• Title/Summary/Keyword: CFA-001

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Antigenicity Study of CFA-001, cefazolin, a cephalosperin Derivative Produced by an :Enzymatic Semisynthesis

  • Park, Jong-Il;Jeong, Tae-Cheon;Kim, Hyoung-Chin;Han, Sang-Seop;Roh, Jung-Koo;Kim, Jeong-Hwan;Jeon, Yeong-Joong;Kim, Dal-Hyun;Kim, Je-Hak;Park, Kwan-Ha
    • Biomolecules & Therapeutics
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    • v.5 no.1
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    • pp.48-52
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    • 1997
  • The antigenic potential of CFA-001, cefazolin, a cephalosporin derivative produced by an enzy-matic semisynthesis, was determined in Hartley guinea pigs. A battery of tests employed consisted of active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA), and indirect hemagglutination test (IHA). The results were as follows: 1) In ASA, no signs attributable to anaphylaxis was observed in guinea pigs sensitized with CFA-001, whereas OVA-sensitized animals induced severe anaphylactic symptoms; 2) guinea pigs did not produce antibodies against CFA-001 when sensitized with or without Freund's complete adjuvant (FCA) in homologous PCA tests. Meanwhile, antibodies against ovalbumin (OVA) were clearly detected; 3) No CFA-001-specific hemagglutination was observed in the IHA using sera obtained from CFA-001- sensitized guinea pigs. These results suggest that CFA-001 has no antigenicity potential in guinea pigs.

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Development of a Reward Scale for Hospital Nurses (병원간호사의 보상 측정도구 개발)

  • Kim, Sun Hee;Kim, Eun-Young
    • Journal of Korean Academy of Nursing
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    • v.53 no.5
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    • pp.525-537
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    • 2023
  • Purpose: This study aimed to develop and test a reward scale for hospital nurses. Methods: The initial items were identified through a literature review and focus group interviews with ten hospital nurses. The content validity of the items was evaluated by ten experts. Fifty-one items were derived from the pilot survey. Four hundred eighty-eight nurses participated in the study: 248 for exploratory factor analysis (EFA) and 240 confirmatory factor analysis (CFA). Data were analyzed using item analysis, EFA, CFA, convergent validity, known-group validity, and internal consistency using IBM SPSS Statistics 29.0 and IBM SPSS AMOS 29.0. Results: The final scale consisted of 31 items and eight factors (decent wage, opportunity to grow and develop, support for special situations, various benefits, flexibility of work, job-related achievement, reflecting career and performance, and recognition), which explained 67.3% of the total variance. The eight-subscale model was validated by CFA. Convergent validity was evaluated by analyzing correlation with intention to leave (r = - .63, p < .001) and job satisfaction (r = .54, p < .001). The known-group validity was evaluated by comparing the reward scales according to age, clinical career, income level and hospital type. The scale was found to be reliable with a Cronbach's α of .89. Conclusion: Both the validity and reliability of the reward scale for hospital nurses are verified, which can enhance the understanding of the range of rewards and may assist nurse managers in establishing an effective reward system.

Does Tangible Clue influence on Perceived Risk and Overall Satisfaction? : Focused on the Customers at Family Restaurants in South Korea (유형적 근거가 지각된 위험 및 총만족에 미치는 영향 (패밀리레스토랑 고객을 대상으로))

  • Yoon, Tae-Hwan;Lee, Gang-Chun;Choi, Young-Jun
    • Culinary science and hospitality research
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    • v.21 no.5
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    • pp.38-49
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    • 2015
  • The purpose of this study was to investigate tangible clues influence on perceived risk and overall satisfaction of customers at family restaurant in South Korea. In this research overall CFA and SEM were employed to analyze the data. Tangible clues were divided to 3 factors and perceived risk to 6 factors. Tangible clue 1 'physical evidence', had negative(-) influence on financial risk(p<0.01), performance risk(p<0.01) and psychological risk(p<0.001). Tangible clue 2 'employee' affected negatively(-) time risk(p<0.001), performance risk(p<0.001), psychological risk(p<0.01) and social risk(p<0.001). And tangible clue 3 'service process' influenced negatively(-) physical risk(p<0.01), time risk(p<0.05), financial risk (p<0.001) and performance risk(p<0.01). And among customer's perceived risks, 3 factors(time risk~p<0.001, performance risk~p<0.001, social risk~p<0.001) influenced negatively(-) their overall satisfaction. Through these results, it appears that customers perceive various tangible clues and risks at family restaurants. And they are likely to satisfy or dissatisfy according to their perceived risks. As a result, food service companies need to research various customers' perceived risks as important marketing strategy, and reduce them for increase and induction of customers' satisfaction.

Accessing Factor Structure and Construct Validity of the Successful Aging Inventory (노인의 성공적 노화 측정도구에 대한 요인 구성타당도 평가)

  • Kim, Eun Joo
    • Journal of Korean Academy of Nursing
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    • v.43 no.4
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    • pp.568-578
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    • 2013
  • Purpose: The purpose of this study was to evaluate the reliability and validity of the Korean version of the Successful Aging Inventory (SAI-K) to determine its suitability for use with older Korean adults. Methods: Exploratory and confirmatory factor analyses were utilized to assess the factor structure and the construct validity of the SAI-K. First- and second-order Confirmatory Factor Analysis (CFA) were conducted to identify the most adequate model. Cronbach's alpha was used to test the reliability. Results: Using a second-order CFA, a four-factor structure was validated (${\chi}^2$=122.82, p<.001, GFI=.92, AGFI=.88, SRMR=.06 RMSEA=.07, 90% CI=.05-.09, CFI=.93). The four-factor SAI-K showed reliable internal consistency with a Cronbach's alpha for the total scale of .86. Conclusion: The four-factor, 13-item SAI-K showed satisfactory reliability and validity and, thus, has the potential to be an appropriate instrument for measuring successful aging in older Korean adults.

Construct Validity of the Life Transition Scale for Parents of Children with Autism (자폐성장애 아동 부모의 삶의 전환과정 측정도구에 대한 구성타당도 평가)

  • Lee, Ae Ran;Hong, Sun Woo;Ju, Se Jin
    • Journal of Korean Academy of Nursing
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    • v.44 no.5
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    • pp.563-572
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    • 2014
  • Purpose: The study was done to identify the construct validity and reliability of the life transition scale (LTS) for parents who have children with autism. Methods: Exploratory factor analysis (EFA) and confirmative factor analysis (CFA) were conducted to identify the most adequate measurement model for structural validity. Convergent validity and discriminant validity were also conducted for structural validity. Data were collected from 208 parents through self-reported questionnaires and analyzed with SPSS/WIN 15.0 and AMOS 20.0 version. Results: A four factor-structure was validated (${\chi}^2$=541.23, p<.001, GFI=.82, RMSEA=.07, IFI=.89, CFI=.89, PNFI=.73, Q (${\chi}^2/df$)=2.20) at the 3rd order of EFA and CFA, and factors were named as denying, wandering, despairing, and accepting. Both convergent and determinant validity for LTS were 100%. Cronbach's alphas for the reliability of each structure were .77-.90 and .83 for total structure. Conclusion: The four structures, 24-item instrument showed satisfactory reliability and validity. LTS has the potential to be appropriate for assessing the transition process of life for parents who have children with autism and provides basic directions for differentiated support and care at each stage.

Verification for Structural Modeling between Servant and Transformational Leadership, Organizational Citizenship Behavior, and Organizational Performance of Private Security Organizations (민간경비 조직의 서번트・변혁적 리더십, 조직시민행동, 조직성과 간의 구조모형 검증)

  • Jung, Sung-Sook
    • Korean Security Journal
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    • no.57
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    • pp.205-230
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    • 2018
  • The purpose of this study is to examine the structural model between servant - transformational leadership, organizational citizenship behavior and organizational performance of private security organizations. The security guards working in private security companies in Seoul and Gyeonggi - do were selected as population, random sampling method. The survey was conducted from September 1, 2016 to November 30. Accoridng to the purpose of the study, this study conducted factor analysis(EFA/CFA), reliability analysis, convergence and discriminant validity analysis, and covariance structure analysis using SPSSWIN 21.0 and AMOS 21.0. The conclusions of this study are as follows. First, servant leadership has a positive (+) effect (${\beta}=.406$) on organizational citizenship behavior statistically at .001 level. Second, transformational leadership has a positive (+) effect (${\beta}=.373$) on organizational citizenship behavior statistically at .001 level. Third, organizational citizenship behavior has a positive (+) effect (${\beta}=.615$) on organizational performance statistically at .01 level. Fourth, servant leadership does not affect the organizational performance statistically (${\beta}=.211$). Fifth, transformational leadership does not affect the organizational performance statistically (${\beta}=.058$). Sixth, organizational citizenship behavior has statistically positive (+) mediation effect (${\beta}=.249$) in the relationship between servant leadership and organizational performance. Seventh, organizational citizenship behavior has statistically positive (+) mediating effects (${\beta}=.230$) on the relationship between transformational leadership and organizational performance. Innovation and Improvement of National Emergency Management System in Korea.

Development and Validation of a Self-control Competency Scale for Late-school-aged Children

  • Jin, Bo Kyoung;Ahn, Hye Young
    • Child Health Nursing Research
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    • v.26 no.4
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    • pp.411-421
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    • 2020
  • Purpose: The aim of this study was to develop a self-control competency scale for school-aged children and to confirm its reliability and validity. Methods: This study involved methodological research to verify the reliability and validity of a self-control competency scale for school-aged children. Data were collected from 438 students in the fifth and sixth grades of elementary school. Results: The self-control competency scale was composed of 13 items and six subscales (control of relationship with one's teacher, problem-solving, peer empathy, control of relationships with one's peers, impulse control, and emotional control). The internal consistency reliability of the scale was evaluated using Cronbach's α, which was .83 for the entire scale and ranged from .65 to .76 for the subscales. The model of six subscales was validated by CFA (CMIN/df=1.977; p<.001, GFI=.94, SRMR=.050, RMSEA=.065, IFI=.95, TLI=.93, CFI=.95). Concurrent validity was evaluated by comparing this scale to the scale developed by Nam and Ok (2000), and a significant correlation was found (r=.82, p<.001). On this scale, higher scores indicate higher levels of self-control among late-school-aged children. Conclusion: This scale can be used as a valid and reliable instrument for examining self-control competency among late-school-aged children.

The Impact of Airline's Creating Shared Value on Trust, Image and Loyalty (항공사 공유가치창출 행위가 신뢰, 이미지 및 충성도에 미치는 영향)

  • Kim, Kwang Il
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.28 no.3
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    • pp.1-11
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    • 2020
  • Despite the importance of Creating Shared Value(CSV), few research has been conducted to understand it. Filling in this existing void, this study was an attempt to provide a clear understanding about what triggers airline customers' decisions according to the airline company's CSV activities. Through this study, we investigated the relationship among CSV, trust, image, and loyalty. An online survey was used as a method to collect data. Through the CFA, we confirmed the adequate level of reliability and validity of the measures. The structural model was found to include an acceptable fit to the collected data. The findings from the structural analysis revealed that CSV exerted and immense on trust and image. Also, trust was significantly associated with image and loyalty while the image was highly associated with loyalty. Based on the findings presented above, implications for practitioners and researchers are stated.

The Effect of Christmas Marketing Communication on Trust and Purchase Intention in the Bakery Industry (베이커리 크리스마스 마케팅 커뮤니케이션이 신뢰, 구매의도에 미치는 영향: 뚜레쥬르와 파리바게뜨 광고를 중심으로)

  • Seo, Kyung-Hwa;Lee, Soo-Bum
    • Culinary science and hospitality research
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    • v.19 no.3
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    • pp.57-72
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    • 2013
  • This study carried out an empirical analysis on the long-term effects of a marketing communication strategy used as a means of promotion(advertisement, free gift) of Christmas cake despite its high costs. Such verification results were considered to provide as important core elements for successful management in the bakery industry. By utilizing SPSS and AMOS, exploratory factor analysis(EFA) and confirmatory factor analysis(CFA) were conducted for the validity of the measurement items, and Structural Equation Model(SEM) was performed to verify the hypothesis. The analysis result is as follows. First, advertisement attribute(${\beta}$=0.269, t=4.512, p,<0.001) and free gift attitude(${\beta}$=0.293, t=5.043, p<0.001) had a positive influence on trust. Second, trust had a positive influence on purchase intention(${\beta}$=0.513, t=8.677, p<0.001). Third, advertisement attribute(${\beta}$=0.104, t=1.966, p,<0.05) and free gift attitude(${\beta}$=0.204, t=3.817, p<0.001) had a positive influence on purchase intention. Lastly, advertisement attitude appeared different by advertisement types(actors and animation), and ads with an actor were evaluated high than animation ads. Also, gift attitude appeared different by gift types(speaker doll/character hat and turtleneck muffler), and a turtleneck muffler was evaluated high than a speaker doll or a character hat.

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Three-Dimensional Computational Flow Analysis on Meteorological-Tower Shading Effect (풍황탑 차폐영향 분석을 위한 3차원 전산유동해석)

  • Rhee, Hui-Nam;Kim, Tae-Sung;Jeon, Wan-Ho;Kim, Hyun-Goo
    • Journal of the Korean Solar Energy Society
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    • v.33 no.1
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    • pp.1-6
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    • 2013
  • It is difficult to avoid measurement errors caused by the shading effect of the meteorological tower, which is used for wind resource assessment according to the IEC Standard. This paper presents a validation of the computational flow analysis results by comparing the results with the wind tunnel experiment conducted for Reynolds numbers in the $10^4$ to $10^5$ range, for the preparation of a database for use in an automatic method of correcting met-tower shading errors. A three-dimensional simulation employing the MP (Modified Production) $k-{\varepsilon}$ turbulence model predicted a wind speed deficit in the wake region according to minimum wind speed ratio, within an MAE (Mean Absolute Error) of 2.4%.