• Journal of Korean Academy of Nursing
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• v.44 no.4
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• pp.446-457
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• 2014

Purpose: This study was done to evaluate the effects of psychosocial interventions on cortisol and immune response in adult patients with cancer. Methods: MEDLINE via PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL and domestic electronic databases were searched. Twenty controlled trials (11 randomized and 9 non-randomized trials) met the inclusion criteria with a total of 862 participants. Methodological quality was assessed using the Cochrane's Risk of Bias for randomized studies and the Risk of Bias Assessment tool for non randomized studies. Data were analyzed using the RevMan 5.2.11 program of Cochrane library. Results: Overall, study quality was moderate to high. The weighted average effect size across studies was -0.32 (95% CI [-0.56, -0.07], p=.010, $I^2 $=45%) for cortisol concentration, -0.62 (95%CI [-0.96,-0.29], p<.001, $I^2 $=0%) for T lymphocyte (CD3) and -0.45 (95%CI [-0.74, -0.16], p=.003, $I^2 $=0%) for Th lymphocyte (CD4) numbers. Psychosocial interventions were not effective for Tc lymphocyte (CD4), NK cell, monocyte, and cytokine response. Conclusion: Although these results provide only small evidence of successful immune modulation, they support the conclusion that psychosocial interventions can assist cancer patients in reducing emotional distress and improving immune response.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.1
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• pp.103-106
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• 2012

To investigate distribution characteristics of heavy metals in soils in the vicinity of King Sejong Station of King George Island, Antarctica, Fe, Mn, Cu, Zn, Pb, Co, Cd, Cr, Ni and Mo contents were investigated under different distances and directions from King Sejong Station. 13 sample sites were distributed from King Sejong Station. In site 4, the Cd content was higher than that in other sites. The Cr content was the highest in site 9, and the Ni and Mn contents were high in site 12. Cu, Co and Zn were highly contained in distance 1~2 km from King Sejong Station. Cd, Cr, Ni and Mo contents were lower, whereas Fe, Mn, Cu, Zn, Pb and Co contents were higher than other heavy metal contents at all sites.

• Bulletin of the Korean Chemical Society
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• v.29 no.1
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• pp.135-138
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• 2008

Two bicarbazyl-containing fluorene copolymers, PFEBCz (95/5) and PFEBCz (75/25), were synthesized for white light electroluminescence from a single emitting polymer. All synthesized polymers were soluble in common organic solvents such as chloroform and toluene. The weight-average molecular weights (Mw) of the PFEBCz (95/5) and PFEBCz (75/25) copolymers were found to be 11,000 and 5,700 with polydispersity indices 1.4 and 1.8. The EL spectrum of the PFEBCz (75/25) device showed bright white-light emission with CIE coordinates of (0.32, 0.34) at 1000 cd/m2, which is very close to that for pure white (0.33, 0.33). This white emission may have been due to strong excimer formation between the bicarbazyl and fluorene polymer backbone. The device exhibited a maximum brightness of 3400 cd/m2 with a maximum efficiency of 0.2 cd/A.

• Korean Journal of Digital Imaging in Medicine
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• v.7 no.1
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• pp.7-13
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• 2005

Purpose : Image plate (IP) is substituted for film in computed radiography. This study is to investigate into a variation of contrast and detail by the number used of image plate in computed radiography. Materials and Methods : A Contrast-Detail(CD)-RAD 2.0 phantom(Nijmegen hospital, The Netherlands) was used for this study. The computed radiography(CR) CD-RAD phantom images were acquired at 40 kVp, 160 mA, 1.6 mAs, and small focus with the Shimadzu general radiography UD-150B-10 system and Fuji FCR 5000 image process system with speed of 200. The IP used including once, 5000 times, and 10000 times also was used. The numerical value of image quality figures (IQF) was produced by CD-RAD analyser(the program is installed in the directory), and then contrast-detail curve was drawn. Results : In this study, the value of IQF was 3.53 in IP used once, 3.40 in 5000 times, and 3.22 in 10000 times. Conclusions : There was a variation of contrast-detail curve by the number used of IP with contrast-detail phantom in computed radiography. Therefore, it is necessary that the IP with lower IQF and a shift of contrast-detail curve to the lower left part is used.

• Journal of Korean Academy of Nursing
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• v.36 no.2
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• pp.310-320
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• 2006

Purpose: The purpose of this study was to investigate the effects of a rehabilitation program on physical health, physiological indicators and quality of life in breast cancer mastectomy patients. Methods: The subjects included thirty-one patients with breast cancer(17 in the experimental group and 14 in the control group). The subjects in the experimental group participated in a rehabilitation program for 10 weeks, which was composed of an exercise program, teaching, counseling and support for 2 sessions per week. Results: There was a significant increase in flexion, internal rotation and external rotation but no significant increase in extension in the experimental group compared to the control group. The total cholesterol, triglyceride, HDL, LDL, and CD56 in the experimental group compared to the control group was not significantly decreased after the rehabilitation program. Compared to the control group, quality of life in the experimental group was significantly improved and fatigue in that group was significantly decreased after the rehabilitation program. Conclusion: The 10-week rehabilitation program showed a large affirmative effect on physical health, physiological indicators and quality of life in breast cancer mastectomy patients.

• Journal of Animal Science and Technology
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• v.50 no.6
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• pp.753-762
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• 2008

The primers for RT-PCR and RACE-PCR were designed by aligning the pig genomic sequence and the human complement factor B(CFB) coding sequence(CDS) from the GenBank. Each PCR product was amplified in pig cDNA and sequencing was carried out. The CDS length of pig CFB gene was determined to be 2298 bp. In addition, the pig CDS was more longer than human and mouse orthologs because of insertion and deletion. The identities of porcine nucleotide sequences with those of human and mice were 84% and 80%, and the identities of amino acids were 79% to 77%, respectively. Three complement control protein(CCP) domains, one Von Willebrand factor A(VWFA) domain and a serine protease domain, that are revealed typically in mammals, were found in the pig CFB gene. Based on the CDSs determined, the primers were designed in intron regions for amplification of entire length of exons. In amplification and direct sequencing with genomic DNAs of six pig breeds, three cSNPs(coding single nucleotide polymorphisms) were identified and verified as missense mutations. Using the Multiplex-ARMS method, we genotyped and verified the mutations identified from direct sequencing. To demonstrate recrudescence, we performed both direct sequencing and Multiplex-ARMS with two randomly selected DNA samples. The genotype of each sample exhibited the same results using both methods. Therefore, three cSNPs were identified from pig CFB gene and that can be used for haplotype analysis of the swine leukocyte antigen(SLA) class III region. Moreover, the results indicate that the Multiplex-ARMS method should be powerful for genotyping of genes in the SLA region.

• Nuclear Engineering and Technology
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• v.54 no.12
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• pp.4620-4624
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• 2022

Several cadmium zinc telluride (CZT) crystals were fabricated into radiation detectors using methods that included slicing, dicing, lapping, polishing, and chemical etching. A wet passivation with sodium hypochlorite (NaOCl) was then carried out on the Br-etched detectors. The Te-rich layer on the CZT surface was successfully compensated to the Te oxide layer, which was analyzed with X-ray photoelectron spectroscopy data of both a Br-etched crystal and a passivated CZT crystals. We confirmed that passivation with NaOCl improved the transport property by analyzing the mobility-lifetime product and surface recombination velocity. The electrical and spectroscopic properties of large volume detectors were compared before and after passivation, and then the detectors were observed for a month. Both bar and quasi-hemispherical detectors show an enhancement in performance after passivation. Thus, we could identify the effect of NaOCl passivation on large volume CZT detectors.

• The Journal of Korean Academic Society of Nursing Education
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• v.10 no.2
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• pp.239-251
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• 2004

The purpose of this study was to find out the effects of education for prevention of child sexual abuse (rape, sexual assault, sexual harassment etc.) of children in elementary school students. Incidences of sexual abuse in Korea is ranked 3rd in the world. Sexual abuse of children, particularly, is one of the most serious crimes that affect both the victimized children and their family. The issue related to sexual abuse of children has been ignored, and there is a lack of systematic education to prevent sexual abuse of children either for children or their parents. Furthermore, lack of knowledge and poor attitude of teachers limit their capability to provide education for sexual abuse prevention to the children. The education for teachers may change their knowledge of the sexual abuse and their attitude toward it and improve their capability in helping children. 223 Korean elementary school students participated in this study. Research design was One group pretest-posttest design. The education given to the subjects included 4 hours through the multimedia CD-ROM on the prevention of child sexual abuse. The education program was developed based on a survey. School- aged- children, parents, and teachers were interviewed to reveal their educational needs based on their experiences related to sexual abuse. This program includes such as safety education, crisis management, resource person(s), and phone numbers of available hospital. Data was collected before, during and after the education was given to the subjects, to assess their knowledge and attitude toward child sexual abuse. Two instruments were used in this study. Using Cronbach's ALPHA validity and reliability of 2 instruments were tested. The analysis of the data was done with Window SPSS 10.0 for descriptive statistics, t-test and ANOVA. The results of this analysis were as follows : 1. After education, the score of school nurses knowledge was higher than before(t= -4.677, p=0.000). 2. After education, the score of school nurses attitude was not higher than before (t=0.131, p=0.896). The findings from this study will provide an intervention strategy for prevention of sexual abuse in children.

• Korean Journal of Clinical Laboratory Science
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• v.46 no.3
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• pp.91-98
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• 2014

Primary gastric lymphoma (PGL) is derived from mucosa-associated lymphoid tissue (MALT) and it differs from nodal lymphoma in histologic features and biologic behavior. Recent studies have showed that Helicobacter pylori (H.pylori ) infection is closely related to the development of low grade gastric lymphoma, and eradication of the infection induces regression of the tumor. H. pylori infection is known to be important to the development of gastric MALT lymphoma. The aim of this study was to elucidate the histopathological behavior of PGL according to the concept of MALT and to compare the predictive value of tests frequently used for diagnosis of H. pylori. The histological features of gastric lymphoma arising from MALT are the replacement of glands by uniform dense infiltration of centrocyte-like cells in the lamina propria and lymphoidepithelial lesion. H. pylori-associated histologic changes of neutrophilic infiltration, lymphoid follicle or aggregates formation and intestinal metaplasia, and H. pylori immunoreactivity were analyzed. Detection of H. pylori in chronic active gastritis and peptic ulcer suggests a possible role of H. pylori in the pathogenesis. Giemsa, Toluidine blue and Long H&E stains were used in H. pylori detection. Histopathological examination of gastric biopsy specimens revealed lymphoepithelial lesions pathognomonic of MALT lymphoma, and immunohistochemical staining for CD20 was diffusely positive. CD3 was positive in reactive T cells. PAX-5 was negative except the follicle. Bcl-2, cytokeratin, Ki-67, and c-myc were positive. The findings may indicate a predictable transition of low grade to high grade, and c-myc may be used as a valuable marker before molecular pathology diagnosis.

• Journal of Microbiology and Biotechnology
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• v.23 no.8
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• pp.1159-1166
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• 2013

Orientia tsutsugamushi, a gram-negative bacterium, causes severe acute febrile illness in humans. Despite this danger, the route of infection, infectivity, and protective mechanisms of the host's immune response to O. tsutsugamushi are unclear. Dendritic cells (DCs) are one of the most important cell types in bridging the innate and adaptive immune responses. In this study, we observed that O. tsutsugamushi infects and replicates in monocyte-derived DCs (MODCs). During infection and replication, the expressions of the cytokines IL-12 and TNF-${\alpha}$, as well as the co-stimulatory molecules CD80, CD83, CD86, and CD40, were increased in MODCs. When O. tsutsugamushi-treated MODCs were co-cultured with autologous $CD4^+$ T cells, they enhanced production of IFN-${\gamma}$, a major Th1 cytokine. Collectively, our results show that O. tsutsugamushi can replicate in MODCs and can simultaneously induce MODC maturation and increase proinflammatory cytokine levels in MODCs that subsequently activate $CD4^+$ T cells.