• PNF and Movement
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• 제20권3호
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• pp.351-358
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• 2022

Purpose: This study aims to determine the correlation between the effects of contract-relax-antagonist-contract (CRAC) and contract-relax (CR) forms of proprioceptive neuromuscular facilitation (PNF) stretching on balance during single-leg standing in elderly people. Methods: The participants were 20 elderly people in healthy condition and divided equally into two groups: the CRAC stretching group and the CR stretching group. Subjects were made to walk on a treadmill for 6 minutes before the stretching as a warm-up. CR and CRAC stretching were performed on the soleus. The dependent variables used to assess single-leg standing balance were overall stability(OSI), anterior/posterior(A/P) movement, and medial/lateral(M/L) movement. The statistical methods used to assess the differences between groups were verified using the Mann-Whitney U test and the Wilcoxon signed-rank test. Results: The CRAC group had significantly increased OSI, A/P and M/L after the PNF stretching intervention (p < 0.05). The CR group had significantly increased OSI and A/P after the PNF stretching intervention (p < 0.05), but M/L did not significantly increase (p > 0.05). There was no significant difference in stretching between CRAC and CR (p > 0.05). Conclusion: The results of this study revealed that CR and CRAC PNF stretching improved single-leg standing balance. CARC stretching before exercise is helpful for elderly people, as it improves balance.

• 대한임상검사과학회지
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• 제49권4호
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• pp.470-476
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• 2017

mTOR 신호전달 단백질의 변화는 다양한 종류의 암에서 관찰 되었다. 따라서 이들 단백질은 최근에 암 치료제에 대한 새롭고 흥미로운 표적이 되고 있다. 우리는 대장암과 선종 환자의 mTOR 세포신호의 활성도를 조사하였다. 면역조직화학적 방법으로 대장암과 선종의 세포신호 단백질 성분인 mTOR, p70-S6K, S6, 4EBP1 발현을 분석하였다. 이번 연구는 모두 100개의 예를 악성(Colorectal Adenocarcinoma, CRAC) 40건, 고등급 선종(Adenoma with High grade intraepithelial neoplasms, HIN) 30건, 저등급 선종(Adenoma with Low-grade intraepithelial neoplasms, LIN) 30건으로 분류하여 진행하였다. p-mTOR의 발현률은 LIN 7%, HIN 30%, CRAC 75%였고 p-S6의 발현률 또한 LIN 10%, HIN 27%, CRAC 55%였다. p-mTOR, p-S6의 발현과 선종-선암 연속성은 중요한 상관관계 있다는 것이 발견되었다. 그리고 흥미롭게도 p-S6 발현률은 진행암보다 초기암에서 더 높았다.

• 한국음향학회지
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• 제17권8호
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• pp.34-40
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• 1998

본 논문에서는 일반 X-ray 필름을 사용하는 기존 아날로그 의료 영상 진단 체계의 문제점들을 해결하기 위해 연구 개발된 포괄적인 영상관리 전송 시스템(PACS)에서의 효율 적인 영상 전송과 저장을 위해 병원에서 매일 다량으로 발생하는 의료 영상들 중 CT와 MR영상을 대상으로 하여 새로운 무손실 영상 압축 기법인 CRAC 압축 알고리즘을 설계하 였다. CRAC 압축 알고리즘에서는 CT와 MR 영상의 파일구조를 분석하여 런랭스 코딩에 적합하도록 데이터를 재배열하는 전처리 작업을 설계하였으며, 이를 CT와 MR 영상에 최적 화 시킨 개선된 런랭스 알고리즘으로 1차 압축시켜 그 결과를 산술 부호화 알고리즘과 결합 함으로써 압축효율을 향상시켰다. 이러한 CRAC 압축 알고리즘은 무손실 압축 기법으로, 의 료 영상을 압축한 수 손실 없이 원 영상을 그대로 복원할 수 있기 때문에 PACS에서의 CT, MR 영상의 판독을 위한 단기 저장시에 적합한 압축 알고리즘으로 CT와 MR 영상의 무손 실 압축에 대해 새로운 전처리 방법을 제시하였고, 기존 무손실 압축 방법들과 비교 분석한 결과 압축률이 2.1%∼5.9% 정도 향상되었다.

• Structural Engineering and Mechanics
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• 제74권3호
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• pp.351-363
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• 2020

Based on the dynamic tests of recycled aggregate concrete (RAC) short columns confined by the hoop reinforcement, the dynamic failure mechanism and the mechanical parameters related to the constitutive relation of confined recycled aggregate concrete (CRAC) were investigated thoroughly. The fracturing sections were relatively flat and smooth at higher strain rates rather than those at a quasi-static strain rate. With the increasing stirrup volume ratio, the crack mode is transited from splitting crack to slipping crack constrained with large transverse confinement. The compressive peak stress, peak strain, and ultimate strain increase with the increase of stirrup volume ratio, as well as the increasing strain rate. The dynamic confining increase factors of the compressive peak stress, peak strain, and ultimate strain increase by about 33%, 39%, and 103% when the volume ratio of hoop reinforcement is increased from 0 to 2%, but decrease by about 3.7%, 4.2%, and 9.1% when the stirrup spacing is increased from 20mm to 60mm, respectively. This sentence is rephrased as follows: When the stirrup volume ratios are up to 0.675%, and 2%, the contributions of the hoop confinement effect to the dynamic confining increase factors of the compressive peak strain and the compressive peak stress are greater than those of the strain rate effect, respectively. The dynamic confining increase factor (DCIF) models of the compressive peak stress, peak strain, and ultimate strain of CRAC are proposed in the paper. Through the confinement of the hoop reinforcement, the ductility of RAC, which is generally slightly lower than that of NAC, is significantly improved.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2008년도 동계학술발표대회 논문집
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• pp.487-492
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• 2008

The cooling of data centers has emerged as a significant challenge as the density of IT server increases. Server installations, along with the shrinking physical size of servers and storage systems, has resulted in high power density and high heat density. The introduction of high density enclosures into a data center creates the potential for "hot spots" within the room that the cooling system may not be able to address, since traditional designs assume relatively uniform cooling patterns within a data center. The cooling system for data center consists of a CRAC or CRAH unit and the associated air distribution system. It is the configuration of the distribution system that primarily distinguishes the different types of data center cooling systems, this is the main subject of this paper.

• PNF and Movement
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• 제7권4호
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• pp.1-7
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• 2009

Purpose : This paper reviews on the method of PNF stretching. Methods : This is literature study with Pubmed, medline, SPORT Discus, EBSCO, ProQuest and books. Results : PNF stretching is effective for increasing range of motion than static and ballistic stretching. CR(contract-relax) technique is effective and CRAC(contract-relax with agonist contraction) technique including agonist contraction is more effective. A minimum of one repetition, twice or three times per week is required for range of motion gains, needs to be conducted continueously. A minimum of 20% contraction intensity and more than 3 seconds contraction duration are needed to increase range of motion. Inclusion of static stretching of antagonist and agonist contraction is more effective. Conclusions : PNF stretching is more effective for increasing range of motion than other stretching methods, but, clinicians need to select proper techniques according to subjects and muscles, and conduct carefully when applying technique.

• 대한기계학회논문집B
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• 제36권8호
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• pp.821-828
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• 2012

CPU의 발열량 증가는 서버를 통과하는 배출공기와 유입공기와의 상당한 온도차를 발생시키고 이로 인해 배출공기의 재순환 현상과 유입공기의 바이패스 현상이 발생한다. 이는 데이터센터 냉각시스템의 효율저하를 발생시킨다. 따라서 CRAC의 제어를 통해 유입공기와 배출공기를 분리하는 것이 데이터센터 냉각시스템의 중요한 목표이다. 본 연구에서는 CFD 해석 코드인 ICEPAK을 이용하여 데이터센터에 대한 수치해석을 진행하였다. 실내부로 유입되는 공기유량의 변화에 따른 CPU의 온도와 실 전체의 온도분포를 분석하였다. 이를 통해 CPU의 발열량에 따른 최적 유입유량을 선정하였다. CPU 발열량이 100, 120, 140 W인 경우 유입유량이 $0.15m^3/s$인 지점에서 발열제거와 온도분배가 가장 잘 이루어졌다. RTI 성능지표를 이용하여 해석결과를 검증하였고 RTI 값이 81인 경우 가장 안정적인 결과를 보였다.

• International Journal of Oral Biology
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• 제47권3호
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• pp.33-40
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• 2022

Store-operated Ca²⁺ entry (SOCE) represents one of the major Ca²⁺ entry routes in non-excitable cells. It is involved in a variety of fundamental biological processes and the maintenance of Ca²⁺ homeostasis. The Ca²⁺ release-activated Ca²⁺ (CRAC) channel consists of stromal interaction molecule and Orai; however, the role and action of Homer proteins as an adaptor protein to SOCE-mediated Ca²⁺ signaling through the activation of CRAC channels in non-excitable cells still remain unknown. In the present study, we investigated the role of Homer2 in the process of Ca²⁺ signaling induced by the interaction between CRACs and Homer2 proteins in non-excitable cells. The response to Ca²⁺ entry by thapsigargin-mediated Ca²⁺ store depletion remarkably decreased in pancreatic acinar cells of Homer2^-/- mice, as compared to wild-type cells. It also showed critical differences in regulated patterns by the specific blockers of SOCE in pancreatic acinar cells of Homer2^-/- mice. The response to Ca²⁺ entry by the depletion in Ca²⁺ store markedly increased in the cellular overexpression of Orai1 and STIM1 as compared to the overexpression of Homer2 in cells; however, this response was remarkably inhibited by the overexpression of Orai1, STIM1, and Homer2. These results suggest that Homer2 has a critical role in the regulatory action of SOCE activity and the interactions between CRAC channels.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2002년도 제9회 학술 발표회 프로그램과 논문초록
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• pp.39-39
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• 2002

Microglia are known to have an important function as brain macrophage during immunological processes, oncogenesis, and regeneration in the central nervous system (CNS). A wide variety of ion channels have been identified and characterized in microglia including inward rectifier $K^{＋}$ channel (Kir), voltage dependent $K^{＋}$ channel (Kv), $Ca^{2＋}$-release activated $Ca^{2＋}$ channel (CRAC).(omitted)

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.47-47
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• 2003

The presenilin 1 (PS1) or PS2 is an essential component of the ${\gamma}$-secretase complex, which mediates the intramembrane proteolysis of selected type-I membrane, including the ${\beta}$-amyloid precursor protein (APP) to yield A${\beta}$. Familial Alzheimer's disease (FAD)-associated mutations in presenilins give rise to an increased production of a highly amyloidogenic A${\beta}$42. In addition to their well-documented proteolytic function, the presenilins play a role in calcium signaling. We have previously reported that presenilin FAD mutations cause highly consistent alterations in intracellular calcium signaling pathways, which include deficits in capacitative calcium entry (CCE), the refilling mechanism for depleted internal calcium stores. However, molecular basis for the presenilin-mediated modulation of CCE remains to be elucidated. In the present study, whole-cell patch clamp method was used to identify a specific calcium-permeable ion channel current(s) that is responsible for the CCE deficits associated with FAD-linked PS1 mutants. Unexpectedly, both voltage-activated and conventional store depletion-activated calcium currents I(CRAC), were absent in HEK293 cells, which were stably transfected either with wild-type or FAD mutant (L286V, M146L, and delta E9) forms of PS1. Recently, magnesium-nucleotide-regulated metal cation current, or I(MagNum), has been described and appears to share many common properties with I(CRAC) including calcium permeability and inhibitor sensitivity (e.g. 2-APB). We have detected I(MagNum) in all 293 cells tested. Interestingly, FAD mutant 293 cells developed only about half of currents compared to PS1 wild type cells.