• Biomedical Science Letters
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• v.13 no.3
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• pp.175-182
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• 2007

In vitro ciprofloxacin (CFX)-release study and bioassay using microorganisms were performed to estimate the retention of the antimicrobial activity of the CFX-incorporated central venous catheters (CFX-CVCs). The release experiments were carried out under the optional CFX-release conditions to mimic the in vivo environment. The release of CFX experienced an initial burst followed by a slow and steady matrix-diffusion controlled release. The 1.0CP (polyurethane catheter containing 1.0% (w/w) of CFX) under dynamic condition showed a near zero-order CFX release profile, which is beneficial for the long-tenn antimicrobial activity. The modified Kirby-Bauer method was performed employing S. aureus and E. coli to evaluate the retention of antimicrobial activity of the catheters retrieved from the release experiments. The 1.0CP showed the long-term antimicrobial activity (${\geq}\;21$ days) against both S. aureus and E. coli. These results indicate that 1.0CP is useful as a long-tenn indwelling CVC.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.05a
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• pp.715-716
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• 2012

• Journal of the Korean Society of Visualization
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• v.9 no.4
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• pp.22-27
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• 2011

In this study, we present methods of coupling a commercial code, ANSYS CFX, and the user Fortran codes for solving an unsteady electro-osmotic flow around a pair of electrodes, receiving DC, attached to the top and the bottom walls of a two-dimensional cavity. We developed a module of Fortran programs for solving the ion-transport equations as well as the Poisson equations for the potential to be used in coupling with the CFX. We present how the developed codes are applied to solving the transient DC electro-osmotic flow problem within a simple cavity. We also address various problems encountered during the development process and explain why such problems are raised.

• Biomedical Science Letters
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• v.15 no.1
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• pp.73-80
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• 2009

Bloodstream infections (BSI) are caused by planktonic microorganisms, sometimes leading to serious infections such as bacteremia and sepsis. BSI occurs more frequently to the patients wearing the central venous catheter (CVC). The ciprofloxacin-incorporated CVC (CFX-CVC) has been reported previously to possess antimicrobial activity. In this study, the antibacterial activity of CFX-CVC and its mechanism against planktonic BSI cells were explored by using the shake flask test and by examining the release rate of 260 nm-absorbing substances from the bacterial cells indicative of the membrane damage of the bacterial cells. CFX-CVC reduced more than 99.9% of the viable planktonic BSI cells demonstrating its potent antibacterial activity. It provoked bacteriolysis causing leakage of a large amount of 260 nm-absorbing materials from the planktonic bacterial cells like S. aureus and E. coli. These results provide evidence that the antibacterial activity of CFX-CVC came from the inhibition of the stability of the planktonic bacterial cells.

• Biomedical Science Letters
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• v.10 no.3
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• pp.245-251
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• 2004

Microbial infection provokes one of the most serious complications to the patients with indwelling catheters. Ciprofloxacin (CFX) was added into the catheter materials (polyurethane or silicone) during the manufacturing process to avoid the microbial infection. Efficacy of the catheters containing CFX was investigated by using the in vitro zone of growth inhibition test method. The catheters made of polyurethane or silicone exhibited a strong antimicrobial activity against the major catheter-related microorganisms (S. aureus, S. epidermidis, P. aeruginosa and E. coli), when CFX was incorporated into the catheters. Fetal bovine serum (FBS) did not affected antimicrobial activities of the polyurethane catheters with CFX loading of 0.5 and 1.0％ (W/W) against S. aureus and S. epidermidis. However, the polyurethane catheters with 1.0％ (W/W) of CFX loading showed a significantly (P<0.05) reduced antimicrobial activity against E. coli when the catheters were exposed to FBS. Silicone catheters with 1.0 and 1.5％ (W/W) of CFX loading demonstrated effective antimicrobial activity against S. epidermidis for at least 2 weeks. These results suggest that the use of catheters containing ciprofloxacin could be effective in preventing catheter-related infections.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.10
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• pp.831-842
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• 2015

An optimization process was developed to improve mixed-flow pump performance. The optimization process was combined with CFX (a computational fluid dynamics (CFD) code) and HEEDS (an optimization code). CFX is a widely used CFD software for turbo machinery, whereas HEEDS, which uses the SHERPA algorithm, is a newly introduced optimization code. HEEDS can use a large number of optimization variables; thus, it is possible to effectively consider interaction effects. In this paper, an impeller model, which is already optimized with design of experiments (DOE), is used as the base model. The optimization process developed in this paper shows an improved design within an acceptable timeframe.

• Proceedings of the Korean Nuclear Society Conference
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• 2001.10a
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• pp.144.2-144
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• 2001

• The KSFM Journal of Fluid Machinery
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• v.15 no.5
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• pp.37-41
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• 2012

High-efficiency and low-noise axial flow fan is developed by combining the FanDAS, a computerized axial fan design/performance analysis system, and CFD software(CFX). Based on fan design requirements, FanDAS conducts 3-D blade geometry design, quasi-3D flow/ performance analyses and noise evaluation by using through-flow analysis method and noise models for discrete frequency and broadband noise sources. Through the parametric studies of fan design variables using FandDAS, preliminary and baseline design is achieved for high efficiency and low noise fan, and then can be coupled with a CFD technique such as the CFX code for constructing final and optimized fan design. The FanDAS-CFX coupled system and its design procedure are applied to actual fan development practice. The FanDAS provides an optimized 3-D fan blade geometry, and its predictions on the performance and the noise level of designed fan are well agreed with actual test results.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.582-586
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• 2012

본 연구에서는 ANSYS CFX 모형을 이용하여 임의형상 파샬플륨 내에서의 유동모의 및 해석을 수행하였다. 상류경계조건으로 파샬플륨 상류 2m 지점을 기점으로 하여 상류수위를 0.2, 0.25 그리고 0.3m로 변화시켰으며, 하류경계조건은 상류수위의 0.5, 0.8 그리고 0.9로 변화시키면서 모의를 수행하였다. 모의된 결과는 수리모형실험으로부터 측정된 결과와 FLOW-3D 모형에 의한 모의결과와의 비교를 통해 검증하였다. 또한, 격자 시스템의 조밀도 정도(T-1, T-2, T-3, T-4)에 따른 유동변화 양상을 분석하였다.

• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.283-284
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• 2004