• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.94.2-94.2
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• 2003

CJ-11668 is a new potent and selective COX-2 inhibitor. CJ-11668 showed COX-2 inhibition (IC50) of 65nM and selectivity ratio (COX-l/COX-2) of 770 in the cell based assay. In the human whole blood assay, CJ-11668 showed COX-2 inhibition (IC50) of 370nM and selectivity ratio (COX-l/COX-2), 135. The treatment of CJ-11668 (5 mg/kg, p.o) produced a significant inhibition (35%) of inflamed rat paw volume in the carrageenan-induced acute inflammation. CJ-11668 also suppressed the PGE2 level (69% inhibition, 1 mg/kg, p.o) in the zymosan-induced mouse air pouch model after 3 hrs. (omitted)

• 한국산업융합학회 논문집
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• 제27권1호
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• pp.97-106
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• 2024

시료의 조단백질은 CJ4가 가장 높고 조지방, 수분, 회분, pH와 물리적인 특성은 주박분말이 많을수록 높았고 보수력은 낮았다. TBA의 CJ1은 지방산패 진행이 빨라 15일부터 가식할 수 없는 결과였다. 미생물 성장은 CJ1이 빠르게 증식하였고 CJ2, CJ3, CJ4는 15일 이후에도 부패취가 없어 주박분말이 저장성에 유용한 것으로 판단된다. 주박분말이 많을수록 L은 낮은 명도 a는 높은 적색 b는 높은 황색을 보였다. 관능검사 CJ1은 Color, Overall CJ2는 Flavor, Taste가 높은 선호도를 보였다. 주박을 첨가한 소시지의 외부 기호도는 CJ1를 내부 표현인 Overall은 CJ2를 활용한 저장성 연장관련 제품개발이 가능할 것으로 사료된다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.241.1-241.1
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• 2003

Purpose: The objective of the study was to elucidate the pharmacokinetics of CJ-11555, anti-cirrhotic agent, in different physical properties and vehicles. Methods: 8-week-old male intact rats were administered CJ-11555 either intravenously (20 mg/0.6 mL/kg, NMP:PEG400, 1:1) or orally (50 mg/2 mL/kg, various vehicles). Different particle sizes of CJ-11668 and various vehicles were applied to characterize CJ-11555 in vivo. Following the administration in rats, the plasma concentrations were determined by HPLC. (omitted)

• 축산식품과학과 산업
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• 제11권1호
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• pp.84-95
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• 2022

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.243.2-244
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• 2003

Purpose: This study evaluated gender differences and extents of accumulation on chronic dose of CJ-1l555 using rats. Method: 0, 10, 50 and 200 mg/kg/day of CJ-11555 (0.5% CMC) were orally administered to rats for 28 days and observed toxicokinetic parameters. Plasma concentrations were analyzed by LC-MS/MS Result: Exposure to CJ-11555 increased with the increase in dose level for both sexes. Mean concentrations at 10 and 50 mg/kg/day were generally similar an Days 1 and 28, but were generally highter on Day 28 than on Day 1 at 200 mg/kg/day. (omitted)

• Biomolecules & Therapeutics
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• 제12권2호
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• pp.114-121
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• 2004

This study was undertaken to evaluate the general pharmacological properties of CJ-11828, an amlodipine adipate, in experimental animals and in vitro system. CJ-11828 had no effects on general behavior, motor coordination, writhing syndromes, pentetrazol-induced chemoshock and electric shock in mice at dose levels of 3,10, anti 30 mg/kg, po. But there were decrease of body temperature, prolongation of sleeping time, and inhibition of intestinal activity in mice treated with CJ-11828 at doses of 10 and 30 mg/kg, po. CJ-11828 decreased the blood pressure in coscuous fog at the dose level of 2mg/kg, po, but it was expected as a result of pharmacological activity of CJ-11828. Any effect on respiratory system was not observed in conscious rat at doses of 3,10, and 30 mg/kg, po. The slight decrease in spontaneous motor activity was observed in mice treated with CJ-11828 at high dose, 30 mg/kg. In vitro experiments, CJ-11828 had no effect on agonists-induced contraction of isolated guinea pig ileum at 0.1, 1, and 10 ${\mu}$M. Based on these results, it was concluded that CJ-11828 had no pharmacological effect ill these studies even up to the 36-fold anticipated clinical dose, 3 mg/kg.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.118.1-118.1
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• 2003

SS cream and its revised formula, CJ-4001 is topical Chinese herbal drugs for premature ejaculation. To evaluate the genotoxic potentials of these drugs, micronucleus test using Acridine orange (AO) staining method was performed. Acridine orange (AO) staining is adopted in OECD guideline 474 and widely used in micronucleus test. In dose range finding study, no mouse was dead at 2000 mg/kg using single treatment subcutaneously. Therefore, 3 dose levels were chosen at 500, 1000, 2000 mg/kg. (omitted)

• 한국엔터테인먼트산업학회논문지
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• 제13권3호
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• pp.333-342
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• 2019

본 연구의 목적은 CJ CGV, 롯데시네마, 메가박스의 멀티플렉스 영화산업에 관한 사례를 비교분석하여 경영전략관점에서 CJ CGV만의 혁신적인 핵심역량이 무엇인지 연구하는 데 있다. 이를 통해, 컬쳐플렉스의 확대과정을 바탕으로 주요 성공요소가 무엇인지 도출하고자 핵심역량 전략인 VRIO(Value, Rareness, Inimitability, Organization)모델 분석하였다. 분석결과, CJ CGV의 차별화된 가치로는 영화관의 문화놀이터인 컬쳐플렉스이고, 희소성에서는 영화관의 기술적 혁신을 통한 종합생활문화공간으로의 변신이며, 모방불가능성에는 사회공헌으로써 CGV의 사회적 브랜드파워 확립하였으며, 조직화하는데 전 세계의 CGV 글러벌화 등이 CJ CGV의 핵심역량으로 나왔음을 알 수 있다. 기존 영화관의 활용도를 넓혀 파격적이고 혁신적인 개발에 앞장서 CJ CGV는 문화 체험영화관의 브랜드 가치를 높이고 고객의 만족도를 높이는데 기여하고 있다. CJ CGV는 끊임없는 경쟁 지배력을 높여 CGV만의 핵심역량 기업 가치를 상승시키고 있는 것이다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.88.1-88.1
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• 2003

CJ-11668 is a new potent and selective COX-2 inhibitor (IC$\sub$50/ COX-2 65nM; COX-l/COX-2 ratio 770). The pharmacokinetic profile of CJ-11668 (20 mg/kg, p.o.) in the rat was characterized by high bioavailability (90%) and long plasma half-life (11.7 hr) with low clearance (0.4 L/hr/kg). In the dog, the PK profiles (2 mg/kg, p.o.) also showed long plasma half-life (l7.9hr) with low clearance (0.5 L/hr/kg), and the bioavalability of 60%. The inhibition of CJ-11668 infive different cytochrome P450 isozymes (1A2, 2C9, 2C19, 2D6 and 3A4) was determined in vitro and had observed no significant effect. (omitted)

• 한국독성학회:학술대회논문집
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• 한국독성학회 2005년도 춘계 국제심포지엄 및 학술대회
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• pp.175-175
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• 2005