• Molecular & Cellular Toxicology
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• 제2권4호
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• pp.244-250
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• 2006

The detection of many synthetic chemicals used in industry that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. In this respect, to regulate and to evaluate the chemical hazard will be important to environment and human health. The genotoxicity of 3 synthetic chemicals was evaluated in L5178Y $tk^{+/-}$ mouse lymphoma cells in vitro. 9H-carbazole (CAS No. 86-74-8) did not induce significant mutation frequencies both in the presence and absence of metabolic activation system. 1, 3-Dichloro-2-propanol (CAS No. 96-23-1) revealed a significant increase of mutation frequencies in the range of $625-373\;{\mu}g/mL$ in the absence of metabolic activation system and $157-79\;{\mu}g/mL$ in the presence of metabolic activation system. And also, fenpropathrin (CAS No. 64257-84-7) appeared the positive results only in the absence of metabolic activation system. Through the results of MLA tk assay with 3 synthetic chemicals in L5178Y cells in vitro, we may provide the important clues on the genotoxic potentials of these 3 chemicals.

• 한국세라믹학회지
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• 제34권7호
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• pp.693-698
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• 1997

The refractive index and dispersion in the (100-x)(0.6CaO.0.4Al2O3).xSiO2(x=0~30) glasses were investigated. As the amount of SiO2 increased, the refractive index decreased. The change of refractive index was attributed to the change of the molar refraction rather than the molar volume. When the amount of SiO2 was smaller than 20 mol%, the average electronic transition energy gaps(E0) and the electronic oscillator strengths(Ed) were about 10.9($\pm$0.1) nd 18($\pm$0.5)eV, respectively. However E0 and Ed of the glass (CAS30) with 30 mol% SiO2 increased to 12.63 and 19.89eV, respectively. The similar results was observed in the variation of Abbe Number. Abbe number of the glass in the range of 0~20 mol% SiO2 was about 46 and that of CAS30 increased to 60. The zero-material dispersion wavelength({{{{ lambda }}0) of pure calcium aluminate glass was 1.8 ${\mu}{\textrm}{m}$. As the amount of SiO2 increased, the zero-material dispersion wavelength shifted to a shorter wavelength. {{{{ lambda }}0 of CAS30 was 1.5 ${\mu}{\textrm}{m}$, that is currently using for the optical telecommunication system.

• 한국세라믹학회지
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• 제53권6호
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• pp.700-706
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• 2016

Etch rate, surface roughness and microstructure as plasma resistance were evaluated for six kinds of oxide glass with different compositions. Borosilicate glass (BS) was found to be etched at the highest etch rate and zinc aluminum phosphate glass (ZAP) showed a relatively lower etch rate than borosilicate. On the other hand, the etching rate of calcium aluminosilicate glass (CAS) was measured to be similar to that of sintered alumina while yttrium aluminosilicate glass (YAS) showed the lowest etch rate. Such different etch rates by mixture plasma as a function of glass compositions was dependent on whether or not fluoride compounds were formed on glass and sublimated in high vacuum. Especially, in view that $CaF_2$ and $YF_3$ with high sublimation points were formed on the surface of CAS and YAS glasses, both CAS and YAS glasses were considered to be a good candidate for protective coating materials on the damaged polycrystalline ceramics parts in semi-conductor and display processes.

• 한국수정란이식학회지
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• 제29권4호
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• pp.339-344
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• 2014

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein (Cas9) system can be applied to produce transgenic pigs. Therefore, we applied CRISPR/Cas9 system to generate FoxN1-targeted pig parthenogenetic embryos. Using single guided RNA targeted to pig FoxN1 genes was injected into cytoplasm of in vitro matured oocyte before electrical activation. In results, regardless of the concentrations of vector, the cleavage rate were significantly (p<0.05) decreased ($4ng/{\mu}l$, 51.24%; $8ng/{\mu}l$, 40.88%; and $16ng/{\mu}l$; 45.22%) compared to no injection group (70.44%). The blastocyst formation rates were also decreased in vector injected 3 groups ($4ng/{\mu}l$, 7.96%; $8ng/{\mu}l$, 6.4%; and $16ng/{\mu}l$; 9.04%) compared to no injection group (29.07%). In addition, the blastocyst formation rates between sham injected group (13.51%) and no injection group (29.07%) also showed significant difference (p<0.05). The mutation rates were comparable between groups ($4ng/{\mu}l$, 18.4%; $8ng/{\mu}l$, 12.5%; and $16ng/{\mu}l$; 20.0%). The sequencing analysis showed that blastocysts derived from each group were successfully mutated in FoxN1 loci regardless of the vector concentrations. However, the deletion patterns were higher than the patterns of point mutation and insertion regardless of the vector concentrations. In conclusion, we described that cytoplasmic microinjection of FoxN1-targeted CRISPR/Cas9 vector could efficiently generate transgenic pig parthenogenetic embryos in one-step.

• 한국환경성돌연변이발암원학회지
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• 제21권1호
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• pp.14-22
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• 2001

The detection of many synthetic chemicals used in industry that may pose a genetic hazard in our environment is of great concern at present. In this respect, administrative authorities has great concern to regulate and to evaluate the chemical hazard to environment and human health. The clastogenicity of 28 synthetic chemicals was evaluated in Chinese hamster lung fibroblast cells in vitro. Glycidylacrylate which is one of the most cytotoxic chemical among 28 chemicals tested revealed clastogenicity in the range of 0.31-1.25 $\mu\textrm{g}$/$m\ell$ both in the presence and absence of metabolic activation system. Neopentyl glycol (340-1360 $\mu\textrm{g}$/$m\ell$) also revealed weak positive result both in the presence and absence of metabolic activation system. Cyanoguanidine (/$420.5-841 $\mu\textrm{g}$m\ell$) and N-butylchloride ($231.5-926 $\mu\textrm{g}$/m\ell$) revealed weak positive result only in the absence of S-9 metabolic activation system. Nevertheless total aberration percentages of N-butylchloride in the presence of metabolic activation system, and 3,4＇-dichlorobenztrifluoride in the absence of S-9 metabolic activation revealed above 5% aberration, there is no statistical significance. From the results of chromosomal aberration assay with 28 synthetic chemicals in Chinese hamster lung cells, glycidylacrylate (CAS No. 106-90-0), neopentyl glycol (CAS No. 126-30-7), N-butyl chloride (CAS No. 109-69-3) and cyanoguanidine (CAS No. 461-58-5) revealed positive clastogenic results in this study.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2003년도 봄 학술발표회 논문집
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• pp.375-382
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• 2003

This study, Using Pusan clay, examined a relationship between Dynamic and Static Liquid Tests. The Static Liquid Tests wow carried out based on BS and JIS. The results of the study are summarized as follows. (1) The result of the Dynamic Liquid Limit Test showed that the liquid limit values of air-dried soil were greater than those of oven-dried soil by 4%~15% (2) The liquid limit value of the Static Liquid Limit Test was greater than that of the Dynamic Liquid Limit Test by 2%~9%. The following equations show the relationship between the two values WL,Fall(JIS) = 0.961ㆍWL,Cas. + 4.209 WL,Fall(BS) = 0.969ㆍWL,Cas + 5.024 (3) The liquid limit value of BS was greater than that of JIS by 1%~6%. The following equation shows the relationship between the two values.

• 한국전기전자재료학회논문지
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• 제15권4호
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• pp.332-337
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• 2002

The applicability of models based on fractal geometry to characterize the surface of the EL devices was investigated. Insulating layer and phosphor layer of EL devices were deposited on ITO glass using e-beam method. The images of phosphor layer by scanning electron microscope(SEM) were transformed to binary coded data. The relations between fractal geometry and electrical characteristics of EL devices were investigated. When the fractal dimension of $Cas:EuF_3$ EL device was 1.82 and its grain boundary area was 19%, the brightness of $Cas:EuF_3$ EL device was 261 cd/$\textrm{m}^2$.

• 환경영향평가
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• 제24권2호
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• pp.134-153
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• 2015

도시 계획적 측면에서 도시의 구조적 변화에 따른 기후영향을 파악하여 그 결과를 도시계획에 반영하는 것은 중요하다. 서울시에서는 도시계획 시나리오 정보를 제공하기 위해 도시계획정보시스템(Urban Plan Information System, UPIS)을 활용 중이다. 지자체의 실제 도시계획에 따른 기후영향을 평가하고 분석하기 위해서는 UPIS에서 제공하는 도시계획시나리오와 도시기후분석모델을 손쉽게 연계할 수 있어야 한다. 본 연구에서는 국립기상과학원의 도시기후분석모델(Climate Analysis Seoul, CAS)과 도시계획 시나리오를 연계하는 기술을 개발하였다. CAS는 건물과 식생의 물리적 배치에 따른 온도, 바람 등의 국지규모 변화와 중규모 기상모델인 MetPhoMod(METeorology and atmospheric PHOtochemistry mesoscale MODel)의 분석결과를 바탕으로 찬공기의 생성, 이동, 정체와 바람흐름, 열적환경 등을 분석하는 기능을 가지고 있다. 정밀한 도시정보를 모델에 적용하기 위해 고해상도의 항공 LiDAR(LIgit Detection And Ranging) 측량을 통해 생성된 래스터자료(1m 해상도)와 KOMPSAT-2(KOrea Multi-Purpose SATellite) 위성영상 자료(4m 해상도)를 이용하여 토지피복 및 수치표고자료로 활용할 입력자료를 생성하였다. 보다 정확한 도시지면 특징을 반영하기 위해 수치표면모델인 DSM(Digital Surface Model)과 수치지형모델인 DTM(Digital Terrain Model)을 전산유체역학모델(Computational Fluid Dynamics, CFD) 입력자료로 사용하여 상세바람분석을 수행하였다. 8방위의 유입류를 고려하여 재정비 전후의 도시구조물 주변의 흐름 및 풍속 분포와 녹지축 형성 전후의 열환경 변화를 분석하였다. 현실적인 기상상태 반영을 위해 CAS의 중규모 기상장을 입력자료로 사용하였으며, 그 결과 재정비에 따른 도시구조물 변화에 의해 바람길에 큰 변화가 확인되었다. 녹지축 형성 이후 전반적으로 재정비지역 주변의 온도가 감소하였다. CAS와 CFD의 연동을 통해 도시지역 재정비와 녹지축 형성 전후의 주변 바람길과 열환경에 대한 실제적인 평가가 가능하며, 도시개발계획과 녹지조성계획 수립에 유용할 것으로 기대된다.

• 한국해안해양공학회지
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• 제17권2호
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• pp.80-85
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• 2005

본 연구는 국내 토질특성에 적합한 Cone관입 시헙법 제정의 기초자료를 제공할 목적으로 수행되었으며, 부산 점토를 이용하여 정적 액성한계시험과 동적 액성한계시험의 상호관계를 규명하고자 하였다. 또한 정적 액성한계시험법에 있어서는 일본 규정과 영국 규정에 의한 시험을 동일 시료에 대하여 각각 수행하여 비교 검토하였다. 그 결과 다음과 같은 결론을 얻을 수 있었다. 1) 건조상태가 다른 두 종류의 시료에 대한 동적 액성한계시험 결과, 자연시료를 사용하여 구한 액성한계 값이 노건조시료를 사용한 액성한계 값보다 $4\%\~15\%$ 크게 나타났다. 2) 동적 액성한계시험과 정적 액성한계시험으로 구한 액성한계 값을 상호 비교한 결과, 정적 액성한계시험으로 구한 액성한계 값이 동적 액성한계시험으로 구한 액성한계 값 보다 $2\%\~9\%$크게 나타났다. 상호 관계식은 다음과 같으며, 이 결과는 Belviso et al.의 연구 결과와 일치함을 알 수 있었다. (1) WL, Fall(JIS)=0.961·WL, Cas+4.209, (2) WL, Fall(BS)=0.969$\cdot$WL, Cas+5.024, (3) 3) 정적 액성한계시험에 있어서 BS 규정과 JIS 규정으로 산출된 액성한계 값을 상호 비교한 결과, BS규정에 의해 산출된 액성한계 값이 JIS규정에 의해 산출된 액성한계 값보다 약 $3\%$ 크게 나타났다 (4) 상호 관계식은 다음과 같다. (5) WL, Fall(BS)=0.976WL, Fall(JIS)+2.638.

• 대한원격탐사학회지
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• 제38권3호
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• pp.311-326
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• 2022

우리나라 산림의 효율적인 관리와 산림 모니터링을 위해 산림청은 농림위성을 개발 중이며 2025년 발사 예정이다. 농림위성을 효율적으로 활용하기 위해 산림청 국립산림과학원은 36종의 농림위성 산림분야 활용산출물 개발을 진행 중이다. 원격탐사 기법을 활용하여 도출된 산출물들은 지상검증이 요구되며 해당 산출물들에 대한 품질 모니터링 결과를 지속적으로 보고해야 한다. 국내 최초로 산림분야 활용 위성이 개발되는 상황이라 국내에는 공식적인 산림분야 활용 산출물 검보정 사이트가 부재하다. 이에 저자들은 국제기준에 맞춰 농림위성 산림분야 활용산출물 검보정을 위한 검보정 사이트를 설계하였다. 또한 전국적으로 검보정 사이트를 설치하기 위해 적정 센서를 선택하여 해당 센서의 활용 가능성을 평가하였다. 평가 결과 지상 관측데이터와 Sentinel-2 영상과의 산림 산출물에 대한 오차가 ±5% 이내로 관측되어 해당 센서를 활용하여 전국적으로 확장이 가능함을 확인하였다.