• 한국환경보건학회지
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• 제32권3호
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• pp.199-206
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• 2006

Various heavy metals have been known for causing ischemic stroke. In order to describe the causative relationship between the blood levels of various heavy metals and stroke patients, 116 patients with stroke and 111 patients without stroke were selected from one Oriental medical hospital in Wonju, Korea. Total of 9 kinds of metals such as As, Cd, Co, Cu, Hg, Mn, Ni, Pb, and Zn were analyzed in blood from patients with and without stroke. There were no significant differences in the means of metal concentrations between the stroke and nonstroke patients except for the mean of Co concentration. In the case of Co, the means for stroke and non-stroke patients were 0.44 ug/l and 0.40 ug/l showing a significant difference at the level of p-value=0.05. The odds ratios for each metal ranged from 0.96 to 2.86. Most odds ratios were not significant but the odds ratio for Co, $2.86{\pm}1.49$ was significant, indicating that Co increases the risk of stroke by 2.86 times. In order to identify the specific risk level of stroke increased by a multiple interaction of metals, regression coefficients and odds ratio for a pair or multiple pair of metals were reanalyzed. However, all of regression coefficients and odds ratios were not significant. In conclusion, Co showed the significant level in blood from patients with stroke. In addition, the odds ratio of stroke was significantly different from other metals. Thus, it is considered that Co among various metals analyzed in this study is the important metal for increasing the risk of stroke.

• 한국토양비료학회지
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• 제47권6호
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• pp.540-546
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• 2014

Acid mine drainage sludge (AMDS) has been classified as mine waste and generally deposited in land. For this reason, studies have been conducted to examine the possibility of recycling AMDS as an amendment for heavy metal stabilization in soil. The main objective of this study was to evaluate heavy metal stabilization efficiency of AMDS comparing with the widely used lime stone. Also, optimum mixing ratio was evaluated for enhancing heavy metal stabilization. AMDS and limestone were mixed at the ratio of 0:100, 25:75, 50:50, 75:25, and 100:0 with five different heavy metal solutions ($100mg\;L^{-1}$ of $NaAsO_2$, $CdCl_2$, $CuCl_2$, $Pb(NO_3)_2$, and $ZnSO_4{\cdot}7H_2O$). The amendments were added at a rate of 3% (w/v). In order to determine the stabilization kinetics, samples were collected at different reaction time of 0, 1, 2, 4, 8, 16, 32, 64, 128, 256, 512, 1024 minutes. The heavy metal stabilization by AMDS was faster and higher than those of limestone for all examined heavy metals. While limestone showed only 20% of arsenic (As) stabilization after 1,024 minutes, 96% of As was stabilized within 1 minute by AMDS. The highest effect on the stabilization of heavy metal (loid) was observed, when the two amendments were mixed at a ratio of 1:1. These results indicated that AMDS can be effectively used for heavy metal stabilization in soil, especially for As, and the optimum mixing ratio of AMDS and lime was 1:1 at a rate of 3% (w/v).

• 벤딩인더스트리
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• 제1권3호통권3호
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• pp.96-99
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• 2001

사회생활을 하는 사람이라면 하루에 꼭 한번 정도는 하는 일이 있다. 출퇴근, 회의, 그리고 자판기 이용이 그것이다. 이른아침 출근을 위해 지하철 무인 패스 판매기를 이용하고 출근해서는 나른한 오후시간을 깨우기위해 으례 커피자판기를 이용하기 일수이고 여가시간을 이용해서는 친구들과 가벼운 스티커 사진촬영을 하는 등 우리의 자판기 이용 문화는 이미 현대인 너무나도 보편화되고 친숙해져버린 생활의 한 단면이 되어버렸다. 그렇다면 자판기는 언제쯤 인간의 일상사 속에 등장하기 시작했을까? 놀랍게도 자판기의 기원은 기원전 215년으로 거슬러 올라간다. 당시 이집트 사원에서 `성수(聖水)`를 판매하기 위해 만들어졌던 동전식 조작장치가 최초의 자판기라는게 정설로 받아들여온 사실로서 동전을 넣으면 투입된 동전이 받치고 있던 접시가 기울어져 그 기울기가 원래대로 돌아올 때까지 출구로 물이 나오는 원리를 이용한 것이다. 누가 만든것인지는 명확히 밝혀지지 않았으나 확실한 것은 자판기의 역사가 이미 기원전으로 거슬러 올라가고 인간생활에 뿌리내린 역사가 깊다는 것이다. 아무튼 이렇게 자판기가 나타난 이래로 17세기에 키산드리아 과학자 헤론이 쓴 책이 발견되기 이전까지 자판기는 잊혀진 발명품이었다. 그러나 그 책의 발견과 함께 사람들은 옛문헌 속의 발명품의 실용성에 관심을 기울이기 시작했고 차츰 영국의 선술집과 여관 담배 자판기가 등장하기 시작했으며 자판기는 식민지까지 보급될 정도로 선풍적인 인기를 끌었다. 19세기에 들어서는 담배 이외의 물건을 판매할 수 있는 자판기에 관심을 두기 시작했고, 자유주의 사상이 풍미하던 시절, 영국에서 나타난 금서(禁書)자판기에서부터 상업문화가 발달한 미국의 껌볼 자판기에 이르기까지 자판기는 점차로 그 영역을 넓혀갔고 또한 발전해 왔던 것이다. 그러나 자동판매기의 이러한 급속한 발전과 소비영역에서 역량의 강화는 비단 단순한 소비패턴의 변화에서 기인하는 것이라고는 보기 어렵다. 이는 노동집약적 산업구조에서 기술집약적 산업사회로의 전환에 따른 대량생산, 대량소비, 소비패턴 변화 등의 마케팅 환경의 변화에 따라 새로운 유통구조의 출현이 요망되었기 때문이었다. 따라서 슈퍼마켓, 쇼핑센터 등의 새로운 유통구조의 출현 외에도 인건비의 상승, 장소의 제한 및 구입의 편리성 등에 따라 무인 자동판매기의 등장은 필연적이었다고 볼수 있다. 이후 자판기의 판매상품의 범위는 더욱 넓어졌고 컵라면, 인형, 마음에 드는 음악만을 골라담는 CD,휴지,구두광택기,사진스티커,콘돔,장난감,담배,여행용품,스낵,아이스크림 등등 소액권과 손가락만 있으면 살 수 있는 물건의 가짓수는 헤아리기 어려울 정도가 되었으며, 그만큼 유통혁신의 기구로서 산업에 미치는 영향 역시 증대되고 있으며, 이러한 경향은 21세기 정보화,첨단화 경향에 발맞추어 더욱 진보된 형태로 발전해오고 있다.

• 한국산업보건학회지
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• 제3권1호
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• pp.37-53
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• 1993

The polynuclear hydrocarbons (PAHs) emitted from coke oven standpipe were sampled using three sampling systems, including glass fiber filter+silver membrane filter, glass fiber filter+silver membrane filter+XAD-2 adsorbent tube, PTFE membrane filter+XAD-2 adsorbent tube, extracted by methylene chloride and analysed by gas chromathography using flame ionization detector. The results of this study were as follows. 1. Because the amounts of coke oven emissions(COE) were large, the analyses of PAHs were simple and possible without evaporation and concentration. Although the generation of COE was high during early stage of coking, the airborne concentration of PAHs was low and increased during late coking. 2. The contents of PAHs in COE were 1.35-2.81%. 3. The index components of PAHs were fluoranthene and pyrene. Their correlation coefficient to total PAHs were 0.96, 0.95, respectively. 4. The particulate PAHs were sampled by filter and gaseous PAHs by adsorbent tube. The collection efficiency of glass fiber filter+silver membrane filter was 20% of total amount sampled by filters+adsorbent and PTFE membrane filter 50%. Adsorbent tube must be attached to the filter to collect light and small PAH components. 5. The generation of acenaphthene and indeno (1,2,3-cd) pyrene were low and concentrations of fluorene and anthracene were $20-40ug/m^3$ throughout coking time. Other PAH eoncentrations were sometimes high. The generation of PAHs was low at 4-6 hours of coking time. The gaseous PAHs were generated earlier than particulate PAHs.

• 한국환경과학회지
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• 제13권9호
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• pp.789-798
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• 2004

Physicochemical characteristics of Kwangyang Bay, have been investigated on the effects of inputting rivers just after rainy season in summer 2003. The results ranged from 4.96～8.01 mg/L for DO, 1.16～3.09 mg/L for COD, 7.21～67.71 uM for DIN and 0.12～121.84 uM for phosphate. The COD of Yeosu Area was 1.19～3.09 mg/L, Kwangyang Area was 1.23～2.76 mg/L. The COD of Wallae cheon in Yeosu Area was 3.09 mg/L and Donghoan in Kwangyang Area was 2.76 mg/L. The reason of high COD might be industrial sewage of organic chemical plants and iron foundry. DIN of Yeosu Area and Kwangyang Area were 7.21～63.43 ${\mu}M$ and 8.43～67.71 ${\mu}M$ respectively. The average phosphate of Yeosu Area was 23.65 u. The source of phosphate might be industrial sewages of fertilizer plant and phosphate gypsum stocked with high amounts. The metal concentrations were measured in the range of 1.01～175.10 ${\mu}g/L$ for Cu, 0.13～1.78 ${\mu}g/L$ for Cd, 1.13～5.21 ${\mu}g/L$ for Pb, 1.58～13.57 ${\mu}g/L$ for Cr and 1.07～20.68 ${\mu}g/L$ for As. The average Cu concentration was 78.99 ${\mu}g/L$ in Kwangyang Area. The source of Cu might be industrial sewage of iron foundry. The average Cr concentration of Yeosu Area was 9.07 ${\mu}g/L$. That is 2 times higher than Kwangyang Bay 5.74 ${\mu}g/L$, because of sewage of chemical plants.

• 한국환경과학회지
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• 제25권6호
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• pp.865-875
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• 2016

In this study, mass concentrations and chemical compositions of $PM_{2.5}$, including water-soluble ions and elements were determined at the 1,100 m-highland of Mt. Hallasan in Jeju Island across four seasons from August 2013 to August 2014. The average mass concentration of $PM_{2.5}$ was $12.5{\pm}8.41{\mu}g/m^3$ with 45.8% of the contribution from eight water-soluble ionic species. Three ionic species ($SO{_4}^{2-}$, $NH{_4}^+$, and $NO{_3}^-$) comprised 96.2% of the total concentration of ions contained in $PM_{2.5}$ and were the dominant ions, accounting for 43.5% of the $PM_{2.5}$ mass at Mt. Hallasan. On the basis of the mass concentration level, seasonal variation, enrichment factor, and relationship among elements, we can presume that Mg, K, Ca, Mn, Fe, Co, Sr, Ba, Nd, and Dy originated mainly from crust or soil and that V, Cr, Ni, Cu, Zn, As, Cd, and Pb were significantly enriched in $PM_{2.5}$ owing to the effects of the anthropogenic emissions. These results and the local distribution of emission sources and topographic characteristics near this sampling site suggest that the compositions of $PM_{2.5}$ collected at the 1100 m-highland of Mt. Hallasan were largely influenced by inflow from outside of Jeju Island.

• Korean Chemical Engineering Research
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• 제44권1호
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• pp.92-96
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• 2006

유기용매에서 효소를 이용하면 다양한 선택적 반응을 쉽게 수행할 수 있어 산업적 적용 가능성이 매우 높지만, 효소의 안정성 저하는 아직까지 큰 문제 중의 하나로 남아있다. 유기용매에서 효소 반응시 효소의 실활 원인과 효소의 안정화 방법 연구를 위하여 단백질의 folding에 관여하는 molecular chaperone의 일종인 heat-shock protein Hsp90을 이용하여, 대표적인 유기용매 반응시스템에서의 과산화효소 HRP 안정성 향상 연구를 수행하였다. 그 결과 Hsp90은 30％ DMSO, 30％ 및 50％ dioxane 완충용액에서 HRP의 실활 방지 효과를 보였고, 실활된 효소의 재생에도 탁월한 효과를 보였다. 그리고 형광분석과 CD(circular dichroism)에 의한 구조분석을 수행하여 Hsp90이 유기용매에 의해 unfolding되어 있는 효소를 다시 refolding하는 데 기여함을 알았다.

• Archives of Plastic Surgery
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• 제36권1호
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• pp.1-10
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• 2009

Purpose: Partial necrosis of skin flaps remains a substantial problem in reconstructive surgery. We investigated the potential use of an adenovirus vector encoding the VEGF, COMP-angiopoietin-1 gene in an attempt to promote the viability of the inferior epigastric artery flap in a rat model. Methods: Three by six cm lower abdominal transverse skin flaps, supplied only by the left inferior epigastric artery, were designed. After skin flap elevation, the adenovirus VEGF and adenovirus COMP-angiopoietin-1 were injected into the distal portion of the flap, which has a high tendency of developing flap ischemia. Control animals were injected with the same volume of normal saline. On 3, 7 and 14 days after the flap elevation, the flap survival and vascularization were assessed using Visitrak digital$^{(R)}$, CD31 immunohistochemistry in addition to evaluating the general histological characteristics. Results: There was a significant increase in the mean percentage of flap viability by 89.8%, 91.1% and 94.8% in flaps transfected with adenovirus VEGF, COMP-angiopoietin-1, coadministraion of VEGF and COMP-angiopoietin-1 at seven days, and by 95.6%, 94.8% and 96.3% at 14 days. Histological assessment revealed that there were more blood vessels formed after adenovirus with VEGF, COMP-angiopoietin-1 or VEGF plus COMP-angiopoietin-1 than with adenovirus Lac Z. Conclusion: The results of this study suggest that adenovirus-mediated VEGF, COMP-angiopoietin-1 gene therapy, promote therapeutic angiogenesis in patients that undergo reconstructive procedures.

• 자원환경지질
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• 제30권3호
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• pp.223-230
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• 1997

The skeletal chemistry of calcareous microfossils may contribute to the classification of various biological processes and be used as an environmental indicator for future pollution. In order to examine the degree of heavy metal pollutions in marine environments, samples of sediment and benthonic foraminifera were taken from 5 study areas from 3 different stations in coastal offshore regions of Korea. After sieving, cleaning and acid digestion, sample were analyzed for heavy metals by ICP-MS, ICP-AES and AAS. Concentrations of Cd, Cu, Pb and Zn in most of marine sediments from 5 study areas are not higher than those in sediments from unpolluted marine environment in the U.K.. However, pollution indices are up to 0.96~0.99 in the Gwangyang and Yulchon areas which are classified as the special control distric along the coast for pollution. The pollution indices decrease in order of Yulchon > Gwangyang > Mokpo > Gamak = Yoja > Yonggwang areas. Concentrations of Mg, Pb, Sr and Zn in Ammonia beccarii Pseudorotalia gaimardii, Quinqueloculina lamarckiana are reduced after pre-treatment of samples. From the result of bioconcentration index, Mg is easily accumulated in microfossils and Quinqueloculina lamarckiana may be used as the best indicator for future pollution.

• 대한영양사협회학술지
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• 제10권4호
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• pp.428-441
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• 2004

This study focused on developing and assessing the effectiveness of maternal and child nutrition education materials that can be used conveniently at health centers. Focus group interviews with pregnant women, research of websites for pregnant women, and questionnaire-based surveys on community residents' needs for maternal and child nutrition services were conducted as preliminary study. The focus group interviews were conducted ten times, with five or six women, and the needs assessment was carried out on 884 pregnant or lactating women. The contents of the education materials developed based on the preliminary study were made up of the pregnant women section and the lactating women section. The entire material was composed of lecture materials, guidelines for educators, and handout materials for mothers, in the form of CD and booklets. The lecture materials were made using MS Power Point and the guidelines were wrote specifically, including basic information, main points to the lectures, and lesson plans, so that even non-professionals can easily use them. The effectiveness of the education materials was assessed based on a pretest and posttest method. The reliability of the test instrument was measured by Cronbach alpha, which was 0.75. The results were that the participants' nutrition knowledge scores showed a significant increase(p<0.05) from 3.79$\pm$0.33 to 3.96$\pm$0.34, and their attitudes changed positively after the education (p<0.05).