• Title/Summary/Keyword: CDP

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Ara - C유도체의 항암작용에 관한 연구 (2) : 암세포에 대한 Ara-C 유도체의 항암효과에 대한 in vitro 연구 및 독성연구

  • Lee, Hyung-Hwan;Cho, Dong-In;Ji, Yong-Hoon;Lee, Chul-Kyu;Kang, Heon;Choi, Hee-Baek;Lee, Hye-Yeol;Kim, Eun-Tae;Kanter, P.M.;Creaven, P.J.;West, C.R.
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.200-200
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    • 1994
  • Thioglycerol과 g1ycerol로부터 rac-1-S-octa-decyl-2-O-palmitoyl-1-S-thioglycerol-3-phosphate (DL -PTBA-P)와 rac -1-O-octadecyl -2-O-palmitoyl-g1ycerol-3-phosphate (DL-PBA-P)등을 합성하였고, 이들에 ara-C유도체인 ara-CMP morpholidate를 반응시켜 최종 산물인 ara-CDP-DL-PCA, ara-CDP-DL-PBA, ara-CDP-DL-PTCA 및 ara-CDP-DL-PTBA등을 합성하였다. 이들 최종 산물의 항암효과는 L1210 lymphoid leukemia, P388 leukemia등의 암세포주를 사용하여 실험하였다. 암세포인 L1210, P388 leukemia 세포의 성장에 대한ara-CDP-DL-PTBA의 시험관 내 세포성장 억제정도를 알아보기 위하여 비색법인 MTT방법을 시행하였으며, 검체의 세포성장 억제능을 비교하기 위하여 대조군으로 5-Fluorouracil (5-FU)을 사용하였다.

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Studies of antitumor activities for ara-CDP-DL-PTBA as a lead compound of anti-cancer agent.

  • Jee, Yong-Hun;Lee, Chul-Kyu;Kang, Sung-Gu;Park, Woo-Yle;Lee, Hyung-Hoan;Hong, Chung-Il;Suh, Jung-Jin
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1995.04a
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    • pp.85-85
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    • 1995
  • 전년도에 ara-C 유도체 중에서 ara-CDP-DL-PTBA가 각종 암세포주에 대한 뛰어난 항암작용이 보고된바 있으며, 이후 시료의 대량확보, Bulk Formulation 및 전임상등의 세가지 분야에 관해 연구를 수행하였다. Ara-CDP-DL-PTBA를 수용액에 현탁, 초음파분쇄후 NICOMP Analysis에 의하여 micellar solution의 입자도를 알아 본 결과 fresh prepared micelles은 11,1mm size가 88.63%이며 50,5mm가 11.37%로 나타나 평균 19,0mm가 되고, Reconstructed micells은 10.9mm size가 99.87%이며 356.1mm가 0.13%로 나타나 평균 11.0mm가 된다. Ara-C와 Ara-CDP-DL-PTBA의 대사작용을 알아본 결과, ara-C는 투여 1시간째 2,850 $\pm$ 450 pmol, 4시간째 450$\pm$190 pmol, 24시간째 30 pmol 이하로 ara-CTP의 혈중 농도가 급격히 감소하는 반면에 ara-CDP-DL-PTBA는 1시간째 650$\pm$120 pmol, 2시간째 1,800$\pm$500 pmol, 24시간째 300$\pm$90 pmol으로 ara-CTP의 혈중 농도가 서서히 감소하였다.

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Development of Code-Domain Power module for CDMA signal (CDMA 신호의 Code Domain Power 모듈 개발)

  • Lee, Young Kyo
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.4 no.1
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    • pp.17-24
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    • 2008
  • This paper describes the measurements that provide a characterization of the code-domain channels of a CDMA base station transmitter. One of the measurements, called code-domain power(CDP), provides the distribution of power in the code domain channels. This measurement can be used to verify that the various channels are at expected power levels and to determine when one code channel is leaking energy into the other code channels. We develop module of CDP measurement in the CDMA system.

The Transmissibility of the Compact Disc Player due to Temperature (온도변화에 기인한 컴팩트디스크 플레이어의 전달율)

  • Kim, Byoung-Sam;Lee, Tae-Keun
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2009.04a
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    • pp.207-211
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    • 2009
  • To investigate the vibration characteristics of compact disc player(CDP) due to excited vibration and disturbances, it is necessary to consider the transmissibility of the CDP. The disturbances as well as the temperature in the vehicle are the one of the important factors when CDP is designed. In this study, the effect on the temperature of the oil damper, which is applied to anti-vibration system of the CDP, was investigated. When the temperature was changed from -30 to 90 and the properties of the oil damper (hardness of rubber, viscosity of oil) were changed, the transmissibility was measured.

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The Transmissibility of the Compact Disc Player due to Temperature (온도변화에 기인한 컴팩트디스크 플레이어의 전달률)

  • Lee, Tae-Keun;Kim, Byoung-Sam;Chi, Chang-Heon
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.19 no.9
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    • pp.967-972
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    • 2009
  • To investigate the vibration characteristics of compact disc player(CDP) due to excited vibration and disturbances, it is necessary to consider the transmissibility of the CDP. The disturbances as well as the temperature in the vehicle are the one of the important factors when CDP is designed. In this study, the effect on the temperature of the oil damper, which is applied to anti-vibration system of the CDP, was investigated. When the temperature was changed from $-30^{\circ}C$ to $90^{\circ}C$ and the properties of the oil damper (hardness of rubber, viscosity of oil) were changed, the transmissibility was measured. When the damper rubber has the large hardness, the difference of the transmissibility and natural frequency due to temperature showed the remarkable change as compared with the those of damper viscosity.

Facilitators and Barriers in the Use of a Checklist by Insurance Physicians during Work Ability Assessments in Depressive Disorder

  • Blok, Sebastiaan;Gouttebarge, Vincent;Slebus, Frans G.;Sluiter, Judith K.;Frings-Dresen, Monique H.W.
    • Safety and Health at Work
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    • v.2 no.4
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    • pp.328-335
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    • 2011
  • Objectives: Depressive disorder (DD) is a complex disease, and the assessment of work ability in patients with DD is also complicated. The checklist depression (CDp) has recently been developed to support such work ability assessments and has been recommended for implementation in insurance medicine, starting with an analysis of the organisational and social contexts. The aim of this study was to identify the potential facilitators and barriers in the use of the CDp by insurance physicians (IPs) during work ability assessments of employees on sick leave due to DD. Methods: A qualitative research was conducted based on semi-structured interviews. The participants were IPs with at least one year of work experience in performing work ability assessments. The interviews were audiotaped, transcribed and analysed qualitatively. Results: Ten IPs (7 males, 3 females; mean 53 years) were interviewed. Important facilitators, which emerged for use of the CDp, were an oral introduction for colleagues and staff, support from management, valuing the increased transparency in work ability assessments with using the CDp, having adequate time for assessments as well as modification of the appearance (colour, plasticised form) and content (clarifying aspects of the examples) of the assessment tool. The fear of the loss of autonomy, lack of added value of the CDp, high workload, inadequate instructions and lack of time were mentioned as barriers. Conclusion: Adequate introduction to the use of CDp and the fear of the loss of autonomy of IPs need special attention in planning its implementation.

상품비교테스트 - 콤팩트디스크플레이어

  • 한국전기제품안전진흥회
    • Product Safety
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    • s.25
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    • pp.37-41
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    • 1994
  • 콤팩트디스크플레이어(CDP)는 생활공간이 방안에서 거실로 옮겨짐에 따라 가정용 TV에 연결하여 노래방기능도 할 수 있는 CDP의 보급이 증가 추세에 있고 특히 고도의 원음재생을 원하는 학생들층에서 큰 인기를 얻고 있는 제품으로 국내 7개업체 제품을 대상으로 음의 재생상태등 21개항목을 비교평가하였다.

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Genetic Differences and DNA Polymorphisms between the Fleshy Prawn Fenneropenaeus chinensis and Chinese Ditch Prawn Palaemon gravieri

  • Yoon Jong-Man;Kim Jong-Yeon
    • Fisheries and Aquatic Sciences
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    • v.8 no.3
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    • pp.151-160
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    • 2005
  • Genomic DNA samples isolated from Fenneropenaeus chinensis (fleshy prawn; FP) and Palaemon gravieri (Chinese ditch prawn; CDP) collected in the West Sea, off the Korean Peninsula, at Buan, were PCR-amplified repeatedly. The sizes of the DNA fragments generated by seven different primers varied from 50 bp to 1,600 bp. We identified 358 fragments for the FP species and 301 fragments for the CDP species. There were 18 polymorphic fragments (5.03$\%$) for the FP species and 12 (3.99$\%$) for the CDP species. In total, 66 common fragments (average of 9.4 fragments per primer) were observed for the FP species and 44 fragments (average of 6.3 fragments per primer) were observed for the CDP species. The numbers of specific fragments seen for the FP species and CDP species were 38 and 47, respectively. The complexity of the banding patterns varied dramatically between the primers and the two species. In the FP species, a specific fragment of approximately 1,200 bp generated by primer OPB-04 exhibited inter-individual-specific characteristics that were indicative of DNA polymorphisms. Moreover, in the CDP species, a major fragment of approximately 550 bp generated by primer OPB-20 was found to be specific for the CDP. The average bandsharing value between the two prawn species was 0.421$\pm$0.006, and ranged from 0.230 to 0.611. The dendrogram obtained using the data from the seven primers indicated seven genetic clusters: cluster 1, FLESHY 01, 02, 03, and 04; cluster 2, FLESHY 05, 06, and 07; cluster 3, FLESHY 08, 09, 10, and 11; cluster 4, DITCH 13, 14, 16, and 18; cluster 5, DITCH 12, 15, and 17; cluster 6, DITCH 19, 20, and 21; and cluster 7, DITCH 22. The genetic distance between the two prawn species ranged from 0.071 to 0.642. Thus, RAPD-PCR analysis revealed a significant genetic distance between the two prawn species. Using various arbitrary primers, RAPD-PCR may be applied to identify specific/polymorphic markers that are particular to a species and geographic population, and to define genetic diversity, polymorphisms, and similarities among shrimp species.

A Study on the GHG Scope 3 Emissions Management Status of the Companies Through CDP Comparative Analysis (CDP 비교 분석을 통한 기업의 GHG Scope 3 배출관리 현황 연구)

  • Sungah Yoon;Hong-Kwan Kim;Young-Woo Chon
    • Journal of the Society of Disaster Information
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    • v.19 no.3
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    • pp.554-561
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    • 2023
  • Purpose: To urge the necessity of disclosure by identifying the relationship between the disclosure status of greenhouse gas emissions from domestic business sites and other indirect emissions to total emissions. Method: The 2021 emission data disclosed in the Carbon Disclosure Project (CDP) was collected by industry and emission category for comparative analysis. Result: The more companies that calculated and disclosed emissions by category within Scope 3, the more active they were in responding to or disclosing evaluation factors other than disclosure of emissions, and those companies were able to obtain higher grades in CDP and ESG evaluations. The number of Scope 3 calculations and disclosures was found to be high. In addition, there was a significant difference in the correlation between the number of Scope 3 disclosures by industry and the share of each scope out of the total in some manufacturing industries. Conclusion: As the number of Scope 3 disclosures, corporate ratings, and total emissions are proportional, it was confirmed that the higher the number of Scope 3 disclosures and GHG emissions, the higher the level of Scope 3 management. Based on Scope 3 emissions calculation and disclosure, effective emissions management and reduction activities are required.

Cempedak Durian (Artocarpus sp.) Peel as a Biosorbent for the Removal of Toxic Methyl Violet 2B from Aqueous Solution

  • Dahri, Muhammad Khairud;Chieng, Hei Ing;Lim, Linda B.L.;Priyantha, Namal;Mei, Chan Chin
    • Korean Chemical Engineering Research
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    • v.53 no.5
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    • pp.576-583
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    • 2015
  • This paper aims to investigate the potential use of cempedak durian peel (CDP) from Negara Brunei Darussalam, which is low-cost, locally available, eco-friendly and highly efficient to remove methyl violet (MV) dye from aqueous solutions. The time required for equilibrium to be reached is 2.0 h with no adjustment of pH necessary. FTIR analysis was indicative of the involvement of -COOH and C=O functional groups in adsorption process. The Langmuir model provided the best fit with maximum adsorption capacity of $0.606mmol\;g^{-1}$. Thermodynamics data indicate that the adsorption is spontaneous, feasible and endothermic in nature. Best regeneration of CDP's adsorption ability is achieved by base solution, showing about 95% removal efficiency of MV even after 5 cycles, indicating that CDP can be regenerated and reused. This, together with its high adsorption capacity, makes CDP a potential adsorbent for the removal of MV in wastewater.