• Journal of the Korean Institute of Telematics and Electronics C
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• v.34C no.12
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• pp.20-27
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• 1997

In this paper, a multiplying digital-to-analog converter (MDAC) circuit for low-power high-resolution CMOS algorithmic A/D converters (ADC's) is proposed. The proposed MDAC is designed to operte properly at a supply at a supply voltge between 3 V and 5 V and employs an analog0domain power reduction technique based on a bias switching circuit so that the total power consumption can be optimized. As metal-to-metal capacitors are implemented as frequency compensation capacitors, opamps' performance can be varied by imperfect process control. The MDAC minimizes the effects by the circuit performance variations with on-chip tuning circuits. The proposed low-power MDAC is implementd as a sub-block of a 10-bit 200kHz algorithmic ADC using a 0.6 um single-poly double-metal n-well CMOS technology. With the power-reduction technique enabled, the power consumption of the experimental ADC is reduced from 11mW to 7mW at a 3.3V supply voltage and the power reduction ratio of 36% is achieved.

• Journal of the Korean Magnetic Resonance Society
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• v.15 no.2
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• pp.115-127
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• 2011

A newly developed cost-effective approach to prepare $^{15}N/^{13}C$-labeled protein for NMR studies is presented. This method has been successfully applied to isotopically labeling of PTK6 SH2 domain and MTH 1880 protein. The production method generates cell density using a growing media containing $^{15}NH_4Cl$, $^{12}C_6$-D-glucose. Following a doubling time period for unlabeled metabolite exhaustion and then addition $^{13}C_6$-D-glucose into a M9 growing media, the cells are induced. Our results demonstrate that in order to get full incorporation of $^{13}C$, the isotopes are not totally required during the initial growth phase before induction. The addition of small amounts of $^{13}C_6$-D-glucose to the induction phase is sufficient to obtain more than 95% incorporation of isotopes into the protein. Our optimized protocol is two-thirds less costly than the classical method using $^{13}C$ isotope during the entire growth phase.

• JSTS:Journal of Semiconductor Technology and Science
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• v.15 no.6
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• pp.695-702
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• 2015

A 1-V 1.6-GS/s 5.58-ENOB flash ADC with a high-speed time-domain comparator is proposed. The proposed time-domain comparator, which consumes low power, improves the comparison capability in high-speed operations and results in the removal of preamplifiers from the first-stage of the flash ADC. The time interpolation with two factors, implemented using the proposed time-domain comparator array and SR latch array, reduces the area and power consumption. The proposed flash ADC has been implemented using a 65-nm 1-poly 8-metal CMOS process with a 1-V supply voltage. The measured DNL and INL are 0.28 and 0.41 LSB, respectively. The SNDR is measured to be 35.37 dB at the Nyquist frequency. The FoM and chip area of the flash ADC are 0.38 pJ/c-s and $620{\times}340{\mu}m^2$, respectively.

• BMB Reports
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• v.46 no.1
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• pp.53-58
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• 2013

We constructed deletion mutants and seven point mutants by polymerase chain reaction to investigate the specificity of feline foamy virus integrase functional domains. Complementation reactions were performed for three enzymatic activities such as 3'-end processing, strand transfer, and disintegration. The complementation reactions with deletion mutants showed several activities for 3'-end processing and strand transfer. The conserved central domain and the combination of the N-terminal or C-terminal domains increased disintegration activity significantly. In the complementation reactions between deletion and point mutants, the combination between D107V and deletion mutants revealed 3'-end processing activities, but the combination with others did not have any activity, including strand transfer activities. Disintegration activity increased evenly, except the combination with glutamic acid 200. These results suggest that an intact central domain mediates enzymatic activities but fails to show these activities in the absence of the N-terminal or C-terminal domains.

• Structural Engineering and Mechanics
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• v.22 no.1
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• pp.53-70
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• 2006

The paper summarizes the dynamic-based assessment of a reinforced concrete arch bridge, dating back to the 50's. The outlined approach is based on ambient vibration testing, output-only modal identification and updating of the uncertain structural parameters of a finite element model. The Peak Picking and the Enhanced Frequency Domain Decomposition techniques were used to extract the modal parameters from ambient vibration data and a very good agreement in both identified frequencies and mode shapes has been found between the two techniques. In the theoretical study, vibration modes were determined using a 3D Finite Element model of the bridge and the information obtained from the field tests combined with a classic system identification technique provided a linear elastic updated model, accurately fitting the modal parameters of the bridge in its present condition. Hence, the use of output-only modal identification techniques and updating procedures provided a model that could be used to evaluate the overall safety of the tested bridge under the service loads.

• Bulletin of the Society of Naval Architects of Korea
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• v.24 no.2
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• pp.36-46
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• 1987

This paper presents the results of seakeeping tests in a container ship model in irregular head waves. A time domain signal generating procedure is devised so that the wave maker behaves in accordance with the specified wave spectrum. The surface elevation of generated waves is measured and analysed to render the recorded wave spectrum for comparison with the specified one. Correction is made to the time domain signal until the differences between the two spectra become negligible. The motion responses and vertical acceleration of the self-propelled ship model are measured and analysed by both the spectral and the double amplitude methods. The two methods give nearly same statistical values. Finally the recorded spectra are compared with those calculated from the frequency domain motion analysis to show the credibility of the experimental results.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.249-255
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• 2005

Angiotensin-converting enzyme (ACE) is primarily responsible for human hypertension. Current ACE drugs show serious cough and angiodema health problems due to the un-specific activity of the drug to ACE protein. The availability of ACE crystal structure (1UZF) provided the plausible biological orientation of inhibitors to ACE active site (C-domain). Three-dimensional quantitative structure-activity relationship (3D-QSAR) models have been constructed using the comparative molecula. field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) for a series of 28 ACE inhibitors. Alignment for CoMFA obtained by docking ligands to 1UZF protein using FlexX program showed better statistical model as compared to superposition of corresponding atoms. The statistical parameters indicate reasonable models for both CoMFA (q$^2$ = 0.530, r$^2$ = 0.998) and CoMSIA (q$^2$= 0.518, r$^2$ = 0.990). The 3D-QSAR analyses provide valuable information for the design of ACE inhibitors with potent activity towards C-domain of ACE. The group substitutions involving the phenyl ring and carbon chain at the propionyl and sulfonyl moieties of captopril are essential for specific activity to ACE.

• Nuclear Engineering and Technology
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• v.55 no.8
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• pp.2952-2965
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• 2023

Advanced reactors, such as Small Modular Reactors or existing Nuclear Power Plants, often use Field Programmable Gate Array (FPGA) based controllers in new Instrumentation and Control (I&C) system architectures or as an alternative to existing analog-based I&C systems. Compared to CPU-based Programmable Logic Controllers (PLCs), FPGAs offer better overall performance. However, programming functions on FPGAs can be challenging due to the requirement for a hardware description language that does not explicitly support the operation of real numbers. This study aims to implement the Reactor Trip (RT) functions of the existing analog-based Reactor Protection System (RPS) using FPGAs. The RT equations for Overtemperature delta Temperature and Overpower delta Temperature involve dynamic compensators expressed with the Laplace transform variable, 's', which is not directly supported by FPGAs. To address this issue, the trip equations with the Laplace variable in the continuous-time domain are transformed to the discrete-time domain using the Z-transform. Additionally, a new operation based on a relative value for the equation range is introduced for the handling of real numbers in the RT functions. The proposed approach can be utilized for upgrading the existing analog-based RPS as well as digitalizing control systems in advanced reactor systems.

• Korean Journal of Microbiology
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• v.49 no.1
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• pp.8-16
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• 2013

A GAL4 type transcription factor gene (formally annotated as AN3912) locating downstream of sndA (AN3911) was characterized. The putative transcription factor carries both Zn(II)2Cys6 binuclear cluster DNA-binding domain and transcription activator domain. The gene named gtfA (gal4 type transcription factor) had an open reading frame which consisted of 762 amino acids and was disrupted by three introns. The deletion mutant produced reduced amount of conidia but increased amount of fruiting bodies, suggesting that the GtfA make function in decision of asexual preferential to sexual development. The forced over expression of gtfA caused the retardation of fruiting body formation on high glucose concentration. The transcript level of gtfA was kept constant through the life cycle except late vegetative stage and early sexual development stage during which slight increase was found. The expression of gtfA was not significantly affected by sexual or asexual development regulators, such as VeA, NsdD or FluG, FadA, and SfaD. The GtfA repressed the nsdC transcription, which suggested that GftA control sexual development negatively via negative regulation of nsdC expression.

• 전기의세계
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• v.19 no.4
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• pp.12-17
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• 1970

BaO.nFe$_{2}$O$_{3}$ Powder ferrite magnet was made by sintering process. The purity of the powder were 99.6% far BaO. 99.5% for Fe$_{2}$O$_{3}$, and the grain size 1-3 micron. The Optimum mixing ratio n=4.4 the optimum density 4.8gr/cm$^{3}$ and the optimum second sintering temperature 1260.deg. C was found. The theoretical bloch wall, dimension of domain and energy per unit volume of BaFe$_{12}$O$_{19}$ were compared with pure Fe. Also, the saturation magnetization and maximum energy product were computed.d.d.