• The Korean Journal of Nuclear Medicine
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• v.29 no.3
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• pp.319-327
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• 1995

$^{131}I$-metaiodobenzylguanidine(MIBG) has been used for the diagnosis and treatment of neural crest tumors. We report our experience with this agent in 8 patients[1 multiple endocrine neoplasia(MEN) type IIb; 2 malignant pheochromocytoma; 5 medullary thyroid carcinoma(MTC)]. The therapeutic procedure consisted of 30-200 mCi of $^{131}I-MIBG$ administered by slow I.V. infusion, given at 3-6 months intervals. Commutative activity ranged from 150 mCi to 410 mCi, in 1 to 4 courses. $^{131}I-MIBG$ therapy resulted in significant disease free interval in 1 malignant pheochromocytoma(no measurable lesion) after surgery; complete hormonal and tumoral response in 2 MTC(1 MEN IIb): stable disease in 1 recurred pheochromocytoma(MEN IIb): stable disease but symptomatic improvement in 1 MTC, progressive disease in 1 malignant pheochromocytoma and 2 MTC. The patients who showed progression appeared to have large inoperable tumors or postoperative remnant tumors.

• Journal of Korea Water Resources Association
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• v.37 no.8
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• pp.653-662
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• 2004

In this study, the method of Increasing the flood control as well as conservation effects is studied by joint operation of Hwacheon and Peace Dam. After completing the second phase of the construction of the Peace Dam, the dam crest height will be increased from 225m and the storage capacity will also be increased. If storage capacity is increased and gates are installed, it will assist not only flood control but also conservation of the entire Han river basin. Considering the change of conservation levels, the change of the restricted water level of the Hwacheon Dam in flood season, and the inflow change into the Peace Dam through the simulated reservoir operation, the annual average power of Hwacheon Dam with 95% reliability, annual firm power, the volume of water supply is calculated. As a result, when the conservation level of the Peace Dam and the restricted water level of the Hwacheon Dam are increased, the generation capacity will be improved. However, even though the inflow decrease, the generation capacity will not be affected. If the inflow decrease under the same conditions, the water supply capability will be reduced to the range from 35% to 40%. It is necessary to increase conservation level to keep the same water supply capability.

• Geophysics and Geophysical Exploration
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• v.9 no.2
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• pp.155-162
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• 2006

An abnormal seepage flow, which is mainly caused by the piping, is one of the major reasons for embankment dam failure. A leakage detection is therefore a vital part of an embankment dam's monitoring. Resistivity method, which is an efficient tool to detect leakage zones, has been used all over the world for an embankment dam's monitoring. Although the resistivity method gives us very useful information about the leakage problem, there is no more quantitative interpretation than the low resistivity zones in the 2-dimensional resistivity section are regraded simply as the anomalous seepage zones. Recently, resistivity monitoring technique is applied for the detection of leakage zones. However, its interpretation still remains in the stage of presenting the resistivity ratio itself. An increased seepage flow increases a porosity and an increasing porosity decreases the dam's stability. Therefore, the porosity is one of the major factors for an embankment dam's stability. Based on Archie's experimental formula, we try to evaluate a porosity distribution from the resistivity data which is obtained on the dam's crest. We also attempt to represent a procedure to evaluate a safety index of the embankment dam from the resistivity monitoring data.

• Journal of Korean Neurosurgical Society
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• v.49 no.5
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• pp.267-272
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• 2011

Objective : Although iliac crest autograft is the gold standard for lumbar fusion, the morbidity of donor site leads us to find an alternatives to replace autologous bone graft. Ceramic-based synthetic bone grafts such as hydroxyapatite (HA) and b-tricalcium phosphate (b-TCP) provide scaffolds similar to those of autologous bone, are plentiful and inexpensive, and are not associated with donor morbidity. The present report describes the use of Polybone$^{(R)}$ (Kyungwon Medical, Korea), a beta-tricalcium phosphate, for lumbar posterolateral fusion and assesses clinical and radiological efficacy as a graft material. Methods : This study retrospectively analyzed data from 32 patients (11 men, 21 women) who underwent posterolateral fusion (PLF) using PolyBone$^{(R)}$ from January to August, 2008. Back and leg pain were assessed using a Numeric Rating Scale (NRS), and clinical outcome was assessed using the Oswestry Disability Index (ODI). Serial radiological X-ray follow up were done at 1, 3, 6 12 month. A computed tomography (CT) scan was done in 12 month. Radiological fusion was assessed using simple anterior-posterior (AP) X-rays and computed tomography (CT). The changes of radiodensity of fusion mass showed on the X-ray image were analyzed into 4 stages to assess PLF status. Results : The mean NRS scores for leg pain and back pain decreased over 12 months postoperatively, from 8.0 to 1.0 and from 6.7 to 1.7, respectively. The mean ODI score also decreased from 60.5 to 17.7. X-rays and CT showed that 25 cases had stage IV fusion bridges at 12 months postoperatively (83.3% success). The radiodensity of fusion mass on X-ray AP image significantly changed at 1 and 6 months. Conclusion: The present results indicate that the use of a mixture of local autologous bone and PolyBone$^{(R)}$ results in fusion rates comparable to those using autologous bone and has the advantage of reduced morbidity. In addition, the graft radiodensity ratio significantly changed at postoperative 1 and 6 months, possibly reflecting the inflammatory response and stabilization.

• Journal of Korea Water Resources Association
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• v.48 no.4
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• pp.281-290
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• 2015

Numerical simulations of free surface flow over a broad-crested rectangular weir are conducted by using the volume of fraction (VOF) method and three different turbulence models, the k-${\varepsilon}$, RNG k-${\omega}$ and k-${\omega}$ SST models. The governing equations are solved by a second-order accurate finite volume method and the grid sensitivity study of solutions is carried out. The numerical results are evaluated by comparing the solutions with experimental and numerical results of Kirkgoz et al. (2008) and some non-dimensionalized experimental results obtained by Moss (1972) and Zachoval et al. (2012). The results show that the present numerical model can reasonably reproduce the experimental results, while three turbulent models yield different numerical predictions of two distinct zones of flow separation, the first zone is in front of the upstream edge of the weir and the second is created immediately behind the upstream edge of the weir where the flow is separated to form the separation bubble. The standard k-${\varepsilon}$ model appears to significantly underestimate the size of both separation zones and the k-${\omega}$ SST model slightly over-estimates the first separation zone in front of the weir. The RNG k-${\varepsilon}$ model predicts both separation zones in overall good agreement with the experimental measurement, while the k-${\omega}$ SST model yields the best numerical prediction of separation bubble at the upstream edge of the weir.

• The Journal of Korean Medicine
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• v.30 no.1
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• pp.83-94
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• 2009

Background and Objectives: The skin barrier protects skin against a harmful environment. Its function includes an antimicrobial barrier as well as a physical barrier. Stress is harmful to the skin barrier and there are many studies on this, but there are few about the effect of stress during pregnancy on the skin barrier of offspring. The aim of this study was to investigate the effect of stress during pregnancy on the skin barrier of offspring by examination with the naked eye, cortisol, weight, TEWL and histologic tests. Materials and Methods: Male hairless mice ten weeks old were coupled with females for three days. After twelve days the females were divided into two groups. We stressed one group and not the other group. The offspring from the non-stressed (N group) and stressed (S group) grew up until four weeks. The S group was exposed to chronic mild stress using the chronic stress model protocol modified method of Wilner and Towell for a week. We made examinations with the naked eye, assessment of cortisol, weight, TEWL, and histologic test to contrast the S group with the N group. Statistical analysis was performed by using Mann-Whitney and Friedman test. Statistical significance was achieved if the probability was less than 5% (p<0.05). Results: 1. By making an examination with the naked eye, S group showed papules, creases and dryness on their skin, but N showed no change compared with normal skin. 2. There was no statistically significant difference between S group and N group in cortisol (p>0.05). 3. There was no statistically significant difference between S group and N group in weight. N group had less weight than S group (p<0.05). 4. There was no statistically significant difference between S group and N group in TEWL (p>0.05). 5. There was no statistically significant difference between S group and N group in TEWL recovery (p>0.05). 6. In TEWL and TEWL recovery, there was statistically significant difference by time between S group and N group (p<0.005). Histologically, S group showed a thicker epidermis and epidermal crest than N group. Conclusions: We found that stress during pregnancy has negative effects on the skin barrier of offspring. Though there were no statistically significant differences between S group and N group in TEWL recovery, we found evidence that the recovery of skin barrier function is interrupted by stress during pregnancy by examination with both the naked eye and histology.

• The korean journal of orthodontics
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• v.31 no.1 s.84
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• pp.15-24
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• 2001

In order to achieve a desirable tooth movement, it is of great importance to control the M/F ratio and to know the location of the center of resistance. The purpose of this study was to locate the center of resistance and the axis of rotation, and to estimate the stress distribution in the periodontal ligament with experimental model. After preparing a model of an upper canine with a simulated periodontal ligament and alveolar bone, the force and moment were applied. The tooth movement was traced using measuring device with LVDTs(Linear variable differential transformers) that can measure three dimensional tooth movement in real time. The results were as follows. 1. The location of center of resistance by transverse force was $29\%$ of root length measured from alveolar crest to apex regardless of force magnitude. The position of the center of resistance is more coronal than that of two-dimensional model($42\%$). 2. The center of resistance and the axis of rotation coincide when couple moment was applied. 3. As the magnitude of moment increases, tooth tends to extrude irrespective of the direction of the moment. 4. The relationship between location of force and axis of rotation (a x b = $49.6\;mm^2$) was obtained. A tooth movement can be predicted through this formula. 5. The centers of rotation by transverse force were plotted linearly.

• The korean journal of orthodontics
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• v.26 no.2 s.55
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• pp.141-151
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• 1996

This study was undertaken to assess the effect of growth on the lips. Not only does lip growth influence the stability of such orthodontic treatment; it also directly influence facial profile, in which the lips have an important part. An understanding of the growth of lips is thus central to a consideration of profile change in orthodontics. By analyzing the serial lateral cephalograms of 15 male and 15 female of 8 years old to 16 yaers old who have normal occlusion. The result of this study were summerized as follows; 1. The largest growth increments in the length of the lips was mod age of 14 in both sexes. 2. The thickness of lips showed lager value for the male than that of the female in the most age group. The lagest growth increments at A point was occured age of 14, while Ls, Li, B point decreased after the age of 10-11. 3. The largest increase in the interval between crest of lower lip and edge of upper incisors was occured between ages 9 and 11 in males. The interval decreased slightly from 8 to 16 years in females. 4. The nasolabial angle decreased slightly from 8 to 16 years in both sexes. 5. The mentolabial angle showed large variation.

• Journal of Periodontal and Implant Science
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• v.32 no.1
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• pp.89-112
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• 2002

The earliest reports of the use of electrical energy to directly stimulate bone healing seem to be in 1853 from England, the techniques involved the introduction of direct current into the non-united fracture site percutaneously via metallic needles, with subsequent healing of the defect. One endpoint of the periodontal therapy is to generate structure lost by periodontal diseases. Several procedural advances may support regeneration of attachment, however, regeneration of alveolar bone does not occur consistently. Therefore, factors which stimulate bone repair are areas for research in periodontal reconstructive therapy. Effects of cytokines or growth factors on bone repair are examples of such areas. Another one is electrical current which occurs in bone naturally, so that such bone may be particularly susceptible to electrical therapy. The purposes of this study were to observe the effects of electrical stimulation on the normal periodontium, to determine whether the electricity is the useful means for periodontal regeneration or not. Forty rats weighted about 100 gram were used and divided into 4 groups, the first group, there was no electrical stimulation with the connection of electrodes only. In the second group, there was stimulated by the 10 mA during 10 minutes per a day, in the third group was stimulated by the 25 mA , and the fourth by the 50 mA. At 3, 5, 10 and 15 days post-appliance , two rats in each group were serially sacrificed. and the maxillae and the mandible processed to paraffin, and the specimens were prepared with Hematoxylin-Eosin stain for the light microscopic evaluation. The results of this study were as follows : 1. There was the distinct reversal line on the lingual alveolar crest, whereas a little changes in the labial alveolarcrest to the duration and amount of currents. 2. In 50 mA group, the cells were highly concentrated at the apex of anterior teeth, and was observed the necrotic tissue. In posterior root apex, the hypercementosis was appeared, and newly formed cementum layer has been increased continuously with the time. 3. The periodontal ligament fiber and Sharpey's fiber were arranged in order, and the bone trabeculae were increased as the experiment proceeded by, relatively the bone marrows were decreased. 4. In the pulp tissue, the blood vessels were increased with blood congestion in the experimetal specimens remarkably, and the dentinal tubules were obstructed . 5. The osteoblasts in alveolar bone proper had been showed highly activity, and also observed the formation of bone trabeculea. In the conclusion, it was suggested that the electrical stimulation has influence on the periodontium and the pulp tissue. However, there might be the injurious effects.

• Journal of the Korean Geotechnical Society
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• v.29 no.5
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• pp.53-64
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• 2013

Resistivity monitoring is based on the fact that a change in the porosity leads to the changes in water content and fine particles, which alter the electrical resistivity. At every embankment dam, internal erosion always occurs as time passes. The internal erosion generally develops into piping over a long time by backward erosion and concentrated leak, and finally leads to dam failure. Resistivity is known to be very sensitive to the changes in porosity in embankment dams. Thus resistivity monitoring is a reasonable method to find out the leakage zone. However, resistivity is strongly influenced by seasonal variation of temperature, TDS of reservoir water and water level. In this paper. we first installed electrodes permanently at the center of the crest. The electrical resistivity monitoring data was acquired every 6 hours from Apr. 3, 2011 to July. 31, 2012. To analyze the characteristics of monitoring data, each resistivity data was calculated from up to 2,950 data sets. The result indicated a seasonal resistivity variation due to related temperature. Finally, a quantitative method to estimate porosities of the embankment dam from the resistivity monitoring data was analyzed. The applicability and reliability were verified and the importance of electrical resistivity monitoring for obtaining reliable result was emphasized.