• BMB Reports
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• v.54 no.6
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• pp.329-334
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• 2021

Collagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effective domain (CED) which promotes collagen type I synthesis. Recombinant hCOL1A1-CED effectively induces cell proliferation and collagen biosynthesis in HDFs, as well as increased cell migration and elastin production. Based on these results, hCOL1A1-CED may be explored further for its potential use as a preventative agent against skin aging.

• Proceedings of the Zoological Society Korea Conference
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• 1997.10b
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• pp.83-83
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• 1997

No Abstract, See Full Text

• Proceedings of the Korean Information Science Society Conference
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• 1999.10c
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• pp.369-374
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• 1999

The problem of bandwidth allocation and routing in VP based ATM networks was studied. A priori reservation of resources for VP's reduces the statistical multiplexing gain, resulting in increased Call Blocking Probability (CBP). The focus of this study is on how to reduce CBP by the efficient bandwidth allocation and routing algorithms. Equivalent capacity concept was used to calculate the required bandwidth by the call. and the effect of traffic dispersion was explored to achieve more statistical gain. A cost-effective traffic dispersion routing algorithm, CED, was designed. The algorithm finds the optimal number of dispersion paths for a call, where the gain balances the dispersion cost. Simulation study showed that CED could significantly reduce the CBP.

• Journal of Electrical Engineering and Technology
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• v.8 no.4
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• pp.744-751
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• 2013

In this paper, Secant method is proposed to solve multi area economic dispatch (MAED) problem. Generator limits of all generators in each area are calculated at given area power demands plus export (or import) using secant method and the generator limits of all generators are modified as modified generator limits. Central economic dispatch (CED) problem is used to determine the output powers of all generators. Here, Secant method is applied to solve the CED problem. The proposed approach has been tested on two-area (two generators in each area) system and four-area (four generators in each area) system. It is observed from various cases that the proposed approach provides optimally best solution in terms of cost with tie line loss with less computational burden.

• Journal of Nutrition and Health
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• v.39 no.3
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• pp.244-251
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• 2006

The purpose of this study was to observe the effects of cellulose and pectin on glucose and plasma lipid concentrations in healthy women. Eight female collage students were participated voluntarily. All subjects received a fiber-free control diet (CD), cellulose diet (CED), pectin diet (PTD) with each diet for a period of three days with a 4 day interval. The food intake of subjects were monitored every day and plasma level of glucose, triglyceride, total cholesterol were determined at last day. Blood glucose, plasma triglyceride, total cholesterol were measured at fasting state and 30, 60, 90, 120, and 180 minute after consuming each diet. Plasma glucose concentrations (AUC: Area Under the Curve) of pectin diet was $122.7{\pm}4.0mg/dl$ and that of cellulose diet was $147.6{\pm}8.4mg/d$, but they were significantly lower than in comparison with those of control diet ($197.1{\pm}11.6mg/dl$) (p<0.05) Plasma triglyceride concentrations of the CED ($-83.9{\pm}22.2mg/dl$) PTD ($-9.7{\pm}26.1mg/dl$) showed gradual decrease after each test diet feeding but not significantly different in each dietary fiber added diet (p<0.05). Plasma cholesterol concentrations of the CD was not significantly different in PTD, but PTD was significantly lower than the CED until 3 hours after consuming each test meal (p<0.05). In conclusion, in spite of total cholesterol was reduced only by pectin, glucose and triglyceride were lower than control diet in dietary fiber intake. But there were no significant differences each dietary fiber.

• Journal of Trauma and Injury
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• v.26 no.3
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• pp.198-206
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• 2013

Purpose: This study was performed to calculate and analyze the effective radiation doses from computed tomography (CT) and radiologic intervention in patients in the emergency department (ED) with trauma critical pathway (CP) activation and further to estimate the lifetime attributable risks (LARs) for the incidence of and mortality from cancers induced by the radiation dose. Methods: Through a retrospective electrical chart review of 104 injured patients who trauma critical pathway were activated from November 2012 to March 2013, we calculated effective radiologic doses by taking the product of the dose-linear product of the scan and the conversion coefficient. After a determination of the image results, we divided the patients into two groups, negative or positive, and calculated the effective dose for each group. With these results, we estimated the LARs for the incidence of and the mortality from cancers by using the table in the Biologic Effects of Ionizing Radiation (BEIR)-VII report. Results: A total of 76 patients were enrolled. The mean age was $49.0{\pm}8.5$ years. The mean injury severity score (ISS) was $12.7{\pm}8.4$. The cumulative effective dose (CED) for individual patients varied from 2.8 mSv to 238.8 mSv, and the mean was $47.6{\pm}39.9$ mSv. The CED in patients with an $ISS{\geq}16$($63.2{\pm}26.6$ mSv) was higher than that of patients whose ISS<16($33.5{\pm}23.1$ mSv) (p<0.001). The CED in patients who were treated with surgery or intervention($69.0{\pm}45.2$ mSv) was higher than that of patients who were treated conservatively($33.6{\pm}22.4$ mSv) (p<0.001). The LARs for cancer incidence and mortality were $328.5{\pm}308.6$ and $189.0{\pm}159.3$ per 100,000 people, respectively. Conclusion: The CED and the LAR for trauma CP-activated patients in the ED were significant, so efforts should be made to decrease the effective dose received by severely injured patients.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.1 no.1
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• pp.91-96
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• 1991

The key exchange idea by using a reduced binary indefinite quadratic form has been introdu-ced. This is based on the difficulty of solving the discrete logarithm problem on the class group of a real quadratic field.

• Journal of Mechanical Science and Technology
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• v.20 no.12
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• pp.2159-2167
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• 2006

In order to find out a physical quantity which controls the fatigue life of a structure and to predict the fatigue life of tires, a finite element simulation methodology to use the cracking energy density (CED) and the virtual crack closure technique (VCCT) was proposed and applied to three different tires of a similar size. CED was calculated to predict the location of a crack initiation, and VCCT was used to obtain the strain energy release rate (SERR) at the tip of an initiated crack. Finite element simulations showed that SERR oscillated in the circumferential direction with its minimum occurring just before the contact zone and its maximum occurring just after the center of the contact zone, and SERR was affected significantly by the frictional force acting on the crack surface. In addition, a durability test was conducted to measure the fatigue life of the three tires. The comparison of SERR values with the test data revealed that the fatigue life increased as the amplitude of SERR decreased or as the R-ratio of SERR increased.

• Microbiology and Biotechnology Letters
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• v.24 no.4
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• pp.408-414
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• 1996

The SecY is a central component of the protein export machinery that mediate the translocation of secretory proteins across the plasma membrane, and has been known to be rate-limiting factor of secretion in Escherichia coli. In order to study the extracellular protein secretion in Gram-positive microorganism, we have, constructed strains harboring more than one copy of the gene for SecY. Firstly, the gene, for B. subtilis SecY and its promoter region was subcloned into pDH32 and the chimeric vector was inserted into amyE locus by homologous recombination. Secondly, low copy number vector, pCED6, was also used for subcloning the secY gene and for constructing a strain which harbors several copies of secY. The KH1 cell which harbor two copies of secY on the chromosome excreted more extracellular proteins than the wild type PB2. Moreover, the KH2 cells which harbor several copies of secY in pCED6 vector excreted more extracellular proteins than the KH1 cells. Here, we found that the capacity of protein secretion is partly controlled by the number of secY and it is suggested that SecY has also an important role in protein secretion in B. subtilis, a gram positive microorganism, as like in E. coli. This will promote the use of B. subtilis as a host for the expression of useful foreign gene and excretion of precious proteins.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.45 no.5
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• pp.56-63
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• 2013

In this study, paper mill applicability of two kinds of cotton pulps which have different initial freeness, fiber length and intrinsic fiber strength were investigated. Basic properties such as CED viscosity, fiber length, and crystallinity of major two kinds of cotton pulps were analyzed, and beatability of cotton pulps and physical properties of handsheet made from two kinds of cotton pulps were compared. Laboratory beating was performed at different refining conditions such as refining loads and freenesses. Relationship between beating degree and physical properties of handsheet were compared to seek optimum condition of refining for different cotton pulps application to paper mill.