• Journal of Chest Surgery
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• 제44권5호
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• pp.373-376
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• 2011

Lymphangiohemangiomas of the mediastinum are exceedingly rare and few cases have been published in the English literature. This report may be the only reported case in which lymphangiohemangiomas were found bilaterally. We report a case of a 7-year-old boy with an incidental finding of an abnormal mediastinal shadow on a chest X-ray. The chest CT showed a large mass in the left superior mediastinum and another in the right posterior mediastinum. The left mass had anomalous venous channels connected to the left innominate vein, and the right mass to the left atrium. We performed an excision of the mass in the left side first and then the right side one month later. Anomalous venous channels were dissected carefully and ligated. There were no complications and no signs of recurrence 30 months after the operation.

• Journal of Chest Surgery
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• 제21권4호
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• pp.787-792
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• 1988

Esophageal duplication constitute about 10% of all the mediastinal tumor and relatively rare condition. We have experienced one case of esophageal duplication which was found 2 years previously by radiologic study of chest, as mediastinal mass, in 37 years old male. He had neither clinical manifestations nor physical findings leading to the surgical discovery of the duplication. During the last 2 years, the size k location of the mass were stationary in character. Operative therapy of complete excision performed without surgical complication. On microscopic study, the lining cell of inner wall of cyst. Noted pseudostratified ciliated columnar epithelium with smooth muscle.

• Mass Spectrometry Letters
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• 제9권3호
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• pp.67-72
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• 2018

Alkaline phosphatase (AP) is a membrane-bound glycoprotein that is widely distributed in the plasma membrane of cells of various organs and also found in many organisms from bacteria to humans. The complete amino acid sequence and three-dimensional structure of human placental alkaline phosphatase have been reported. Based on the literature data, AP consists of two presumptive glycosylation sites, at Asn-144 and Asn-271. However, it only contains a single occupied N-linked glycosylation site and no occupied O-linked glycosylation sites. Hydrophilic interaction chromatography (HILIC) has been primarily employed for the characterization of the glycan structures derived from glycoproteins. N-glycan structures from human placental alkaline phosphatase (PLAP) were investigated using HILIC-Orbitrap MS, and subsequent data processing and glycan assignment software. 16 structures including 10 sialylated N-glycans were identified from PLAP.

• 대한기계학회논문집B
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• 제26권7호
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• pp.937-944
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• 2002

An experimental study has been conducted to investigate the heat/mass transfer characteristics within a square film cooling hole with asymmetric inlet now condition. The asymmetric inlet now condition is achieved by making distances between side walls of the secondary now duct and the film cooling hole different; one side wall is $2D_h$ apart from the center of the film cooling hole, while the other side wall is $1.5D_h$ apart from the center of the film cooling hole. The heat/mass transfer experiments for this study have been performed using a naphthalene sublimation method and the now field has been analyzed by numerical calculation using a commercial code. Swirl now is generated at the inlet region and the heat/mass transfer pattem with the asymmetric inlet now condition is changed significantly from that with the symmetric condition. In the exit region, the effect of mainstream on the inside hole now is reduced with the asymmetric condition. The average heat/mass transfer coefficient is higher than that with the symmetric condition due to the swirl now generated by the asymmetric inlet condition.

• 천문학회보
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• 제38권2호
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• pp.60.1-60.1
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• 2013

We study tidal disruption and subsequent mass fallback process for stars approaching supermassive black holes on bound orbits, by performing three dimensional Smoothed Particle Hydrodynamics simulations with a pseudo-Newtonian potential. We find that the mass fallback rate decays with the expected -5/3 power of time for parabolic orbits, albeit with a slight deviation due to the self-gravity of the stellar debris. For eccentric orbits, however, there is a critical value of the orbital eccentricity, significantly below which all of the stellar debris is bound to the supermassive black hole. All the mass therefore falls back to the supermassive black hole in a much shorter time than in the standard, parabolic case. The resultant mass fallback rate considerably exceeds the Eddington accretion rate and substantially differs from the -5/3 power of time. We also show that general relativistic precession is crucial for accretion disk formation via circularization of stellar debris from stars on moderately eccentric orbits.

• 방사선산업학회지
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• 제17권2호
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• pp.127-134
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• 2023

Pharmacokinetic (PK) data provide pivotal information in drug development, and they are usually first studied in the preclinical stage using various animals. However, quite often, animal PK data may not match with human PK, especially in metabolites. Thus, most regulatory agencies in the world make it mandatory to obtain metabolite information using ¹⁴C radiolabeled drug in human for small molecule drug candidates. However, such studies are expensive and time consuming and they are usually done at the end of Phase II trials using ~3.7 MBq of ¹⁴C labeled drug in a limited number of human subjects. Introduction of accelerator mass spectrometry (AMS) in this kind of study has revolutionized it. Since AMS can measure ¹⁴C level as close as natural abundance, it can quantify the amounts of ¹⁴C labeled drugs and their metabolites produced in human body that consumes less than the amount of 0.0037 MBq of ¹⁴C labeled drug, a very safe level of radioactive dose in human. Therefore, it is now possible to conduct human ¹⁴C studies safely in early clinical trials without spending hefty amount of money and time. Korea Radioisotope Center for Pharmaceuticals(KRICP) at Korea Institute of Biological and Medical Sciences(KIRAMS) has established an AMS facility in 2018, housing a 0.5MV AMS manufactured at the US National Electrostatics Corps (NEC). The AMS instrument has been validated using various standard samples that have been prepared at Lawrence Livermore National Laboratory in the US, a worldly reputable provider of AMS standards. In this paper, we present a mass balance study for acetaminophen in rats using AMS and prove that the study results are equivalent with those of literature, which shows the AMS facilities at KRICP has successfully installed and be ready to be used in the various PK studies using ¹⁴C labelled compounds for new drug development.

• Membrane and Water Treatment
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• 제4권3호
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• pp.191-202
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• 2013

The application of ultrafiltration operation to the dialysis in countercurrently parallel-flow rectangular membrane modules was investigated. The assumption of uniform ultrafiltration flux was made for operation with slight concentration polarization and declination of transmembrane pressure. Considerable improvement in mass transfer is achievable if the operation of ultrafiltration is applied, especially for the system with low mass transfer coefficient. The enhancement in separation efficiency is significantly increased with increasing ultrafiltration flux, as well as with increasing the volumetric flow rates. Furthermore, increasing the volumetric flow rate in retentate phase is more beneficial to mass transfer than increasing in dialysate phase.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집B
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• pp.14-21
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• 2001

An experimental study has been conducted to investigate the heat/mass transfer characteristics within a square film cooling hole with asymmetric inlet flow conditions. The asymmetric inlet flow condition is achieved by making distances between side walls of secondary flow duct and film cooling hole different; one side wall is $2D_h$ apart from the center of film cooling hole, while the other side wall is $1.5D_h$ apart from the center of film cooling hole. The heat/mass transfer experiments for this study have been performed using a naphthalene sublimation method and the flow field has been analyzed by numerical calculation using a commercial code. Swirl flow is generated at the inlet region and the heat/mass transfer pattern with the asymmetric inlet flow condition is changed significantly from that with the symmetric condition. At the exit region, the effect of mainstream on the inside hole flow is reduced with asymmetric condition. The average heat/mass transfer coefficient is higher than that with the symmetric condition due to the swirl flow generated by the asymmetric inlet condition.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2009년도 9th International Meeting on Information Display
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• pp.250-253
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• 2009

Effective methods for monitoring the quality of polycrystalline silicon (poly-Si) films are discussed. Raman spectroscopy is typically used to determine crystallinity of poly-Si, but this method has limitations for data gathering on large substrates for mass production of poly-Si TFT backplanes. Spectroscopic ellipsometry is proposed as an alternative for fast and simple estimation of poly-Si quality on large substrates. By using both ellipsometry and Raman spectroscopy, it is possible to determine whether the quality and uniformity of the poly-Si films meet the criteria required for mass production of TFT backplanes for AMOLED panels.

• 대한세포병리학회지
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• 제8권1호
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• pp.62-68
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• 1997

Acinic cell carcinoma is a slow-growing solid neoplasm of salivary gland. Although their cytological and histological finding is bland-looking, their biological behavior is unpredictable. We experienced two cases of acinic cell carcinoma of the salivary gland diagnosed by fine needle aspiration biopsy and confirmed by tissue examination. They showed different clinical courses. We compared their cytologic and histologic findings. The first case was a right preauricular mass in a 58 year-old female of 3 years duration. The cytologic smear revealed sheets or small clusters of monotonous cells mimicking normal serous acinar cells with little cellular pleomorphism. She underwent superficial parotid lobectomy. The tumor was a well demarcated 1.5cm sized nodular mass without infiltration into surrounding parenchyme. The second case was a left submandibular mass in a 23 year-old male of 4 years duration. The smear showed more severe pleomorphism of the tumor cells than those of previous case. Excisional biopsy was done. The excised tumor was $5.5{\times}3.5{\times}3cm$ sized multilobulated solid mass with invasion into surrounding parenchyme. The tumor recurred after 20months, thus total excision of the mass and modified radical neck dissection was carried out. From the above findings, cytologic atypism, infiltrative growth pattern and type of initial therapy may be correlated with biologic behavior.