• Journal of Periodontal and Implant Science
• /
• 제46권1호
• /
• pp.22-34
• /
• 2016

Purpose: Gingival recession is a major esthetic concern and may lead to root sensitivity during periodontal treatment. Coronally advanced flaps (CAFs) with and without acellular dermal matrix (ADM) are widely used in root coverage procedures. The aim of this study was to analyze the efficacy of CAF in combination with ADM in the treatment of gingival recession. Methods: PubMed, The Cochrane Library, and Embase were used to identify relevant articles. The articles were screened, data were extracted, and the quality of the studies was assessed by three reviewers with expertise in clinical practice, trials, statistics, and biomedical editing. The clinical endpoints of interest included changes in recession, probing depth (PD), clinical attachment level (CAL), and keratinized tissue (KT). Results: Ten randomized controlled trials were identified, including six studies that compared CAFs with ADM and CAFs using connective tissue grafting (CTG) and four studies that compared CAFs with or without ADM. No statistically significant differences were found between the use of ADM and CTG, whereas statistically significant differences were found between groups in which ADM and CAF were combined and groups that underwent CAF alone with regard to recession coverage, CAL, and KT. The combination of CAF with an ADM allograft achieved more favorable recession coverage and recovery of CAL and KT than CAF alone. Conclusions: The results from the ADM and CTG groups suggest that both procedures may be equally effective in clinical practice. Given the limitations of this study, further investigation is needed to clarify the effectiveness of ADM and CAF in clinical practice.

• 한국터널지하공간학회 논문집
• /
• 제18권5호
• /
• pp.413-418
• /
• 2016

최근 한중, 한일 해저터널과 같은 대규모 프로젝트가 구체화되고 있으며, 해저터널에 대한 관심이 높아지고 있다. 해저터널은 일반 지상터널에 비해 열차화재에 따른 대규모 피해가 발생할 수 있으며, 기존의 일반터널 방재설계 이외에도 효율적인 소화방안에 관한 연구가 필요하다. 이에 따라, 본 연구에서는 열차화재를 구난역에서 신속하게 진압하기 위하여, 일반적인 포 소화설비를 개량한 '압축공기포(CAF) 소화설비'를 활용한 실물 화재실험을 7차례 수행하였다. 실험은 가상의 터널에 구난역을 설치하고 KTX 열차의 1 량 규모의 가상열차를 대상으로 실시하였다. 압축공기포를 화원에 직접 분사한 경우에 햅탄(Heptane) 원료 30 L의 가연물을 1분 이내에 소화시켰다. 본 실험 연구를 통하여 해저터널 구난역 열차화재 소화설비에 압축공기 포 소화설비가 적합한지 확인하였으며, 해저터널 외에 일반터널에서도 CAF가 갖는 장점을 활용하여 빠르고 손쉬운 소화가 가능하도록 노즐 각도 및 설치위치 등을 변경하여 소화수와 소화약제를 최소화하기 위하여 추가로 실험 연구를 진행해야 한다고 판단된다.

• Clinical and Experimental Pediatrics
• /
• 제51권10호
• /
• pp.1118-1122
• /
• 2008

단일관상동맥에서 우심실로 유출되는 동정맥루는 보고가 매우 드물며 이 경우 치료 방침이나 예후에 대해 명확하지 않다. 저자들은 지속성심잡음이 들려 시행한 심초음파 검사상 단일 좌관상동맥이 확장되어 있으며 우심실로 유출되는 동정맥루를 진단하였으며 관상동맥조영술로 확진하였다. 체외순환하에 우심실에서 동정맥루를 결찰하였다. 18개월 후 추적시 증상은 없었고 관상동맥조영술상 동정맥루의 재발도 없었다.

• BMB Reports
• /
• 제39권3호
• /
• pp.304-310
• /
• 2006

Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II detoxifying enzymes and antioxidant enzymes in response to many cancer chemopreventive compounds. In this study, we investigated the role of receptor associated coactivator (RAC3) or steroid receptor coactivator-3 (SRC3) and other nuclear co-regulators including CBP/p300 (CREB-binding protein), CARM1 (Coactivator-associated arginine methyltransferase), PRMT1 (Protein arginine methyl-transferase 1), and p/CAF (p300/CBP-associated factor) in the transcriptional activation of a chimeric Gal4-Nrf2-Luciferase system containing the transactivation domain (TAD) of Nrf2 in HepG2 cells. The results indicated that RAC3 up-regulated the transactivation activity of Gal4-Nrf2-(1-370) in a dose-dependent manner. The enhancement of transactivation domain activity of Gal4-Nrf2-(1-370) by RAC3 was dampened in the presence of dominant negative mutants of RAC3. Next we studied the effects of other nuclear co-regulators including CBP/p300, CARM1, PRMT1 and p/CAF, and the results showed that they had different level of positive effects on this transactivation domain activity of Gal4-Nrf2-(1-370). But importantly, synergistic effects of these co-regulators in the presence of RAC3/SRC3 on the transactivation activity of Gal4-Nrf2-(1-370) were observed. In summary, our present study showed for the first time that the 160 RAC3/SRC3 is involved in the functional transactivation of TAD of Nrf2 and that the other nuclear co-regulators such as CBP/p300, CARM1, PRMT1 and p/CAF can also transcriptionally activate this TAD of Nrf2 and that they could further enhance the transactivation activity mediated by RAC3/SRC3.

• Tuberculosis and Respiratory Diseases
• /
• 제86권4호
• /
• pp.304-318
• /
• 2023

Background: Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and significantly contribute to immune evasion. We investigated the effects of CAFs on the immune function of CD4+ and CD8+ T cells in non-small cell lung cancer (NSCLC). Methods: We isolated CAFs and normal fibroblasts (NFs) from tumors and normal lung tissues of NSCLC patients, respectively. CAFs were co-cultured with activated T cells to evaluate their immune regulatory function. We investigated the effect of CAF conditioned medium (CAF-CM) on the cytotoxicity of T cells. CAFs were also co-cultured with activated peripheral blood mononuclear cells and further incubated with cyclooxygenase-2 (COX2) inhibitors to investigate the potential role of COX2 in immune evasion. Results: CAFs and NFs were isolated from the lung tissues (n=8) and lymph nodes (n=3) of NSCLC patients. Immune suppressive markers, such as COX2 and programmed death-ligand 1 (PD-L1), were increased in CAFs after co-culture with activated T cells. Interestingly, CAFs promoted the expression of programmed death-1 in CD4+ and CD8+ T cells, and strongly inhibited T cell proliferation in allogenic and autologous pairs of CAFs and T cells. CAF-CM decreased the cytotoxicity of T cells. COX2 inhibitors partially restored the proliferation of CD4+ and CD8+ T cells, and downregulated the expression of COX2, prostaglandin E synthase, prostaglandin E2, and PD-L1 in CAFs. Conclusion: CAFs promote immune evasion by suppressing the function of CD4+ and CD8+ T cells via their effects on COX2 and PD-L1 in NSCLC. The immunosuppressive function of CAFs could be alleviated by COX2 inhibitors.

• 한국조리학회지
• /
• 제24권1호
• /
• pp.82-95
• /
• 2018

The purpose of this study is to investigate the relationship between experiential value, customer loyalty and eating out tendency of dessert $caf{\acute{e}}$ in college students. This survey was conducted for college students who have used dessert $caf{\acute{e}}$ mainly in college areas where dessert cafes are concentrated in Seoul. The survey was conducted on August 17, 2017 to 28 August. A total of 250 copies of the questionnaires were distributed and 208 copies of valid data were used for the analysis. The results of the analysis are as follows. First, emotional experience value and service experience value were found to affect customer loyalty, and cognitive experience value did not affect customer loyalty. Second, the economic and health seeking type showed a positive(+) moderating effect between emotional experience value and customer loyalty, and negative(-) moderating effect between cognitive experiential value and customer loyalty. Next, atmosphere seeking type showed a moderating effect between service experience value and customer loyalty, and the eating out seeking type showed a moderating effect between emotional experience value and customer loyalty. Finally, convenience seeking type showed positive(+) moderating effect between cognitive experiential value and customer loyalty, and negative(-) moderating effect between service experience value and customer loyalty. Based on the results of this study, the dessert cafe operator can grasp the experience value of college students in order to secure college students who are using dessert cafe as loyal customers. In particular, the relationship between experience value and customer loyalty, it is expected to provide useful data for constructing a specific positioning strategy according to each segment market.

• Investigative Magnetic Resonance Imaging
• /
• 제21권4호
• /
• pp.259-263
• /
• 2017

Calcifying aponeurotic fibroma (CAF) is an uncommon benign tumor and a locally aggressive fibroblastic lesion. It commonly affects the palmar side of the hand and fingers, and the soles of the feet. The typical clinical manifestations are known as a poorly circumscribed, slow-growing, and asymptomatic firm mass. Most CAFs usually reveal low to intermediate or isointensity on T1-weighted images, and strong heterogeneous enhancement. However, various signal intensities on T2-weighted images have been reported depending on the degree of hypocellularity or the amount of calcification or collagen within the tumor. This report provides the radiographic and MRI finding of CAF arising in uncommon site, the knee region, of a 19-year-old male who presented with a painful and palpable mass.

• 한국어교육
• /
• 제28권4호
• /
• pp.1-38
• /
• 2017

This longitudinal study analyzed syntactic development (Complexity, Accuracy, and Fluency; CAF) of six L2 Korean learners in a natural learning context. The learners recalled the stories of a short animated video through speaking and writing every 3 months, from month 0 to 15. The learners' responses were analyzed for a series of CAF measures and their cognitive, psychological, and social variables were investigated. The results showed that (i) L2 Korean learners' speaking and writing in various time periods showed significant differences in spoken and written accuracy, and complexity; (ii) the correlation between spoken and written complexity, spoken and written accuracy, as well as spoken and written fluency were significant, and (iii) the regression analysis showed that learners' cognitive, social, and psychological variables have significant effect on the L2 Korean syntactic development. The current study reports that L2 Korean learners engaged in self-learning in a natural learning environment without formal instruction made significant syntactic development.

• 동아시아식생활학회지
• /
• 제17권3호
• /
• pp.409-416
• /
• 2007

본 연구는 일상의 기호 음료이며 기능성 식품으로 각광을 받고 있는 녹차 중 수공 덖음 제다기법으로 제조한 보성 녹차의 제조 공정 및 저장 보관 중의 catechin 및 alkaloids의 함량 변화를 파악하고자 HPLC 와 UV-VIS Spectrophotometer 를 이용하여 실험하였다. 그 결과는 다음과 같다. 덖음차 제조 과정 중의 catechin, alkaloid 류의 변화를 조사한 결과, 차나무로부터 채취한 신선한 차잎은 EGCG 가 50.44 mg/g 으로 가장 많았으며 다음이 ECG 28.41 mg/g, CAF 25.13 mg/g, CG 가 1.26 mg/g, THB 1.24 mg/g, THP 0.10 mg/g 으로 소량 함유되어 있었다. Catechin, alkaloid류의 각 제조 과정 중의 함량 변화를 살펴보면 CG 를 제외한 모든 성분에서 제조 과정중의 유의미한 차이를 나타내었다(p<0.05, p<0.01, p<0.001). Catechin의 함량은 생잎일 때는 6.58 mg/g 이었으나 건조 후에는 증가하는 경향을 보였으며, GCG는 생잎일 때는 6.43 mg/g 이었으나 건조 후에는 3.61 mg/g 으로 급격하게 감소하였다. 또한 THB와 THP 역시 생잎일 때보다 건조한 후에 함량이 증가하는 것을 알 수 있었다. 또한, 저장 중 녹차 잎의 catechin 과 alkaloid 류의 함량 변화를 조사해 본 결과, $5^{\circ}C,\;25^{\circ}C$ 저장 중의 녹차 잎 모두에서 EGCG, ECG, CAF의 감소가 많았고, 1 년간 저장 시에는 $20{\sim}30%$나 감소하였으며, 저장 온도에 따른 catechin 및 alkaloid 류의 양적 차이는 거의 나타나지 않아 저장 온도에 따른 catechin 과 alkaloid 류의 함량 변화는 거의 없는 것을 알 수 있었다.

• Journal of Chest Surgery
• /
• 제57권1호
• /
• pp.79-86
• /
• 2024

Background: This study investigated the surgical outcomes associated with coronary artery fistulas (CAFs) in children. Methods: We retrospectively reviewed the medical records of 23 pediatric patients who underwent surgical closure of CAFs between 1995 and 2021. At presentation, 7 patients (30.4%) exhibited symptoms. Associated cardiac anomalies were present in 8 patients. Fourteen fistulas originated from the right coronary artery and 9 from the left. The most common drainage site was the right ventricle, followed by the right atrium and the left ventricle. The median follow-up duration was 9.3 years (range, 0.1-25.6 years) Results: The median age and body weight at repair were 3.1 years (range, 0-13.4 years) and 14.4 kg (range, 3.1-42.2 kg), respectively. Cardiopulmonary bypass was used in 17 cases (73.9%), while cardioplegic arrest was employed in 14 (60.9%). Epicardial CAF ligation was utilized in 10 patients (43.5%), the transcoronary approach in 9 (39.1%), the endocardial approach in 2 (8.7%), and other methods in 2 patients (8.7%). The application of cardioplegic arrest during repair did not significantly impact the duration of postoperative intensive care unit stay or overall hospital stay. One in-hospital death and 1 late death were recorded. The overall survival rate was 95.7% at 10 years and 83.7% at 15 years. A residual fistula was detected in 1 patient. During the follow-up period, no surviving patient experienced cardiovascular symptoms or coronary events. Conclusion: Surgical repair of CAF can be performed safely with or without cardioplegic arrest, and it is associated with a favorable prognosis in children.