• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.7
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• pp.53-61
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• 2004

In this paper, we proposed a new architecture of MAC(Multiplier-Accumulator) to operate high-speed multiplication-accumulation. We used the MBA(Modified radix-4 Booth Algorithm) which is based on the 1's complement number system, and CSA(Carry Save Adder) for addition of the partial products. During the addition of the partial product, the signed numbers with the 1's complement type after Booth encoding are converted in the 2's complement signed number in the CSA tree. Since 2-bit CLA(Carry Look-ahead Adder) was used in adding the lower bits of the partial product, the input bit width of the final adder and whole delay of the critical path were reduced. The proposed MAC was applied into the DWT(Discrete Wavelet Transform) filtering operation for JPEG2000, and it showed the possibility for the practical application. Finally we identified the improved performance according to the comparison with the previous architecture in the aspect of hardware resource and delay.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.5A
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• pp.554-565
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• 2004

In this paper, we implement single cycle and multi cycle adders. We can compare area and time by using the implemented adders. The size of adders is 64, 128, 256-bits. The architecture of hybrid adders is that the carry-out of small adder groups can be interconnected by utilizing n carry propagate unit. The size of small adder groups is selected in three formats - 4, 8, 16-bits. These adders were implemented with Verilog HDL with top-down methodology, and they were verified by behavioral model. The verified models were synthesized with a Samsung 0,35(um), 3.3(V) CMOS standard cell library while a using Synopsys Design Compiler. All adders were synthesized with group or ungroup. The optimized adder for a Crypto-processor included Smart Card IC is that a 64-bit RCA based on 16-bit CLA. All small adder groups in this optimized adder were synthesized with group. This adder can operate at a clock speed of 198 MHz and has about 961 gates. All adders can execute operations in this won case conditions of 2.7 V, 85 $^{\circ}C$.

• Journal of Applied Biological Chemistry
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• v.54 no.3
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• pp.197-205
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• 2011

This study was carried out to investigate the dietary effects of Monascus pilosus mycelial extract on obesity in high-fat with cholesterol-induced obese rat models. It was observed that M. pilosus mycelial extract contains $25.85{\pm}1.98mg%$ of total monacolin K without citrinin by highperformance liquid chromatography (HPLC). The rats were randomly divided into 2 groups; normal control and a high-fat with cholesterol diet group. The high-fat with cholesterol diet group was fed a 5L79 diet with an added 15% lard and 1% cholesterol supplemented diet for 3 weeks for induction of obesity. After induction, obesity was confirmed by checking obesity indexes, the animals were divided into 4 groups (n=5); first, the normal control (NC), and then taken from the obese model of rats, a high-fat with cholesterol diet obesity control group (HF), 0.5% M. pilosus mycelial extract supplemented high-fat with cholesterol diet group (MPMs), 2% conjugated linoleic acid supplemented high-fat with cholesterol diet group (CLA) for 7 weeks. Body weight gains, obesity indexes, and body fat contents in the experimental groups (MPMs and CLA) were decreased compared with HF group. Feed Efficiency Ratio (FER) in MPMs was significantly lower than that of HF without change of feed intake. These results suggested that the anti-obesity effects of the M. pilosus mycelial extracts (MPMs) could prevent obesity induced by high-fat with cholesterol diet possibly via inhibition of lipid absorption.

• Nutrition Research and Practice
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• v.11 no.1
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• pp.17-24
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• 2017

BACKGROUND/OBJECTIVES: In this study, we investigated whether Gelidium amansii extract (GAE) ameliorates obesity in diet-induced obese (DIO) mice. MATERIALS/METHODS: The mice were maintained on a high-fat diet (HD) for 5 weeks to generate the DIO mouse model. And then mice fed HD plus 0.5% (GAE1), 1% (GAE2) or 2% (GAE3) for 8 weeks. RESULTS: After the experimental period, GAE-supplemented groups were significantly lower than the HD group in body weight gain and liver weight. GAE supplemented groups were significantly lower than the HD group in both epididymal and mesenteric adipose tissue mass. The plasma leptin level was significantly higher in the HD group than in GAE-supplemented groups. The leptin level of HD+GAE3 group was significantly lower than that of the HD+conjugated linoleic acid (CLA) group. In contrast, plasma adiponectin level of the HD group was significantly lower than those of HD+GAE2 and HD+GAE3 groups. The expression levels of adipogenic proteins such as fatty acid synthase, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor ${\gamma}$, and CCAAT/enhancer binding protein ${\alpha}$ in the GAE supplemented groups were significantly decreased than those in HD group, respectively. In addition, the expression levels of HD+GAE2 and HD+GAE3 groups are significantly decreased compared to those of HD+CLA group. On the contrary, the expression levels of hormone-sensitive lipase and phospho-AMP-activated protein kinase, proteins associated with lipolysis, were significantly increased in the GAE supplemented groups compared to those in the HD group. HD+GAE3 group showed the highest level among the GAE supplemented groups. CONCLUSIONS: These results suggested that GAE supplementation stimulated the expressions of lipid metabolic factors and reduced weight gain in HD-fed C57BL/6J obese mice.

• Preventive Nutrition and Food Science
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• v.5 no.2
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• pp.114-118
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• 2000

The inhibitory effects of doenjang extracts and linoleic acid(LA) which was identified as one of the active compounds in doenjang on the growth of human cancer cells were studied, comparing to the actions on normal cells. Methanol extract and hexane fraction from doenjang exhibited the strong growth inhibitory effect on HT-29 human colon carcinoma cells. Inhibitory effects of chloroform, ethyl acetate, butanol and aqueous fractions on the cancer cells were observed, moderately or weakly. When cell counts of SNU-C$_1$human colon carcinoma cells were determined daily for 6 days, the inhibitory effect of hexane fraction on this cell line was higher than that of the methanol extract from doenjang. LA completely suppressed the growth of SNU-C$_1$cells after 4 days, while conjugated linoleic acid(CLA) resulted in 98% inhibition after 6 days. With the addition of LA and other free fatty acids such as stearic acid, oleic acid, linolenic acid and ${\gamma}$-linolenic acid (${\gamma}$-LnA) to the culture system, the growth of HT-29 cells and SNU-C$_1$cells was greatly suppressed after 6 days. Inhibitory effects of LA ${\gamma}$-LnA on the growth of these cells were stronger than other fatty acids. On the growth of AZ-521 human gastric carcinoma cells, LA and CLA completely cuppressed the growth of the cells after 4 days and 3 days, respectively. At the level of 0.001%~0.01% of LA, there was no cytotoxic effect on normal rat kidney cells and normal intestine human cells. These results showed that LA, a major active compound of doenjang, had strong inhibitory effects on the growth of human cancer cells without damaging normal cells.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.9
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• pp.1363-1372
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• 2019

Objective: This study was designed to investigate the effect of diet supplementation with rubber seed oil and flaxseed oil on serum fatty acids profile, oxidation stability of serum and milk, and immune function of dairy cows. Methods: Forty-eight mid-lactation Holstein dairy cows were randomly assigned to one of four treatments for 8 wk, including basal diet (CON) or the basal diet supplemented with 4% rubber seed oil (RO), 4% flaxseed oil (FO) or 2% rubber seed oil plus 2% flaxseed oil (RFO) on a dry matter basis. Results: Compared with CON, all the oil groups increased the levels of trans-11 C18:1 (vaccenic acid), cis-9, trans-11 C18:2 (conjugated linoleic acid, CLA) and C18:3 (${\alpha}$-linolenic acid, ALA) in serum. Both the activity of glutathione peroxidase and catalase in serum and milk in oil groups were decreased, which were negatively correlated with the levels of cis-9, trans-11 CLA and ALA. The concentrations of proinflammatory factors (tumor necrosis factor ${\alpha}$ and interferon ${\gamma}$) in serum of oil groups were lower than that from the CON cows. Conclusion: These results indicate that diet supplementation with RO or FO could alter serum fatty acid profile and enhance the immune function of dairy cows. However, the negative effect on milk oxidation stability should be considered when feeding these n-3 polyunsaturated fatty acid-enriched oils in dairy production.

• Animal Bioscience
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• v.37 no.1
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• pp.84-94
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• 2024

Objective: The objective of this study was to investigate how cellulase or/and lactic acid bacteria (LAB) affected the fermentation characteristic and microbial community in wet brewer's grains (WBG) and corn stover (CS) mixed silage. Methods: The WBG was mixed thoroughly with the CS at 7:3 (w/w). Four treatment groups were studied: i) CON, no additives; ii) CEL, added cellulase (120 U/g fresh matter [FM]), iii) LAB, added LAB (2×10⁶ cfu/g FM), and iv) CLA, added cellulase (120 U/g FM) and LAB (2×10⁶ cfu/g FM). Results: All additive-treated groups showed higher fermentation quality over the 30 d ensiling period. As these groups exhibited higher (p<0.05) LAB counts and lactic acid (LA) content, along with lower pH value and ammonia-nitrogen (NH₃-N) content than the control. Specifically, cellulase-treated groups (CEL and CLA) showed lower (p<0.05) neutral detergent fiber and acid detergent fiber contents than other groups. All additives increased the abundance of beneficial bacteria (Firmicutes, Lactiplantibacillus, and Limosilactobacillus) while they decreased abundance of Proteobacteria and microbial diversity as well. Conclusion: The combined application of cellulase and LAB could effectively improve the fermentation quality and microbial community of the WBG and CS mixed silage.

• Journal of Practical Engineering Education
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• v.16 no.2
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• pp.129-141
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• 2024

In recent times, there has been a shift towards student-centered higher education policies, leading to a growing interest among universities to improve students' learning outcomes. To aid in this endeavor, this study aims to provide guidance for University K to enhance their learning outcome management by comparing and analyzing their learning outcome indicators with those of other domestic and foreign universities. The study examined detailed measurement questions from major learning outcome measurement tools such as AHELO, NSSE, and CLA+. Upon comparison and analysis of University K's major learning outcome indicators with those of other universities, it was found that most of the indicators overlapped. However, some indicators such as student support/facilities for learning, instructor quality, and communication were absent from University K. Therefore, it is crucial to decide whether to add these indicators to the existing learning outcomes or to confirm them through other surveys. Moreover, even for the same indicator, some indicators with different measurement need to consider changing the measurement.

• Proceedings of the IEEK Conference
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• 2004.06a
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• pp.47-50
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• 2004

In this paper, we implement an Elliptic Curve Cryptosystem(ECC) processor for DTCP. Because DTCP(Digital Transmission Content Protection) uses GF(p), where p is a 160-bit prime integer, we design a scalar multiplier based on GF(p). The scalar multiplier consists of a modular multiplier and an adder. The multiplier uses montgomery algorithm which is implemented with CSA(Carry-save Adder) and CLA(Carry-lookahead Adder). Our new scalar multiplier has been synthesized using Samsung 0.18 um CMOS technology and the maximum operation frequency is estimated 98 MHz, with the size about 65,000 gates. The resulting performance is 29.6 kbps, that is, it takes 5.4 msec to process a 160-bit data frame. We assure that this performance is enough to be used for digital signature, encryption/decryption, and key exchanges in real time environments.

• Proceedings of the Korean Society of Food Science and Nutrition Conference
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• 2004.11a
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• pp.103-109
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• 2004

The obese population has been increasing over the world wide and obesity became a socioeconomic problems. It is become more serious by the accumulation of the knowledge that the obesity is related directly or indirectly with several diseases like, diabetes, hypertension, etc. With these reasons, many functional food or agents for the purpose of weight loss have been developed. However, most of these remedies are unproven and some have produced even dangerous side effects due to the ephedrine alkaloids contained in Ma-Hang. Because of these reasons, they banned using of these agents in US and regards the antiobesity functional agents as drugs in Europe. Several functional agents are known for weight loss activities like, HCA, L-canitine, CLA, chitosan, calcium supplements and capsaicin containing red pepper, kimchi and kochujang. We describe here about the function, efficacy and mechanism of these antiobesity functional agents. Furthermore, the trial of the mixture of weight loss related herbal ingredients for safe multifunctional antiobesity functional agents are discussed here, as well.