• Radiation Oncology Journal
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• v.1 no.1
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• pp.61-67
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• 1983

Two cases of primary malignant lymphoma of the brain and six cases of secondary CNS lymphoma seen at Yonsei cancer center, radiotherapy department for recent 4 years are presented. Primary lymphomas revealed single tumor mass on corpus callosum area and secondary lymphoma were intracranial (3 cases) or leptomeningeal type (3 cases). Histology of primary lymphoma were reticulum cell sarcoma and secondary lymphomas were either diffuse histiocytic or diffuse poorly differentiated lymphocytic lymphoma. All patients showed good response to radiation. Two patients with primary CNS lymphoma and two of six secondary CNS lymphoma are alive after radiotherapy (34, 31, 26, 12 months). But the prognosis of secondary CNS lymphoma is grave, because of progressive systemic disease. Incidence, risk factors, diagnosis and therapeutic management of CNS involvement are also discussed.

• The Magazine of the IEIE
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• v.36 no.12
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• pp.38-44
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• 2009

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.26 no.11
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• pp.40-46
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• 2008

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.29 no.5
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• pp.56-61
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• 2011

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.28 no.12
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• pp.59-66
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• 2010

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.23 no.11 s.198
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• pp.61-64
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• 2005

• Journal of Advanced Navigation Technology
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• v.14 no.3
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• pp.313-320
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• 2010

Preparing for the rapidly increment of air traffic volume of the 21st century, International Civi1 Aviation Organization(ICAO) started for studying a newly developed CNS/ATM System from the 1980s and after 2010, expect that the existing aeronautical facility is overloaded because air traffic volume increase rapidly. For this reason new CNS/ATM System will be the international standard system in the future. Especially, ADS-B(Automatic Dependent Surveillance-Broadcast) as the key component of Surveillance and ATM in new CNS/ATM System provides the real-time and same air traffic information to pilots in the aircraft cockpit, air traffic controllers on the ground and surface vehicles at the same time. Information provided is displayed precisely and accurately through Multi-Function Display(MFD). We implement the MFD system being supporting for new CNS/ATM System. And we show the good performance of MFD system in labortory environment using the MIL-STD-1553B data bus.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3979-3985
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• 2013

Background: Although primary malignant CNS tumors are registered in the national cancer registry (NCR) of Iran, there are no available data on the incidence of the primary malignant or benign CNS tumors and their common histopathologies in the country. This study analyzed the 10-year data of the Iranian NCR from March 21, 2000 to March 20, 2010, including a systematic review. Materials and Methods: The international and national scientific databases were searched using the search keywords CNS, tumor, malignancy, brain, spine, neoplasm and Iran. Results: Of the 1,086 primary results, 9 papers were selected and reviewed, along with analysis of 10-year NCR data. The results showed that primary malignant brain tumors have an overall incidence of 2.74 per 100,000 person-years. The analysis of the papers revealed a benign to malignant ratio of 1.07. The most common histopathologies are meningioma, astrocytoma, glioblastoma and ependymoma. These tumors are more common in men (M/F=1.48). Primary malignant spinal cord tumors constitute 7.1% of the primary malignant CNS tumors with incidence of 0.21/100,000. Conclusions: This study shows that CNS tumors in Iran are in compliance with the pattern of CNS tumors in developing countries. The NCR must include benign lesions to understand the definitive epidemiology of primary CNS tumors in Iran.

• The Journal of Korean Physical Therapy
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• v.25 no.5
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• pp.352-359
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• 2013

Purpose: For patients with CNS injury who are restricted in the use of public transportation, car driving means more than simple movements and is essential for their independent lives, such as participation in society and returning to jobs. Therefore, in order to enhance the quality of life of disabled persons, their high perception and necessity of driving rehabilitation are required. The purpose of this study is to determine the perception and necessity of driver rehabilitation in patients with CNS injury. Methods: In order to survey the perception of patients with CNS injury and necessity of driving rehabilitation, questionnaires were distributed to patients with CNS injury. Questionnaires were composed of demographic characteristics, disability related characteristics, and driver's license related characteristics. Results: Our results showed that the number of driving participants with a driver's license for the disabled was significantly higher than that for non- driving participants with a previous general driver's license in the perception of driving rehabilitation. Conclusion: We suggest that driving rehabilitation for patients with CNS injury should be supported in terms of evaluation and treatment.

• Molecules and Cells
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• v.39 no.12
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• pp.888-897
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• 2016

Stable expression of Foxp3 is ensured by demethylation of CpG motifs in the Foxp3 intronic element, the conserved non-coding sequence 2 (CNS2), which persists throughout the lifespan of regulatory T cells (Tregs). However, little is known about the mechanisms on how CNS2 demethylation is sustained. In this study, we found that Ten-Eleven-Translocation (Tet) DNA dioxygenase protects the CpG motifs of CNS2 from re-methylation by DNA methyltransferases (Dnmts) and prevents Tregs from losing Foxp3 expression under inflammatory conditions. Upon stimulation of Tregs by interleukin-6 (IL6), Dnmt1 was recruited to CNS2 and induced methylation, which was inhibited by Tet2 recruited by IL2. Tet2 prevented CNS2 re-methylation by not only the occupancy of the CNS2 locus but also by its enzymatic activity. These results show that the CNS2 methylation status is dynamically regulated by a balance between Tets and Dnmts which influences the expression of Foxp3 in Tregs.