• The Korea Journal of Herbology
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• v.30 no.1
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• pp.33-42
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• 2015

Objectives : The aim of this study was to evaluate the antitumor effects of Cheongpyesagan-tang(CST) and YKK012 on colon cancer. Methods : MTT assay was used to evaluate the cytotoxicity of Single herbs and combinations of CST and YKK012 on murine colon cancer cells, Colon 38. To explain effects of apoptosis in colon cancer, we performed the western blot. Effects of CST and YKK012 on antitumor activity of CPT-11 using the murine colon38 allograft tumor in BDF1 mice. Results : Single herbs and combinations of CST and YKK012 was tested in vitro, Rhei Radix (RH) and Scutellariae Radix (SC) and YKK012 showed dose-response cytotoxicity on Colon 38. This might be due to the apoptosis, as we see Bax and Caspase-3, which are apoptotic factors, was expressed in RH and SC treated cells. YKK012 also showed increased expression of Caspase-3. In mouse colorectal cancer xenograft model of colon38 cells, herbal combinations showed tendencies of tumor regression, but was not significant. Furthermore, because toxicity was observed in CST group, we reduced the dose of CST for the next experiment. The anti-tumor effects of herbal combinations were insufficient to be used as single anti-tumor agent. With simultaneous usage of CPT-11, contrary to that CST showed no synergistic effects, YKK012 which was composed by the combination of four $ER{\beta}$ selective herbs, significantly reduced the size of tumor and Bax expression was increased. Conclusions : We suggest YKK012 can be a effective cancer adjuvant therapy with CPT-11 on colon cancer.

• Journal of Acupuncture Research
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• v.18 no.6
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• pp.59-69
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• 2001

Objective : The aim of this study is to assess the ability of the CPT test to dignosis radiculopathy in Korean with NeuvalTM CPT database. Method : Electrical stimulation(at 2000, 250, and 5Hz) using Neurometer was applied to the 19 patients who felt back and sciatic pain with herniated intervertevral disc(HIVD) of L-spine, dignosisd by lumbar CT or MRI, and the 33 patients who felt only back or hip or leg pain without HIVD, stenosis, spondylolisthesis which causing radiculopathy. The test sites were toe1, toe3 and toe5 related to L4, L5 and S1 nerve roots. Results : The mean values of the CPT of HIVD group was stiatically lower than LBP group at toe1-250Hz, toe3-2000Hz, 250Hz and toe5-250Hz, 5Hz. The grading CPT score of HIVD group was stastically higher than LBP group at the toe3(L5). The VAS of HIVD group was stastically higher than LBP group. Conclusion : These results suggest that the CPT test can be a valuable testing for diagnosing radiculopathy in Korean. In using CPT test further study is needed for the diagnosis and evaluation of sensory nerve dysfunction in the musculoskeletal disease.

• Information Display
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• v.7 no.6
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• pp.3-6
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• 2006

Slim CRT의 등장은 CRT 산업에 다시 한번 생기를 불어 넣어주는 기회가 되었다. TV용 Slim CPT(Color Picture Tube)의 성공과 함께 모니터용 CDT(Color Display Tube)의 Slim 성공은 한층 더 치열한 디스플레이 산업을 예고하고 있다. CDT는 CPT보다 더 높은 해상도와 정교한 Linearity 특성을 가져야 하므로 Slim CRT를 구현을 위한 광각 편향에 대하여 더 높은 기술적 대응이 요구된다. LG.Philips Displays(LPD)는 CDT에서 106도 편향을 구현함으로써 전장이 320mm인 CDT를 세계 최초로 실현하였다. 이는 기존 Flat CDT가 90도 편향에 전장이 375mm 인 것 대비하여 전장을 56mm 축소하는 성과를 가져왔다. [그림 1]은 기존의 17"Normal CDT와 17"CDT SuS를 비교한 것이다.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.3
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• pp.173-177
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• 2005

The purpose of this study was to discern the critical point in skeletal muscle fatty acid oxidation by changing plasma free fatty acids (FFA) level in rat. In the study, 3 key steps in lipid oxidation were examined after changing plasma FFA level by acipimox. The rates of both palmitate and palmitoylcarnitine oxidation were decreased by decrease of plasma FFA level, however, carnitine palmitoyl transferase (CPT) 1 activity was not changed, suggesting CPT1 activity may not be involved in the fatty acid oxidation at the early phase of plasma FFA change. In the fasted rats, ${\beta}-hydroxy$ acyl-CoA dehydrogenase (${\beta}$-HAD) activity was depressed to a similar extent as palmitate oxidation by a decrease of plasma FFA level. This suggested that ${\beta}-oxidation$ might be an important process to regulate fatty acid oxidation at the early period of plasma FFA change. Citrate synthase activity was not altered by the change of plasma FFA level. In conclusion, the critical step in fatty acids oxidation of skeletal muscles by the change of plasma FFA level by acipimox in fasting rats might be the ${\beta}-oxidation$ step rather than CPT1 and TCA cycle pathways.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.5
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• pp.269-274
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• 2013

To proportionally control the electronic valve position of the actuator, we designed and fabricated PCU, CPT, and rotary absolute optical encoder for the detection of absolute angular position in the actuator. We also designed and constructed the test system by using DAQ hardware and Labview. We designed PCU to convert 1-5 V, 0-5 V, 0-10 V, 2-10 V voltage signals and 4-20 mA current signals to the voltage signals in the common 0.5-2.5 V range. We designed CPT to output 4-20 mA current signals corresponding to the valve positions based on the PWM signal input from the MCU. We also designed 20 bit optical encoder by using infrared LED and infrared transistor and made the serial communication with the main board possible. When we tested PCU and CPT with DAQ hardware and Labview software, they operated correctly with the small errors within ${\pm}0.003$ V and ${\pm}0.01$ mA, respectively, showing that our actuator has the excellent performance to employ as the industrial proportional-valve-actuator. The resolution of the encoder was $11.25^{\circ}$ and the maximum revolution to detect was 32,768.

• Resources Recycling
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• v.22 no.6
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• pp.64-72
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• 2013

The purpose of this study is to confirm the possibility of obtaining high grade coal from 57.39% of fixed carbon fine coal. Also, the mineralogical, physical/chemical and liberation characteristics are to be identified to decrease in ash amount, during the pre-processing of clean coal technology. In this study, batch flotation and CPT column flotation proper for the processing of fine particles were used with the variation in kinds and quantity of frother, collector and depressant. Also air flow rate and feeding rates were examined. As a result of batch flotation using 20% of pulp density DMU 101 collector(100 mL/ton), AF65 frother(300 mL/ton), sodium metaphosphate depressant (1 kg/ton), 67.57% of ash rejection and 70.90% of combustible recovery were obtained. The result of CPT column flotation was 85.59% of ash rejection and 88.97% of combustible recovery under the conditions of 5% of pulp density, DMU-101 collector (100 mL/ton), AF65 frother(10 L/ton), SMP depressant(1 kg/ton), wash water(100 mL/min.) and air flow rate(1,200 mL/min.).

• YAKHAK HOEJI
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• v.53 no.4
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• pp.222-227
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• 2009

Human topoisomerase I (Topo I) plays a pivotal role in cell replication, transcription and repair and, therefore, is an important anti-cancer target. 20S-camptothecin (CPT) is a representative Topo I inhibitor. Compounds belonging to CPT family inhibit the religation step of Topo I-DNA by binding to the DNA cleavage site. Computational docking studies with Surflex-Dock were carried out to investigate the binding modes between Topo I-DNA binary complex structure and the ligand such as 20S-CPT and 9,10-substituted 20S-CPT analogues. The docking results demonstrated that most of the compounds with $IC_{50}$ value under $0.5{\mu}M$ intercalated exactly between the -1 and +1 DNA bases, deeply toward the cleavage site. The complex was stabilized by hydrogen-bonding and hydrophobic interactions with both the enzyme and the DNA. The compounds with $IC_{50}$ value above $0.5{\mu}M$ were poorly docked and did not intercalate. In addition, the docking results confirmed the overall correlation between the $IC_{50}$ values and docking scores, indicating the possible use of the modeling for the prediction of biological activity and design of potential inhibitors.

• Fibers and Polymers
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• v.2 no.2
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• pp.86-91
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• 2001

Liquid crystalline (LC) poly(ethylene terephthalate-co-2(3)-chloro-1,4-phenylene terephthalate) [copoly(ET/CPT)] was prepared using poly(ethylene terephthalate) (PET) as a flexible spacer, terephthalic acid (TPA), and chlorohydroquinone diacetate (CHQDA). All reactions involved in the copolymerization were investigated using some model compounds: TAP was used for acidolysis, diphenylethyl terephthalate (DPET) for interchange reaction between PET chains, and 야-o-chlorophenyl terephthalate (DOCT) and di-m-chlorophenyl terephthalate (DMCT) for interchange reaction between PET and rigid rodlike segments. Activation energies obtained for the acidolysis of PET with TPA and for interchange reaction of PET with DPET, DOCT, and DMCT were 19.8 kcal/mol, 26.5 kcal/mole, and 45.9 kcal/mole, respectively. This result supports that the copolymerization proceeds through the acidolysis of PET with TPA first and subsequent polycondensation between carboxyl end group and CHQDA or acetyl end group, which is formed from the reaction of CHQDA and TPA. Also, it was found that ester-interchange reaction can be influenced by the steric hindrance. Copoly(ET/CPT)s obtained has ethylene acetate end groups formed from acetic acid hydroxy ethylene end groups and showed almost the random sequence distribution for all compositions.

• Nutrition Research and Practice
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• v.7 no.4
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• pp.287-293
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• 2013

This study determined the effects of fucoxanthin on gene expressions related to lipid metabolism in rats with a high-fat diet. Rats were fed with normal fat diet (NF, 7% fat) group, high fat diet group (HF, 20% fat), and high fat with 0.2% fucoxanthin diet group (HF+Fxn) for 4 weeks. Body weight changes and lipid profiles in plasma, liver, and feces were determined. The mRNA expressions of transcriptional factors such as sterol regulatory element binding protein (SREBP)-1c, Carnitine palmitoyltransferase-1 (CPT1), Cholesterol $7{\alpha}$-hydroxylase1 (CYP7A1) as well as mRNA expression of several lipogenic enzymes were determined. Fucoxanthin supplements significantly increased plasma high density lipoprotein (HDL) concentration (P < 0.05). The hepatic total lipids, total cholesterols, and triglycerides were significantly decreased while the fecal excretions of total lipids, cholesterol, and triglycerides were significantly increased in HF+Fxn group (P < 0.05). The mRNA expression of hepatic Acetyl-CoA carboxylase (ACC), Fatty acid synthase (FAS), and Glucose-6-phosphate dehydrogenase (G6PDH) as well as SREBP-1C were significantly lower in HF+Fxn group compared to the HF group (P < 0.05). The hepatic mRNA expression of Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) and Acyl-CoA cholesterol acyltransferase (ACAT) were significantly low while lecithin-cholesterol acyltransferase (LCAT) was significantly high in the HF+Fxn group (P < 0.05). There was significant increase in mRNA expression of CPT1 and CYP7A1 in the HF+Fxn group, compared to the HF group (P < 0.05). In conclusion, consumption of fucoxanthin is thought to be effective in improving lipid and cholesterol metabolism in rats with a high fat diet.

• Magazine of the Korean Society of Agricultural Engineers
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• v.40 no.2
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• pp.112-122
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• 1998

Measurement of electrical resistivity in soils has been used for many years with purpose of estimating in situ porosity or density. Recently electrical resistivity has also been used as an indicator of soil contaimination. This paper presents the result of laboratory experiment to investigate the resistivity variation in contaminated sandy soils. The results can be used with the Cone Penetrometer Test (CPT) result to analyse ground condition. In the experiment, the water content and leachate concentration of soils were controlled by groundwater and leachate, and then the resistivity measurement was made with 'STING-R1' by Advanced Geosciences Inc. In the case of using groundwater, the resistivity was in the range of over 1000${\omega}{\cdot}m$, but in the case of using polluted water by leachate, the resistivity decreased significantly down to 10~ 100${\omega}{\cdot}m$ for the same moisture content. Also the resistivity varied according to the degree of saturatrion. Therefore, if soil is contaminated by leachate, the CPT with electrical resistivity sensor might be used to investigate the contamination status and plume migration. But exact component of leachate and the pollutant concentration are still hard to identify.