• Journal of Animal Reproduction and Biotechnology
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• v.37 no.4
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• pp.255-265
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• 2022

The cellular communication network factor (CCN) family proteins regulate many biological events such as angiogenesis, tumor growth, placentation, implantation, and embryogenesis. The expression and function of CCN1, CCN2, and CCN3 at the maternal-conceptus interface are established in humans and rodents, but little is known about the role of CCN4 to CCN6 in the reproductive organs in any other species. Several studies in transcriptome analysis in pigs have shown that the expression of CCN4 and CCN6 increases in the endometrium during early pregnancy. However, their expression, regulation, and function in the endometrium throughout the estrous cycle and pregnancy have not been fully understood in pigs. Thus, we determined the expression, localization, and regulation of CCN4 and CCN6 during the estrous cycle and at the maternal-conceptus interface in pigs. We found that the levels of CCN4, but not CCN6, changed during the estrous cycle. The levels of CCN4 were greater during mid- to late pregnancy than in the early stage, and the levels of CCN6 were greatest on Day 15 of pregnancy. CCN4 and CCN6 were detected in conceptus tissues during early pregnancy and in chorioallantoic tissues during the later stage of pregnancy. CCN4 mRNA was mainly localized to epithelial cells, CCN6 mRNAs to epithelial and stromal cells in the endometrium. In endometrial explant cultures, CCN4 expression was increased by progesterone, and CCN6 expression by interferon-𝛾. These results suggest that CCN4 and CCN6 may play roles in the establishment and maintenance of pregnancy by regulating the endometrial epithelial cell functions in pigs.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.6
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• pp.1113-1120
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• 2021

Content Central Network (CCN) appeared to improve network efficiency by transforming IP-based network into content name-based network structures. Each router performs caching mechanism to improve network efficiency in the CCN. And the cache replacement policy applied to the CCN router is an important factor that determines the overall performance of the CCN. Therefore various studies has been done relating to cache replacement policy of the CCN. In this paper, we proposed a cache replacement policy that improves the limitations of the LFU policy. The proposal algorithm applies real-time producer popularity-based variables. And through experiments, we proved that the proposed policy shows a better cache hit ratio than existing policies.

• Journal of Korea Multimedia Society
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• v.20 no.9
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• pp.1527-1540
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• 2017

Recently, due to the rapid development of the internet, the production and demand of high capacity contents are rapidly increasing. In order to accommodate the changing trend of internet usage, researches on CCN, the future internet architecture, are actively being conducted. Mobility support is an important challenge in CCN real-time services, given that today's internet environment is changing to mobile and real-time services are increasing. In CCN real-time services, the mobility problem can be largely divided into consumer mobility, provider mobility, and intermediate-node mobility. Among them, when the intermediate-node moves in the CCN real-time services, the service disconnection occurs and the QoS degradation is caused. In this paper. we propose Intermediate-Node Mobility Support(INMS) to support the intermediate-node mobility in CCN real-time services. Experimental results show that the proposed scheme shows better performance than CCN in terms of service disconnection time and packet loss.

• Journal of Digital Convergence
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• v.15 no.8
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• pp.341-349
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• 2017

CCN proposes that intermediate network nodes on a network path for a transmitted data-packet cache the data-packet. If the nodes receive request packets for the cached data, the nodes can directly respond to the request-packets using the cached data. Since a request-packet can be responded by one of the intermediate nodes on a path of the request-packet, both faster response time and decreased data transmission amount are expected comparing to the existing host centric networking. However, CCN is vulnerable against forgery attacks because data-packet receivers cannot identify a data provider. Hence, a data authentication scheme is essentially needed to make CCN more secure. But such a data authentication process is one of the main causes of CCN-based service delays. This paper first analyzes the problems of a CCN data authentication scheme, then proposes an improved authentication operation scheme for efficiently authenticating data, and finally evaluates its performance.

• Biomedical Science Letters
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• v.24 no.2
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• pp.64-75
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• 2018

CCN3 (also known as NOV, Nephroblastoma overexpressed) proteins are involved in various pathologies during different developmental stages. We have previously shown that intracellular levels and normal extracellular secretion of CCN3 are important for neuronal differentiation. Furthermore, we demonstrated that a single amino acid in the CCN3 TSP-1 domain is important for extracellular secretion and that palmitoylation of CCN3 is required in this process. However, the effect of abnormal CCN3 accumulation on cells remains to be studied. Here, we found mutations in the TSP-1 domain of CCN3 that led to intracellular accumulation and abnormal aggregation of CCN3. It was observed that this mutation resulted in a phenomenon similar to neurodegeneration when overexpressed in the developing mouse cortex. This mutation also confirmed the activation of apoptotic gene expression in Neuro2a cells. In addition, we confirmed the in vivo transcriptional changes induced by this mutation using microarray analysis. We observed a significant increase in the expression of Anp32a, an apoptosis-related gene. Collectively, these results indicate that a single mutation in CCN3 can lead to abnormal cell death if it shows intracellular accumulation and abnormal aggregation.

• BMB Reports
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• v.51 no.10
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• pp.486-492
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• 2018

The CCN protein family is composed of six matricellular proteins, which serve regulatory roles rather than structural roles in the extracellular matrix. First identified as secreted proteins which are induced by oncogenes, the acronym CCN came from the names of the first three members: CYR61, CTGF, and NOV. All six members of the CCN family consist of four cysteine-rich modular domains. CCN proteins are known to regulate cell adhesion, proliferation, differentiation, and apoptosis. In addition, CCN proteins are associated with cardiovascular and skeletal development, injury repair, inflammation, and cancer. They function either through binding to integrin receptors or by regulating the expression and activity of growth factors and cytokines. Given their diverse roles related to the pathology of certain diseases such as fibrosis, arthritis, atherosclerosis, diabetic nephropathy, retinopathy, and cancer, there are many emerging studies targeting CCN protein signaling pathways in attempts to elucidate their potentials as therapeutic targets.

• Journal of the Korea Institute of Military Science and Technology
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• v.19 no.6
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• pp.721-729
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• 2016

CCN(Content-Centric Network) enables users to retrieve content using the content's name. Researchers face critical challenges in terms of mobility. Since the routing information is part of the content name, when the provider moves, it is necessary to update all the routers routing information. However, this requires significant costs. In this paper, we propose PNPCCN(Proactive Neighbor Pushing CCN), considering the popularity and rarity of mobility support, for providers in CCN environments. Via simulation studies, we demonstrate that our solutions are effective in terms of shorter numbers of retransmitted Interest packets, and average download times and higher delivery ratios during mobility.

• Journal of Korea Multimedia Society
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• v.22 no.12
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• pp.1438-1446
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• 2019

Recently, the number of mobile users as well as high-speed Internet user has been increasing rapidly. Moreover, traffic is growing fast as services that provide real-time content such as Youtube and Netflix become popular. The problem of traffic control in real-time content services is important because many people use cell phones to receive real-time content. In this regard, the field of CCN is currently being studied. We studied the mobility of nodes among CCN research fields. Node mobility can be divided into three categories : consumer mobility, intermediate node, and provide mobility. In this paper, we propose Mobility Node Support(MD-INS) to support the intermediate-node mobility in CCN real-time services. Experimental results show that the proposed scheme shows better performance than CCN in terms of service disconnection time and packet loss.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.262-265
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• 2015

차세대 미래 인터넷으로 관심을 모으고 있는 CCN은 ICN, CDN, NDN과 비슷한 개념으로 출발한다. 즉, 사용자가 관심을 가지는 데이터를 하나의 컨텐츠로 바라보고 네트워킹을 한다. CCN은 이러한 컨텐츠에 대해 요청 패킷을 보내면 컨텐츠를 가지고 있는 노드에서는 해당 패킷을 보내는 방식이다. IP 기반의 네트워크에서와 마찬가지로 CCN에서도 한정된 네트워크 대역폭에서 소비자에게 전송되는 패킷의 전송 시간에 따른 처리량 향상은 주요 관심사 중의 하나이다. 본 논문에서는 CCN에서의 CCN-Helper 프로토콜을 사용한 소비자의 다운로드 시간 감소 방법을 제안하여 생산자에서 소비자로의 패킷 전송 처리량을 향상시키고자 한다.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.745-748
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• 1996

Korea Composite Stock Price Index (KOSPI) was predicted using Cascade Correlation Network (CCN) model. CCN was suggested, by Fahlman and Lebiere [1990], to overcome the limitations of backpropagation algorithm such as step size problem and moving target problem. To test the applicability of CCN as a function approximator to the stock price movements, CCN was used as a tool for univariate time series analysis. The fitting and forecasting performance fo CCN on the KOSPI was compared with those of Multi-Layer Perceptron (MLP).