• Journal of Preventive Medicine and Public Health
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• v.32 no.3
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• pp.306-316
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• 1999

Objectives: In Korea, as in most countries, there will be a sharp increase in the number of dementia patients in the near future. However basic data on dementia prevalence, which is important in defining epidemiologic characteristics and in implementing preventive strategy, are limited. This study was conducted to estimate the prevalence rate of dementia in the urban elderly aged 65 or older in Kwangmyung, Korea. Methods: A two phase design was used for case finding and case identification. In phase I, a representative sample aged 65 or older was selected and interviewed by door-to-door survey with a Korean version of the Mini-Mental State Examination (K-MMSE). In phase II, Of the 946 subjects interviewed in phase 1,356 elderly were randomly selected disproportionately according to K-MMSE score. Of these elderly, 223 (61.5%) underwent standardized clinical evaluations, including psychiatric interview, neurological examination, and neuropsychological assessment. Dementia was diagnosed by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. The diagnosis of Alzheimer's disease (AD) was made by National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and feinted Disorders Association(NINCDS-ADRDA) criteria and vascular dementia (VD) by DSM-IV. Results: The overall weighted prevalence rate of all dementia among Kwangmyung residents aged 65 or older was 12,8%(age-adjusted rate: 13,0%, 95% Confidence Interval[CI]: 10.6-15.3%). Women had much higher prevalence rate than men even when age was controlled(15.9%[95% CI 12.6-19.2%] vs 7.5%[95% CI 4.0-10.4%]), The rates of dementia were 5.2%, 12.2%, 17.0%, and 34.3% for the age groups of 65-69, 70-74, 75-79 and 80 and over, respectively. The rate of AD appeared to be slightly higher than that of VD(5.2% vs 4.8%), though not statistically significant. Most of the cases(69%) were mild dementia according to CDR(<1) in these subjects. Conclusions : These results showed that the prevalence rate of dementia among urban elderly in Korea appears to be higher than those of other Asian countries.

• BMB Reports
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• v.42 no.10
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• pp.636-641
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• 2009

The penetrating of monoclonal antibodies (mAbs) into solid tumor may be hampered by their large size. The antibody mimetics, composed of two complementarity-determining regions (CDRs) through a cognate framework region (FR), have been demonstrated to have the capacity to penetrate tumors superior to its parental intact IgG. In this study, we used CDR and FR sequences from the humanized anti-HER2 monoclonal antibody trastuzumab to design four antibody mimetics. Then these antibody mimetics were fused to human IgG Fc to generate mimetics-Fc small antibodies. One of the four mimetics-Fc antibodies binds well to HER2-overexpressing SK-BR3 cells and effectively inhibits the binding of trastuzumab. This mimetics-Fc, denoted as HMTI-Fc, was shown to be effective in mediating antibody-dependent cellular cytotoxicity and exhibit an antiproliferative effect in SK-BR3 cells. To our knowledge, the HMTI-Fc antibody shown here is the smallest fully functional antibody and may have a potential for treatment of cancer.

• Journal of agricultural medicine and community health
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• v.43 no.3
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• pp.180-190
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• 2018

Objectives: The purpose of this study is to investigate the influencing factor of the quality of life of the elderly with mild dementia in rural community. Methods: A total of 123 elderly who were managed by public health center participated. They were diagnosed as mild dementia by MMSE-DS and CDR. Data were collected during the period from May to September in 2017 by a structured questionnaire that included general characteristics, depression, dependence, comorbidity, sleep scale. Data were analyzed by t-test, ANOVA, Pearson's correlation analysis, and multiple regression analysis. Results: The quality of life was correlated significantly with depression. Depression was the factor affecting the quality of life of the elderly with mild dementia in rural community. Depression accounted for 54.0% as a variable of quality of life. Conclusion: This study was meaningful in that it directly measured the quality of life of the elderly with mild dementia is known to be difficult to measure and found meaningful results. it is necessary to identify the cause of depression and establish a linkage system between public health centers and health related organizations in the community. We suggest the need for individualized preventive intervention program and integrated psychological health service considering depression.

• The Journal of the Acoustical Society of Korea
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• v.41 no.3
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• pp.326-334
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• 2022

In this paper, we propose speech enhancement algorithm as a pre-processing for robust speech recognition in noisy environments. Auxiliary-function-based Independent Vector Analysis (AuxIVA) is performed with weighted covariance matrix using time-varying variances with scaling factor from target masks representing time-frequency contributions of target speech. The mask estimates can be obtained using Neural Network (NN) pre-trained for speech extraction or diffuseness using Coherence-to-Diffuse power Ratio (CDR) to find the direct sounds component of a target speech. In addition, outputs for omni-directional noise are closely chained by sharing the time-varying variances similarly to independent subspace analysis or IVA. The speech extraction method based on AuxIVA is also performed in Independent Low-Rank Matrix Analysis (ILRMA) framework by extending the Non-negative Matrix Factorization (NMF) for noise outputs to Non-negative Tensor Factorization (NTF) to maintain the inter-channel dependency in noise output channels. Experimental results on the CHiME-4 datasets demonstrate the effectiveness of the presented algorithms.

• The KIPS Transactions:PartC
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• v.12C no.4 s.100
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• pp.597-602
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• 2005

In this study, file size for measurement and the service system's billing data were submitted to a comparative analysis by performing a verification test on the billing system of three major mobile communication services providers, based on the wireless Internet service packet. As shown in the result of the verification test, there were some differences in the billing data due to transmission overhead, according to the network quality that is affected by the wireless environment of mobile operators. Consequently, the packet analysis system was proposed as a means of applying consistent packet billing to all service providers being compared. If the packet analysis system is added to supplement the current billing system various user requirements can be met. Billing by Packet among mobile operators and differentiated billing based on the content value are available, since the packet data can be extracted through protocol analysis by service, and it can be classified by content tape through traffic data analysis. Furthermore, customer's needs can be satisfied who request more information on the detailed usage, and more flexible and diverse billing policies can be supported like application of charging conditions to the non-charging packet handling. All these services are expected to contribute to the popularization of the wireless Internet service, since user complaints about the service charge could be reduced.