results to high velocity impact test results in different characteristics such as perforation mechanisms, performance of perforators, energy absorption, friction force, etc. The effects of perforator nose shape, nose length and nose-shank connection shapes were investigated. The results showed that the quasi-static indentation test has a great ability to predict the high velocity impact behavior of the composite laminates especially in several characteristics such as perforation mechanisms, perforator performance. In both experiments, the highest performance occurs for 2.5 CRH projectile and the lowest is related to blunt projectiles. The results show that sharp perforators indicate lower values of dynamic enhancement factor and the flat-ended perforator represents the maximum dynamic enhancement factor among other perforators. Moreover, damage propagation far more occurred in high velocity impact tests then quasi-static tests. The highest damage area is mostly observed in ballistic limit of each projectile which projectile deviation strongly increases this area.

• 원예과학기술지
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• 제31권5호
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• pp.558-564
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• 2013

수축성이 강한 원예용 상토를 용기에 충전할 때 충전량 변화에 따른 물리성 변화를 구명하기 위해서 본 연구를 수행하였다. 피트모스 + 팽연왕겨(8:2, v/v; PM + ERH), 피트모스 + 훈탄(6:4; PM + CRH) 및 피트모스 + 분쇄부숙수피(8:2; PM + GRPB)의 세 종류 상토를 혼합 조제하였다. 작물 재배를 위한 최적 가비중을 기초로 직경이 6.0, 7.5, 8.5, 10.5 및 12.5cm의 용기에 90, 100, 110, 120 및 130%가 되도록 상토 충전량을 조절한 후 공극률, 용기용수량 및 기상률의 변화를 측정하였다. 모든 크기의 화분에 세 종류 혼합상토의 충전량이 많아질수록 뚜렷하게 공극률이 감소하였다. 그러나 용기의 크기가 작아질수록 세 종류 상토의 공극률이 유사한 경향을 보이며 감소하고 각 상토별 차이도 크지 않았지만 용기의 크기가 커질수록 공극률 감소의 상토별 차이가 커지는 경향이었다. 상토 충전량이 많아질수록 용기용수량도 뚜렷하게 낮아졌다. 훈탄이 포함된 PM + CRH 상토는 직경 8.5cm 이하의 작은 용기에서 세 종류 상토중 용기용수량이 가장 낮았지만 직경 10.5cm 이상으로 용기가 커질수록 용기용수량이 가장 높았으며 화분의 크기 및 상토종류에 따라 다른 경향을 보이며 물리성이 변함을 알 수 있었다. 모든 규격의 화분에서 상토 충전량 증가는 기상률이 뚜렷하게 감소하는 원인이 되었다. 그러나 PM + GRPB가 혼합된 상토가 팽연왕겨나 훈탄이 포함된 상토 보다 모든 충전밀도에서 기상률이 2배 이상 높았다. 또한 상토 충전량이 많아져도 큰 화분에서는 기상률의 감소한 정도가 크지 않았지만 액상률의 감소한 정도가 컸다. 이상의 연구 결과는 혼합상토를 이용한 작물 재배에서 상토의 충전량이 증가할 경우 공극률, 기상률 및 액상률이 감소하지만 이는 용기의 크기 및 상토 종류에 따라 감소 정도가 달라질 수 있음을 나타낸다. 또한 본 연구 결과는 상토를 이용한 용기재배에서 충전량 차이에 따른 물리성 변화를 예측하기 위한 자료로 활용될 수 있을 것이다.

• 원예과학기술지
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• 제19권3호
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• pp.325-328
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• 2001

종자(種子) 파종에 의한 토마토 실생묘(實生苗)를 대체하고 반드시 제거(除去)해야하는 측지(側枝)를 이용한 삽목묘(揷木苗)를 다량생산(多量生産)하여 종자수입을 대체하고 공정육묘의 가능성을 검토하기 위하여 본(本) 시험(試驗)을 수행(遂行)하였다. 처리는 관행 삽목상과 배지용량 23mL인 트레이 128구부터 300mL 용량의 직경 8cm 비닐폿트를 이용하여 삽목하였다. 그리고 배지의 조성은 훈탄단용과 훈탄과 펄라이트, 훈탄과 피트모스, 펄라이트와 피트모스를 혼용하여 이용하였다. 토마토 삽목묘(揷木苗)의 생육량(生育量)은 배지용량(培地容量)이 120mL 이상으로 증가되어도 크게 영향을 받지 않았다. 그러나 배지 용량이 감소되어 플러그 수가 증가되면 묘(苗)의 생육은 저하되었으나 23mL 용량의 128구 플러그 트레이에서도 정상적인 묘(苗)가 생산되었다. 배지용량이 감소되면 지상부보다 지하부중이 크게 감소되었다. 토마토 측지삽목묘(側枝揷木苗)의 생육은 방울토마토 뻬뻬가 완숙토마토 모모타로 품종보다 양호하고 T/R율이 높았으며, 발근율(發根率)도 뻬뻬 품종은 100%였으나 모모타로는 90% 수준(水準)이었다. 배지용량과 배지종류에 관계없이 삽목후(揷木後) 15-20일경에 정식 가능한 묘가 생산되었다. 삽목 육묘용(育苗用) 배지(培地)의 조성이 발근(發根)과 근발달(根發達)에 미치는 영향은 처리간(處理間)에 유의차(有意差)가 인정되지 않았다.

• 동의생리병리학회지
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• 제35권2호
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• pp.56-63
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• 2021

This study was conducted to find a candidate prescription with anti-inflammatory efficacy of 7 herbal prescriptions known to be effective in atopic dermatitis and sleep disorders in Korean medicine. The anti-inflammatory of the 7 herbal prescriptions extracts were evaluated by ELISA assay and Western blot assay. 7 herbal prescriptions, Seongyutang(SU), Danseontoetang(DST), Sotosajahwan(ST), Jisiljagyagsan(JJ), Seokchangpo(SCP), Wiryeongseon(WLS), Gogojohwan(GGJ) 30 % EtoH extract was used for in vitro experiments. In TNF-α + IFN-γ(TI) stimulated HaCaT cells, all 7 herbal prescriptions reduced TARC and MDC production, and JJ strongly reduced TARC and MDC production at 100 ㎍/ml concentration. SCP strongly reduced MDC production at 10 ㎍/ml and 100 ㎍/ml concentration. In addition, in substance P(SP)/CRH stimulated HMC-1 cells, JJ strongly inhibited VEGF production at both 10 and 100 ㎍/ml concentrations. In LPS/CRH stimulated Raw264.7 cells, all 7 herbal prescriptions significantly inhibited TNF-α. PMA + Ionomycin(PI)/CRH stimulated EL4 cells, SU significantly reduced IL-4 production at both concentrations of 10 and 100 ㎍/ml. WLS significantly reduced IL-17 production at both concentrations of 10 and 100㎍/ml. This suggests that 7 herbal prescriptions have anti-inflammatory effects by reducing inflammatory cytokines in keratinocytes, mast cells and macrophages caused by inflammation. Therefore, it is expected that 7 herbal prescriptions that are effective for sleep disorders and atopic dermatitis can be used as therapeutic materials for sleep disorders and diseases associated with atopic dermatitis.

• 생물정신의학
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• 제15권3호
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• pp.147-151
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• 2008

This review briefly summarizes the relevant knowledge of psychoneuroimmunological basis for neuroimmunology, with particular emphasis on bidirectional neural-immune interactions. The immune system and the nervous system maintain extensive communication, including hardwiring of sympathetic and parasympathetic nerves to lymphoid organs. Immune system is modulated by various neurotransmitters such as acetylcholine, norepinephrine, substance P and histamine. Neuroendocrine hormones such as corticotrophin-releasing hormone(CRH) or substance P regulate cytokine balance. The immune system modulates brain activity including sleep and body temperature. Recent studies have revealed that psychological factors which influence immunity and immune-related disease may modulate brain-to -immune interaction. But, we still await the scientific research and evidences to prove whether or how behavioral or treatment intervention of stress can influence the development, progress or prevention of a specific disease.

• 통합자연과학논문집
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• 제8권3호
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• pp.176-183
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• 2015

Corticotropin-releasing actor receptors (CRFRs) activates the hypothalamic pituitary adrenal axis, one of the 2 parts of the fight or flight response to stress. Increased CRH production has is associated with Alzheimer's disease and major depression and hypoglycemia. In this study, we report the important structural and chemical parameters for CRFR inhibitors using the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolines. A 3D QSAR study, Comparative molecular field analysis (CoMFA) was performed. The best predictions were obtained for the best CoMFA model with a $q^2$ of 0.607 with 6 components and $r^2$ of 0.991. The statistical parameters from the generated CoMFA models indicated that the data are well fitted and have high predictive ability. The contour map resulted from the CoMFA models might be helpful in the future designing of novel and more potent CRFR derivatives.

• Structural Engineering and Mechanics
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• 제13권6호
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• pp.639-652
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• 2002

The present study aims to improve an existing model for the prediction of deceleration time history, penetration depth and forces on ogive and conical nose shaped missiles under normal impact into geo-material targets. The actual ogive nose shaped missile has been considered in the analysis and the results thus obtained have been compared with the existing model and significant improvements are found. A close proximity in the results has also been observed with the experimental values. The results of ogive nose shaped missile have also been compared with equivalent conical nose shaped missile. Variation of radial stresses along nose length and radial direction has been studied. Effect of CRH on missile penetrating performance has been investigated.

• 통합자연과학논문집
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• 제9권4호
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• pp.241-248
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• 2016

Corticotropin-releasing factor receptors (CRFRs) activate the hypothalamic-pituitary-adrenal axis, which is an integral part of the fight or flight response to stress. Increase in CRH level is observed in Alzheimer's disease and major depression and hypoglycemia. Here, we report on the relevant physicochemical parameters required for the CRFR inhibitors. Comparative molecular similarity indices analysis (CoMSIA) was performed with the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolinesas CRFR inhibitors. The best predictions were obtained for the best CoMSIA model with a $q^2$ of 0.576 with 6 components and $r^2$ of 0.977. The statistical parameters from the generated CoMSIA models indicated that the data are well fitted and have high predictive ability. CoMSIA contour maps could be useful in the designing of more potent and novel CRFR derivatives.

• Perspectives in Nursing Science
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• 제2권1호
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• pp.61-75
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• 2005

Physical and psychological events can produce stress response in various degrees. Stress affects many aspects of physiology including both brain and peripheral elements which is represented as hypothalamus-pituitary-adrenal axis. Brain elements consist of corticotropin-releasing hormone(CRH), locus ceruleus(LC)-norepinephrine(NE)/autonomic system. Peripheral elements include pituitary-adrenal axis and the autonomic nervous system, which coordinate the stress response. Current trend of the stress researches is emphasizing the mechanisms of the stress response which is adaptive or become maladaptive. This review introduces 1) the concepts of stress, 2) physiological and behavioral aspects of stress responses, 3) the consequences of stress response, 4) the measurements of stress and 5) stress management for those interested in stress research.

• Journal of Power Electronics
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• 제14권3호
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• pp.572-579
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• 2014

As a non-linear time variant system, the four-quadrant line converter of an electric multiple unit (EMU) was expressed by linear time periodic functions near an operating point and modeled by a steady-state harmonic domain matrix. The components were then combined according to the circuit connection and relations of the feedback control loops to form a complete converter model. The proposed modeling method allows the study of the amplitude of harmonic impedances to explore harmonic coupling. Moreover, the proposed method helps provide a better design for the converter controllers, as well as solves the problem in coordination operation between the EMUs and the AC supply. On-site data from an actual $CRH_2$ high-speed train were used to validate the modeling principles presented in the paper.