• 제목/요약/키워드: CEN

검색결과 136건 처리시간 0.029초

Determination of HER2 Gene Amplification in Breast Cancer using Dual-color Silver Enhanced in situ Hybridization (dc-SISH) and Comparison with Fluorescence ISH (FISH)

  • Unal, Betul;Karaveli, Fatma Seyda;Pestereli, Hadice Elif;Erdogan, Gulgun
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권10호
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    • pp.6131-6134
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    • 2013
  • Background: The two basic methods that are currently accepted to identify the HER2 status are immunohistochemistry and flyorescence in situ hybridization (FISH). The aim of this study was to perform the dual-color silver in situ hybridization (dc-SISH) technique as an alternative to FISH. Materials and Methods: A total of 40 invasive breast carcinoma cases were assessed for HER2 gene amplification by FISH and dual-color SISH. Results: Significant correlation was found in the HER2 expression results obtained with the two approaches (p=0.001, p<0.05). The concordance rate was 92.3%. Conclusions: Foutine practical use of the dc-SISH method, which is much easier to apply, score, and evaluate, has many advantages. HER2 and CEN17 status can be evaluated simultaneously with the newly developed "Dual-Color Probe". All these specifications and the reliable results obtained support the widespread use of SISH technique in clinical practice.

한국유고와 중국고습의 보편성과 특수성에 관한 연구 (The Universality and Uniqueness of Korean you-Go and Chiness You-Go(유.고 an upper grment-a pair of trousers) and Chiness You-Go(유.고))

  • 김미자
    • 복식
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    • 제33권
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    • pp.73-88
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    • 1997
  • In old Korea from the 4th century of 6th cen-tury the lapels of You and upper garment folded slightly. It had tight sleeves and its length was not long reaching to the hips. but from the 7th century the sleeve of You became wider and its length became longer, Chinese You folded very deeply across the breast and its sleeve was tight. The length of Chinese You was short too strectching out to the hips. From the 5th century the sleeve of the Chinese You became wider Chinese trousers with wide crotch appeared in the 4th century during the time when Ezst Jin Dyn-asty ruled China. The upper garments with the wide sleeve was common by the 7th century in China. What is specially noteworthy is that Short-dalnyung appeared in the 5th ∼6th century. In old Korea strings were used to tie the bottoms of the trousers. Trousers with tight crotch did not need the strins. korean trousers with wide lines were narrower than the Chinese trousers at the bottom and it was not necessary to use the strings for people to put them on In China there were both of wide trousers and tight trousers. People tied trousers around the kness with the strings in the formal places but they did not tied the trousers with the strings when they wore the ordinary clothes. Chinese trousers were very wide just like a skirt and they were much wider than wide Korean trousers.

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국내에 적합한 외부메타데이터 표준에 관한 연구 (A Study on proper domestic external metadata standards)

  • 김계현;김희두
    • 한국공간정보시스템학회:학술대회논문집
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    • 한국공간정보시스템학회 1999년도 학술회의 논문집 2권2호
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    • pp.193-200
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    • 1999
  • 본 연구는 국내의 수치지도의 효율적인 관리와 공급을 위하여 외부메타데이터 설계를 목적으로 수행되었다. 보다 효율적이고 세계표준에 부합하는 메타데이터의 표준안을 제작하기 위하여 국외의 표준화 관련 기구의 동향 분석과 함께 선진국의 메타데이터 구축사례를 분석하였으며 이와 함께 국내의 구축 사례를 조사하였다. 사용자의 요구를 최대한 수용하기 위하여 대표적인 사용자 기관인 국립지리원의 메타데이터 관련 자료를 최대한 수집하여 실무자의 의견을 바탕으로 항목별로 분류를 하였으며, 데이터의 유형별 중요도를 부과하였다. 이러한 기존 자료의 분석을 바탕으로 외부메타데이터의 설계안을 도출하였으며 ISO의 표준안을 최대한 수용하는 표준메타데이터를 제시하였다. 제시된 표준안은 향후 ISO와 CEN 등 국제 표준화 관련 기구의 동향을 지속적으로 갱신되어야 한다.

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REVIEW OF 15 YEARS OF HIGH-DENSITY LOW-ENRICHED UMo DISPERSION FUEL DEVELOPMENT FOR RESEARCH REACTORS IN EUROPE

  • Van Den Berghe, S.;Lemoine, P.
    • Nuclear Engineering and Technology
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    • 제46권2호
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    • pp.125-146
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    • 2014
  • This review aims to provide a synthesis of the knowledge generated and the lessons learned in roughly 15 years of UMo dispersion fuel R&D in Europe through a series of irradiation experiments. A lot of irradiations were also performed outside of Europe, particularly in the USA, Russia, Canada, Korea and Argentina. In addition, a large number of out-of-pile investigations were done throughout the world, providing support to the understanding of the phenomena governing the UMo behaviour in pile. However, the focus of this article will be on the irradiations and Post-Irradiation Examination (PIE) results obtained in European experiments. The introduction of the article provides a historic overview of the evolution and progress in the high density UMo dispersion fuel development. The ensuing sections then provide further details on the various phases of the development, from the UMo dispersion in a pure Al matrix through the addition of Si to the matrix to address the interaction layer formation and finally to the more advanced solutions to the excessive swelling encountered in various experiments. This review was based only on published results or results that are currently in the process of being published.

$5\~6$세기 영산강유역 고분의 성격 (The Yeongsan Basin Tomb during the 5th and 6th Centuries)

  • 이정호
    • 고문화
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    • 59호
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    • pp.35-63
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    • 2002
  • 대형옹관고분이 성행하던 5세기까지의 영산강유역은 나주 반남고분군을 정점으로 한 정치체로 발전하나 그 결속력은 비교적 느슨한 한계에 머물고 있었다. 그리고 5세기 말을 즈음한 시기에 나주 반남지역을 제외한 광주, 함평, 영광, 해남 등지의 주변지역에서 횡혈식석실분과 함께 전방후원형고분이라는 백제 및 일본-왜-적인 묘제들이 토착요소들과 함께 복합되어 나타난다. 이는 반남중심의 통치체제가 붕괴되고 각지의 군소수장세력이 동시다발적으로 이탈되어가는 상황을 보여준다. 이처럼 반남세력의 통치력이 붕괴된 이유로는 백제가 고구려에게 패배하고 한성유역을 상실하는 등 급격히 쇠퇴함에 따라 반남고분 세력의 배후기반이 약화되었기 때문이다. 또한 대형옹관고분이 독자적인 1인의 분묘로 발전하지 못하였던, 비교적 느슨한 통치체제도 지배력의 붕괴를 가중시키는 요소 중 하나였을 것이다. 결국 영산강유역의 고대사회는 반남중심의 통치력의 와해와 더불어 군소수장의 세력재편을 위한 경쟁이 각지에서 일어나고 이 경쟁이 미처 완결되지 않은 상태에서 백제의 정국안정, 지방에 대해 적극적인 통치정책에 의해 개별적으로 백제의 지방관화 하였던 것으로 보인다.

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Asymmetric Light curves of Contact and Near-Contact Binaries

  • ;강영운
    • 천문학회보
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    • 제37권2호
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    • pp.143.1-143.1
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    • 2012
  • We attempt to investigate the main reason of the asymmetrical light curves of contact and near-contact eclipsing binary base on the hypothesis that cool spot was produced on late type star while hot spot was produced from transferred material from their companion star hitting surface. We select 7 eclipsing binary systems which showed asymmetric light curves and mass transfer. Period variation and mass transfer rate were obtained from O-C diagram. Radial velocity curves and light curves of those 7 eclipsing binary system were adopted from available literature in order to obtain the absolute dimension. For four contact eclipsing binary system (AD Phe, EZ Hya, AG Vir and VW Boo), their component stars belonged to spectral type G to K was fitted by cool spot model. While the other two near-contact systems (RT Scl and V1010 Oph) and one contact system (SV Cen) was fitted by cool spot model. The densities of the materials are adopted from stellar model which calculate by stellar structure code. The calculated spot temperature turns out to agree with the photometric solution but there are no correlate between period variation rate and type of spot.

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한국의 개고기 식용의 역사와 문화 (Dog Meat Eating History and Culture in Korea)

  • 안용근
    • 한국식품영양학회지
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    • 제12권4호
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    • pp.387-396
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    • 1999
  • Dog meat was begun to be edible by the Chinese, Japanese, the French, Belginan, German Philippines Vietnamese, North-Americans African-Indians Canadian-aborigines Alaskan aborigines including Kor-eans. According to the record, Korea has a long history to have eaten dog meat from the era of Sam-kug(three kingdoms BC 57∼AC 668) and so there are numerous languages proverbs, and customs re-lated to the dog meat. Over the long history there have been many records and recipes about the edib-leness of dog meat. But at present time only the way of cooking such as Bosintang(a soup) Suyuk(a boiled meat) Duruchighi(boiled meat added spice and slightly roasted) Muchim(boiled meat added by spice and mixed) Gaesoju(an extract) Jeongol(boiled meat mixed with spices vegetables and water on the pot) remains. Koreans eat dog meat following the traditional customs n the Boknal(hottest day in summer). Also the areas of Buyo. Sochon, Boryong adn Chongyang of Chungnam province and the ad-jacent areas like Kongju, Iksan, and Nonsan have customs to kill the dog and offer dog meat to the gue-sts in time of small or big occasions such as funeral ceremony Hoigap(anniversary of one's 60th birth-day) and one's birthday. This range of customs is expanding larger and larger. These areas are the cen-ter of past Baekche(BC 57∼AC 660). In spite of this it is unreasonable, and excessive action for foreig-ner to fine fault with the dog meat or Korean food culture.

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A Novel Iron(III) Complex with a Tridentate Ligand as a Functional Model for Catechol Dioxygenases: Properties and Reactivity of [Fe(BBA)DBC]$ClO_4$

  • 윤성호;이호진;이강봉
    • Bulletin of the Korean Chemical Society
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    • 제21권9호
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    • pp.923-928
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    • 2000
  • [FeIII(BBA)DBC]ClO4 as a new functional model for catechol dioxygenases has been synthesized, where BBA is a bis(benzimidazolyl-2-methyl)amine and DBC is a 3,5-di-tert-butylcatecholate dianion.The BBA complex has a structuralfeature that iron cent er has a five-coordinate geometry similar to that of catechol dioxygenase-substrate complex.The BBA complex exhibits strong absorptionbands at 560 and 820 nm in CH3CN which are assigned to catecholate to Fe(III) charge transfer transitions. It also exhibits EPR signals at g = 9.3 and 4.3 which are typical values for the high-spin FeIII (S = 5/2) complex with rhombicsymmetry. Interestingly, the BBA complex reacts with O2 within an hour to afford intradiol cleavage (35%) and extradiol cleavage (60%) products. Surprisingly, a green color intermediate is observed during the oxygenation process of the BBA com-plex in CH3CN. This green intermediate shows a broad isotropic EPR signal at g = 2.0. Based on the variable temperature EPR study, this isotropic signalmight be originated from the [Fe(III)-peroxo-catecholate] species havinglow-spin FeIII center, not from the simple organic radical. Consequently,it allows O2 to bind to iron cen-ter forming the Fe(III)-superoxide species that converts to the Fe(III)-peroxide intermediate. These present data can lead us tosuggest that the oxygen activation mechanism take place for the oxidative cleavingcatechols of the five-coordinate model systems for catechol dioxygenases.

상호교류 헬스케어시스템을 위한 사용자정의 온톨로지 매핑 (Customized Ontology Mappings for Data Interoperability among Healthcare Systems)

  • 와자하트 알리 칸;마크불 후세인;무하마드 아프잘;이승룡;정태충
    • 한국정보처리학회:학술대회논문집
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    • 한국정보처리학회 2013년도 춘계학술발표대회
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    • pp.470-471
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    • 2013
  • Accuracy of mappings is the key for achieving true interoperability among different healthcare systems. The initial step towards interoperable healthcare systems is compliancy with healthcare standards (HL7, openEHR, CEN 13606). Ontologies for these standards are developed that require ontology matching to generate generalized ontology mappings. Organizations conform to specific concepts of different standards based on their requirements. This step is called as conformance claims and is based on Personalized-Detailed Clinical Model. It invalidates some of the generalized mappings because of non-conformed concepts and leads to the necessity of the proposed technique of customized ontology mappings. These customized ontology mappings compliment the generalized ontology mapping to increase the level of accuracy of mappings and thus achieving data interoperability. The proposed system ensures quality of care to patients by timely delivery of healthcare information.

고기능 RFID 태그를 위한 동적 ID 할당 프로토콜 (A Dynamic ID Allocation Protocol for High-Performance RFID Tag)

  • 박진성;최명렬
    • 정보보호학회논문지
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    • 제15권6호
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    • pp.49-58
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    • 2005
  • 본 논문에서는 상호인증을 통하여 RFID에 안전하게 동적으로 ID를 부여하는 프로토콜을 제안하였다. 현재 RFID 태그의 보안을 위해 제안된 대부분의 방식들은 계산 능력과 메모리 저장 능력에 많은 제약을 가지고 있는 저가형 태그에 초점을 맞추고 있다. 본 논문에서 제안한 프로토콜은 현재의 저가형 태그보다 훨씬 높은 성능을 가지는 고기능형 RFID가 수행할 수 있도록 대칭형 암호화 알고리듬을 기반으로 동적으로 ID를 부여함으로써 RFID의 보안 취약점들은 물론, ID에 의한 추적과 위조를 방지할 수 있는 방법이다.