• 대한토목학회논문집
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• 제38권2호
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• pp.303-310
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• 2018

충격적인 헤드라인 중 하나는 심각한 연쇄추돌 교통사고(chain collision accident, CCA)이다. CCA의 진행과정은 시공간적으로 국부성을 가지며, 그 정보는 시간 임계적(time-critical)이다. 따라서 연쇄추돌을 감소시키기 위해서는 1차 사고 발생 직후 교통사고 정보를 운전자에게 신속하게 전파시켜야 한다. 국부적 긴급 정보전파의 유력한 대안 중 하나는 Ad hoc 통신에 기반을 둔 차량 간 통신(Inter-Vehicle Communication, IVC)이다. 이러한 IVC의 잠재력에도 불구하고, CCA 감소에 대한 IVC의 효과에 대한 연구는 현재까지 보고되지 않고 있다. 따라서 본 연구는 미시적 차량 시뮬레이터와 IVC 시뮬레이터가 결합된 병렬 플랫폼을 개발하고, 이를 이용하여 CCA 감소에 대한 IVC의 효과를 분석하였다. CCA를 감소시키기 위한 IVC기반 긴급 교통사고정보 전파의 가능성을 증명하기 위하여, IVC 장치의 시장 점유율과 교통량 시나리오에 따른 차량의 접근속도 감소, 사고정보의 전파속도, 그리고 CCA의 감소를 분석하였다. 분석결과, IVC 장비의 시장 점유율 10%와 50%에서 CCA는 40~60% 그리고 80~82%로 각각 감소될 수 있는 것으로 나타났다.

• Earthquakes and Structures
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• 제23권3호
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• pp.259-269
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• 2022

In this study, we introduce a canonical correlation analysis method to accurately assess the tunnel damage potential of ground motion. The proposed method can retain information relating to the initial variables. A total of 100 ground motion records are used as seismic inputs to analyze the dynamic response of three different profiles of tunnels under deep and shallow burial conditions. Nine commonly used ground motion parameters were selected to form the canonical variables of ground motion parameters (GMP_CCA). Five structural dynamic response parameters were selected to form canonical variables of structural dynamic response parameters (DRP_CCA). Canonical correlation analysis is used to maximize the correlation coefficients between GMP_CCA and DRP_CCA to obtain multivariate ground motion parameters that can be used to comprehensively assess the tunnel damage potential. The results indicate that the multivariate ground motion parameters used in this study exhibit good stability, making them suitable for evaluating the tunnel damage potential induced by ground motion. Among the nine selected ground motion parameters, peck ground acceleration (PGA), peck ground velocity (PGV), root-mean-square acceleration (RMSA), and spectral acceleration (Sa) have the highest contribution rates to GMP_CCA and DRP_CCA and the highest importance in assessing the tunnel damage potential. In contrast to univariate ground motion parameters, multivariate ground motion parameters exhibit a higher correlation with tunnel dynamic response parameters and enable accurate assessment of tunnel damage potential.

• 한국인터넷방송통신학회논문지
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• 제13권1호
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• pp.27-34
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• 2013

본 논문은 시분산 통신 채널에서 부호간 간섭을 수신측에서 경감시키기 위하여 사용되는 CCA (Compact Constellation Algorithm) 적응 등화 알고리즘의 성능을 비교하였다. 이 알고리즘은 기본적으로 CMA 등화기의 위상 미복원 문제를 해결하기 위하여 등장하였으며 DDA(Decision Directed Algorithm)와 RCA(Reduced Constellation Algorithm)의 개념을 조합하였다. DDA는 단일 레벨 신호에 대해서는 안정된 수렴 특성을 갖지만 다중 레벨의 수가 큰 QAM 신호에 대해서는 매우 불안한 문제점을 가지며, RCA는 초기 수렴 상태가 보장되지 않거나, 수렴후 안정 상태에서 misadjustment에 의한 등화 잡음이 DDA보다 큰 문제점이 있으므로, 이와 같은 점들을 개선하기 위해 CCA 적응 등화 알고리즘이 등장하였다. CCA 적응 등화 알고리즘의 성능 분석을 위하여 컴퓨터 시뮬레이션을 수행하였으며, 이를 위해 수신측에서의 등화기 출력 신호인 복원된 신호 성상도, 잔류 isi와 MD (Maximum Distortion) 곡선에 의한 수렴 특성 및 SER (Symbol Error Rate) 성능을 DDA, RCA와 비교하였다. 시뮬레이션 결과 모든 성능 지수에서 DDA가 가장 우월하였지만 수렴이 보장되지 않으며, 멀티 레벨 신호에서의 불안정성이 있으므로 이를 해결할 수 있는 CCA가 RCA보다 우월한 성능을 가짐을 확인하였다.

• 한국환경과학회지
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• 제11권10호
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• pp.1031-1037
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• 2002

CCA (Canonical Correspondence Analysis) was used so as to analyze the relation between vegetation and soil environment of Mankyeong river located in Jeollabuk-do. Vegetation survey consulted 1:5,000 topographical map, set up 30 plot and analyzed from June, 2001, to september, 2001. Plant communities of Mankyeong river was investigated by phytosocialogical method. The species composition of plant communities showed high correlation to soil pH, soil organic matter, $P_2$$O_5$, total nitrogen, EC, when they were analyed by CCA. According to the results of CCA hydrophyte communities were distributed in the region that high pH. But the vegetation of disturbed site and wetland plants were distributed in a good nutrients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7473-7478
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• 2014

Cholangiocarcinoma (CCA) is a fatal cancer with poor prognosis and less than 10% of CCA patients can be offered surgical cure. Conventional chemotherapy results in unfavorable outcomes. At present, plant-derived compounds are gaining interest as potential cancer therapeutics, particularly for treatment-refractory cancers. In this study, antitumor activity of tiliacorinine, the major alkaloid isolated from a tropical plant, on CCA was first demonstrated. Antiproliferative effects of tiliacorinine on human CCA cell lines were investigated using SRB assays. Acridine orange/ethidium bromide staining, flow cytometric analysis and DNA laddering assays were used for apoptotic determination. Apoptosis-related proteins were verified by Western blotting and antitumor activity of tiliacorinine in vivo was demonstrated in CCA xenografted mice. Tiliacorinine significantly inhibited proliferation of human CCA cell lines with $IC_{50}$ $4.5-7{\mu}M$ by inducing apoptosis through caspase activation, upregulation of BAX, and downregulation of $Bcl_{xL}$ and XIAP. Tiliacorinine considerably reduced tumor growth in CCA xenografted mice. These results demonstrated antitumor effects of tiliacorinine on human CCA in vitro and in vivo. Tiliacorinine may be an effective agent for CCA treatment.

• Journal of Microbiology and Biotechnology
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• 제32권10호
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• pp.1262-1274
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• 2022

Cholangiocarcinoma (CCA) is a complex and refractor type of cancer with global prevalence. Several barriers remain in CCA diagnosis, treatment, and prognosis. Therefore, exploring more biomarkers and therapeutic drugs for CCA management is necessary. CCA gene expression data was downloaded from the TCGA and GEO databases. KEGG enrichment, GO analysis, and protein-protein interaction network were used for hub gene identification. miRNA were predicted using Targetscan and validated according to several GEO databases. The relative RNA and miRNA expression levels and prognostic information were obtained from the GEPIA. The candidate drug was screened using pharmacophore-based virtual screening and validated by molecular modeling and through several in vitro studies. 301 differentially expressed genes (DEGs) were screened out. Complement and coagulation cascades-related genes (including AHSG, F2, TTR, and KNG1), and cell cycle-related genes (including CDK1, CCNB1, and KIAA0101) were considered as the hub genes in CCA progression. AHSG, F2, TTR, and KNG1 were found to be significantly decreased and the eight predicted miRNA targeting AHSG, F2, and TTR were increased in CCA patients. CDK1, CCNB1, and KIAA0101 were found to be significantly abundant in CCA patients. In addition, Molport-003-703-800, which is a compound that is derived from pharmacophores-based virtual screening, could directly bind to CDK1 and exhibited anti-tumor activity in cholangiocarcinoma cells. AHSG, F2, TTR, and KNG1 could be novel biomarkers for CCA. Molport-003-703-800 targets CDK1 and work as potential cell cycle inhibitors, thereby having potential for consideration for new chemotherapeutics for CCA.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 춘계학술대회
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• pp.164-167
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• 2012

음성 신호와 함께 섞인 자동차 배기 소음을 서로 분리해 내는 기술은 점점 음성을 중심으로 발전해가는 인터페이스를 현실화하는데 실질적으로 필요한 기술이다. 따라서 자동차 배기음이 섞인 음성신호를 두 신호간의 독립성이 보장되지 않고 두 신호에 대한 사전 정보가 없는 상태에서 분리해 내기 위해 정준 상관 분석을 사용하여 두 신호를 분리해 내는 연구를 진행하였다. 정준 상관 분석을 이용하여 음성을 분리해 내기 위해서는 분석에 쓰이는 신호의 구성이 중요하다. 정준 상관 분석에 대해 알아보고 음성과 자동차 배기 소음이 섞인 두 개의 신호를 받아서 이를 재구성하여 정준 상관분석을 이용하여 자동차 소음과 음성을 분리해 내었다. Blind Source Separation에 쓰이는 다른 방법과 비교했을 때 독립성이 보장되지 않는 신호에 대해서도 분리가 가능하므로 응용 대상이 상대적으로 넓어 실용적 응용이 가능하다고 할 수 있다.

• 대한산업공학회지
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• 제41권6호
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• pp.579-587
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• 2015

Semiconductor manufacturing industry is a high density integration industry because it generates a vest number of data that takes about 300~400 processes that is supervised by numerous production parameters. It is asked of engineers to understand the correlation between different stages of the manufacturing process which is crucial in reducing production costs. With complex manufacturing processes, and defect processing time being the main cause. In the past, it was possible to grasp the corelation among manufacturing process stages through the engineer's domain knowledge. However, It is impossible to understand the corelation among manufacturing processes nowadays due to high density integration in current semiconductor manufacturing. in this paper we propose a canonical correlation analysis (CCA) using both wafer test voltage variables and fail bit counts variables. using the method we suggested, we can increase the semiconductor yield which is the result of the package test.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1011-1018
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• 2015

This study was conducted to investigate the plasma phosphoproteome and differential plasma phosphoproteins in cases of of Opisthorchis viverrini (OV)-related cholangiocarcinoma (CCA). Plasma phosphoproteomes from CCA patients (10) and non-CCA subjects (5 each for healthy subjects and OV infection) were investigated using gel-based and solution-based LC-MS/MS. Phosphoproteins in plasma samples were enriched and analyzed by LC-MS/MS. STRAP, PANTHER, iPath, and MeV programs were applied for the identification of their functions, signaling and metabolic pathways; and for the discrimination of potential biomarkers in CCA patients and non-CCA subjects, respectively. A total of 90 and 60 plasma phosphoproteins were identified by gel-based and solution-based LC-MS/MS, respectively. Most of the phosphoproteins were cytosol proteins which play roles in several cellular processes, signaling pathways, and metabolic pathways (STRAP, PANTHER, and iPath analysis). The absence of serine/arginine repetitive matrix protein 3 (A6NNA2), tubulin tyrosine ligase-like family, member 6, and biorientation of chromosomes in cell division protein 1-like (Q8NFC6) in plasma phosphoprotein were identified as potential biomarkers for the differentiation of healthy subjects from patients with CCA and OV infection. To differentiate CCA from OV infection, the absence of both serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform and coiled-coil domain-containing protein 126 precursor (Q96EE4) were then applied. A combination of 5 phosphoproteins may new alternative choices for CCA diagnosis.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 추계학술대회 논문집
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• pp.48-53
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• 2014

Rocket, held using the CCA for the mission, a plurality of recording devices, and navigation equipment. In case of a projectile which is entered the water after fired into the air, after performing stages and fairing separated in flight to enter the underwater. It is caused by the explosion of gunpowder mainly, vibration phenomenon of a large transition is induced structurally very, also on entering the water, have a significant shock structurally separated. If shock is transmitted directly to the CCA through the body, it can be caused malfunction of payloads, resulting in failure of the mission of the projectile. In order to ensure the stability against shock, in this paper, Calculating a target resonacne frequency of the CCA, and verified through modal test and analysis. Maximum acceleration position of CCA is checked by SRS analysis. In addition, effectiveness of shock isolation system through shock analysis.