• The Korean Journal of Applied Statistics
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• v.22 no.1
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• pp.115-127
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• 2009

The purpose of statistical analyses of array-CGH experiment data is to divide the whole genome into regions of equal copy number, to quantify the copy number in each region and finally to evaluate its significance of being different from two. Several statistical procedures have been proposed which include the circular binary segmentation, and a Gaussian based local regression for detecting break points (GLAD) by estimating a piecewise constant function. We propose in this note a penalized spline regression and its simultaneous confidence band(SCB) approach to evaluate the statistical significance of regions of genetic gain/loss. The region of which the simultaneous confidence band stays above 0 or below 0 can be considered as a region of genetic gain or loss. We compare the performance of the SCB procedure with GLAD and hidden Markov model approaches through a simulation study in which the data were generated from AR(1) and AR(2) models to reflect spatial dependence of the array-CGH data in addition to the independence model. We found that the SCB method is more sensitive in detecting the low level copy number alterations.

• Journal of the Korean Institute of Telematics and Electronics
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• v.26 no.6
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• pp.97-101
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• 1989

Scale and rotation invariant polar-logarithmic coordinate transformation is used to achieve deformation invariant pattern recognition. The coordinate transformation is produce by a computer generated hologram (CGH). The mask fabricated by a photo (UV light) pattern generator for the 1nr-$theta$ coordinate transformation is made of the CGH whose transmission function is derived by the use of Lee's method. The optically produced coordinate transformed function is derived by the use of Lee's method. The optically produced coordinate transmission input pattern is interfaced on real-time holography. Variations of autocorrelation for scaled and rotated input patterns are suggested experimentally using implemented optical correlator.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.37 no.3
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• pp.39-47
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• 2000

In this paper, we propose a new method of finding the true length of the line and long axis of the ellipse at the $\theta$=$\theta$o＋ 90$^{\circ}$ and short axis of the ellipse at the $\theta$ = $\theta$o from the Hough transform (HT) results. Through the simulations, we showed that the true length of the line and ellipse could be obtained with 98 % accuracy by using the distance from the maximum envelope to the minimum envelope. To compare the simulation results with the experimental results, we performed optical experiments by using a HT CGH filter. Through the experiments, we showed that our results were very similar to those of the simulation.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.71-76
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• 2006

Comparative genomic hybridization (CGH) is a technique for studying chromosomal changes in cancer. As cancerous cells multiply, they can undergo dramatic chromosomal changes, including chromosome loss, duplication, and the translocation of DNA from one chromosome to another. Chromosome aberrations have previously been detected using optical imaging of whole chromosomes, a technique with limited sensitivity, resolution, quantification, and throughput. Efforts in recent years to use microarrays to overcome these limitations have been hampered by inadequate sensitivity, specificity and flexibility of the microarray systems. The oligonucleotide CGH microarray system overcomes several scientific hurdles that have impeded comparative genomic studies of cancer. This new system can reliably detect single copy deletions in chromosomes. The system includes a whole human genome microarray, reagents for sample preparation, an optimized microarray processing protocol, and software for data analysis and visualization. In this study, we determined the sensitivity, accuracy and reproducibility of the new system. Using this assay, we find that the performance of the complete system was maintained over a range of input genomic DNA from 5 ug down to 0.15 ug.

• Journal of Broadcast Engineering
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• v.19 no.6
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• pp.866-876
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• 2014

Generating of digital hologram of video contents with computer graphics(CG) requires natural fusion of 3D information between real and virtual. In this paper, we propose the system which can fuse real-virtual 3D information naturally and fast generate the digital hologram of fused results using multiple-GPUs based computer-generated-hologram(CGH) computing part. The system calculates camera projection matrix of RGB-Depth camera, and estimates the 3D information of virtual object. The 3D information of virtual object from projection matrix and real space are transmitted to Z buffer, which can fuse the 3D information, naturally. The fused result in Z buffer is transmitted to multiple-GPUs based CGH computing part. In this part, the digital hologram of fused result can be calculated fast. In experiment, the 3D information of virtual object from proposed system has the mean relative error(MRE) about 0.5138% in relation to real 3D information. In other words, it has the about 99% high-accuracy. In addition, we verify that proposed system can fast generate the digital hologram of fused result by using multiple GPUs based CGH calculation.

• Journal of Genetic Medicine
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• v.5 no.1
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• pp.65-68
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• 2008

Molecular cytogenetics allows the identification of unknown chromosome rearrangements, which is clinically useful in patients with mental retardation and/or development delay. We report on a 31-year-old woman with severe mental retardation, behavior development delay, and verbal performance delay. Conventional cytogenetic analysis showed a 46,XX,add(8)(p23.3) karyotype. To determine the origin of this unbalanced translocation, we performed array CGH and subtelomeric FISH. The results showed that the distal region of chromosome 8p was added to the terminal of chromosome 13q. This was confirmed the final result of 46,XX,der(8)t(8:13)(p23.3;q32.1)dn.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.1
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• pp.15-31
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• 2013

This paper proposes an intermediate image generation method for the viewer's view point by tracking the viewer's face, which is converted to a digital hologram. Its purpose is to increase the viewing angle of a digital hologram, which is gathering higher and higher interest these days. The method assumes that the image information for the leftmost and the rightmost view points within the viewing angle to be controlled are given. It uses a stereo-matching method between the leftmost and the rightmost depth images to obtain the pseudo-disparity increment per depth value. With this increment, the positional informations from both the leftmost view point and the rightmost view point are generated, which are blended to get the information at the wanted intermediate viewpoint. The occurrable dis-occlusion region in this case is defined and a inpainting method is proposed. The results from implementing and experimenting this method showed that the average image qualities of the generated depth and RGB image were 33.83[dB] and 29.5[dB], respectively, and the average execution time was 250[ms] per frame. Also, we propose a prototype system to service digital hologram interactively to the viewer by using the proposed intermediate view generation method. It includes the operations of data acquisition for the leftmost and the rightmost viewpoints, camera calibration and image rectification, intermediate view image generation, computer-generated hologram (CGH) generation, and reconstruction of the hologram image. This system is implemented in the LabView(R) environments, in which CGH generation and hologram image reconstruction are implemented with GPGPUs, while others are implemented in software. The implemented system showed the execution speed to process about 5 frames per second.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 1991.04a
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• pp.122-124
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• 1991

• Molecular & Cellular Toxicology
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• v.3 no.sup4
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• pp.35.4-35.4
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• 2007

• Molecular & Cellular Toxicology
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• v.3 no.sup4
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• pp.36.2-36.2
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• 2007