• Journal of Acupuncture Research
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• 제20권5호
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• pp.50-62
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• 2003

Objective: Bee Venom(BV) has been used for various kinds of inflammatory or painful conditions in Oriental Medicine clinics, and there publishes reports on its therapeutic effects and the probable mechanism of those therapeutic effects, where CDs and cytokines plays important role. This study investigated the influences of bee venom on the expressions of CDs and cytokines of HMC cell line Methods: In this study we analysed the expression profile of HMC cell line treated with BV of 10-2ug/ml in relation to that of HMC cell line treated with vehicle by way of CD/cytokine microarray hybridization with 342 genes on it. Results: There were no upregulated genes by more than 3 fold, while there showed some downregulated genes by less than 1/3 fold as follows: colony stimulating factor 2, CD122, IL-7, CD112, TNF-alpha, CD138, CD166, TGFbetaR2, CD42b, CD62L, CD111, interleukin 10 receptor alpha, colony stimulating factor 1(macrophage), CD38 antigen(p45), CD121a, CD33 antigen(gp67), colony stimulating factor 1 receptor, B cell linker protein (SLP65) mRNA, CD94, alanyl(membrane) aminopeptidase, immunoglobulin(CD79A) binding protein 1, CD205, CD241, CD207, CDw121b, integrin alpha L(CD11a), integrin beta 1(CD29), CD91, CD42b. Conclusions: Bee venom treatment induced downregulation of some CDs or cytokines including $TNF-{\alpha}$. IL-1R with its possible implication in an antiinflammatory action of BV. Further research on expression profile changes induced by BV treatment is expected.

• 한국항행학회논문지
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• 제27권5호
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• pp.610-620
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• 2023

4차 산업 혁명에 기반한 기술발전 및 항공사들의 고객 유치를 위한 경쟁으로 인해 항공기 인테리어 시장에 대한 관심이 증가하고 있으며, 그 일환으로 국내에서는 FAA Part.25급 민항기를 대상으로 한 CDS (Cabin Display System)이 개발되고 있다. CDS는 IDPM (Integrated Display Processing Module)로 제어되는 대형 Flexible 및 투명 OLED (Organic Light Emitting Diodes)를 활용하여 승객들에게 다양한 멀티미디어 서비스를 제공하는 시스템으로 고품질의 서비스 제공을 위해 대용량의 미디어 콘텐츠 활용이 필수적으로 요구된다. 본 논문에서는 대용량 파일들의 효율적인 Data Load Process를 수행하기 위한 새로운 방안을 제시하고 그 구현 및 성능을 다룬다. 본 연구 결과는 기존 ARINC-615A 대비 Data Load Process 개발 비용의 절감과 더불어 신뢰성 높은 대용량 파일 전송이 필요한 항공 장비의 Data Load Process 개발에 대체 적용이 가능할 것으로 기대된다.

• 동의신경정신과학회지
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• 제20권1호
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• pp.177-197
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• 2009

Objectives : Gliosis disturbs recovery of damaged astrocytes following central nervous system(CNS) injury. Gliosis relates to up-regulation of CD81 and GFAP. In glial cells at injured CNS, the expression of CD81 and GFAP is increased. It is possible that when the gliosis formation is suppressed, regeneration of oxons can occur. According to the recent study, the treatment with anti CD81 antibodies enhanced functional recovery in rats with spinal injury. So, the author studies the effect of water extract of Radix Ginseng on regulation of CD81 and GFAP with CNS injury. Methods : In the cell study, hypoxic damage was induced by CoC12. And according to Longa et al, cerebral ischemia was made by middle cerebral artery occlusion in the rat. Cross sections of rat brain were examined under microscope. MTT analysis was performed to examine cell viability, cell based ELISA, Western Blot and PCR were used to detect the expression of CD81 and GFAP. Results : The following results were obtained. 1. We found that CD81 and GFAP were decreased in hypoxic injured cells following Radix Ginseng administration. 2. We injected the extract of Radix Ginseng to the middle cerebral artery occlusion in rats, and the immunohistochemistry analysis showed that CDS1 and GFAP were decreased. Conclusions : These results show that the extract of Radix Ginseng could suppress the gliosis formation and prevent cell death, by controlling the expression of CDS1 and GFAP. Therefore, Radix Ginseng could be a useful to regenerate CNS injury.

• 대한인간공학회지
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• 제28권3호
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• pp.135-145
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• 2009

This study surveyed standardization activities of the International Standard Organization (ISO) Technical Committee 159 (TC 159) (ergonomics) in the year 2008. The subcommittee 1 (SC 1) dealing with general ergonomics principles produced one committee draft (CD). The subcommittee 3 (SC 3) dealing with anthropometry and biomechanics systematically reviewed two ISO standards issued in 2003 and 2004 respectively. The subcommittee 4 (SC 4) dealing with ergonomics of human system interaction issued 11 final draft international standards (FDIS), 3 draft international standards (DIS), 4 CDs, and 4 new work item proposals (NWIP). The SC 4 also systematically reviewed 10 international standards due on the year 2008. The subcommittee 5 (SC 5) dealing with ergonomics of the physical environment issued one FDIS, 3 CDs, and one NWIP. This paper summarized the major features of the FDIS approved by each subcommittee of TC 159 for publication in the year 2008.

• 천문학회보
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• 제37권2호
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• pp.140.1-140.1
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• 2012

We investigate properties of maser emission for 3373 O-rich AGB stars. We divide the sample stars into four different groups whether they were detected by OH, SiO and $H_2O$ maser emission or not. To understand the nature of the maser sources, we present various infrared two-color diagrams (2CDs) using IRAS, near infrared and AKARI data. For each group, we compare the positions on the various infrared 2CDs with theoretical models. We find that OH maser sources generally show higher color indices and larger dust optical depths than SiO or $H_2O$ maser sources. This could be due to differences of the mass-loss rates and/or variability which may influence the maser pumping mechanisms.

• 전기전자학회논문지
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• 제22권2호
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• pp.432-439
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• 2018

본 논문에서는 플렉시블 솔라셀의 수광면을 원통형으로 만들어 수평면상에서 균일한 수광패턴을 가지는 전방향 가시광 검출기를 개발하였다. 이 솔라셀 광검출기는 서로 다른 위치에서 입사하는 여러 개의 신호광을 동시에 검출하며, 수신부의 ASK복조기에 전력을 공급한다. 실험에서는 시분할 전송 방식을 사용하여 서로 다른 방향으로부터 입사하는 3개 신호광을 솔라셀 광검출기로 수신하였다. 각 신호광은 40 kHz의 캐리어를 사용하여 ASK 변조하였으며, 시분할 전송에 필요한 동기펄스는 실내의 조명램프에 포함된 120 Hz의 AC 신호를 Cds셀로 검출하여 같은 주기로 생성하였다. 이러한 수신구조는 가시광통신에서 $N{\times}1$ 광연결을 구성하는 데에 적합하다.

• 핵의학기술
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• 제13권1호
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• pp.51-56
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• 2009

목적 : Small-scalled PACS, Pc-based PACS로 표현되는 MicroPACS 시스템 구축에 대한 관심도가 급격하게 증가하고 있는 추세이다. MicroPACS 시스템은 PACS를 작은 규모에서 사용할 수 있도록 구성해놓은 것이고, 이 시스템을 구성하기 위해서는 DICOM viewer나 연결프로그램 등이 필요하다. 이것은 공개소스프로그램(Open Source Program)을 통해서 어느 누구나 쉽게 무료로 다운로드를 받을 수 있게 되어있다. 본 논문은 Open source program으로 MicroPACS를 직접 구성해보았고, 저장매체로서의 활용가치를 측정하기위하여 성능, 안정성 측면에서 기존의 광 저장매체(CD, DVDRAM)와 비교 분석하였다. 실험재료 및 방법 : 1. 소형 PACS를 구축하기 위해서 먼저 다음 기준에 맞는 DICOM Server Software를 검색한다. (1) 윈도우체제에서 사용가능할 것. (2) Free ware일 것. (3) PET/CT scanner와 호환되어야 할 것. (4) 사용하기 쉬워야 할 것. (5) 저장의 한계가 없어야 할 것. 2. (1) MicroPACS의 성능을 평가하기 위해 환자 1명의 Data ($^{18}F$-FDG Torso PET/CT)를 현재 Back-up장치로 쓰이는 광 저장매체(CD, DVD-RAM)와 MicroPACS에 저장하는데 소요되는 시간(Back up time)과 workstation으로 복구되기까지의 시간(Retrieval time)을 비교해 보았다. (2) PET/CT 검사를 시행했던 환자 1명의 병록번호와 검사 시행날짜를 핵의학과 직원 7명을 대상으로 알려주고 Data를 찾는데 소요되는 시간을 MicroPACS와 광 저장매체(CD, DVD-RAM)에서 각각 측정하여 비교하였다. 3. 기존의 백업장치로 쓰였던 CD들 중에서 2004년부터 2006년까지 500장을 무작위로 뽑아서 loading을 하였고 그중에서 얼마만큼의 에러가 발생하였는지를 측정하여 MicroPACS의 안정성을 비교평가하였다. 결과 : 1. Server와 DICOM viewer 기능을 갖춘 11개의 open source software 중에서 Conquest DICOM Server를 선택하였다. 2. (1) Backup과 Retrieval 시간 비교(단위 : 분)는 다음과 같다; DVD-RAM(5.13,2.26)/Conquest DICOM Server (1.49,1.19) by GE DSTE (p<0.001), CD (6.12,3.61)/Conquest (0.82,2.23) by GE DLS (p<0.001), CD (5.88,3.25)/Conquest (1.05,2.06) by SIEMENS. (2) CD ($156{\pm}46$초), DVD-RAM ($115{\pm}21$초) and Conquest DICOM Server ($13{\pm}6$초). 3. 1년간 MicroPACS에서의 데이터손실은 없었으며(0%), 500장의 CD 중에서 14개(2.8%)가 Loading하는데 실패하였다. 결론 : 현재 많은 병원에서 도입되고 있는 Full PACS를 open source software를 통하여 소규모의 PACS로 재현해 보았고, 그 결과 가능하다는 결론이 나왔다. 데이터 저장의 유용성을 평가한 결과에서 MicroPACS를 이용하는 것이 기존의 광저장매체를 사용하는 것보다 효율적이고 작업속도가 향상 된다는 것을 확인할 수 있다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 춘계학술대회
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• pp.116-116
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• 1997

Complex formation of practically insoluble dexamethasone dipropionate (DDP) with ${\beta}$-cyclodextrin (${\beta}$-CD), dimethyl-${\beta}$-cyclodextrin (DMCD), trimethyl-${\beta}$-cyclodextrin (TMCD), 2-hydroxypropyl-${\beta}$-cyclodextrin (HPCD) and sulfobutyl ether ${\beta}$-cyclodextrin (SBCD) in water was investigated by solubility method at various temperatures. Water solubility of DDP was found to be 1.78 $\mu\textrm{g}$/$m\ell$ at 37$^{\circ}C$. Propylene glycol (PG)-water cosolvent increased the solubility of DDP, but the solubilization was not sufficient (8.93 $\mu\textrm{g}$/$m\ell$ in 20% PG). The addition of CD markedly increased the solubility of DDP in water, and A$\sub$L/ type phase solubility diagrams were obtained with ${\beta}$-CD, TMCD, HPCD and SBCD, where the apparent stability constants of the soluble complexes at 25$^{\circ}C$ were determined to be 1388, 216, 1054, and 1992 M$\^$-1/, respectively. However, DMCD remarkably increased the solubility of DDP, and showed an A$\sub$P/ type diagram, suggesting that DMCD forms a soluble complex of high order with DDP. The stability constant for the DDP-DMCD complex at 25$^{\circ}C$ was determined to be 19132 M$\^$-1/. The thermodynamic parameters were calculated for the inclusion complex formation in aqueous solution. CD (1${\times}$10$\^$-2/M) remarkably decreased the partition coefficients of DDP between isopropyl myristate/water in the order of TMCD < ${\beta}$-CD < HPCD < SBCD < DMCD, and in squalane/water system in the order of HPCD < TMCD < ${\beta}$-CD < DMCD < DMCD $\leq$ SBCD. This finding represents that, in a o/w type cream, cyclodextrin complexation with DDP may result in high concentration of DDP in aqueous phase. The permeation of DDP through a cellophane membrane was highly suppressed by the addition of CD, and the degree of suppression was different among CDs, indicating that CD may control the skin permeation of DDP. The dissolution rates of solid dispersions with CDs were much faster than those of drugs alone and corresponding physical mixtures. All DDP-CD solid dispersions exceeded the equilibrium solubility. Consequently these results suggest that complex formation of DDP with CDs may provide useful means to markedly enhance the solubility, and CDs are useful in the semi-solid preparations such as creams and gels for topical application.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권4호
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• pp.293-300
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• 2001

A polyrotaxane-biotin conjugate was synthesized and its interaction with streptavidin measured using surface plasmon resonance(SPR) detection. A biodegradable polyrotaxane in which ca, 22 molecules of ${\alpha}$-cyclodextrina(${\alpha}$-CDs) were threaded onto a poly(ethylene oxide) chain(M$\sub$n:4,000) capped with benzyloxycarbonyl-L-phenylalanine was conjugated with a biotin hydorazide and 2-aminoethanol after activing the hydroxyl groups of ${\alpha}$-CDs in the polyrotaxane using N, N'-carbonyldiimidazole. The results of the high-resolution $^1$H-nyclear lmagnetic resonance($^1$H-NMR)spectra and gel permeation chromatography of the conjugate showed that ca, 11 biotin molecules were actually introduced to the polyrotaxane scaffold. An SPR analysis showed that the binding curves of the biotin molecules in the conjugate on the streptavidin-deposited surface changed in a concentration dependent manner, indicating that the biotin in the conjugate was ac-tually recognized by streptavidin. The association equilibrium constant(K$\sub$a/) of the interaction be-tween the conjugate and steptavidin tetramer was of the order 10$\^$7/. These results suggest that polyrotaxane is useful for scaffolds as a polymeric ligand in biomedical fields.

• 한국군사과학기술학회지
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• 제10권2호
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• pp.152-159
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• 2007

This paper describes the design, fabrication, and measurement of ROIC(ReadOut Integrated Circuit) for $320{\times}256$ IRFPA(InfraRed Focal Plane Array). A ROIC plays an important role that transfer photocurrent generated in a detector device to thermal image system. Recently, the high performance and low power ROIC adding various functions is being required. According to this requirement, the design of ROIC focuses on 7MHz or more pixel rate, low power dissipation, anti-blooming, multi-channel output mode, image reversal, various windowing, and frame CDS(Correlated Double Sampling). The designed ROIC was fabricated using $0.6{\mu}m$ double-poly triple-metal Si CMOS process. ROIC function factors work normally, and the power dissipation of ROIC is 33mW and 90.5mW at 7.5MHz pixel rate in the 1-channel and 4-channel operation, respectively.