• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 2002년도 춘계학술발표대회 및 심포지움
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• pp.215-215
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• 2002

Catalytic subunit of pyruvate dehydrogenase phosphatase (PDPc) has been suggested to have three major funational domains such as dihydrplipoamide adetyltransferase(E2)-binding domain, regulatory subunit of PDP(PDP)r-binding domain, and calcium-binding domain. In order to identify functional domains, recombinant catalytic subunit of pyruvate dehydrogenase phosphatase(rPDPc) was expressed in E. coli JM101 and purified to near homogeneity using the unique property of PDPc: PDPc binds to the inner lipoyl domain (L2) of E2 of ppyruvate dehydrogenase complex (PDC) in the presence of Ca+2, not under EGTA. PDPc was limited-proteolysed by typsin, chymotypsin, Arg-C, and elastase at pH 7.0 and 30C and N-terminal analysis of the fragments was done. Chymotrypsin, trypsin, and elastase made two major fragments: N-terminal large fragment, approx. 50kD and C-terminal small fragment, approx.10 kDa. Arg-C made three major fragments: N-terminal fragment, approx. 35kD, and central fragment, approx. 15 kD, and C-terminal fragment, approx. 10 kD. This study strongly suggest that PDPc consists of three major functional domains. However, further study should be necessary to identify the functional role.

• Molecules and Cells
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• 제22권1호
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• pp.13-20
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• 2006

Hepatitis C virus (HCV) non-structural protein 5A protein (NS5A), which consists of three functional domains, is involved in regulating viral replication, interferon resistance, and apoptosis. Recently, the three-dimensional structure of the domain 1 was determined. However, currently the molecular basis for the domains 2 and 3 of HCV NS5A is yet to be defined. Toward this end, we expressed, purified the domain 2 of the NS5A (NS5A-D2), and then performed biochemical and structural studies. The purified domain 2 was active and was able to bind NS5B and PKR, biological partners of NS5A. The results from gel filtration, CD analysis, 1D $^1H$ NMR and 2D $^1H-^{15}N$ heteronuclear single quantum correlation (HSQC) spectroscopy indicate that the domain 2 of NS5A appears to be flexible and disordered.

• Korean Journal of Mathematics
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• 제19권4호
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• pp.343-349
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• 2011

Let D be an integral domain, $D^w$ be the $w$-integral closure of D, X be an indeterminate over D, and $N_v=\{f{\in}D[X]{\mid}c(f)_v=D\}$. In this paper, we introduce the concept of $t$-locally APVD. We show that D is a $t$-locally APVD and a UMT-domain if and only if D is a $t$-locally APVD and $D^w$ is a $PvMD$, if and only if D[X] is a $t$-locally APVD, if and only if $D[X]_{N_v}$ is a locally APVD.

• 대한수학회보
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• 제50권6호
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• pp.1905-1914
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• 2013

Let D be an integral domain with quotient field K, M a torsion-free D-module, X an indeterminate, and $N_v=\{f{\in}D[X]|c(f)_v=D\}$. Let $q(M)=M{\otimes}_D\;K$ and $M_{w_D}$={$x{\in}q(M)|xJ{\subseteq}M$ for a nonzero finitely generated ideal J of D with $J_v$ = D}. In this paper, we show that $M_{w_D}=M[X]_{N_v}{\cap}q(M)$ and $(M[X])_{w_{D[X]}}{\cap}q(M)[X]=M_{w_D}[X]=M[X]_{N_v}{\cap}q(M)[X]$. Using these results, we prove that M is a strong Mori D-module if and only if M[X] is a strong Mori D[X]-module if and only if $M[X]_{N_v}$ is a Noetherian $D[X]_{N_v}$-module. This is a generalization of the fact that D is a strong Mori domain if and only if D[X] is a strong Mori domain if and only if $D[X]_{N_v}$ is a Noetherian domain.

• Applied Biological Chemistry
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• 제32권2호
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• pp.126-131
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• 1989

암소에서 기른 귀리로부터 얻은 59 kD phytochrome의 liposome과 Cibacron Blue dye에 대한 결합성질을 규명하였다. 124 kD 및 118 kD phytochrome과는 달리 Pfr형의 59 kD phytochrome은 liposome 및 Cibacron Blue dye와 정전기적 힘으로 결합한다. 이러한 결과는 124 kD 및 118 kD phytochrome이 Pr형에서 Pfr형으로 광변환시 노출되는 소수표면이 59kD Pfr에는 존재하지 않음을 의미한다. 비교적으로 강한 소수부분이 59 kD polypeptide에 존재함이 알려져 있으므로 C-말단부위로부터 잘려져나간 55 kD tryptic domain이 l18kD 및 124kD Pfr의 소수표면 노출에 중요할 역할을 하는 것으로 믿어진다.

• 대한수학회보
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• 제44권4호
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• pp.731-742
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• 2007

Let X be a Banach space, $A:D(A){\subset}X{\rightarrow}X$ the generator of a compact $C_0-semigroup\;S(t):X{\rightarrow}X,\;t{\geq}0$, D a locally closed subset in X, and $f:(a,b){\times}C([-q,0];X){\rightarrow}X$ a function of Caratheodory type. The main result of this paper is that a necessary and sufficient condition in order that D be a viable domain of the semi linear differential equation of retarded type $$u#(t)=Au(t)+f(t,u_t),\;t{\in}[t_0,\;t_0+T],{u_t}_0={\phi}{\in}C([-q,0];X)$$ is the tangency condition $$\limits_{h{\downarrow}0}^{lim\;inf\;h^{-1}d(S(h)v(0)+hf(t,v);D)=0}$$ for almost every $t{\in}(a,b)$ and every $v{\in}C([-q,0];X)\;with\;v(0){\in}D$.

• Korean Journal of Mathematics
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• 제25권2호
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• pp.215-227
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• 2017

Let D be an integral domain with quotient field K, X be an indeterminate over D, K[X] be the polynomial ring over K, and $R=\{f{\in}K[X]{\mid}f(0){\in}D\}$; so R is a subring of K[X] containing D[X]. For $f=a_0+a_1X+{\cdots}+a_nX^n{\in}R$, let C(f) be the ideal of R generated by $a_0$, $a_1X$, ${\ldots}$, $a_nX^n$ and $N(H)=\{g{\in}R{\mid}C(g)_{\upsilon}=R\}$. In this paper, we study two rings $R_{N(H)}$ and $Kr(R,{\upsilon})=\{{\frac{f}{g}}{\mid}f,g{\in}R,\;g{\neq}0,{\text{ and }}C(f){\subseteq}C(g)_{\upsilon}\}$. We then use these two rings to give some examples which show that the results of [4] are the best generalizations of Nagata rings and Kronecker function rings to graded integral domains.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.250-253
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• 2005

A Programmable Automation Controller (PAC) has been developed by Turbotek Co., Ltd. The developed system has multi-domain functionality-including sequence control, motion control and HMI- on a single platform. The PAC also has a common development platform for the design and integration of multi-domain automated systems. Since hardware of the developed system has modular architectures, performance and specification of the controller are determined by combination of specific modules. The developed system employs de facto standards such as OPC interface that allow users to easily exchange data as part of networked multi-vendor systems.

• 정보처리학회논문지D
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• 제18D권5호
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• pp.329-338
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• 2011

문헌에서의 전문용어 인식 연구는 정보검색, 정보추출, 시맨틱 웹, 질의응답 분야 등의 연구를 위한 선행 연구로서, 지금까지 대부분 특정 분야, 특히 생의학 분야에서 집중되어 연구되어 왔다. 그러나 기존 연구들이 특정 도메인 또는 문헌 내부 통계 정보를 활용함으로써 범용적인 전문용어 인식에 한계점을 보여 왔기 때문에, 본 연구에서는 웹 검색 결과와 사전, 후보용어의 문형 특징 등을 활용하는 기계 학습 기반 범용 전문용어 인식 방법을 제안하였다. 제안한 방법을 문헌의 지역 통계 정보를 사용하는 방법(C-value)과 비교 실험하여 80.8%의 F-값으로 6.5%의 성능향상을 보였다. 다양한 응집도 자질들을 접목한 두 번째 실험에서는 Normalized Google Distance 방법과 접목한 방식이 F-값 81.8%의 성능으로 최고의 성능을 나타냈다. 기계 학습 방법으로는 로지스틱 회귀분석, C4.5, SVMs 등을 적용하였는데, 일반적으로 이진 분류에 좋은 성능을 보이는 SVMs과 로지스틱 회귀분석 방법보다 결정 트리 방식의 C4.5가 전반적으로 좋은 성능을 보였다.