• Biomolecules & Therapeutics
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• v.7 no.3
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• pp.234-241
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• 1999

The present study assessed the cerebroprotective effect of platelet-activating factor(PAF) antagonists in transient cerebral ischemia of rats. Right middle cerebral artery (MCA) of Sprague-Dawley rats was occluded for 2 hours using an intraluminal filament technique, and was reperfused for 6 hours following cerebral ischemia. The infarct area of seven coronal brain slices was measured morphometrically following stain ing in the 2% 2,3,5-triphenyltetrazolium chloride solution. The changes in regional cerebral blood flow (rCBF) and pial arteriolar diameter were measured by laser-Doppler flowmetry and by a videomicroscopy, respectively. The infarct size was significantly reduced by PAF antagonists, BN 52021 and CV-6209, which were administered i.p. 10 min before MCA occlusion. Pretreatment with PAF antagonists significantly restored the changes in pial arterial diameter as well as those in rCBF during the period of cerebral ischemia-reperfusion. PAF antagonists significantly inhibited the inducible nitric oxide synthase activity in the pial arteries ipsilateral to ischemia. These results suggest that PAF antagonists exert a cerebroprotective effect against ischemic brain damage through an improvement of postocclusive cerebral blood flow.

• Korea Information Processing Society Review
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• v.28 no.2
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• pp.50-58
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• 2021

• Journal of IKEEE
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• v.18 no.3
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• pp.427-434
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• 2014

The Multihop Routing of vehicle communication environment is difficult to maintain due to heavy fluctuation of network topology and routing channel according to the movement of the vehicle, road property, vehicle distribution. We implemented GeoNetworking on the basis of ETSI(European Telecommunication Standard Institute) to maintain the vehicle safety service. GeoNetworking has its own way that delivers the data through the Unicast and Broadcast. In this paper, we compared performance index such as packet delivery ratio, end-to-end delay about GeoNetworking using the QualNet Network Simulator. Previous research assessed performance of GeoUnicast. This research has been additionally performed about GeoBroadcast, and we progressed algorithm performance through the comparison of CBF(Contention based Forwarding) of GeoUnicast with Greedy forwarding of GeoBroadcast.

• Steel and Composite Structures
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• v.20 no.4
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• pp.749-776
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• 2016

In this paper, a Performance Based Design (PBD) approach is validated for multi-storey concentrically braced frame (CBF) systems. Direct Displacement Based Design (DDBD) procedure is used and validated by designing 4- and 12-storey CBF buildings. Nonlinear time history analysis (NLTHA) is used to check the performance of the design methodology by employing different accelerograms having displacement spectra matching the design displacement spectrum. Displacements and drifts obtained from NLTHA are found to fall within the design displacement limits used in the DDBD procedure. In NLTHA, both tension and compression members are found to be resisting the base shear, $F_b$, not only the tension members as assumed in the design methodology and suggested by Eurocode 8. This is the reason that the total $F_b$ in NLTHA is found to be greater than the design shear forces. Furthermore, it is found that the average of the maximum ductility values recorded from the time history analyses for the 4-and 12-storey buildings are close to the design ductility obtained from the DDBD methodology and ductility expressions established by several researchers. Moreover, the DDBD is compared to the Forced Based Design (FBD) methodology for CBFs. The comparison is carried out by designing 4 and 12-storey CBF buildings using both DDBD and FBD methodologies. The performance for both methodologies is verified using NLTHA. It is found that the $F_b$ from FBD is larger than $F_b$ obtained from DDBD. This leads to the use of larger sections for the structure designed by FBD to resist the lateral forces.

• Journal of Korean Neurosurgical Society
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• v.54 no.3
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• pp.159-163
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• 2013

Objective : Cerebral hyperperfusion syndrome (CHS) is a serious complication after carotid endarterectomy (CEA). However, the prevalence of CHS has decreased as techniques have improved. This study evaluates the role of strict blood pressure (BP) control for the prevention of CHS. Methods : All 18 patients who received CEA from February 2009 through November 2012 were retrospectively reviewed. All patients were routinely managed in an intensive care unit by a same protocol. The cerebral perfusion state was evaluated on the basis of the regional cerebral blood flow (rCBF) study by perfusion computed tomography (pCT) and mean velocity by transcranial doppler (TCD). BP was strictly controlled (<140/90 mm Hg) for 7 days. When either post-CEA hyperperfusion (>100% increase in the rCBF by pCT or in the mean velocity by TCD compared with preoperative values) or CHS was detected, BP was maintained below 120/80 mm Hg. Results : TCD and pCT data on the patients were analyzed. Ipsilateral rCBF was significantly increased after CEA in the pCT (p=0.049). Post-CEA hyperperfusion was observed in 3 patients (18.7%) in the pCT and 2 patients (12.5%) in the TCD study. No patients developed clinical CHS for one month after CEA. Furthermore, no patients developed additional neurological deficits related to postoperative cerebrovascular complications. Conclusion : Intensive care with strict BP control (<140/90 mm Hg) achieved a low prevalence of post-CEA hyperperfusion and prevented CHS. This study suggests that intensive care with strict BP control can prevent the prevalence of post-CEA CHS.

• The Journal of the Acoustical Society of Korea
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• v.20 no.7
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• pp.31-36
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• 2001

Passive sonar system forms the various beams in any desired directions to obtain the improvement in Signal-to-Noise (S/N) ratio, bearing detection and localization of targets, and the attenuation of interferences from other directions. The improvement of beamforming is very important to detect modern underwater targets as noise reduction technology leads to considerably low-level acoustic emissions in the long range in complex environmental sea. In this paper, we proposed the spatial cross correlation beamforming (SCCBF) algorithm using cross correlation matrix of individual hydrophone pairs of linear array sensors. By the theoretical analysis and simulation, the proposed SCCBF is demonstrated that its performances compared to conventional beamforming (CBF) output can be obtain above 3dB of array gain and about half of beam width represented the bearing accuracy in target detection. Also, this paper presents sea test result of linear passive sonar system that the proposed algorithm implemented.

• Journal of the Korean Magnetic Resonance Society
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• v.6 no.1
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• pp.54-68
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• 2002

PEBP2/CBF (Polyomavirus Enhancer-core Binding Protein 2/Core Binding Factor), represents a new family of heterodimeric transcription factor. Those members play important roles in hematopoiesis and osteogenesis in mouse and human. PEBP2/CBF is a sequence-specific DNA binding protein. Each member of the PEBP2/CBF family of transcription factors is composed of two subunits, ${\alpha}$ and ${\beta}$. The evolutionarily conserved 128 amino acid region in ${\alpha}$ subunit has been called the Runt domain, which harbors two different activities, the ability to bind DNA and interact with the ${\beta}$ subunit. Recently, cDNA clones encoding the C. elegans Runt domain were isolated by screening a cDNA library. This gene was referred to run (Runt homologous gene). In this study, the basic experiments for the structural characterization of RUN protein were performed using spectroscopic methods. We have identified the structural properties of RUN using bioinformatics, CD and NMR. The limit temperature of the structural stability was up to 60$^{\circ}C$ with irreversible thermal process, and the structure of RUN seems to adopt ${\alpha}$ helices and one or more ${\beta}$ sheet or turn. The degree of NMR peak dispersion and intensity was increased by addition of glycine. Therefore, glycine could be used to alleviate the aggregation property of RUN in NMR experiment.

• Annals of Clinical Neurophysiology
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• v.4 no.1
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• pp.38-43
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• 2002

Background & Purpose : Dynamic susceptibility contrast MR imaging, one method of perfusion MRI, was developed to define cerebral hemodynamic status with good anatomical resolution. The authors investigated hemodynamic parameters using this imaging method, in an effort to identify hemodynamic changes on the remote crossed cerebellum of patients with a supratentorial infarct. Methods : Dynamic susceptibility contrast MR imaging was performed in 15 patients with only unilateral supratentorial infarcts. Imaging was obtained at the anatomic level of the cerebellum. rCBF, rCBV, MTT and TP were determined over both cerebellar hemispheres of interest. Results : The rCBF and rCBV values of the contralateral cerebellar hemisphere were significantly more decreased than those of the ipsilateral cerebellar hemisphere in 12 patients(p=0.028, 0.033). MTT and TP values of the contralateral and ipsilateral cerebellar hemispheres didn't reveal any differences(p=0.130, 0.121). Conclusions : The results of this work suggest that the region which are remote from the ischemic brain lesion shows no changes of MTT or TP but show decrease of rCBF and rCBV, mean to diaschisis, it also demonstrates that perfusion MRI is an easily available method to evaluate the hemodynamic status of the brain.

• Advances in Computational Design
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• v.3 no.3
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• pp.233-267
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• 2018

Conventional seismic design of concentrically braced frame (CBF) structures suggests that the gusset plate connecting a steel brace to beams and/or columns should be designed as non-dissipative in earthquakes, while the steel brace members should be designed as dissipative elements. These design intentions lead to thicker and larger gusset plates in design on one hand and a potentially under-rated contribution of gusset plates in design, on the other hand. In contrast, research has shown that compact and thinner gusset plates designed in accordance with the elliptical clearance method rather than the conventional standard linear clearance method can enhance system ductility and energy dissipation capacity in concentrically braced steel frames. In order to assess the two design methods, six cyclic push-over tests on full scale models of concentric braced steel frame structures were conducted. Furthermore, a 3D finite element (FE) shell model, incorporating state-of-the-art tools and techniques in numerical simulation, was developed that successfully replicates the response of gusset plate and bracing members under fully reversed cyclic axial loading. Direct measurements from strain gauges applied to the physical models were used primarily to validate FE models, while comparisons of hysteresis load-displacement loops from physical and numerical models were used to highlight the overall performance of the FE models. The study shows the two design methods attain structural response as per the design intentions; however, the elliptical clearance method has a superiority over the standard linear method as a fact of improving detailing of the gusset plates, enhancing resisting capacity and improving deformability of a CBF structure. Considerations were proposed for improvement of guidelines for detailing gusset plates and bracing members in CBF structures.

• Korean Journal of Biological Psychiatry
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• v.9 no.2
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• pp.152-158
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• 2002

Background & Purpose:Neuropsychological disorders after traumatic brain injury(TBI) are poorly correlated with structural lesions detected by structural neuroimaging techniques such as computed tomography(CT) scan or magnetic resonance imaging(MRI). It is well known that patients with TBI have cognitive and behavioral disorders even in the absence of structural lesions of the brain. This study investigated whether there are abnormalities of regional cerebral blood flow(rCBF) in TBI patients without structural abnormality on MRI, using technetium 99m ethyl cysteinate dimer(Tc-99m-ECD) single photon emission computed tomography(SPECT) scans. Materials and Methods:Twenty-eight TBI patients without structural abnormality on MRI(mild, n=13/moderate, n=9/severe, n=6) and fifteen normal controls were scanned by SPECT. A voxel-based analysis using statistical parametric mapping(SPM) was performed to compare the patients with the normal controls. Results:rCBF was reduced in the right uncus and the right lateral orbitofrontal gyrus in the TBI patients. However, no increase of rCBF was noted in the patients in comparison to the normal controls. Conclusions:These results suggest that the TBI patients, even in the absence of structural lesion of the brain, may have dysfunction of the brain, particularly of the orbitofrontal and anterior pole of the temporal cortex. They also suggest that SPECT can be a useful method to identify brain dysfunctions in combination with structural brain imaging and neuropsychological tests.