• Journal of Korean Neurosurgical Society
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• 제49권5호
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• pp.267-272
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• 2011

Objective : Although iliac crest autograft is the gold standard for lumbar fusion, the morbidity of donor site leads us to find an alternatives to replace autologous bone graft. Ceramic-based synthetic bone grafts such as hydroxyapatite (HA) and b-tricalcium phosphate (b-TCP) provide scaffolds similar to those of autologous bone, are plentiful and inexpensive, and are not associated with donor morbidity. The present report describes the use of Polybone$^{(R)}$ (Kyungwon Medical, Korea), a beta-tricalcium phosphate, for lumbar posterolateral fusion and assesses clinical and radiological efficacy as a graft material. Methods : This study retrospectively analyzed data from 32 patients (11 men, 21 women) who underwent posterolateral fusion (PLF) using PolyBone$^{(R)}$ from January to August, 2008. Back and leg pain were assessed using a Numeric Rating Scale (NRS), and clinical outcome was assessed using the Oswestry Disability Index (ODI). Serial radiological X-ray follow up were done at 1, 3, 6 12 month. A computed tomography (CT) scan was done in 12 month. Radiological fusion was assessed using simple anterior-posterior (AP) X-rays and computed tomography (CT). The changes of radiodensity of fusion mass showed on the X-ray image were analyzed into 4 stages to assess PLF status. Results : The mean NRS scores for leg pain and back pain decreased over 12 months postoperatively, from 8.0 to 1.0 and from 6.7 to 1.7, respectively. The mean ODI score also decreased from 60.5 to 17.7. X-rays and CT showed that 25 cases had stage IV fusion bridges at 12 months postoperatively (83.3% success). The radiodensity of fusion mass on X-ray AP image significantly changed at 1 and 6 months. Conclusion: The present results indicate that the use of a mixture of local autologous bone and PolyBone$^{(R)}$ results in fusion rates comparable to those using autologous bone and has the advantage of reduced morbidity. In addition, the graft radiodensity ratio significantly changed at postoperative 1 and 6 months, possibly reflecting the inflammatory response and stabilization.

• 한국수자원학회논문집
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• 제48권4호
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• pp.281-290
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• 2015

표준 k-${\varepsilon}$, RNG k-${\omega}$ 그리고 k-${\omega}$ SST 난류 모형과 VOF (volume of fluid)기법을 이용하여 사각형 광정위어를 통과하는 난류 흐름의 수면 변화와 유속분포를 수치모의 하였다. 지배방정식은 2차 정확도의 유한체적기법을 이용하여 해석하였으며, 두 개의 서로 다른 격자해상도에서 계산을 수행하여 수치해석 결과의 격자 민감도를 분석하였다. 계산 결과를 Kirkgoz et al. (2008)의 실험 결과 그리고 Moss (1972) 및 Zachoval et al. (2012) 무차원화된 실험값과 비교 분석하여 적용한 수치모형의 정확도를 평가하였다. 수치모의 결과는 사각형 개수로에 설치된 광정위어 흐름의 실험결과들을 합리적으로 예측하고 있으면 적용한 난류모형에 따라서 두 개의 주요 흐름분리 영역에서 계산 결과에 차이가 있는 것으로 나타났다. 표준 k-${\varepsilon}$ 모형은 이들 두 개의 흐름분리영역의 크기를 과소산정하고 있으며, k-${\omega}$ SST 모형은 위어 전면부에서 발생하는 흐름분리 영역을 다소 과대 산정하는 것으로 나타났다. RNG k-${\varepsilon}$ 모형은 전반적으로 양호하게 두 흐름분리 영역을 예측하는 한편, k-${\omega}$ SST 모형은 위어 상류부 모서리에서 발생하는 박리거품의 발생 형태를 가장 잘 예측하는 것으로 나타났다.

• 대한한의학회지
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• 제30권1호
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• pp.83-94
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• 2009

Background and Objectives: The skin barrier protects skin against a harmful environment. Its function includes an antimicrobial barrier as well as a physical barrier. Stress is harmful to the skin barrier and there are many studies on this, but there are few about the effect of stress during pregnancy on the skin barrier of offspring. The aim of this study was to investigate the effect of stress during pregnancy on the skin barrier of offspring by examination with the naked eye, cortisol, weight, TEWL and histologic tests. Materials and Methods: Male hairless mice ten weeks old were coupled with females for three days. After twelve days the females were divided into two groups. We stressed one group and not the other group. The offspring from the non-stressed (N group) and stressed (S group) grew up until four weeks. The S group was exposed to chronic mild stress using the chronic stress model protocol modified method of Wilner and Towell for a week. We made examinations with the naked eye, assessment of cortisol, weight, TEWL, and histologic test to contrast the S group with the N group. Statistical analysis was performed by using Mann-Whitney and Friedman test. Statistical significance was achieved if the probability was less than 5% (p<0.05). Results: 1. By making an examination with the naked eye, S group showed papules, creases and dryness on their skin, but N showed no change compared with normal skin. 2. There was no statistically significant difference between S group and N group in cortisol (p>0.05). 3. There was no statistically significant difference between S group and N group in weight. N group had less weight than S group (p<0.05). 4. There was no statistically significant difference between S group and N group in TEWL (p>0.05). 5. There was no statistically significant difference between S group and N group in TEWL recovery (p>0.05). 6. In TEWL and TEWL recovery, there was statistically significant difference by time between S group and N group (p<0.005). Histologically, S group showed a thicker epidermis and epidermal crest than N group. Conclusions: We found that stress during pregnancy has negative effects on the skin barrier of offspring. Though there were no statistically significant differences between S group and N group in TEWL recovery, we found evidence that the recovery of skin barrier function is interrupted by stress during pregnancy by examination with both the naked eye and histology.

• 대한치과교정학회지
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• 제31권1호
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• pp.15-24
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• 2001

원하는 형태의 치아이동을 얻기 위해서는 M/F(Moment/Force) ratio의 조절이 필요하며, 이출 위해서는 치아의 저항중심의 위치를 아는 것은 매우 중요한 일이다. 본 연구에서는 실제 치아주위 환경을 비교적 유사하게 재현할 수 있는 치조골상과 치아의 이동을 시뮬레이션하는 장치를 제작하고, LVDT출 이용한 3차원 운동을 실시간으로 측정할 수 있는 시스템을 사용하여, 힘에 대한 3차원 공간상에서의 치주인대 응력 분포 양상 및 치아 저항중심과 회전축의 위치변화를 계측한 결과 다음과 같은 결론을 얻었다. 1. 상악 견치에 원심방향으로 힘을 가했을 때, 치아의 저항중심의 위치는 힘의 크기와는 무관하였으며, 치근의 치경부측 약 $29\%$ 부위에 위치하였다. 이는 2차원 모형($42\%$) 보다 치관 쪽에 위치한다. 2. 모멘트만 가하는 경우 치아의 저항중심과 회전축은 일치하였다. 3. 치아에 가해지는 모멘트가 증가하는 경우 방향에 관계없이 치아는 정출되는 경향을 보였다. 4. 힘이 가해진 위치, 저항중심, 회전축간에는 일정한 관계가 성립했다 (a x b = $49.6\;mm^2$). 이 관계식을 통해서 수평력이 가해질 때 예상되는 치아운동 양상을 알 수 있다. 5. 수평력이 가해질 때 회전축의 위치는 일직선으로 나타난다.

• 대한치과교정학회지
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• 제26권2호
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• pp.141-151
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• 1996

악안면 부위의 연조직은 기능, 심미성 그리고 치료후의 안정에 크게 영향을 주므로 진단과 치료계획 수립시 경조직 뿐 아니라 연조직을 포함한 평가가 이루어져야 한다. 구순부는 전체적인 안모형태 결정에 상당한 영향을 미치며 교정치료로 인한 치아의 이동에 따라 구순부 외형이 변화하므로 교정치료시 고려해야할 중요한 부분이다. 본 연구에서는 구순부 외형의 연령 증가에 따른 변화 양상을 규명하여 치료계획 수립과 진단및 치료의 예후 판정등, 임상 교정학 분야에 도움이 되는 지침을 얻고자 8세부터 16세까지 (남자 15명, 여자 15명) 촬영된 연속 두부 방사선 규격사진을 이용하여 구순부 외형의 누년적인 변화를 조사하여 다음과 같은 결론을 얻었다. 1. 상하순 고경은 남,녀 모두가 14세에서 가장 많은 성장량을 보였다. 2. 상하순 후경은 대부분의 연령군에서 여자보다 남자에서 큰 값을 보였으며 성장량에 있어서 A point에서는 14세에서 가장 많았고 Ls, Li, B point에서는 10-11세 이후로 성장량의 감소를 보였다. 3. 하순에 의해 가려지는 상악 절치부의 길이는 남자에서 9-11세때 가장 큰 값을 보였고 여자는 연령에따라 점차 증가하였다. 4. Nasolabial angle은 남, 녀 모두에서 연령이 증가함에 따라 약간씩 감소하였다. 5. Mentolabial angle은 변이도(variability)가 매우 높았다.

• Journal of Periodontal and Implant Science
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• 제32권1호
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• pp.89-112
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• 2002

The earliest reports of the use of electrical energy to directly stimulate bone healing seem to be in 1853 from England, the techniques involved the introduction of direct current into the non-united fracture site percutaneously via metallic needles, with subsequent healing of the defect. One endpoint of the periodontal therapy is to generate structure lost by periodontal diseases. Several procedural advances may support regeneration of attachment, however, regeneration of alveolar bone does not occur consistently. Therefore, factors which stimulate bone repair are areas for research in periodontal reconstructive therapy. Effects of cytokines or growth factors on bone repair are examples of such areas. Another one is electrical current which occurs in bone naturally, so that such bone may be particularly susceptible to electrical therapy. The purposes of this study were to observe the effects of electrical stimulation on the normal periodontium, to determine whether the electricity is the useful means for periodontal regeneration or not. Forty rats weighted about 100 gram were used and divided into 4 groups, the first group, there was no electrical stimulation with the connection of electrodes only. In the second group, there was stimulated by the 10 mA during 10 minutes per a day, in the third group was stimulated by the 25 mA , and the fourth by the 50 mA. At 3, 5, 10 and 15 days post-appliance , two rats in each group were serially sacrificed. and the maxillae and the mandible processed to paraffin, and the specimens were prepared with Hematoxylin-Eosin stain for the light microscopic evaluation. The results of this study were as follows : 1. There was the distinct reversal line on the lingual alveolar crest, whereas a little changes in the labial alveolarcrest to the duration and amount of currents. 2. In 50 mA group, the cells were highly concentrated at the apex of anterior teeth, and was observed the necrotic tissue. In posterior root apex, the hypercementosis was appeared, and newly formed cementum layer has been increased continuously with the time. 3. The periodontal ligament fiber and Sharpey's fiber were arranged in order, and the bone trabeculae were increased as the experiment proceeded by, relatively the bone marrows were decreased. 4. In the pulp tissue, the blood vessels were increased with blood congestion in the experimetal specimens remarkably, and the dentinal tubules were obstructed . 5. The osteoblasts in alveolar bone proper had been showed highly activity, and also observed the formation of bone trabeculea. In the conclusion, it was suggested that the electrical stimulation has influence on the periodontium and the pulp tissue. However, there might be the injurious effects.

• 한국지반공학회논문집
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• 제29권5호
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• pp.53-64
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• 2013

전기비저항 모니터링 탐사법은 공극의 변화는 입자와 함수율의 변화에 기인한다는 사실에 근간을 두고 있다. 모든 댐에서 내부 침식은 시간이 지날수록 발생하며, 시간이 지남에 따라 누수가 집중되고 결국 댐의 파괴에 이르게 한다. 전기비저항은 제체내 공극의 변화에 매우 민감하게 변화하는 것으로 알려져 있어 전기비저항 모니터링 탐사법은 누수탐지에 효과적으로 적용되어 왔다. 그러나 전기비저항은 온도의 계절 변화와 총고용용존물, 운영수위 등의 변화에 큰 영향을 받는다. 본 논문에서 우리는 댐마루 중앙부에 영구적으로 전극을 설치하고 2011년 4월 3일부터 2012년 7월 31일까지 매 6시간 마다 전기비저항 모니터링 탐사 자료를 획득하였다. 모니터링 데이터의 해석을 위해 각 전기비저항 데이터의 2,950여개가 넘는 데이터를 분석하였다. 그 결과 전기비저항은 온도의 영향으로 계절변화에 따라 변화함을 확인할 수 있었으며, 전기비저항 모니터링탐사로부터 제체의 공극률을 산출하고 분석하였다. 댐체에서 전기비저항 모니터링 탐사의 적용성과 안정성을 확인하였으며, 신뢰할 만한 전기비저항 모니터링 데이터의 중요성을 강조할 수 있었다.

• Ocean Systems Engineering
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• 제6권1호
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• pp.23-60
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• 2016

The major objective of this study was to develop further understanding of 3D nearshore hydrodynamics under a variety of wave and tidal forcing conditions. The main tool used was a comprehensive 3D numerical model - combining the flow module of Delft3D with the WAVE solver of XBeach - of nearshore hydro- and morphodynamics that can simulate flow, sediment transport, and morphological evolution. Surf-swash zone hydrodynamics were modeled using the 3D Navier-Stokes equations, combined with various turbulence models (${\kappa}-{\varepsilon}$, ${\kappa}-L$, ATM and H-LES). Sediment transport and resulting foreshore profile changes were approximated using different sediment transport relations that consider both bed- and suspended-load transport of non-cohesive sediments. The numerical set-up was tested against field data, with good agreement found. Different numerical experiments under a range of bed characteristics and incident wave and tidal conditions were run to test the model's capability to reproduce 3D flow, wave propagation, sediment transport and morphodynamics in the nearshore at the field scale. The results were interpreted according to existing understanding of surf and swash zone processes. Our numerical experiments confirm that the angle between the crest line of the approaching wave and the shoreline defines the direction and strength of the longshore current, while the longshore current velocity varies across the nearshore zone. The model simulates the undertow, hydraulic cell and rip-current patterns generated by radiation stresses and longshore variability in wave heights. Numerical results show that a non-uniform seabed is crucial for generation of rip currents in the nearshore (when bed slope is uniform, rips are not generated). Increasing the wave height increases the peaks of eddy viscosity and TKE (turbulent kinetic energy), while increasing the tidal amplitude reduces these peaks. Wave and tide interaction has most striking effects on the foreshore profile with the formation of the intertidal bar. High values of eddy viscosity, TKE and wave set-up are spread offshore for coarser grain sizes. Beach profile steepness modifies the nearshore circulation pattern, significantly enhancing the vertical component of the flow. The local recirculation within the longshore current in the inshore region causes a transient offshore shift and strengthening of the longshore current. Overall, the analysis shows that, with reasonable hypotheses, it is possible to simulate the nearshore hydrodynamics subjected to oceanic forcing, consistent with existing understanding of this area. Part II of this work presents 3D nearshore morphodynamics induced by the tides and waves.

• 지구물리
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• 제8권1호
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• pp.1-6
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• 2005

댐체 안정성 문제는 무엇보다 투수 내지 누수 과정에서 유발될 수 있는 댐체 내부 결함(예: 균열)에 귀결된다고 볼 수 있다. 이러한 댐체 내부 결함은 댐 붕괴를 조장할 수 있기 때문에 우선 적절한 탐사 기법을 이용하여 그에 대한 위치 및 규모가 파악되어야 하며 그 결과에 따라 그라우팅에 의한 보수 작업 및 그에 대한 성과 검증 작업이 철저히 이루어져야 한다. 본 연구의 조사 대상이 된 댐은 중심 코어형 흙 댐으로 댐 소단 사면에는 누수로 인한 여러 형태의 결함이 관찰되고 있어 그에 대한 진단 및 보수 보강이 필요한 상태였다. 본 연구에서는 댐체 진단 및 그라우팅 성과 판단을 위해 그라우팅 이전(2001년 8월) 및 이후(2004년 11월)에 댐 마루 측선 상에서 고분해능 탄성파 반사법 탐사를 수행하였다. 탐사 자료의 질을 향상시키기 위해 표면파를 약화시키고 P파 반사파 에너지를 증대시킬 수 있는 발생원 에너지 방사형 변조 기법(P빔발생원)도 응용되었다. 그라우팅 이전 탐사 결과(탄성파 중합단면도)에서는 댐체 내부 균열로 판단되는 강한 반사파가 일 부 구간에서 인식되었으며, 그라우팅 이후 탐사 결과에서는 상기 강한 반사파가 인식되지 않음으로써 3년의 시차를 둔 두개의 탄성파 탐사 결과는 댐체 진단 및 그라우팅 성과 판단을 위한 기본 자료로 반영될 수 있었다. 따라서 고분해능 탄성파 반사법 탐사는 댐 모니터링을 위한 하나의 바람직한 탐사 기법으로 크게 활용될 수 있을 것으로 기대된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권5호
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• pp.405-418
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• 2007

Mesenchymal stem cells(MSCs) have been though to be multipotent cells that can replicate that have the potential to differentiate into lineages of mesenchymal tissue including the bone, cartilage, fat, tendon, muscle, and marrow stroma. Especially, scaffolds to support cell-based tissue engineering are critical determinants of clinical efforts to regenerate and repair the body. Selection of a matrix carrier imvolves consideration of the matrix's role as a scaffold for physical support and host tissue integration as well as its ability to support of synergize the osteoinductive program of the implanted mesenchymal stem cell. The aim of this study is to evaluate the effect of autobone and Bio-$Oss^{(R)}$ to adherent mesenchymal stem cells as scaffolds on sinus augmentation with fibrin glue mixture in a rabbit model. 16 New Zealand White rabbits were divided randomly into 4 groups based on their time of sacrifice(1, 2, 4 and 8 weeks). First, mesenchymal stem cells were isolated from iliac crest marrow of rabbits and expanded in vitro. Cell culture was performed in accordance with the technique described by Tsutsumi et al. In the present study, the animals were sacrificed at 1, 2, 4 and 8 weeks after transplantation, and the bone formation ability of each sides was evaluated clinically, radiologically, histologically and histomorphologically. According to the histological observations, autobone scaffolds group showed integrated graft bone with host bone from sinus wall. At 2 and 4 weeks, it showed active newly formed bone and neovascularization. At 8 weeks, lamellae bone was observed in sinus graft material area. Radiologically, autobone with stem cell showed more radiopaque than Bio-$Oss^{(R)}$ scaffolds group. there were significant differences in bone volume between 4 and 8 weeks(p<0.05).