• Proceedings of the PSK Conference
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• 2003.10b
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• pp.94.2-94.2
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• 2003

CJ-11668 is a new potent and selective COX-2 inhibitor. CJ-11668 showed COX-2 inhibition (IC50) of 65nM and selectivity ratio (COX-l/COX-2) of 770 in the cell based assay. In the human whole blood assay, CJ-11668 showed COX-2 inhibition (IC50) of 370nM and selectivity ratio (COX-l/COX-2), 135. The treatment of CJ-11668 (5 mg/kg, p.o) produced a significant inhibition (35%) of inflamed rat paw volume in the carrageenan-induced acute inflammation. CJ-11668 also suppressed the PGE2 level (69% inhibition, 1 mg/kg, p.o) in the zymosan-induced mouse air pouch model after 3 hrs. (omitted)

• Journal of the Korean Society of Industry Convergence
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• v.27 no.1
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• pp.97-106
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• 2024

This study aimed to quality characteristics date for the industrialization of sausage prepared from chicken meat. The sausages were prepared by chicken meat and Jubak powder of CJ1(0%), CJ2(5%), CJ3(10%), CJ4(15%). In the proximate composition of the crude fat content of CJ4 was high and was increased according to Jubak powder addition ratios. Crude protein of CJ1 showed the highest. pH was increased but TBA, WHC, total cell counts were decreased according to Jubak powder addition ratios. WHC was decreased from the initial 46.77% to the final 38.81% according to Jubak powder addition ratios. TBA was increased from initial 0.16-0.19 to 0.2-0.59 at 15 days. Total cell counts in CJ2, CT3 and CJ4 showed the trend to be decreased according to Jubak powder addition ratios. Number of total cell counts of CJ1, CJ4 were increased from initially 2.2 to 8.9, 6.2 at 15 days. Elasticity, hardness, gumminess and cohesiveness of CT4 showed high value. L, a, b were increased according to Jubak powder addition ratios. In the sensory evaluation, Preference for color, overall of CJ1 showed high value. Preference for appearance flavor, taste of CJ2 showed high value. This result can be applied in storage property of chicken meat sausage added with Jubak powder.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.241.1-241.1
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• 2003

Purpose: The objective of the study was to elucidate the pharmacokinetics of CJ-11555, anti-cirrhotic agent, in different physical properties and vehicles. Methods: 8-week-old male intact rats were administered CJ-11555 either intravenously (20 mg/0.6 mL/kg, NMP:PEG400, 1:1) or orally (50 mg/2 mL/kg, various vehicles). Different particle sizes of CJ-11668 and various vehicles were applied to characterize CJ-11555 in vivo. Following the administration in rats, the plasma concentrations were determined by HPLC. (omitted)

• 축산식품과학과 산업
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• v.11 no.1
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• pp.84-95
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• 2022

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.243.2-244
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• 2003

Purpose: This study evaluated gender differences and extents of accumulation on chronic dose of CJ-1l555 using rats. Method: 0, 10, 50 and 200 mg/kg/day of CJ-11555 (0.5% CMC) were orally administered to rats for 28 days and observed toxicokinetic parameters. Plasma concentrations were analyzed by LC-MS/MS Result: Exposure to CJ-11555 increased with the increase in dose level for both sexes. Mean concentrations at 10 and 50 mg/kg/day were generally similar an Days 1 and 28, but were generally highter on Day 28 than on Day 1 at 200 mg/kg/day. (omitted)

• Biomolecules & Therapeutics
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• v.12 no.2
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• pp.114-121
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• 2004

This study was undertaken to evaluate the general pharmacological properties of CJ-11828, an amlodipine adipate, in experimental animals and in vitro system. CJ-11828 had no effects on general behavior, motor coordination, writhing syndromes, pentetrazol-induced chemoshock and electric shock in mice at dose levels of 3,10, anti 30 mg/kg, po. But there were decrease of body temperature, prolongation of sleeping time, and inhibition of intestinal activity in mice treated with CJ-11828 at doses of 10 and 30 mg/kg, po. CJ-11828 decreased the blood pressure in coscuous fog at the dose level of 2mg/kg, po, but it was expected as a result of pharmacological activity of CJ-11828. Any effect on respiratory system was not observed in conscious rat at doses of 3,10, and 30 mg/kg, po. The slight decrease in spontaneous motor activity was observed in mice treated with CJ-11828 at high dose, 30 mg/kg. In vitro experiments, CJ-11828 had no effect on agonists-induced contraction of isolated guinea pig ileum at 0.1, 1, and 10 ${\mu}$M. Based on these results, it was concluded that CJ-11828 had no pharmacological effect ill these studies even up to the 36-fold anticipated clinical dose, 3 mg/kg.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.118.1-118.1
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• 2003

SS cream and its revised formula, CJ-4001 is topical Chinese herbal drugs for premature ejaculation. To evaluate the genotoxic potentials of these drugs, micronucleus test using Acridine orange (AO) staining method was performed. Acridine orange (AO) staining is adopted in OECD guideline 474 and widely used in micronucleus test. In dose range finding study, no mouse was dead at 2000 mg/kg using single treatment subcutaneously. Therefore, 3 dose levels were chosen at 500, 1000, 2000 mg/kg. (omitted)

• Journal of Korea Entertainment Industry Association
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• v.13 no.3
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• pp.333-342
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• 2019

The purpose of this study is to compare and analyze the cases of the multiplex cinema industry of CJ CGV, Lotte Cinema and Megabox to study what CJ CGV's innovative core competence is from a management strategy perspective. Through this, the core competence strategies, Value, Rareness, Inimitability, and Organization(VRIO) were analyzed in order to derive from the major success factors based on the expansion process of Cultureplex. According to the analysis results, CJ CGV's differentiated value roots from Cultureplex, which CJ CGV priorities in creating movie theaters a cultural entertainment hub. The ability of CJ CGV in transforming the cinema into a cultural and living playground through technological innovation is it's cutting edge from its competitors under the rareness factor. A CJ CGV attains its inimitability by establishing social brand power as an inclusive social contribution. An organization of CJ CGV is a globalization worldwide. CJ CGV is to increase the brand value of cultural experience movie theaters and enhance customer satisfaction by expanding the use of existing movie theaters and pioneering with innovative development to theaters. As more to be sought out from this thesis, CJ CGV has steadily increased its competitive edge, raising its core competence of business value.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.88.1-88.1
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• 2003

CJ-11668 is a new potent and selective COX-2 inhibitor (IC$\sub$50/ COX-2 65nM; COX-l/COX-2 ratio 770). The pharmacokinetic profile of CJ-11668 (20 mg/kg, p.o.) in the rat was characterized by high bioavailability (90%) and long plasma half-life (11.7 hr) with low clearance (0.4 L/hr/kg). In the dog, the PK profiles (2 mg/kg, p.o.) also showed long plasma half-life (l7.9hr) with low clearance (0.5 L/hr/kg), and the bioavalability of 60%. The inhibition of CJ-11668 infive different cytochrome P450 isozymes (1A2, 2C9, 2C19, 2D6 and 3A4) was determined in vitro and had observed no significant effect. (omitted)

• Proceedings of the Korean Society of Toxicology Conference
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• 2005.05a
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• pp.175-175
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• 2005